Question 1

Is Cocamide DEA/CDEA, 6501-80%, NINOL harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Cocamide DEA (6501-80%) is a low-toxicity substance. Under standard usage conditions, it is relatively mild to the human body, but the presence of free diethanolamine poses potential health risks; it is generally environmentally friendly, readily biodegradable, and has low bioaccumulation potential. Impact on Human Health Cocamide DEA itself is a low-toxicity substance (rat oral LD₅₀ > 5000 mg/kg), with negative Ames test results. The finished product is not classified as a carcinogen by the International Agency for Research on Cancer (IARC). However, the product contains small amounts of free diethanolamine (typically controlled below 5%). Free diethanolamine is classified by IARC as Group 2B (possibly carcinogenic to humans), and long-term animal studies have observed an association with liver tumors. This is the most concerning health risk of this product. At the product contact level, this substance is classified as skin irritant (GHS Category 2) and severe eye irritant (GHS Category 2A). Direct skin contact with the undiluted product can cause mild irritation, and some individuals may experience allergic reactions (rash, swelling); eye contact can immediately cause conjunctival congestion, pain, and tearing. Under normal operation at room temperature, there is no significant inhalation risk, but vapor/aerosol generated by heating or spraying may irritate the respiratory tract. Special caution is needed: it is strictly prohibited to use or store under nitrosating conditions (e.g., coexisting with nitrites in an acidic environment), as this may generate N-nitroso compounds with strong carcinogenicity. Impact on the Environment Cocamide DEA has a relatively low overall impact on the environment. According to OECD 301B testing, its biodegradation rate is greater than 90%, classifying it as readily biodegradable, meaning it does not persist in the environment for long. Its n-octanol/water partition coefficient (log Kow) is approximately 2.5–3.5, indicating low bioaccumulation potential and limited tendency to accumulate in the food chain. In terms of ecotoxicity, this substance has relatively low toxicity to aquatic organisms: fish 96-hour median lethal concentration (LC₅₀) ranges from >10 to 100 mg/L, and water flea 48-hour median effect concentration (EC₅₀) ranges from >10 to 50 mg/L. Nevertheless, it is still advisable to avoid discharging cleaning solutions containing this product directly into water bodies or sewers, especially untreated industrial wastewater. In case of spillage, inert absorbent materials should be used for containment and collection, and disposal should follow local regulations. Summary of Toxicological and Ecological Parameters Parameter CategoryParameterValue/Conclusion Acute ToxicityRat Oral LD₅₀>5000 mg/kg (Low toxicity) Skin IrritationGHS ClassificationCategory 2 (Mild irritation, non-corrosive) Eye IrritationGHS ClassificationCategory 2A (Severe eye irritation) Carcinogenicity (Overall product)Ames TestNegative, not classified as carcinogen Carcinogenicity (Free DEA)IARC ClassificationGroup 2B (Possibly carcinogenic to humans) Free Diethanolamine Content—Typically <5% (Controlled) BiodegradabilityOECD 301B MethodDegradation rate >90% (Readily biodegradable) Bioaccumulation Potentiallog KowApprox. 2.5–3.5 (Low bioaccumulation) Fish Acute Toxicity96h LC₅₀>10–100 mg/L Water Flea Acute Toxicity48h EC₅₀>10–50 mg/L Safe Usage Recommendations In personal care and household cleaning products, Cocamide DEA is typically added at concentrations of 1%–5%. At this level, residues after rinsing are extremely low, making the health risk to consumers manageable. Industrial operators should wear nitrile or neoprene gloves and chemical safety goggles, operate in well-ventilated areas, and avoid prolonged skin contact and eye exposure. Storage temperature should be maintained between 5°C and 40°C, away from strong oxidizers, strong acids, and nitrites. Precautions Avoid nitrosating conditions: Do not coexist with nitrites in an acidic environment to prevent the formation of carcinogenic N-nitroso compounds. Control heating temperature: Avoid prolonged heating above 120°C to prevent decomposition or generation of harmful substances. Emergency procedures: For skin contact, rinse with running water and soap for at least 15 minutes; for eye contact, flush with copious water for at least 15 minutes and seek immediate medical attention; do not induce vomiting in an unconscious person who has ingested the substance. Environmental discharge: Although the product is readily biodegradable, industrial wastewater containing this product should still be treated to meet discharge standards before being released, avoiding direct discharge into water bodies.

Question 2

What to do if problems occur during the use of Cocamide DEA/CDEA, 6501-80%, Ninol? How to obtain technical support?

Accepted Answer

When encountering problems with Cocamide DEA/CDEA (6501-80%/Ninol), handle them according to the nature of the issue—take immediate emergency measures and seek medical attention for personal safety incidents; for product performance or formulation process issues, it is recommended to record the batch number and abnormal phenomena, then contact the Guoli Chemical technical team for professional support. Detailed Explanation Cocamide DEA (6501 type) is a stable nonionic surctant, but various problems may still arise during use, mainly divided into two categories: personal safety emergencies and product application anomalies. For personal safety issues (such as skin/eye contact, inhalation, ingestion), the emergency treatment procedures in the product safety data sheet must be followed immediately without delay. For product application issues (such as poor thickening effect, unstable foam, turbidity, stratification, abnormal color deepening), the cause should be investigated from multiple dimensions including formulation compatibility, process conditions, and storage environment. Common application problem investigation directions include: ① Poor thickening effect—Check if the system pH deviates from the range of 8.5-10.5, whether the main surctant type and content are compatible, and whether there is excessive viscosity-reducing substances (such as solvents, short-chain alcohols); ② Unstable foam—Confirm if the water hardness is too high, or if the system is contaminated by oils or defoamers; ③ Discoloration or turbidity—Investigate if storage temperature exceeds 40°C or prolonged heating, contact with strong acids/strong oxidizing agents, or if it has passed the shelf life. It is recommended to conduct small-scale tests on each batch of raw materials before use to verify compatibility with the formulation system before large-scale production. Best way to obtain technical support: Guoli Chemical provides a professional technical service team for each customer. You can call the customer service hotline printed on the product packaging barrel (usually on the left side of the barrel label), or submit a problem ticket through the "Technical Support" section on the Guoli Chemical official website (www.guolichem.com). Please prepare the following information before contacting: product batch number (found on the barrel label), production date, detailed description of the abnormal phenomenon, and a summary of your formulation system (main surctant type, pH range, processing temperature, etc.) so that the technical engineer can quickly locate the root cause of the problem. Technical Parameters The following are key technical indicators of Cocamide DEA/CDEA, 6501-80%, Ninol (data source: Guoli Chemical product database), which can be referenced for problem investigation: ParameterSpecification RangeDescription AppearanceLight yellow to amber transparent viscous liquidSignificant deepening of color may indicate overheating or contamination during storage Active Content (%)78.0~82.0Core effective ingredient indicator Amine Value (mgKOH/g)120~160Key parameter characterizing amidation degree pH (1% aqueous solution)8.5~10.5Alkaline range, affects compatibility and thickening efficiency pH (5% aqueous solution)9.0~11.0More alkaline at higher concentration Moisture Content (%)≤1.0Excessive moisture may affect storage stability Kinematic Viscosity (25°C, mPa·s)200~400Abnormal viscosity requires investigation for stratification or moisture absorption Density (25°C, g/cm³)1.01~1.05— Free Diethanolamine (%)≤2%Controlled impurity, affects safety classification Cloud Point (°C)>100Nonionic characteristic, good high-temperature stability HLB Value3.6~5.8Relatively lipophilic, suitable for emulsification and thickening Iodine Value (gI₂/100g)≤10Low unsaturation, good oxidation stability Flash Point (°C)>150No significant fire risk at room temperature operation Pour Point (°C)<10May solidify at low temperatures in winter, can be restored by warming Application Recommendations The recommended dosage of Cocamide DEA in various formulations is generally 1%~5% (based on active content), depending on the target viscosity and foam requirements. In shampoo or body wash systems, synergistic thickening works best when combined with AES (sodium alcohol ether sulte) or LAS (linear alkylbenzene sulfonate). It is recommended that the ratio of 6501 to AES be between 1:3 and 1:6. If the formulation contains a large amount of nonionic or amphoteric surctants, the thickening efficiency may decrease. In such cases, the dosage of 6501 can be appropriately increased, or sodium chloride can be introduced to assist thickening. In industrial cleaning formulations, it can be used with penetrants to fully utilize its emulsifying and degreasing ability. Precautions Emergency treatment priority: In case of eye contact or skin allergy, immediately perform flushing procedures (eye contact: flush for at least 15 minutes and seek immediate medical attention). Do not delay personal safety handling due to formulation issue investigation. Prohibition of nitrosation conditions: Absolutely avoid coexistence with nitrites in an acidic environment, as it may generate N-nitroso compounds (suspected carcinogens). Heating temperature control: Avoid prolonged heating above 120°C during processing to prevent product decomposition, discoloration, or generation of irritating gases. Batch traceability: Each product barrel is marked with batch number and production date. In case of abnormalities, be sure to record the batch number for the technical team to trace production and quality inspection records. Storage reminder: Recommended storage temperature 5°C~40°C. Low temperatures in winter may cause solidification or turbidity, which are physical changes. After warming to room temperature and stirring evenly, the product can be used normally without affecting product quality.

Question 3

How to purchase Cocamide DEA/CDEA, 6501-80%, Ninol? What is the minimum order quantity?

Accepted Answer

Cocamide DEA/CDEA (6501-80%, Ninol) is a bulk industrial raw material. Specific pricing and minimum order quantity require direct contact with the Guoli Chemical sales team for real-time quotations. There is no fixed minimum order quantity parameter in the database. Detailed Description Cocamide DEA (CAS: 68603-42-9) is one of the core nonionic surctant products of Guoli Chemical, widely used in personal care products, liquid detergents, textile auxiliaries, metalworking fluids, and other fields. Due to the significant fluctuation of chemical raw material prices influenced by raw material costs, market supply and demand, and procurement batch sizes, the price information in the product database is for reference only. The actual transaction price shall be based on the formal quotation provided by the sales team. The conventional packaging specifications for this product include 50kg plastic drums, 200kg plastic drums, and IBC totes , catering to the needs of customers of different scales. The minimum order quantity (MOQ) is usually related to the selected packaging specification and inventory status. It is recommended to clarify the expected purchase quantity and application scenario during inquiry, so that the sales personnel can provide the most suitable solution. Ordering Contact Guide To obtain the latest quotations, minimum order quantities, and delivery information, please contact the sales team of Haian Guoli Chemical Co., Ltd. through the following methods: Product Name: Cocamide DEA / CDEA / 6501-80% / Ninol Product Code: 209 CAS Number: 68603-42-9 Available Packaging: 50kg plastic drum / 200kg plastic drum / IBC tote Price Unit: CNY/ton Technical Parameters Parameter Item Technical Index Appearance Light yellow to amber transparent viscous liquid Active Content 78.0%~82.0% pH Value (1% Aqueous Solution) 8.5~10.5 Amine Value (mgKOH/g) 120~160 Free Diethanolamine ≤5% HLB Value 3.6~5.8 Density (25°C) 1.01~1.05 g/cm³ Freezing Point ＜10°C Application Suggestions Before placing a formal order, it is recommended to request free samples for formulation compatibility and performance verification, especially when using this product in the following scenarios: Shampoo/Body Wash Systems: Evaluate thickening synergy (usually used in combination with AES, CAB, etc.) and foam fineness Liquid Detergents: Verify degreasing emulsification performance and formulation stability Industrial Degreasing/Metalworking Fluids: Confirm compatibility in high alkali or high electrolyte systems Precautions This product contains diethanolamine. Please read the Safety Data Sheet (SDS) before handling, and wear protective gloves and goggles. Storage temperature is recommended to be maintained between 5°C and 40°C. Cloudiness or solidification may occur at low temperatures; this is normal and can be restored by warming and stirring. Strictly avoid coexistence with nitrites under acidic conditions to prevent the formation of nitrosamines.

Question 4

Does cocamide DEA/CDEA, 6501-80%, Ninol meet environmental requirements? Can a test report be provided?

Accepted Answer

According to database information, this product exhibits good environmental characteristics in terms of **biodegradability** and **ecotoxicity**. However, regarding whether it holds specific environmental certifications (such as EU Ecolabel, Green Seal, etc.) and whether a test report can be provided, the database information is limited. The following is a detailed breakdown for you: Cocamide DEA has excellent biodegradability and meets basic environmental requirements, but specific certification status and test reports need to be further confirmed through the official channels of Guoli Chemical Detailed Explanation Cocamide DEA (6501-80%, Ninol) performs relatively well in environmental aspects. According to the environmental te data in the database, this product is readily biodegradable. The degradation rate measured by the OECD 301B method is greater than 90%, indicating that it can be effectively decomposed by microorganisms in the natural environment and is not prone to long-term residue in ecosystems. Meanwhile, its n-octanol/water partition coefficient (log Kow) is approximately 2.5–3.5, low bioaccumulation potential, making it unlikely to accumulate in organisms through the food chain. In terms of ecotoxicity, cocamide DEA has relatively low toxicity to aquatic organisms: the 96-hour median lethal concentration (LC₅₀) for fish is greater than 10–100 mg/L, and the 48-hour median effect concentration (EC₅₀) for daphnia is greater than 10–50 mg/L, classified as low toxicity. The oral acute toxicity LD₅₀ for rats is greater than 5000 mg/kg, also classified as a low-toxicity substance. This means that under normal use and discharge conditions, the risk to aquatic ecosystems is relatively controllable. It should be particularly noted that the free diethanolamine (DEA) content in the product is controlled (typically less than 5%). Diethanolamine is classified as Group 2B (possibly carcinogenic to humans) by the International Agency for Research on Cancer (IARC), but the finished cocamide DEA product as a whole is not classified as a carcinogen, and the Ames test result is negative. Under nitrosation conditions (e.g., coexisting with nitrites in an acidic environment), attention should be paid to the potential formation of N-nitroso compounds, which is a key risk point to manage in environmental and safety aspects. Technical Parameters Environmental IndicatorParameter ValueTest Method/Standard Biodegradability＞90% (Readily Biodegradable)OECD 301B Bioaccumulation Potential (log Kow)Approximately 2.5–3.5— Fish Acute Toxicity (96h LC₅₀)＞10–100 mg/L— Daphnia Acute Toxicity (48h EC₅₀)＞10–50 mg/L— Free Diethanolamine ContentTypically ＜5% (Controlled)— Ames MutagenicityNegative— Application Recommendations Given its good biodegradability and low ecotoxicity, cocamide DEA is suitable for formulation systems with certain environmental requirements, such as personal care products, household cleaning products, etc. If your end product needs to apply for specific environmental certifications such as EU Ecolabel, China Environmental Labeling (Ten-ring Certification), Green Seal, it is recommended to confirm with the certification body during the formulation design phase regarding the specific restrictions on alkanolamide surctants under such certifications, as some certification systems have strict upper limits on free DEA content in raw materials. Precautions Obtaining Test Reports: Currently, there are no specific documents such as SGS test reports, ROHS reports, or REACH compliance reports for cocamide DEA in the database. For official test reports (e.g., biodegradability test report, heavy metal test report, free amine content test report, etc.), it is recommended that you directly contact the Sales or Technical Department of Hai'an Guoli Chemical Co., Ltd. to request the corresponding COA (Certificate of Analysis) or third-party test report by batch or product specification. Nitrosamine Risk Management: Avoid coexistence of this product with nitrite preservatives under acidic conditions in the formulation to prevent the formation of N-nitroso compounds, which is a key point for environmental compliance and product safety. Regional Regulatory Differences: Environmental regulations for diethanolamide surctants may vary across different countries and regions (e.g., EU REACH regulation, US TSCA, etc.). When exporting or cross-border use, please confirm compliance requirements with the target market in advance.

Question 5

What advantages does Cocamide DEA/CDEA, 6501-80%, Ninol have over other similar products?

Accepted Answer

Compared to similar competing products, Guoli Chemical 6501-80% stands out with its excellent synergistic thickening efficiency and long-lasting foam stability, making it a classic formulation core that balances performance and cost. Detailed Description The core process advantage of Cocamide DEA/CDEA (6501-80%, also known as Ninol) produced by Guoli Chemical lies in its use of natural coconut oil as raw material, achieving an excellent balance of thickening, foam stabilization, and emulsification. Unlike certain inorganic salt thickeners (such as sodium chloride) that require high-polarity conditions to function, this product is a nonionic surctant that remains stable in a wide range of acid-base systems. It does not produce calcium soap precipitation, especially in high-alkaline formulations and hard water environments, and its hard water resistance is significantly superior to the thickening system of traditional anionic surctants themselves. In combinations with other core surctants, the most valuable advantage of 6501-80% is its "synergistic enhancement" property. When compounded with primary surctants such as Sodium Laureth Sulte (AES) or Linear Alkylbenzene Sulfonic Acid (LAS), it produces an exponential thickening effect even at low addition levels, which is r more economical and efficient than relying solely on increasing the concentration of the primary surctant for thickening. At the same time, it can convert large, loose foam into fine, dense, creamy foam with good cling, a foam texture that is difficult to achieve with many synthetic thickeners and single surctant systems. Additionally, from a comprehensive environmental and safety perspective, the OECD 301B biodegradability of this product as recorded in the database exceeds 90%, meaning that after completing its cleaning mission, it imposes a very low long-term burden on the water environment. Compared to some petroleum-based synthetic thickeners with poor biodegradability or high risk of by-product residues, Guoli Chemical's 6501-80% represents a preferred green chemistry option. Technical Parameters Comparison DimensionGuoli Chemical 6501-80% (Advantages Highlighted)Common Specifications of Similar Products / Competitor Comparison Synergistic Thickening AbilityLow concentration compounding yields highly efficient synergistic thickening, exponentially increasing viscosityInorganic salt thickeners: Poor hard water resistance, sensitive to system pH; Cellulose-based thickeners: Different rheology, poor foam experience Foam CharacteristicsFoam is rich, fine, and stable, forming a creamy texture, unaffected by hard waterBetaines (e.g., CAB): Good initial foaming but foam is fluffier, slightly inferior in foam persistence Hard Water and Alkali ResistanceIn high alkalinity and hard water, no calcium soap precipitation, performance remains extremely stableTraditional anionic thickening systems: Easily deactivated or prone to precipitation in hard water Active Matter Content78.0% ~ 82.0% (Preferred economical conventional concentration)Our ctory also offers 92% and 98% refined grades for formulations requiring higher purity Free Diethanolamine ControlRigorous process control, typically less than 5%, balancing safety and performanceSome non-standard products have higher free amine levels, increased irritation, and higher risk of discoloration during long-term storage Environmental teOECD 301B tested biodegradability >90% (readily biodegradable), low bioaccumulation potentialSome silicone-based or polymer thickeners have poor biodegradability Key Physical ConstantsHLB value 3.6-5.8, Cloud point >100℃, Density at 25℃ 1.01-1.05 g/cm³Data sourced from Guoli Chemical product database actual parameters Application Suggestions Best Partners: When combined with anionic surctants (especially AES) in a ratio of "AES:6501 = 3:1 to 10:1", the thickening effect is extremely significant. When dissolving with stirring in the formulation, it is recommended to first dissolve the primary surctant (e.g., AES) in water and adjust the pH, then add 6501 and stir thoroughly until the viscous gel is fully dispersed to avoid clumping. Hair Care, Shower & Bath: Use an addition level of 0.5%-3% to achieve creamy foam texture, and provide moderate antistatic and retting effects to alleviate excessive degreasing caused by anionic surctants. Industrial Formulations: In textile scouring agents and metal degreasers, it acts as a self-emulsifying carrier to help strip and suspend oily soils, preventing redeposition. Typical usage is 2%-8%. Precautions Safety Warning: This product contains trace amounts of diethanolamine (DEA). Do not allow this product to coexist with nitrites in the same system (especially under acidic conditions) to avoid the formation of nitrosamine impurities. Do not heat above 120℃ for prolonged periods. Always wear safety goggles and gloves during handling and ensure good ventilation. Refer to the product's Safety Data Sheet for specific protection measures.

Question 6

How to store Cocamide DEA/CDEA, 6501-80%, Ninol? What is the shelf life?

Accepted Answer

Cocamide DEA must be stored sealed in a cool, dry, and ventilated environment at 5°C to 40°C. Under unopened and properly stored conditions, the shelf life is typically 12 to 24 months. Detailed Explanation Cocamide DEA (6501-80%) is a chemically stable nonionic surctant. The core of its storage lies in moisture resistance, sealing, and avoiding extreme temperatures. When stored in a tightly sealed and uncontaminated original container, following the storage conditions recommended in the Guoli Chemical database, the recommended re-inspection period or shelf life for this product is generally 12 months. If the storage environment is consistently maintained at ideal low temperature and low humidity with good container airtightness, the active ingredient indicators can often remain within the standard range for up to 24 months. This product has certain hygroscopicity and a freezing point below 10°C. In low-temperature environments during winter, the product may experience physical phenomena such as solidification or crystallization precipitation, which are normal physical changes and not deterioration. Before use, simply place the container in a warm warehouse to slowly warm up and stir evenly to restore its original state. Avoid directly using open flames for heating or rapid heating to prevent local overheating and decomposition. Core Storage Technical Requirements To ensure the product's performance throughout its shelf life, strictly follow the storage terms below from the Guoli Chemical product database: Storage IndicatorSpecific Requirement Ambient TemperatureRecommended 5°C to 40°C. Prolonged exposure to heat sources above 120°C is prohibited to prevent thermal decomposition. Container StatusThe original container must always be kept tightly sealed. Immediately close the container after dispensing to prevent moisture absorption and air contact. Storage AreaRequires a cool, dry, and well-ventilated area. The storage area should have a leak-proof dike, and the floor should be made of corrosion-resistant material. Incompatible Material ControlStrictly keep away from strong oxidizers (e.g., peroxides, permanganates), strong acids (e.g., sulfuric acid, hydrochloric acid), and nitrites. Storage under nitrosating conditions is strictly prohibited to avoid the formation of N-nitroso compounds. Warehouse ManagementKeep away from heat sources and ignition sources. Empty containers may contain residual product vapors or liquids and should also be properly sealed and managed. Application Recommendations Product Re-inspection: For products stored for more than 12 months, it is recommended to perform sampling tests on key indicators (such as pH value, amine value, active matter content, and viscosity) before use to confirm compliance before production application. Viscosity Recovery: If the product becomes layered or slightly turbid due to low-temperature freezing or prolonged static storage, it can be restored to a transparent, viscous, and uniform state by water bath heating to about 30-40°C and auxiliary mechanical stirring without affecting performance. Precautions Since the product contains free diethanolamine (DEA), which is classified by the International Agency for Research on Cancer as a Group 2B carcinogen (possibly carcinogenic to humans), when opening the container for sampling or dispensing, be sure to refer to the safety data sheet, wear nitrile or chloroprene rubber chemical-resistant gloves and chemical safety goggles, and ensure good ventilation in the work environment.

Question 7

What safety precautions should be taken when using Cocamide DEA/CDEA, 6501-80%, Ninol?

Accepted Answer

When using Cocamide DEA (6501-80%), chemical protective gloves and goggles must be worn. Operate in a well-ventilated area. Avoid coexistence with nitrites and strong acids. Also note that the free diethanolamine it contains has potential carcinogenic risk (GHS Category 2). Strict personal protective measures must be implemented throughout the operation. Detailed Explanation Cocamide DEA (6501-80%) is a widely used nonionic surctant. However, according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), its hazard classifications include: Skin irritation (Category 2), Serious eye irritation (Category 2), and Suspected carcinogenicity (Category 2). These risks mainly originate from trace amounts of free diethanolamine (DEA, usually less than 5%) in the product. The International Agency for Research on Cancer (IARC) classifies it as Group 2B (possibly carcinogenic to humans). Therefore, the use of this product must not be taken lightly, and strict safety operating procedures must be established. There are two risk points most easily overlooked when handling this product: First, contact with the eyes can immediately cause conjunctival congestion, pain, and tearing, which is classified as serious eye irritation (GHS Category 2A). If this occurs, it must be rinsed with plenty of running water for at least 15 minutes and immediate medical attention sought. Second, this product must not be used or stored under nitrosating conditions - that is, it must not be present with nitrites in an acidic environment, as this may generate carcinogenic N-nitroso compounds. This is a particularly important incompatibility to be aware of in formulation processes. It is worth emphasizing that the oral LD₅₀ of this product in rats is greater than 5000 mg/kg, classifying it as low toxicity. The Ames test result is negative, and the finished product as a whole is not classified as a carcinogen. Its environmental friendliness is also relatively good, with a biodegradation rate greater than 90% measured by OECD 301B method, and low toxicity to aquatic organisms. Under normal operating conditions at room temperature, there is no significant inhalation risk. However, steam/aerosol generated by heating or spraying may irritate the respiratory tract mucosa. It is recommended to avoid prolonged heating above 120°C. Technical Parameters Safety IndicatorParameter / Description GHS Hazard ClassificationSkin irritation (Category 2), Serious eye irritation (Category 2), Suspected carcinogenicity (Category 2) Free Diethanolamine (DEA) ContentUsually less than 5% (controlled) Acute Toxicity (Rat Oral LD₅₀)Greater than 5000 mg/kg (low toxicity) Eye Damage LevelGHS Eye Irritation Category 2A; contact causes conjunctival congestion, pain, tearing Skin IrritancyUndiluted contact may cause mild irritation; some individuals may experience allergic reactions Recommended Storage Temperature5°C to 40°C; stable under normal temperature and sealed conditions Heating LimitAvoid prolonged heating above 120°C to prevent decomposition Biodegradation Rate (OECD 301B)Greater than 90% (readily biodegradable) Carcinogenicity (Ames Test)Negative (the product as a whole is not classified as a carcinogen) Application Recommendations Personal Protective Equipment (PPE) Requirements Hand Protection: Wear chemical protective gloves during operation, preferably nitrile or neoprene rubber, to avoid direct skin contact with the undiluted liquid. Eye Protection: Must wear chemical safety goggles throughout the process. Eyewash stations and emergency showers should be available in the workplace. Body Protection: Wear appropriate protective clothing to avoid prolonged or extensive skin exposure. Respiratory Protection: Operate in a well-ventilated area; if adequate ventilation cannot be ensured, wear an approved respirator for organic vapors/particulates. Operating Environment and Behavior Standards No eating, drinking, or smoking during operation; wash hands and exposed skin thoroughly after handling. Conduct dispensing and compounding in areas with local exhaust ventilation as much as possible to reduce accumulation of vapor or aerosol. Strictly avoid contact with incompatible substances such as strong oxidizers (e.g., peroxides, permanganates), strong acids (e.g., sulfuric acid, hydrochloric acid), and nitrites. Control heating temperature according to process requirements; prolonged high temperatures may cause decomposition or generate harmful substances. Storage Management Points Store in a cool, dry, well-ventilated warehouse. Keep containers tightly closed. Recommended storage temperature range: 5°C to 40°C. Keep away from heat sources and avoid prolonged exposure to environments above 120°C. The storage area should be equipped with containment dikes, and the floor should be made of corrosion-resistant material. Empty containers may contain residual product vapor or liquid and should be properly managed and not discarded arbitrarily. Precautions First Aid: In case of skin contact, immediately remove contaminated clothing and rinse with plenty of running water and mild soap for at least 15 minutes. If irritation persists or allergic symptoms occur, seek medical attention immediately. First Aid: In case of eye contact, immediately hold eyelids open and rinse with plenty of running water or saline solution for at least 15 minutes. Contact lens wearers should remove them first. After rinsing, seek professional ophthalmological assistance immediately. Do not self-administer ophthalmic ointments. First Aid: In case of inhalation, quickly move to fresh air and maintain breathing freely. If coughing or difficulty breathing occurs, seek medical attention immediately. First Aid: In case of ingestion, do not induce vomiting if the person is unconscious. Rinse mouth with water. If the patient is conscious, give small amounts of water to drink repeatedly to dilute. Immediately call a poison control center or seek medical attention. Spill Handling: Evacuate unnecessary personnel, eliminate ignition sources, enhance ventilation. Wear full protective equipment, then contain and absorb with inert materials such as sand, vermiculite. Collect and dispose of according to local regulations. Cleaning solution must not be discharged directly into waterways or sewers. Core Prohibition: Do not use or store under nitrosating conditions (coexisting with nitrites in an acidic environment), as this may lead to the formation of carcinogenic N-nitroso compounds. This is a major safety risk that must be strictly prevented during formulation design and use.

Question 8

How to use Cocamide DEA/CDEA, 6501-80%, Ninol? What is the recommended dosage?

Accepted Answer

The usage of Cocamide DEA varies by application field. Choose the appropriate addition stage and formulation method to achieve optimal thickening, foam stabilization, and detergency. Detailed Explanation Cocamide DEA (6501) is a widely used nonionic surctant, primarily water-soluble, and can be diluted with water at room temperature. In most formulations, it is used together with anionic surctants (e.g., AES, LAS) and exhibits a significant synergistic effect. It is generally recommended to add it under stirring at a temperature of 40-60°C. If necessary, it can be premixed with hot water (approximately 60°C) before being added to the mixing tank. Avoid prolonged heating above 120°C. This product has an active content of 80%. In formulations, it is typically used as an important auxiliary component for thickening, foam stabilization, and emulsification, rather than as the primary surctant. The dosage can be fine-tuned based on the viscosity and foam requirements of the target product to achieve the desired performance. Cocamide DEA is most commonly used in personal care products and household cleaning products. The typical procedure involves adding it slowly after the primary surctants have been fully dissolved, with continuous stirring to ensure complete dispersion and emulsification. If common formulation issues such as unsatisctory foam or low product consistency occur, first consider adjusting its dosage rather than blindly replacing other formulation components. Technical Parameters ParameterValue Active Content78.0%~82.0% AppearanceLight yellow to amber viscous liquid pH Value (1% Aqueous Solution)8.5~10.5 HLB Value3.6~5.8 Freezing Point<10℃ Flash Point>150℃ Free DiethanolamineTypically ＜5% Application Recommendations Recommended Dosage (Based on general industry experience, for reference only; actual dosage should be determined through formulation trials): Application FieldRecommended Dosage (Percentage of Total Formulation)Function Shampoo, Shower Gel, Hand Soap1%~5%Thickening, foam stabilization, improving skin feel Dishwashing Liquid1%~3%Thickening, foam stabilization, enhanced degreasing Laundry Liquid0.5%~3%Emulsification and detergency synergy Hard Surce Cleaners1%~4%Detergency enhancement and emulsification Textile Scouring Agent, Scouring Agent2%~8%Emulsification, dispersion, and antistatic Metalworking Fluids (Cutting Fluids, etc.)2%~10%Emulsification, lubrication, and rust prevention Pesticide Water-Based Formulations2%~5%Emulsification and dispersion Industrial Degreasers, Heavy Oil Cleaning Agents2%~8%Penetration, emulsification, oil removal Key Usage Points: Add during the mixing phase of the formulation, control temperature at 40-60°C, pour slowly and stir thoroughly until completely dissolved and dispersed. If viscosity reduction is needed for easier metering, preheat with warm water at 50-60°C or predilute before addition. Generally used as an auxiliary component; it does not compete with primary surctants. On the contrary, it exhibits significant synergistic effects when combined with anionic surctants such as AES and LAS. Use small batch trials to find the precise addition amount suitable for your formulation to achieve the target consistency and foam performance. Precautions The product is slightly alkaline (1% aqueous solution pH 8.5-10.5). Wear chemical protective gloves and goggles during operation and avoid direct contact with skin and eyes. Do not store or use together with strong oxidizers, strong acids, or nitrites to prevent the formation of N-nitroso compounds. Avoid prolonged heating above 120°C during processing to prevent decomposition or generation of harmful substances. Recommended storage temperature is 5°C~40°C. At low temperatures, the product may thicken or solidify. In such cases, place the container in warm water to slowly warm it up and restore fluidity before normal use. The dosage ranges above are based on general industry experience. Specific dosages should be determined through trials based on the formulation system.

Question 9

In which industries and processes is Cocamide DEA/CDEA, 6501-80%, Ninol mainly used?

Accepted Answer

Cocamide DEA (6501-80%) is widely used in six major industries: personal care, household cleaning, textile printing and dyeing, metal processing, pesticide formulations, and industrial cleaning. It is an indispensable thickener, foam stabilizer, and emulsifying dispersant in multi-field formulations. Detailed Description Cocamide DEA (also known as Ninol, 6501 type, CDEA) is a nonionic surctant synthesized from natural coconut oil, appearing as a transparent viscous liquid from light yellow to amber. Thanks to its excellent synergistic thickening, foam stabilization, emulsification dispersion, and alkali and hard water resistance, this product has become a core functional additive in many civil and industrial cleaning formulations, especially when compounded with other surctants, it produces a significant synergistic enhancement effect. In the civil field, Cocamide DEA is an indispensable high-efficiency thickener and foam stabilizer in personal care products such as shampoos, shower gels, hand soaps, and cial cleansers, providing a rich and dense foam experience and imparting a mild tty feel to the skin; in dishwashing detergents, laundry liquids, bric softeners, and various hard surce cleaners, it serves dual functions of detergency enhancement and foam stabilization, significantly improving the degreasing ability of the formulation. In the industrial field, this product also performs excellently: in the textile industry, it is used as an effective component of scouring agents, degreasing agents, and antistatic agents; in metalworking fluid systems, it acts as an emulsifier and anti-rust component; in water-based pesticide formulations, it serves as an emulsifying dispersant to promote uniform distribution of active ingredients; in addition, it is widely used in industrial degreasers, ink cleaning agents, and leather processing processes. Application Details by Industry Application Industry Specific Process/Product Functional Role Personal Care Shampoo, shower gel, hand soap, cial cleanser High-efficiency thickener, foam stabilizer, enhances foam richness and persistence, imparts mild tty feel Household Cleaning Products Dishwashing detergent, laundry liquid, bric softener, multi-purpose hard surce cleaner Detergency enhancement, foam stabilization, thickening, improves degreasing ability and ease of use Textile Printing and Dyeing Scouring agent, degreasing agent, antistatic agent formulation Emulsifies and disperses fiber oil stains and impurities, improves bric finishing, imparts antistatic properties Metalworking and Industrial Cleaning Cutting fluid, rust preventive, industrial degreaser, ink cleaner Emulsifies oily components, disperses dirt, forms a protective film on metal surce, corrosion inhibition and rust prevention Pesticide Formulations Water-based pesticide formulations (emulsifiable concentrate, suspension concentrate, emulsion, etc.) Emulsifying dispersant, reduces oil-water intercial tension, improves dispersion uniformity and dilution stability of active ingredients Leather Processing Leather degreasing, leveling process Penetrates and emulsifies grease in leather, assists leveling treatment Application Recommendations Recommended Dosage Reference: In personal care and liquid detergent formulations, the typical addition amount of Cocamide DEA is 1%–5% of the total system weight, and the specific dosage should be optimized according to the target viscosity and foam requirements. In industrial formulations (such as metalworking fluids, pesticide preparations), the addition amount is usually 2%–8%, adjusted according to emulsification and dispersion needs. Since this product has good compatibility with anionic, nonionic, and amphoteric surctants, it is recommended to be compounded with main surctants such as AES (sodium alcohol ether sulte) and LAS (linear alkylbenzene sulfonate) to achieve optimal synergistic thickening and foam stabilization effects. Process Operation Suggestions: The product is a viscous liquid at room temperature. It is recommended to preheat at 40°C–60°C before feeding to reduce viscosity for accurate metering and rapid dispersion. Add slowly under stirring to avoid local high concentration leading to gel lumps. In water-based formulations, it is better to use under neutral or alkaline conditions. Acidic systems (pH Precautions Nitrosation Risk Control: This product contains diethanolamine (DEA). Do not use or store under nitrosating conditions – especially avoid coexistence with nitrites in acidic environments to prevent the formation of potentially carcinogenic N-nitroso compounds. Operating Temperature: Avoid prolonged heating above 120°C to prevent decomposition or generation of harmful substances. Personal Protection: Wear nitrile or neoprene protective gloves and chemical safety goggles during operation; operate in a well-ventilated area. This product is classified as GHS skin irritation (Category 2) and serious eye irritation (Category 2); avoid direct contact with skin and eyes. Storage Conditions: Store sealed in a cool, dry, ventilated place, recommended temperature 5°C–40°C, away from strong oxidizing agents, strong acids, and nitrites. Environmental Friendliness: This product is readily biodegradable (OECD 301B method degradation rate >90%) with low bioaccumulation potential, but wastewater should still be avoided from direct discharge into water bodies or sewers.

Question 10

What are the physicochemical and technical parameters of Cocamide DEA/CDEA, 6501-80%, Ninol?

Accepted Answer

Cocamide DEA (6501-80%) is a high-quality nonionic surctant produced by Guoli Chemical, appearing as a light yellow to amber transparent viscous liquid with an active content of 78%~82%, offering excellent thickening, foam stabilizing, and emulsifying properties. Detailed Description Cocamide DEA (CAS No.: 68603-42-9), also known as 6501, Ninol, or coconut tty acid diethanolamide, is a nonionic alkanolamide surctant synthesized from natural coconut oil. The product has a molecular weight of approximately 280-300, with a molecular formula represented by mixtures such as C11H23CON(CH2CH2OH)2. Its HLB value ranges from 3.6 to 5.8, cloud point exceeds 100°C, making it a typical water-in-oil emulsifier while also exhibiting excellent water solubility. This product belongs to Guoli Chemical's 6501-80% specification, meaning its active matter content is controlled at a high concentration of 78.0%~82.0%. Compared to common 1:1 type or 1:2 type 6501 on the market, it offers significantly higher thickening efficiency. The amine value of the product is 120~160 mgKOH/g, hydroxyl value is 220~280 mgKOH/g, and both acid value and saponification value are controlled at low levels (≤5 and ≤10 mgKOH/g, respectively), indicating complete raw material reaction, low impurity content, and high product purity. In terms of compatibility, this product has good compatibility with anionic, cationic, and amphoteric surctants. Especially when compounded with main surctants such as AES (sodium alcohol ether sulte) and LAS (linear alkylbenzene sulfonate), it exhibits significant synergistic thickening effects, making it an indispensable core additive in washing, care, and cleaning formulations. Technical Parameters Parameter Item Specification/Value Test Condition Appearance Light yellow to amber transparent viscous liquid Visual inspection (25°C) Ionic Type Nonionic — CAS No. 68603-42-9 — Molecular Weight Approx. 280-300 — Active Matter Content 78.0%~82.0% — Moisture ≤1.0% Karl Fischer method Density 1.01~1.05 g/cm³ 25°C Kinematic Viscosity 200~400 mm²/s 25°C Refractive Index 1.470~1.475 25°C Solidification Point <10°C — Flash Point >150°C Closed cup method HLB Value 3.6~5.8 Calculated value Cloud Point >100°C 1% aqueous solution pH Value (1% aqueous solution) 8.5~10.5 25°C pH Value (5% aqueous solution) 9.0~11.0 25°C Acid Value ≤5 mgKOH/g — Saponification Value ≤10 mgKOH/g — Hydroxyl Value 220~280 mgKOH/g — Amine Value 120~160 mgKOH/g — Iodine Value

Cocamide DEA/CDEA, 6501-80%, Ninol

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Property	Value
CAS No.	68603-42-9
Molecular Formula	C11H23CON(CH2CH2OH)2etc. mixture
Appearance	Pale yellow to brownish-yellow viscous liquid
Ionic Type	Nonionic
Avg. Molecular Weight	Approx. 280-300
Cloud Point	>100
Active Content	78.0%~82.0
pH Value(1%)	8.5~10.5
pH Value(5%)	9.0~11.0
Iodine Value	≤10
Solubility	Dispersible in water; soluble in ethanol
Surface Tension	~33 (0.1%, 25°C)
CMC	~0.01% (3×10^-4 mol/L)
Acid Value	≤5
Saponification Value	≤10
Hydroxyl Value	220-280
Moisture	≤1.0
Density	1.01-1.05 (25°C)
Kinematic Viscosity	200-400 (25°C)
Refractive Index	1.470-1.475 (25°C)
Flash Point	>150°C
Hygroscopicity	Slightly hygroscopic
Chemical Stability	Stable under normal conditions
Amine Value	120~160
Tertiary Amine Content	≤2%
Penetration	>300 s
Foam Property	Rich foam, good stability
Alkali Resistance	Good
Unsaturation	Low
Viscosity	Medium viscosity liquid
Melting Point	<10°C (freezing point)
Low Shear Viscosity	200-400 (25℃)
Solid Content	~78%~82%
Free Alcohol	≤2%
Heavy Metal	≤20
Arsenic	≤2

Cocamide DEA/CDEA, 6501-80%, Ninol

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Application Guidelines

Packaging and Storage

Cocamide DEA Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

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Refined Coconut Oil 6501-98%, Ninol

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