According to the product safety data and toxicological evaluation provided by Hai'an Guoli Chemical Co., Ltd., PEG400MO (Polyethylene Glycol 400 Monooleate) poses extremely low risk to human health under normal conditions of use. This product is not classified as any physical, health, or environmental hazard under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or the EU CLP regulation, demonstrating overall excellent safety performance.
From a toxicological perspective, the acute oral toxicity test (rats) shows an LD₅₀ greater than 5,000 mg/kg, indicating low toxicity level; the acute dermal toxicity test (rabbits) shows an LD₅₀ greater than 2,000 mg/kg, also within the low toxicity range. In the skin irritation test, the primary irritation index (PII) was 0.0, indicating no skin irritation; the skin sensitization test (guinea pigs) was negative, showing no sensitizing potential. Only in the eye irritation test, it may cause slight transient discomfort, with a 24-hour average score below 2.0, classified as a very mild reaction. Overall, this product exhibits a very favorable safety profile for humans and is suitable for applications with high safety requirements such as personal care products.
Regarding the environment, ecotoxicological data show that the 96-hour acute toxicity (LC₅₀) to zebrafish is greater than 100 mg/L, and the 48-hour acute toxicity (EC₅₀) to Daphnia magna is also greater than 100 mg/L, indicating very low toxicity to aquatic organisms. The product itself is biodegradable, but it is still recommended to prevent undiluted large spills from directly entering water bodies or the ecological environment and to follow compliant waste disposal procedures.
| Assessment Item | Test Subject/Conditions | Result/Data | Conclusion |
|---|---|---|---|
| Acute Oral Toxicity | Rat | LD₅₀ > 5,000 mg/kg | Low toxicity |
| Acute Dermal Toxicity | Rabbit | LD₅₀ > 2,000 mg/kg | Low toxicity |
| Skin Irritation | Rabbit | PII = 0.0 | Non-irritating |
| Eye Irritation | Rabbit | 24h average score < 2.0 | Possible slight discomfort |
| Skin Sensitization | Guinea pig | Negative | No sensitization |
| Fish Acute Toxicity (96h) | Zebrafish | LC₅₀ > 100 mg/L | Low toxicity to aquatic organisms |
| Aquatic Invertebrate Toxicity (48h) | Daphnia magna | EC₅₀ > 100 mg/L | Low toxicity to aquatic organisms |
| GHS Hazard Classification | — | Not classified as any hazard category | Non-hazardous substance |
| Flash Point (Closed Cup) | — | Usually > 150°C | Non-flammable liquid |
Based on its excellent safety characteristics, PEG400MO is highly suitable for the following fields with strict health and environmental requirements: