Polyethylene glycol PEG-600 is a water-soluble non-ionic polymer compound, and its specific usage varies depending on the application field. It can usually be directly dissolved in the aqueous phase or blended with other components.
Detailed Description
Polyethylene glycol PEG-600 appears as a viscous liquid or semi-solid at room temperature (melting point 15~25°C), easily soluble in water, ethanol, and acetone. In practical applications, its usage methods can be roughly divided into three categories: Direct Addition Method (e.g., directly added to the system as a lubricant or humectant), Pre-dissolution Method (pre-dissolved in water or solvent before compounding), and Melting Method (used as a base for pharmaceutical ointments\/suppositories, heated to 40~50°C to completely melt, then mixed with other ingredients).
In pharmaceutical preparations, PEG-600 is often used as an ointment base or suppository base: heat it in a water bath until completely melted (not exceeding 60°C), add the active drug at this temperature, stir until uniformly dispersed, pour into molds or dispense while hot, and cool to obtain the finished product. As a droplet pill carrier, mix the drug with PEG-600 according to the prescription ratio, heat and melt to form a uniform liquid, drip into a cooling liquid to condense into pills. As a solubilizer for injections, generally dilute PEG-600 with water for injection to a concentration of 10%~30%, then add the drug and stir to dissolve.
In industrial applications (such as metalworking fluids, ceramic dispersants, textile auxiliaries, etc.), PEG-600 is usually directly added to the aqueous phase and stirred to dissolve, or it can be compounded with surfactants before use. In pesticide formulations as an emulsifying dispersant, it is recommended to first mix PEG-600 thoroughly with the pesticide technical material and other surfactants, then dilute with water to the required concentration.
Technical Parameters
| Parameter Name |
Value |
| Appearance |
Colorless to slightly yellow transparent liquid or semi-solid |
| Molecular Weight |
570~630 |
| HLB Value |
19 |
| Hydroxyl Value (mgKOH\/g) |
178~196 |
| pH Value (1% Aqueous Solution) |
5.0~7.0 |
| Density (g\/cm³) |
1.11~1.13 |
| Kinematic Viscosity (40°C, mm²\/s) |
13~17 |
| Melting Point (°C) |
15~25 |
| Flash Point (°C) |
≥220 |
| Moisture Content (%) |
≤1.0 |
| Active Content (%) |
≥99 |
| Cloud Point (1% Aqueous Solution) |
>100°C |
| Solubility |
Easily soluble in water, ethanol, acetone |
Application Recommendations
The reference dosages in each field below are based on the application practice of Guoli Chemical products and general formulation experience in the industry:
- Pharmaceutical Ointment Base: Dosage is 10%~85% of the total prescription, often compounded with PEG-400, PEG-1500, etc. to adjust consistency. Heating melting temperature is 40~50°C, avoid exceeding 60°C to prevent degradation of active ingredients.
- Suppository Base: Dosage is 70%~95% of the total prescription, melt and pour into molds to cool and form.
- Droplet Pill Carrier: The ratio of drug to PEG-600 is usually 1:2 to 1:5, with melting temperature controlled below the drug's stability temperature (generally 60~90°C).
- Personal Care Humectant: Recommended addition amount is 1%~5%, directly added to the aqueous phase and stirred to dissolve.
- Metalworking Fluid: As a lubricant and coolant component, recommended addition amount is 5%~20%.
- Ceramic Slurry Dispersant: Dosage is 0.2%~1.0% of the powder mass, pre-dissolved in water before adding ceramic powder for grinding.
- Textile Antistatic Agent: Working solution concentration 0.5%~3%, pad or spray treatment on fiber surface.
- Pesticide Emulsifying Dispersant: Dosage is 2%~8% of the total formulation, better effect when compounded with other surfactants.
- Coating Leveling Agent: Recommended addition amount is 0.1%~0.5% of the total formula.
- Mold Release Agent: Can be prepared as a 2%~10% aqueous solution for spraying on mold surface.
Precautions
- This product is hygroscopic. Immediately seal the packaging container after weighing and use to prevent moisture absorption and caking.
- At low temperatures (below 15°C), it may solidify into a waxy solid. Before use, it can be melted in a water bath below 40°C, restored to liquid state, and shaken evenly before use; product quality is not affected.
- When handling, it is recommended to wear chemical safety goggles and nitrile rubber gloves to avoid contact with eyes (this product is slightly irritating to the eyes).
- Avoid simultaneous use or mixed storage with strong oxidizers (e.g., peroxides, hypochlorites, permanganates).
- Actual dosage in each field should be determined through small-scale tests based on specific formulation and process conditions; the above recommended dosages are for reference only.
- Storage temperature should not exceed 40°C, keep away from fire sources and direct sunlight.
- This product is non-hazardous; transportation and storage can be managed as general chemicals.
