Question 1

Is polyethylene glycol PEG-600 harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Polyethylene glycol PEG-600 has low toxicity and low irritation to the human body. It is a recognized safe chemical raw material, but it requires proper disposal to avoid potential load on environmental water bodies. Detailed Description According to the Guoli Chemical Product Database and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), polyethylene glycol PEG-600 is not classified as a dangerous good. Acute oral toxicity tests in rats show an LD50 greater than 2000 mg/kg, classifying it as a low toxicity substance. Animal tests indicate that this product is not irritating to the skin (rabbit test) and only mildly irritating to the eyes. Due to its good biocompatibility and low toxicity, PEG-600 is widely used in the pharmaceutical field (e.g., as ointment base, suppository base, pill carrier, and injection solubilizer) and in personal care products as a moisturizer, which indirectly confirms that its safety for the human body has been verified through long-term practice. In terms of the environment, PEG-600 is a water-soluble non-ionic polymer, easily soluble in water, and has certain mobility. The database safety instructions clearly require: Prevent the leak from entering drainage systems, waterways, or soil. If environmental release has occurred, immediately notify the environmental protection authorities. Although PEG substances themselves do not have significant bioaccumulation and acute aquatic toxicity, large-scale discharge into water bodies will increase the chemical oxygen demand (COD), consume dissolved oxygen in the water, and impose an indirect burden on aquatic ecosystems. Therefore, waste should be handed over to licensed waste treatment agencies for incineration or appropriate treatment in accordance with regulations. Discharge is strictly prohibited. In summary, PEG-600 is safe for the human body under normal use conditions, non-irritating to the skin, mildly irritating to the eyes, and the risk of daily exposure is extremely low. For the environment, under standard use and disposal conditions, the impact is controllable. The key is to avoid large-scale leakage into natural water bodies. Industrial users should strictly comply with the leakage emergency treatment and waste disposal regulations in the safety data sheet. Technical Parameters ParameterDataParameterData TypeNon-ionic surctantAppearanceColorless to slightly yellow transparent liquid or semi-solid Content≥99%pH value (1% aqueous solution)5.0~7.0 Molecular weight570~630Moisture≤1.0% Heavy metals≤20 mg/kgArsenic≤2 mg/kg Acid value≤0.5 mgKOH/gFlash point≥220℃ SolubilityEasily soluble in water, ethanol, acetoneIodine value≤0.1 Application Suggestions Given the low toxicity and low irritation of PEG-600, its conventional use in various fields is safe: in the pharmaceutical industry, as an ointment and suppository base, it can directly contact human mucous membranes; in personal care products, as a moisturizer and emollient, it is suitable for all skin types; in industrial applications, as a lubricant or dispersant, operators only need to follow basic protective specifications (wear protective goggles and gloves). It is recommended that industrial users ensure good ventilation in the operating area, avoid prolonged and repeated skin contact, and wash hands thoroughly after operation. Precautions Eye protection: Although irritation is mild, if splashed into eyes, rinse with plenty of water for at least 15 minutes. If irritation persists, seek medical attention. Ingestion: If accidentally ingested in large amounts, rinse mouth with water and drink 1-2 glasses of water to dilute. Do not induce vomiting. Seek immediate medical attention. Environmental control: Wastewater containing PEG-600 generated during production and use should be sent to the sewage treatment system. It should not be discharged directly into water bodies or soil. Waste disposal: Waste liquid and empty containers must be handed over to qualified disposal agencies for disposal in accordance with the law. Empty drums cannot be used to hold other materials until thoroughly cleaned. Storage conditions: Keep containers tightly closed. Storage temperature should not exceed 40℃. Keep away from strong oxidizers, strong acids, strong bases, and food and beverages.

Question 2

What should I do if problems occur during the use of polyethylene glycol PEG-600? How to obtain technical support?

Accepted Answer

If problems occur during the use of polyethylene glycol PEG-600, preliminary investigation can be conducted based on the phenomenon, and then professional technical support can be obtained by calling the Guoli Chemical technical service hotline or contacting the regional sales manager. Detailed Explanation Polyethylene glycol PEG-600 (Polyethylene Glycol 600, CAS: 25322-68-3) is a non-ionic polymer compound with stable properties and is not prone to chemical deterioration under normal use conditions. If abnormalities occur, they are usually related to ctors such as improper storage conditions, formulation compatibility, and operating methods. It is recommended to first conduct a self-check against the product technical parameters and safety instructions. Common problems and investigation directions include:Abnormal product state (solidification, stratification, turbidity): The freezing point (melting point) of PEG-600 is between 15~25℃. Under low temperature environments, it appears as a waxy solid, which is normal. It can be restored to a transparent liquid by heating in a water bath to above 25℃. If the product exhibits permanent turbidity or stratification, it may be caused by long-term storage at excessive temperatures (above 40℃) or contamination with incompatible impurities (such as strong acids, strong bases, or strong oxidizers). Poor application effect (reduced emulsifying power, poor dispersibility): Please check whether the pH in the formulation exceeds the stable range (1% aqueous solution pH 5.0~7.0 is optimal), whether there is compatibility conflict with anionic\/cationic substances, and whether the addition order and mixing conditions are appropriate. Irritation or allergic reactions: This product is non-irritating to the skin but slightly irritating to the eyes. If operators experience significant discomfort, immediately implement the emergency treatment measures in the safety data sheet (e.g., rinse with plenty of water for at least 15 minutes) and seek medical attention. When self-check cannot resolve the issue, contact Guoli Chemical immediately for official technical support. Technical personnel will conduct an in-depth analysis based on your specific application scenario, batch number, and operation records, and can provide sample re-inspection or formulation optimization suggestions if necessary. The product safety data sheet (SDS) and detailed technical application guide are also available upon request. Technical Parameters The following are the core technical parameters of polyethylene glycol PEG-600 for reference during troubleshooting: Parameter ItemValue\/Description Appearance (25℃)Colorless to slightly yellow transparent liquid or semi-solid Molecular Weight Range570~630 Hydroxyl Value (mg KOH\/g)178~196 pH Value (1% Aqueous Solution)5.0~7.0 Kinematic Viscosity (40℃, mm²\/s)13~17 Low Shear Viscosity (25℃, mPa·s)100~150 Density (25℃, g\/cm³)1.11~1.13 Water Content (%)≤1.0 Acid Value (mg KOH\/g)≤0.5 Freezing Point (℃)15~25 Flash Point (℃)≥220 Cloud Point (1% Aqueous Solution)>100℃ HLB ValueApproximately 19 Heavy Metals (mg\/kg)≤20 Note: The above data is sourced from the Guoli Chemical product database. Batch inspection reports can be requested from the technical support department. Application Recommendations Polyethylene glycol PEG-600, with its excellent solubilizing, lubricating, and moisturizing properties, is widely used in pharmaceuticals, cosmetics, metal processing, textiles, pesticides, and many other fields. Application recommendations for different scenarios are as follows: Pharmaceutical Field: When used as an ointment base or suppository base, it is recommended to compound with other molecular weight PEGs to adjust hardness and melting point; in drop pill carrier applications, control the cooling rate to prevent excessive crystal size from affecting drug dissolution. Personal Care Products: As a humectant and emulsion stabilizer, it is recommended to add at 2%~8% and incorporate into the water phase before emulsification. Note its high HLB value (approximately 19), making it suitable for O\/W emulsion systems. Metalworking Fluids: Recommended addition amount is 5%~15%, utilizing its inverse solubility to provide lubrication at high-temperature interces and form a cooling layer, while also offering low foam advantages. Ceramics and Pigment Slurries: As a dispersant, it is recommended to first dissolve in water, then add powder for grinding, which can significantly reduce slurry viscosity and increase solid content. Textiles and Papermaking: When used as an antistatic agent and softener, it is recommended to prepare a 0.5%~2% aqueous solution for padding or spraying treatment. How to Obtain Official Technical Support from Guoli Chemical 1. Phone Consultation: Call the technical service hotline of Haian Guoli Chemical Co., Ltd. and directly describe the problem you encountered, including the product batch number, usage environment, and abnormal phenomena. 2. Email Support: Send a detailed description of the problem (preferably with photos or test data) to the technical department email, and technical personnel will reply within working days. 3. Regional Sales Representative: Contact the regional sales manager in charge, who will coordinate the technical team for on-site visits or remote diagnosis. 4. Sample Submission for Re-inspection: Under the guidance of technical personnel, seal the problematic batch sample and send it to the company's quality inspection center for free re-inspection and issuance of an analysis report. Precautions When contacting technical support, please have the product batch number (found on the container label) and purchase channel information ready for quick traceability. If personal injury is involved, prioritize first aid measures and seek immediate medical attention, then contact the company's safety and environmental department to report the incident. Do not add other chemical substances to attempt to "fix" the problem product without confirmation from the technical department, to avoid secondary contamination or safety risks. Waste problem products should be disposed of by qualified organizations in accordance with local regulations, and must not be discharged into water bodies or soil. Haian Guoli Chemical Co., Ltd. provides product quality assurance that meets出厂 standards. Specific after-sales service terms are subject to the purchase and sales contract.

Question 3

How to purchase polyethylene glycol PEG-600? What is the minimum order quantity?

Accepted Answer

To purchase polyethylene glycol PEG-600, you need to directly contact the Guoli Chemical sales team for the latest quotation and ordering details. The product has no online list price, and the minimum order quantity is not disclosed in the database. Detailed Explanation Polyethylene glycol PEG-600 (CAS No.: 25322-68-3) is one of the core products of Haian Guoli Chemical Co., Ltd. It belongs to nonionic polymer compounds, appearing as a colorless to slightly yellow viscous liquid, widely used in pharmaceuticals, personal care products, metalworking, textiles, pesticides, and many other industries. Due to the ct that the price of chemical raw materials fluctuates greatly under the influence of market supply and demand, raw material costs, procurement batch size, and other ctors, the specific pricing of this product is currently not displayed in the Guoli Chemical database. The price column note clearly states: "The above price is for reference only. For actual price, please contact the sales team for the latest quotation." Regarding the minimum order quantity (MOQ), the packaging specifications in the database can serve as an important reference. The standard packaging forms of PEG-600 include: 50kg plastic drums, 200kg plastic drums, and IBC totes. Generally, orders in chemical enterprises usually start with a single drum as the minimum unit, but the specific minimum order quantity needs to be ultimately confirmed by the Guoli Chemical sales team based on inventory status, transportation region, and cooperation method. There is no clear minimum order quantity parameter in the database. Purchase Channels and Process Suggestions Contact Guoli Chemical Sales Department directly — Inquire via the company's official website, corporate email, or official contact phone to obtain the latest quotation, inventory status, and minimum order quantity; Clarify requirements and parameters — Inform your required monthly usage or single purchase quantity, target application field (e.g., pharmaceutical grade or industrial grade requirements), so that the salesperson can recommend the most suitable specifications and packaging; Request samples — If it is the first cooperation or for new formula development, you can apply for free or paid samples for small-scale trial verification; Sign a purchase and sales contract — After confirming the price, delivery time, payment method, and transportation plan, sign a formal contract to protect the rights and interests of both parties. Quick Overview of Core Product Parameters ItemParameter Product NamePolyethylene Glycol PEG-600 CAS No.25322-68-3 AppearanceColorless to slightly yellow viscous liquid/semi-solid Effective Content≥99% Molecular Weight570-630 HLB ValueApprox. 19 pH Value (1% Aqueous Solution)5.0~7.0 Cloud Point>100℃ (1% Aqueous Solution) Packaging Specifications50kg plastic drum / 200kg plastic drum / IBC tote PriceNo public quotation available, please contact the sales team Precautions This product is non-hazardous, but has slight hygroscopicity. Keep the container tightly sealed during storage, store in a cool, dry, and well-ventilated place, recommended temperature not exceeding 40℃; Avoid high temperature and direct sunlight during transportation to prevent package damage; The above product data comes from the Guoli Chemical official database. For actual purchase, please refer to the product quality inspection report (COA); For bulk purchases, tiered discounts can usually be applied. Please negotiate specific preferential policies with the Guoli Chemical sales representative.

Question 4

Does Polyethylene Glycol PEG-600 meet environmental protection requirements? Can a test report be provided?

Accepted Answer

Polyethylene Glycol PEG-600 has good environmental protection characteristics, but there is currently no third-party environmental test report in the database. For a formal report, please contact the sales department of Guoli Chemical. Detailed Description Polyethylene Glycol PEG-600 (CAS Number: 25322-68-3) exhibits good environmental protection characteristics from the perspective of chemical structure and environmental behavior. This product is a nonionic polymer compound. The ether bonds (C-O-C) in the molecular main chain can be slowly degraded in the environment through pathways such as photooxidation and biological enzymatic hydrolysis, ultimately decomposing into carbon dioxide and water. According to the Guoli Chemical product database, the acute oral toxicity LD50 of this product in rats is greater than 2000 mg/kg, belonging to the low toxicity level; it is non-irritating to skin and only slightly irritating to eyes, indicating low direct harm to organisms. The limits of heavy metals and harmful elements also reflect the environmental attributes of the product. The product quality standard clearly controls the total heavy metal content to ≤20 mg/kg and the arsenic content to ≤2 mg/kg, which are r below the limit requirements for general industrial chemicals, meeting the strict standards for pharmaceutical and cosmetic applications. In terms of waste disposal, Guoli Chemical clearly requires that waste be handed over to licensed waste disposal agencies for incineration or appropriate treatment in accordance with local and national regulations, prohibiting discharge into sewers, waterways, or soil, reflecting the company's emphasis on environmental responsibility. Regarding test reports, the current Guoli Chemical product database does not include third-party environmental test reports (such as RoHS, REACH, SGS test reports, etc.) for this product. To obtain a formal Certificate of Analysis (COA), Safety Data Sheet (SDS), or specific environmental compliance statements, it is recommended to directly contact the sales department or quality management department of Guoli Chemical, who can provide test data for the corresponding batch according to your specific needs. Technical Parameters Parameter NameSpecificationEnvironmental Significance Active Content≥99%High purity, few impurities, reducing introduction of harmful by-products Total Heavy Metals≤20 mg/kgMeets heavy metal limit requirements for pharmaceutical and cosmetic grades Arsenic Content≤2 mg/kgControls harmful elements, ensures safe use Free Alcohol≤0.1%High degree of reaction, very low residual unreacted monomers Acid Value≤0.5 mgKOH/gNeutral pH, reducing corrosiveness and ecotoxicity pH (1% Aqueous Solution)5.0~7.0Close to neutral, minimal impact on water pH when discharged Flash Point≥220℃High flash point indicates low volatility, reducing VOC emissions Iodine Value≤0.1Extremely low unsaturation, chemically stable Application Suggestions Polyethylene Glycol PEG-600, with its good biodegradability and low ecotoxicity, is particularly suitable for fields with high environmental protection requirements. In the pharmaceutical and personal care industries, its purity and safety indicators already have inherent advantages, making it a preferred choice for green formulations. When used as an emulsifying dispersant in pesticide formulations, the molecular structure will gradually degrade after the solution enters the soil, without long-term accumulation in the environment. When used in the textile and paper industries, it is recommended to equip with wastewater treatment cilities to ensure that the COD of discharged water meets standards. Precautions Although PEG-600 itself has good environmental performance, leakage emergency handling specifications must still be followed during use, and wastewater containing the product is strictly prohibited from being directly discharged into natural water bodies. Empty drums may contain product residues and should be uniformly recycled and disposed of in accordance with hazardous waste or industrial solid waste management requirements, and must not be discarded arbitrarily. If compliance confirmation is needed for specific national or regional environmental regulations (such as EU REACH, China's New Chemical Substance Environmental Management, etc.), please request the latest compliance statement documents from Guoli Chemical.

Question 5

What are the advantages of polyethylene glycol PEG-600 compared to other similar products?

Accepted Answer

According to the technical data of Guoli Chemical, the core competitive advantage of polyethylene glycol PEG-600 lies in its achievement of an ideal balance in **molecular weight, physical form, and performance parameters**, making it the most versatile "all-rounder" choice with optimal comprehensive performance in multiple key application areas, especially in the pharmaceutical and personal care industries. Detailed explanation: PEG series products are classic non-ionic surctants. Different molecular weight grades determine the morphological changes from liquid, semi-solid to solid, as well as differences in key properties such as hygroscopicity, viscosity, and solubility. The advantage of Guoli Chemical PEG-600 stems precisely from its position in this "middle ground." ### 1. Unique Advantages of Physical Form - **Compared to low molecular weight products (e.g., PEG-200, PEG-300, PEG-400)**: These products are viscous liquids at room temperature (e.g., the viscosity of PEG-400 at 40°C is about 13-17 mm²/s, much lower than PEG-600). The physical form of PEG-600 has advantages. At room temperature (15~25°C), PEG-600 is a **colorless to slightly yellow transparent liquid or semi-solid**. This state allows it to be easily handled and mixed like a liquid when heated, while providing a certain consistency and structural support to the formulation upon cooling, which is unachievable with pure liquid PEG. - **Compared to high molecular weight products (e.g., PEG-800, PEG-2000)**: High molecular weight PEG is a waxy solid at room temperature and typically requires hot melting for use, making the process more complex. PEG-600 has moderate viscosity (low shear viscosity 100-150 mPa·s at 25°C), allowing operation at low temperatures with lower energy consumption and broader process adaptability. ### 2. Balance of Core Performance Parameters The key technical indicators of PEG-600 determine its balanced performance across multiple applications. | Key Performance | PEG-600 (Guoli Chemical) | Advantage Description | | :--- | :--- | :--- | | **Hydroxyl value (mg KOH/g)** | **178-196** | **Moderate reactivity**. It retains sufficient reaction sites for subsequent modification such as esterification (better than high molecular weight PEG with low hydroxyl value), while not being too difficult to control due to excessively st reactions. | | **HLB value** | **19** | **Extremely strong hydrophilicity**. This value is much higher than most non-ionic emulsifiers (usually 8-16), making its solubilization and moisturizing capabilities very prominent. | | **Cloud point of 1% aqueous solution** | **>100°C** | **Good high-temperature stability**. Compared with some non-ionic surctants with low cloud points, PEG-600 does not precipitate and lose efficacy due to the "cloud point" phenomenon in high-temperature processes (e.g., high-temperature leveling in textiles). | | **Solubility** | **Easily soluble in water, ethanol, acetone** | **Broad formulation compatibility**. Whether in a pure water system or a pharmaceutical or coating formulation containing organic solvents, it can be easily dissolved, which many specialized emulsifiers lack. | | **Moisturizing property** | **Hygroscopic** | **Core capability as a humectant**. The chain length of PEG with molecular weight 600 can effectively bind water molecules without causing an overly strong film-forming sensation like high molecular weight PEG, providing a refreshing and moist skin feel. | | **Safety** | **Non-hazardous, non-irritating to skin** | **Foundation for application fields**. In animal tests, it is non-irritating to skin, enabling its safe use in direct human contact pharmaceutical areas such as ointments, suppositories, dropping pills, and injection solubilization, as well as long-lasting cosmetics like creams and lotions, an advantage that many industrial-grade surctants cannot match. | ### 3. Breadth and Depth of Application Fields It is precisely the above balanced advantages that give PEG-600 unparalleled application breadth: - **Pharmaceutical Field**: As an **ointment base**, its water solubility makes it easier to spread and clean than oil-based bases like petrolatum; as a **suppository base**, it quickly dissolves in body fluids and releases the drug; as a **solid dispersion carrier for dropping pills**, it effectively improves the bioavailability of poorly soluble drugs. Low molecular weight PEG has insufficient moisturizing capacity, while high molecular weight PEG has slow hydration and dissolution rates. Only PEG-600 achieves the optimal balance between rapid release and formability due to its molecular weight and form. - **Personal Care Products**: Compared with the sticky feeling of low molecular weight PEG, PEG-600 as a **humectant** provides a more lasting moisturized skin feel; as an **emulsion stabilizer**, it significantly increases the viscosity of the water phase and enhances the intercial film strength to prevent emulsion stratification, with better thickening and stabilizing effects than PEG-400. - **Industrial Field**: In **ceramic slurries**, the molecular chain length of PEG-600 is sufficient to form an effective steric stabilization layer on the particle surce, preventing agglomeration and obtaining slurries with high solid content and high fluidity, with better effects than short-chain PEG; as a **rubber mold release agent** and **metalworking fluid lubricant**, its moderate viscosity and inverse solubility provide a good balance of lubrication and cooling, with better processability than solid PEG. **Application Recommendations** - **Pharmaceutical suppositories/ointments**: Recommended dosage 5-30%, compounded with PEG-400 or PEG-4000 as needed according to desired consistency. - **Cosmetic moisturizing essence**: Recommended dosage 1-5%, can be used synergistically with glycerin, sodium hyaluronate, etc. for moisturizing. - **Ceramic dispersant**: Add 0.2-1.0% by dry weight of powder to significantly reduce slurry viscosity. **Precautions** - **Storage**: PEG-600 is hygroscopic; it must be sealed and stored in a cool, dry place. It will solidify into a semi-solid or solid at low temperatures; this is a physical change. Before use, gently heat in a warm water bath to melt and mix evenly; product quality is not affected. - **Safety**: Non-irritating to skin, but safety glasses should still be worn during operation to prevent minor eye irritation. - **Prohibitions**: Avoid storage together with strong oxidizing agents (e.g., peroxides, permanganates).

Question 6

How to store polyethylene glycol PEG-600? What is the shelf life?

Accepted Answer

Polyethylene glycol PEG-600 should be stored in a cool, dry, well-ventilated warehouse, keep the container tightly sealed to prevent moisture absorption, and the recommended temperature should not exceed 40°C. Under proper storage conditions, the shelf life is typically 2 years. Detailed Description Polyethylene glycol PEG-600 (CAS No.: 25322-68-3) is a hygroscopic non-ionic polymer compound. The key to its storage is moisture prevention and temperature control. This product will become a waxy solid at low temperatures, which is a normal physical change and does not affect product quality. It only needs to be gently heated to return to a liquid state before use. PEG-600 is chemically stable and exhibits good tolerance to acids, alkalis, and hard water. However, prolonged exposure to high temperature or high humidity environments may cause product dilution through water absorption, color deepening, or pH value changes. Therefore, the storage environment should be strictly controlled, and the product should be used as soon as possible after opening. Storage Conditions Storage RequirementSpecific Description Environmental ConditionsCool, dry, well-ventilated warehouse, away from fire, heat sources and direct sunlight Temperature ControlRecommended storage temperature not exceeding 40°C to avoid solidification or overheating Container RequirementKeep container tightly sealed to prevent product moisture absorption Isolation RequirementStore separately from strong oxidizers (such as peroxides, hypochlorites, permanganates) and strong acids, strong bases OthersKeep away from food, beverages and animal feed; regularly check package integrity to prevent leakage Shelf Life Description According to Guoli Chemical product data, when strictly following the above storage conditions and keeping the container sealed intact, the recommended shelf life of polyethylene glycol PEG-600 is 2 years. Products beyond the shelf life should be retested for key indicators such as appearance, pH value, hydroxyl value, and can only be used after confirming compliance. Precautions After opening, use as soon as possible. Use clean and dry tools for material handling to avoid introducing moisture and impurities. Do not heat the product directly with an open flame after solidification; use a warm water bath (not exceeding 60°C) to slowly melt it. Empty containers may have product residue; they should be thoroughly cleaned before disposal or recycling, and should not be discarded arbitrarily or used to hold other materials. The storage area should be equipped with emergency response cilities, and operators should be miliar with leakage handling methods.

Question 7

What safety precautions should be taken when using polyethylene glycol PEG-600?

Accepted Answer

Polyethylene glycol PEG-600 has good overall safety, but operating, storage, emergency, and fire protection specifications must still be followed to ensure personnel and environmental safety. Detailed Explanation According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), polyethylene glycol PEG-600 (CAS: 25322-68-3) is not classified as a hazardous substance. The oral acute toxicity LD50 in rats is greater than 2000 mg/kg, indicating low acute toxicity. In animal tests, this product is non-irritating to the skin (rabbit) and slightly irritating to the eyes (rabbit). Therefore, in daily operations, eye protection is the primary focus. Although toxicity and irritation are low, good industrial hygiene practices should still be followed in large-scale industrial use or long-term exposure scenarios. Chemical safety goggles and appropriate protective gloves (e.g., nitrile rubber or polyvinyl alcohol gloves) should be worn during operation to avoid prolonged or repeated skin contact. The work area should have good ventilation, and eating, drinking, or smoking is prohibited at the job site. Hands must be thoroughly washed after operation, and contaminated work clothes should be cleaned before reuse. Key Points for Safe Operation and Storage CategorySpecific Requirements Personal ProtectionWear chemical safety goggles, nitrile rubber or polyvinyl alcohol protective gloves Ventilation RequirementsEnsure general ventilation or local exhaust; engineering controls preferred when aerosols are generated Storage TemperatureRecommended not to exceed 40°C, avoid solidification or overheating Storage EnvironmentCool, dry, well-ventilated; keep containers tightly closed to prevent moisture absorption; keep away from heat, sparks, and direct sunlight Incompatible MaterialsKeep away from strong oxidizers (peroxides, hypochlorites, permanganates), strong acids, and strong bases Segregation RequirementsStore separately from food, beverages, and animal feed Emergency Response Guidelines Accident TypeResponse Measures Skin ContactRemove contaminated clothing, wash thoroughly with running water and soap for at least 15 minutes; seek medical attention if discomfort occurs Eye ContactImmediately flush eyes with plenty of water or saline for at least 15 minutes, holding eyelids open; seek medical attention if irritation persists InhalationMove to fresh air, keep at rest; administer oxygen if respiratory discomfort, seek medical attention if symptoms persist IngestionRinse mouth with water, do NOT induce vomiting; drink 1-2 glasses of water to dilute; if vomiting occurs, keep head lower than hips to prevent aspiration; seek medical attention immediately Spill ResponseCover with inert absorbent material (sand, vermiculite, etc.), collect in a closed container; do not allow entry into sewers or waterways Fire FightingUse water fog, alcohol-resistant foam, dry chemical, or carbon dioxide; do not use direct water stream; firefighters must wear positive pressure self-contained breathing apparatus Application Recommendations When using PEG-600 in daily applications, safety emphases vary by scenario: in pharmaceuticals and personal care products, strict control of product purity and microbial indicators is required, and the operating environment must comply with GMP or hygiene standards; in industrial fields (metalworking, textiles, ceramics, etc.), focus on ventilation and skin protection to avoid prolonged or repeated contact; for large-scale production or dispensing, pre-train operators on the above emergency procedures and equip the work area with eyewash stations and emergency showers. Precautions This product is combustible; fire may release carbon monoxide, carbon dioxide, and irritating fumes. Do not underestimate fire risks. Empty containers may contain residues; do not fill with other materials or discard without thorough cleaning. Waste must be handled by licensed disposal cilities in compliance with local regulations for incineration or proper disposal; do not discharge directly into the environment. Regularly inspect container integrity to prevent moisture absorption leading to quality degradation or leakage risk.

Question 8

How to use polyethylene glycol PEG-600? What is the recommended dosage?

Accepted Answer

The usage method of polyethylene glycol PEG-600 varies depending on the application field. Generally, it can be directly added to the formula and stirred evenly. The recommended dosage is usually 1% to 20% of the total formula, and the specific amount should be adjusted according to the application and system. Detailed Description Polyethylene glycol PEG-600 (CAS No.: 25322-68-3) is a nonionic high molecular weight compound produced by Guoli Chemical. It appears as a colorless to slightly yellow transparent liquid or semi-solid (melting point 15~25°C), with a molecular weight range of 570~630 and an HLB value of up to 19. It has excellent water solubility, emulsifying, wetting, dispersing, and solubilizing capabilities. Before use, if the product is waxy solid due to low temperature, it can be gently warmed to liquid in an environment not exceeding 40°C, stirred evenly, and then directly added to the formula system. This product has good compatibility with acids, alkalis, and hard water, and has wide compatibility. PEG-600 can be used flexibly in various ways: In the pharmaceutical field, it is usually melted and mixed with other matrix materials (such as PEG-400, PEG-4000, etc.) in proportion to make ointment bases or suppository bases; in personal care products, it can be directly added during the water phase heating stage, fully dissolved in water before participating in emulsification; in industrial fields (such as metalworking fluids, ceramic slurries, coatings, etc.), it is generally added slowly to the system as a functional additive under stirring to ensure uniform dispersion. Since the product is hygroscopic, it should be sealed promptly after opening to avoid absorbing moisture from the air and affecting weighing accuracy. Technical Parameters Parameter ItemSpecification Value AppearanceColorless to slightly yellow transparent liquid or semi-solid Molecular Weight570~630 Hydroxyl Value (mg KOH/g)178~196 HLB Value19 pH Value (1% Aqueous Solution)5.0~7.0 Moisture Content≤1.0% Density (g/cm³)1.11~1.13 Melting Point15~25°C Flash Point≥220°C Active Content≥99% Application Recommendations The recommended dosage for different application scenarios is as follows (data source: Guoli Chemical product database combined with industry application experience): Application FieldPurposeRecommended Dosage (as percentage of total formula) Pharmaceutical — Ointment/Suppository BaseWater-soluble drug carrier20%~50% (compounded with other PEGs) Pharmaceutical — Dropping Pill CarrierSolid dispersion matrix10%~30% Personal Care — Humectantce creams, lotions, toners1%~5% Personal Care — tting Agent in DetergentsBody washes, hand washes0.5%~3% Metalworking FluidsLubricants, coolants3%~15% Ceramic/Pigment SlurriesDispersant0.2%~2% (based on solid content) Rubber/Plastic ProcessingInternal lubricant, mold release agent0.1%~1% Coatings/InksLeveling agent0.5%~3% Textiles — Antistatic Agent/Leveling AgentFinishing liquor or dye bath0.5%~5% Pesticide FormulationsEmulsifying dispersant, synergist penetrant3%~10% Precautions Pretreatment and Feeding Sequence: In the case of low-temperature solidification, gently heat to melt below 40°C, avoiding localized high-temperature heating. It is recommended to pre-dissolve in the water phase before subsequent emulsification or mixing processes. Hygroscopicity Management: This product is hygroscopic. After weighing, the packaging container should be sealed immediately. Prolonged exposure to air can cause the product to absorb water, affecting active ingredient content and thus formula accuracy. Safety Protection: Although the product is non-irritating to the skin (according to rabbit test data), it is slightly irritating to the eyes. It is recommended to wear chemical safety goggles and protective gloves (e.g., nitrile rubber gloves) during operation, avoiding contact with eyes. Wash hands thoroughly after work. Storage Requirements: The recommended storage temperature should not exceed 40°C. Keep away from strong oxidizers, strong acids, and strong bases. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse. Compatibility Testing: When compounding with anionic surctants or other functional additives, it is recommended to first conduct small-scale compatibility verification to confirm no precipitation, separation, gelation, or other adverse phenomena before scaling up.

Question 9

In which industries and processes is polyethylene glycol PEG-600 mainly used?

Accepted Answer

Polyethylene glycol PEG-600, with its excellent emulsifying, wetting, dispersing, and solubilizing properties, is widely used in eight major fields including pharmaceuticals, personal care products, metalworking, ceramics, rubber, textiles, papermaking, and pesticides. It is a cross-industry, multifunctional non-ionic polymer adjuvant. Detailed Description Polyethylene glycol PEG-600 (CAS: 25322-68-3) is a non-ionic polymer compound, appearing as a colorless to slightly yellow viscous liquid, and as a waxy solid at low temperatures. Its molecular chain contains a large number of ether oxygen groups, which can form hydrogen bonds with water molecules, imparting excellent water solubility, moisturizing properties, and intercial activity. Additionally, PEG-600 exhibits high tolerance to acids, bases, and hard water, making it widely applicable in complex industrial environments. In the pharmaceutical industry, PEG-600 is the most widely used, serving as an ointment base, suppository base, pill carrier, and as a solubilizer and suspending agent for injections. Its good biocompatibility and low skin irritation make it an indispensable pharmaceutical excipient. In the personal care sector, PEG-600 primarily utilizes its moisturizing and thickening properties, functioning as a humectant, emulsion stabilizer, and tting agent in cleansing products, providing long-lasting skin moisturization. In industrial applications, PEG-600 acts as a lubricant and coolant in metalworking fluids, forming a boundary lubricating film under high temperature and pressure; as an efficient dispersant in ceramics and pigment manucturing, preventing particle aggregation through entropic repulsion; as an internal lubricant and mold release agent in rubber and plastic processing, improving flowability and demolding; and as a leveling agent and defoamer in coatings and inks. Furthermore, it is used as an antistatic agent, softener, and leveling agent in textile dyeing and printing, for felt cleaning in papermaking, and as an emulsifying dispersant and penetration enhancer in pesticide formulations. Application Recommendations Pharmaceutical Preparations: When used as an ointment base, it is recommended to adjust the compounding ratio of PEG-600 and PEG-4000 according to drug release characteristics to achieve suitable consistency. When used as a solubilizer for injections, the dosage must be strictly controlled, and the risk of hemolysis should be evaluated. Personal Care Products: The recommended addition amount in lotions and creams is 2% to 8%, which can effectively improve system stability and skin feel. As a tting agent in shampoos and shower gels, the recommended dosage is 1% to 3%. Metalworking Fluids: As a lubricating and cooling additive, the recommended addition amount is 5% to 15%, utilizing its inverse solubility to form a protective film at processing hot spots while ensuring cooling effects. Ceramic Slurry Dispersion: Adding 0.5% to 2% by weight of powder can significantly reduce slurry viscosity, increase solid content, and improve flowability. Textile Leveling: Adding 1 to 3 g\/L in the dye bath can slow down the dye uptake rate, preventing color spots and uneven dyeing. Pesticide Formulations: When used as an emulsifying dispersant, the recommended dosage is 3% to 8% of the total formulation, and better results are achieved when combined with other surctants. Precautions PEG-600 has strong hygroscopicity; the container must be kept sealed during storage, and it is recommended to store in a cool, dry, and well-ventilated warehouse at a temperature not exceeding 40°C. Although this product is non-irritating to the skin, it may cause mild eye irritation. It is recommended to wear chemical safety goggles and protective gloves during operation. This product is flammable and should be kept away from fire and heat sources. It must be stored separately from strong oxidizing agents (such as peroxides, hypochlorites, permanganates). For pharmaceutical applications, specifications that meet pharmaceutical excipient standards (such as the Chinese Pharmacopoeia) must be selected; industrial-grade products should not be directly used in pharmaceutical preparations. When used as a dispersant, it is recommended to determine the optimal addition amount through pre-tests, as excessive use may lead to viscosity rebound of the system.

Question 10

What are the physicochemical technical parameters of polyethylene glycol PEG-600?

Accepted Answer

Polyethylene glycol PEG-600 is a nonionic high-molecular compound, appearing as a colorless to slightly yellow transparent liquid or semi-solid (waxy at low temperatures). It has excellent emulsifying, wetting, dispersing, and solubilizing properties, with an HLB value as high as 19, making it a highly hydrophilic surctant. Detailed Description Polyethylene glycol PEG-600 (CAS No.: 25322-68-3) is a linear high-molecular compound obtained by stepwise addition polymerization of ethylene oxide with water or ethylene glycol. Its molecular formula is HO(C2H4O)nH, where n is approximately 12~14, and the molecular weight ranges from 570 to 630. At room temperature, it appears as a colorless to slightly yellow viscous liquid, which solidifies into a waxy semi-solid at low temperatures (15~25°C). This product is a nonionic surctant with high tolerance to acids, bases, and hard water, exhibiting excellent chemical stability and is not easily decomposed at room temperature. Due to the ability of ether oxygen groups to form hydrogen bonds with water molecules, PEG-600 has significant hygroscopicity and excellent water solubility. It is miscible with water in any proportion and also soluble in organic solvents such as ethanol and acetone. Its cloud point exceeds 100°C (1% aqueous solution), indicating that the system remains clear under boiling water at normal pressure, a characteristic that offers unique advantages in processes requiring high-temperature operations. The product has low foaming properties, with a surce tension of approximately 44 mN\/m, making it a low-foam additive suitable for industrial applications where excessive foam is undesirable. This product is an industrial-grade product manuctured by Guoli Chemical in strict accordance with standards, with an active content of ≥99%, moisture content controlled at ≤1.0%, total heavy metals ≤20 mg\/kg, and arsenic content ≤2 mg\/kg, meeting the quality requirements for various fields such as pharmaceuticals and daily chemicals. Available packaging options include 50kg plastic drums, 200kg plastic drums, and IBC totes. Technical Parameters The following is the main physicochemical technical parameter table of polyethylene glycol PEG-600 produced by Haian Guoli Chemical Co., Ltd. (Data source: Guoli Chemical product database): Parameter ItemIndicator\/Value CAS No.25322-68-3 Molecular FormulaHO(C2H4O)nH, n ≈ 12~14 Molecular Weight570 - 630 AppearanceColorless to slightly yellow transparent liquid or semi-solid (waxy at low temperatures) Ion TypeNonionic Active Content \/ Solid Content≥99% Moisture≤1.0% Density (25°C)1.11 - 1.13 g\/cm³ Melting Point \/ Freezing Point15 - 25°C Refractive Index1.466 - 1.468 Kinematic Viscosity (40°C)13 - 17 mm²\/s Low Shear Viscosity (25°C)100 - 150 mPa·s Flash Point≥220°C HLB Value19 Cloud Point (1% Aqueous Solution)>100°C pH Value (1% Aqueous Solution)5.0 - 7.0 pH Value (5% Aqueous Solution)4.5 - 7.5 Surce Tension (1% Aqueous Solution, 25°C)Approximately 44 mN\/m Hydroxyl Value178 - 196 mgKOH\/g Acid Value≤0.5 mgKOH\/g Iodine Value≤0.1 gI2\/100g Free Alcohol≤0.1% Heavy Metals≤20 mg\/kg Arsenic≤2 mg\/kg Foaming PropertyLow foam HygroscopicityHygroscopic Chemical StabilityStable at room temperature, not easily decomposed Alkali ResistanceStable SolubilityEasily soluble in water, ethanol, acetone CMC (Critical Micelle Concentration)Not available Saponification ValueNot available Penetration PowerNot available Application Suggestions Based on the above physicochemical parameters, PEG-600 offers outstanding advantages in the following application scenarios: Pharmaceutical Field: With an HLB value as high as 19 and excellent water solubility, it is an ideal choice for ointment bases, suppository bases, and drop pill carriers. The hydroxyl value of 178~196 mgKOH\/g indicates moderate activity of the terminal hydroxyl groups, cilitating drug dispersion and release. Personal Care Products: Low irritation (non-irritating to skin), good hygroscopic and moisturizing properties, and low foam characteristics make it suitable for use as a humectant and viscosity regulator in creams, lotions, cial cleansers, and other products. Metalworking Fluids: The high flash point of ≥220°C ensures safety during high-temperature operations, and the kinematic viscosity of 13~17 mm²\/s (40°C) provides an excellent balance of lubrication and cooling performance. Pesticide Formulations: Excellent solubilization and dispersion capabilities combined with low foam properties prevent excessive foam during field dilution and application, while the surce tension of approximately 44 mN\/m helps the liquid spread and penetrate on leaf surces. Ceramics and Coatings: Good dispersion stability and chemical stability play an important role in slurry preparation and film leveling. Precautions Moisture Protection: The product is hygroscopic. After opening, it should be sealed promptly and stored in a cool, dry place to prevent moisture absorption leading to excessive moisture content affecting performance. Temperature Control: The freezing point (melting point) is 15~25°C. At low temperatures, the product may solidify into a solid. Before use, it can be slowly heated in a warm water bath (not exceeding 40°C) to return to a liquid state, avoiding localized overheating. Safety Protection: Although this product is non-irritating to the skin, it is mildly irritating to the eyes. It is recommended to wear chemical safety goggles and protective gloves during operation. Incompatibility: Avoid mixing or storing with strong oxidizers (such as peroxides, hypochlorites, permanganates) and strong acids or strong bases to prevent chemical reactions. Packaging Specifications: Depending on the required quantity, choose 50kg plastic drums, 200kg plastic drums, or IBC totes. Do not store other materials in empty containers before thorough cleaning.

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Property	Value
CAS No.	25322-68-3
Molecular Formula	HO(C2H4O)nH, n ≈ 12~14
Appearance	Colorless to slightly yellow transparent liquid or semi-solid
Ionic Type	Nonionic
Avg. Molecular Weight	570-630
Cloud Point	>100°C (1%aq. soln.)
Active Content	≥99%
pH Value(1%)	5.0~7.0
pH Value(5%)	4.5~7.5
Iodine Value	≤0.1
Solubility	Readily soluble in water, ethanol and acetone
Surface Tension	~44 mN/m (1%aq. soln., 25°C)
Acid Value	≤0.5
Hydroxyl Value	178-196
Moisture	≤1.0
Density	1.11~1.13
Kinematic Viscosity	13~17 (40°C)
Refractive Index	1.466~1.468
Flash Point	≥220°C
Hygroscopicity	Hygroscopic
Chemical Stability	Stable at room temperature, does not readily decompose
Foam Property	Low foam
Alkali Resistance	Stable
Viscosity	100~150
Melting Point	15~25°C
Low Shear Viscosity	100~150 mPa·s (25℃)
Solid Content	≥99%
Free Alcohol	≤0.1%
Heavy Metal	≤20 mg/kg
Arsenic	≤2 mg/kg