Question 1

Is polyethylene glycol PEG-4000/6000 harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Polyethylene glycol PEG-4000/6000 is a practically non-toxic substance, which is basically harmless to the human body under normal use conditions and has relatively limited negative impact on the environment. Detailed Explanation According to the safety data from the Guoli Chemical Product Database, the acute oral toxicity LD50 (rat) of polyethylene glycol PEG-4000/6000 is greater than 5000 mg/kg, which lls under the "practically non-toxic" category according to toxicological classification standards. This product poses a very low safety risk to humans under normal industrial and daily chemical uses, which is why it is widely applied in fields such as pharmaceuticals (ointment bases, suppository bases, drop pill carriers), toothpaste, skincare products, and other areas directly in contact with the human body. The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and EC No 1272/2008 regulations do not classify it as a hazardous substance or mixture. It should be noted that despite its low toxicity, attention is still needed under specific exposure conditions: dust inhalation may cause mild mechanical irritation to the respiratory tract; long-term repeated skin contact may lead to degreasing and drying; eye contact may cause mild irritating discomfort. These are physical/mechanical irritations rather than chemical toxic reactions. In addition, this product has strong hygroscopicity; it should be stored in sealed containers after opening. These risks can be effectively controlled by wearing basic protective equipment (dust mask, gloves, goggles). Regarding environmental impact, the database does not currently include detailed ecotoxicological data for PEG-4000/6000 (such as LC50, EC50, biodegradability, and other specific indicators). However, based on the chemical properties of polyethylene glycols, PEG series polymers generally have good water solubility and certain biodegradability, and do not cause persistent bioaccumulation in the environment. Under normal industrial discharge concentrations, their impact on aquatic ecosystems is relatively limited. It is recommended that enterprise users still comply with local environmental regulations, avoid large-scale untreated discharges, and implement wastewater treatment measures. Technical Parameters Parameter Item Value/Description Data Source Hazard Classification Not classified as hazardous substance or mixture GHS / EC No 1272/2008 Acute Oral Toxicity LD50 (Rat) > 5000 mg/kg Guoli Chemical Product Database Toxicity Level Practically non-toxic Toxicological Classification Standard Flash Point (Open Cup) > 240 °C Guoli Chemical Product Database Dust Explosion Class St1 Guoli Chemical Product Database Minimum Ignition Temperature of Dust Cloud (MIT) > 400 °C Guoli Chemical Product Database Skin Irritation Long-term repeated contact may cause degreasing and drying Guoli Chemical Product Database Eye Irritation May cause mild mechanical irritation Guoli Chemical Product Database Biodegradability Not available (no specific ecological data in product database) — Aquatic Ecotoxicity (LC50/EC50) Not available — Application Recommendations Given the low toxicity characteristics of PEG-4000/6000, its use in fields such as pharmaceuticals, daily chemicals, and indirect food contact is highly safe. In formulation design, it is recommended to: Pharmaceutical uses: Strictly follow pharmacopoeia standards to ensure raw material purity meets pharmaceutical grade requirements. Daily chemical products: Adjust recommended dosage according to specific formulation, generally within the range of 0.5% to 10% to achieve moisturizing, lubricating, and shaping effects. Industrial uses: In applications such as textiles, papermaking, and metal processing, no special protective measures are required under normal operating conditions, but it is still recommended to wear basic personal protective equipment. Precautions Dust control: Avoid generating and accumulating dust during operation; fine dust mixed with air at a certain concentration poses an explosion risk (St1 class). It is recommended to equip local exhaust ventilation and dust collection systems, and keep away from open flames and high-temperature ignition sources. Moisture-proof storage: The product is highly hygroscopic; store sealed in a cool (recommended 10~30°C) and dry environment. Personal protection: It is recommended to wear dust masks (FFP2 standard), nitrile rubber gloves, and safety goggles. Thoroughly wash exposed skin after operation. Emergency handling: In case of eye contact, rinse with plenty of water for at least 15 minutes; if discomfort occurs from dust inhalation, move to fresh air; if symptoms persist, seek medical attention promptly. Environmental discharge: Although the product itself is low-toxicity, avoid large-scale untreated discharge into the environment, and comply with local wastewater treatment regulations.

Question 2

What should I do if problems occur during the use of polyethylene glycol PEG-4000/6000? How to obtain technical support?

Accepted Answer

If problems occur during the use of polyethylene glycol PEG-4000/6000, it is recommended to first conduct a preliminary investigation based on the phenomenon of common causes. If unresolved, contact the technical team of Haian Guoli Chemical Co., Ltd. for professional support. Detailed Description Polyethylene glycol PEG-4000/6000 is a stable non-ionic high molecular polymer, and problems rarely occur under normal usage conditions. If you encounter abnormalities during use, it is usually related to ctors such as moisture absorption and deterioration during storage, dust accumulation, mismatch of process parameters. It is recommended to first use the following common problem self-check table for preliminary diagnosis, most problems can be quickly located and resolved. If the cause still cannot be determined after self-check, or if deeper technical guidance is required due to formula adjustments or process changes, it is recommended to contact Guoli Chemical's technical service team directly. As the manucturer, Guoli Chemical has a complete application laboratory and senior technical engineers who can provide one-on-one formula optimization suggestions and troubleshooting solutions for your specific application scenario. It is worth noting that although PEG-4000 and PEG-6000 belong to the same polyethylene glycol series, they differ in molecular weight (4000 vs 6000), resulting in differences in melting point, viscosity, dissolution rate, etc. If problems occur when replacing models, it is likely due to improper selection. Common Problems and Troubleshooting Guide Common ProblemPossible CauseTroubleshooting and Solution Suggestions Product caking or moistHigh humidity in storage environment, loose packaging seal leading to moisture absorptionPEG-4000/6000 has strong hygroscopicity and should be stored in a dry and ventilated place (recommended temperature 10-30°C). Check if the packaging is damaged or sealed. Slight moisture absorption can be dried at a temperature below 50°C before use; severely deteriorated due to moisture absorption should be discarded. Slow dissolution or insolubilityMoisture absorption and deterioration, molecular chain degradation, solvent system mismatchConfirm whether the product is within the shelf life and storage conditions are qualified. PEG-4000/6000 is soluble in water and various organic solvents (such as ethanol, acetone, chloroform), but insoluble in aliphatic hydrocarbons. Appropriate heating and stirring (40-60°C) can accelerate dissolution. Precipitation or stratification in formulaPoor compatibility with other components, excessive dosage, drastic pH environment changesAlthough PEG is stable over a wide pH range, prolonged storage under extremely high acid/base conditions may lead to degradation. It is recommended to check the electrolyte concentration and solvent ratio in the formula, and adjust the addition order or dosage if necessary. Dust issuesFine dust accumulation during operation⚠️ Dust mixed with air at a certain concentration poses an explosion risk (dust explosion class St1, minimum ignition temperature >400°C). The operating area must have good ventilation, be away from open flames and ignition sources, use explosion-proof electrical equipment, and be equipped with a dust collection system. Operators should wear dust masks (FFP2 standard). Batch-to-batch performance variationFluctuation in molecular weight distribution range between batches, confusion in supply modelCheck the product packaging label to confirm the correct model (PEG-4000 or PEG-6000). Guoli Chemical provides a quality inspection report for each batch of product, which can be used to check whether key indicators such as hydroxyl value, average molecular weight, viscosity, etc., are within the acceptable range. Poor lubricating/moisturizing effect in applicationInsufficient or excessive dosage, unsuitable process temperatureRefer to the recommended dosage range and adjust according to the specific process. For example, textile lubricants generally recommend 0.5%-3%, and pharmaceutical ointment bases are typically 20%-50%. Application Recommendations To avoid problems during use, it is recommended to refer to the following best practices for different application scenarios: Pharmaceutical ointment base: Mix PEG-4000 and PEG-6000 in a certain ratio to precisely adjust the melting point and consistency of the base to meet the release requirements of different drugs. Textile lubricant: It is recommended to prepare a 5%-10% aqueous solution, control the liquid application temperature at 40-50°C to achieve optimal smoothness and antistatic effects. Paper coating: Recommended dosage is 0.5%-1.5% of the dry pigment weight. Pre-dissolve in warm water before adding to the coating system to avoid clumping caused by direct addition of dry powder. Metalworking quenchant: The concentration is usually controlled at 0.5%-5%, and should be precisely adjusted according to the workpiece material and quenching requirements to obtain a uniform cooling curve. Pesticide formulation carrier: Recommended dosage is 5%-20% in wettable powder, which can significantly improve suspension rate and dispersion uniformity. How to Obtain Guoli Chemical Technical Support Phone consultation: Call the official technical service hotline of Haian Guoli Chemical Co., Ltd. to communicate directly with engineers about the problems you encounter. Sample submission: If it involves batch quality issues, send the problematic sample and the same batch retained sample to the Guoli Chemical quality inspection center for re-inspection and analysis. On-site service: For major process issues, Guoli Chemical can arrange technical engineers to go to the site for diagnosis and commissioning guidance. Technical support email: Send an email with a description of the problem, on-site photos or videos, batch number, etc., and the technical team will respond as soon as possible. Official website message: Submit the problem through the technical support entry on the Guoli Chemical official website to get online help. Please Prepare the Following Information Before Contact To solve your problem more efficiently, it is recommended to prepare the following information before contacting the technical team: ① Product name and batch number; ② Application scenario and process conditions (temperature, concentration, pH, etc.); ③ Specific phenomenon of the problem (photos or videos are better); ④ Measures already tried. This will help engineers quickly locate the root cause of the problem and reduce waiting time.

Question 3

How to purchase Polyethylene Glycol PEG-4000/6000? What is the minimum order quantity?

Accepted Answer

For purchasing Polyethylene Glycol PEG-4000\/6000, please contact the Guoli Chemical sales team directly for the latest quotation and ordering plan. Detailed Description Polyethylene Glycol PEG-4000\/6000 (CAS No.: 25322-68-3) is one of the core products of Guoli Chemical, widely used in pharmaceuticals, daily chemicals, textiles, rubber, papermaking, metal processing, and pesticide formulations. This product is a nonionic high molecular polymer, appearing as a white waxy solid or granules. It is non-hazardous, with relatively friendly transportation and storage conditions. Due to the significant impact of raw material market fluctuations on chemical raw material prices, the actual selling price of this product is based on the real-time quotation provided by the sales team. The prices currently marked in the product database are for reference only. The specific transaction price needs to be determined based on ctors such as purchase quantity, packaging specifications, settlement method, and transportation distance. Purchasing Information ItemDetails Packaging Specifications200kg iron drum \/ 50kg plastic drum Minimum Order QuantityNo fixed minimum order quantity data available currently; it is recommended to use a single package as the order unit. Please consult the sales team for details. Price DescriptionThe price is subject to market fluctuations. Please contact the sales team for the latest quotation. Price Update Date2026-06-10 How to Place an Order The Guoli Chemical sales team will provide you with one-on-one product consultation and order services. The communication content may include: Confirm the specific molecular weight specifications of the required product (PEG-4000 or PEG-6000) Select packaging type (200kg iron drum or 50kg plastic drum) Determine the purchase quantity and delivery cycle Negotiate transportation methods and cost responsibility Provide product Certificate of Analysis (COA) and Safety Data Sheet (SDS) Precautions This product is highly hygroscopic. During storage, keep the packaging sealed and store in a cool, dry place (recommended room temperature 10-30°C). Avoid packaging damage during transportation and keep away from strong oxidizing agents. It is recommended to wear dust masks and protective gloves during operation, and take dust prevention measures.

Question 4

Does polyethylene glycol PEG-4000/6000 meet environmental requirements? Can a test report be provided?

Accepted Answer

Polyethylene glycol PEG-4000/6000 meets basic environmental requirements under normal use conditions, but for formal test reports, please contact the sales department of Guoli Chemical. Detailed Explanation Polyethylene glycol PEG-4000/6000 is a nonionic high-molecular polymer. Based on existing product data, its environmental characteristics are mainly reflected in the following aspects: First, according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and EC No 1272/2008 regulations, this product is not classified as a dangerous substance or mixture. Second, its acute oral toxicity LD50 (rat) is greater than 5000 mg/kg, which is classified as practically non-toxic, posing a relatively low risk of direct harm to the ecological environment and human health. In addition, this product has good water solubility and can be gradually biodegraded in the natural environment without causing persistent organic pollution. It should be noted that PEG-4000/6000 itself is not listed as a key controlled pollutant. However, in large-scale industrial use, when fine dust mixes with air to a certain concentration, there is a risk of dust explosion (dust explosion class St1). Therefore, enterprises need to equip appropriate dust collection and ventilation systems, which is both a production safety requirement and an important part of environmental compliance. During operation, dust should be prevented from escaping into the atmospheric environment. Regarding the test report you mentioned, there are no directly downloadable environmental test report files (such as RoHS, REACH, biodegradation rate test reports, etc.) in the product database. Test reports usually vary depending on the batch, customer requirements, and target market. It is recommended that you directly contact the sales or quality inspection department of Haian County Guoli Chemical Co., Ltd., specifying the type of report required (such as REACH compliance statement, SGS test report, RoHS test report, biodegradability test report, etc.) to obtain the formal documents for the corresponding batch. Technical Parameters Parameter ItemValue/Description GHS Hazard ClassificationNot classified as dangerous substance or mixture Acute Oral Toxicity LD50 (Rat)> 5000 mg/kg (practically non-toxic) Dust Explosion ClassSt1 Minimum Ignition Temperature of Dust Cloud (MIT)> 400 °C Flash Point (Open Cup)> 240 °C BiodegradabilityBiodegradable (specific degradation rate data not available, please contact the manucturer for test report) REACH Compliance StatusPlease contact the sales department for the latest compliance statement Application Recommendations In applications such as pharmaceuticals, daily chemicals, textiles, and papermaking, PEG-4000/6000, due to its low toxicity and good water solubility, can replace some traditional additives that have a higher environmental burden. In wastewater treatment, industrial wastewater containing PEG is recommended to be treated using conventional biochemical treatment processes such as the activated sludge method. Its biodegradable properties help reduce the COD load of the wastewater. In the field of pesticide formulations, when used as a dispersion carrier, it can reduce the use of organic solvents, offering certain green formulation advantages. Precautions Environmental compliance requirements vary by industry and destination country. For example, export to the EU requires attention to REACH regulations, and export to the electronics industry requires attention to the RoHS directive. Please confirm with Guoli Chemical in advance whether the product meets specific regulatory requirements. This product has strong hygroscopicity. During storage, the packaging should be kept sealed to avoid quality changes due to moisture absorption and leakage risks caused by packaging damage. Avoid contact with strong oxidizing agents (such as peroxides, potassium permanganate, concentrated nitric acid, etc.) during operation to prevent hazardous reactions. If third-party test reports from organizations such as SGS or Intertek are required, Guoli Chemical can assist in arranging testing according to customer needs. Please communicate with the sales staff for specific costs and timelines.

Question 5

What are the advantages of Polyethylene Glycol PEG-4000/6000 compared to other similar products?

Accepted Answer

The core advantages of Polyethylene Glycol PEG-4000/6000 lie in its high purity (≥99%), extremely low impurity residues, excellent chemical stability, and wide applicability across eight major industries including pharmaceuticals, daily chemicals, textiles, and metal processing. It is a nonionic high-molecular-weight polymer that combines high safety and multifunctionality. Detailed Description The Guoli Chemical Polyethylene Glycol PEG-4000/6000 (CAS No.: 25322-68-3) series belongs to high-molecular-weight nonionic polymers with a molecular weight range of 3400~6600. Compared with low-molecular-weight liquid PEG (such as PEG-200/400), PEG-4000/6000 is a white waxy solid with a melting point as high as 50~63°C, enabling unique functions such as solid excipient and hot-melt processing. It is particularly suitable for applications requiring specific melting point characteristics, such as pharmaceutical suppository bases, drip pill carriers, and rubber mold release agents. From the technical specifications, the active content of PEG-4000/6000 is ≥99%, moisture content ≤1.0%, acid value ≤0.1, and iodine value ≤1. These stringent controls on key impurities ensure the reliability of the product in precision applications. Compared with some low-purity competitive products on the market, its extremely low ash content allows it to serve as a lubricating component in cutting fluids for precision metal processing without leaving residues on the workpiece surce. Additionally, its HLB value is as high as 18.9~19.0, and the cloud point is >100°C, endowing the product with excellent water solubility and compatibility, enabling good miscibility with various formulation systems. In terms of safety, the acute oral toxicity LD50 of PEG-4000/6000 is greater than 5000 mg/kg, classifying it as a practically non-toxic substance, r superior to many similar functional additives with significant irritation or toxicity. It remains stable over a wide pH range and exhibits excellent tolerance to acids, bases, and hard water environments, which is notably superior to some ester or amide additives that are prone to hydrolysis under acidic or alkaline conditions. However, it should be noted that its fine dust, when mixed with air to a certain concentration, poses a risk of dust explosion (St1 level). Operating areas should maintain good ventilation and be equipped with dust collection systems. Technical Parameters Technical Index Value Description Molecular Weight Range 3400~6600 High molecular weight solid, providing excellent formability Ion Type Nonionic Widely compatible with various systems HLB Value 18.9 / 19.0 Extremely high hydrophilicity, excellent water solubility Active Content ≥99% High purity, extremely low impurities Melting Point 50~63°C Suitable for hot-melt processing and solid excipient applications Moisture ≤1.0% Low moisture content ensures storage stability Acid Value ≤0.1 mgKOH/g Extremely low acidity, no interference with formulation system Hydroxyl Value 8~16 mgKOH/g Controllable terminal hydroxyl content Iodine Value ≤1 Nearly saturated, excellent oxidation stability Density 1.20~1.21 g/cm³ Derived from database pH Value (1% Aqueous Solution) 5.0~7.0 Near neutral, wide application range Cloud Point ＞100°C Remains water-soluble at high temperatures, good thermal stability Flash Point (Open Cup) ＞240°C High flash point, good processing safety Acute Oral Toxicity LD50 ＞5000 mg/kg Practically non-toxic, extremely high safety Heavy Metal Content ≤10 ppm Complies with pharmaceutical and daily chemical standards Arsenic Content ≤2 ppm Complies with pharmaceutical and daily chemical standards Application Recommendations Based on its unique technical characteristics, the recommended applications of PEG-4000/6000 in different industries are as follows: Pharmaceutical Industry: Used as ointment base, suppository base, and drip pill carrier, leveraging its melting point of 50~63°C and excellent water solubility to achieve uniform drug release; as a solid dispersion carrier, it can significantly enhance the bioavailability of poorly soluble drugs. Daily Chemical Industry: Replaces glycerin as a humectant in toothpaste to prevent cracking; acts as a conditioning agent in shampoos and body washes to provide a smooth feel while reducing the irritation of surctants. Textile Industry: Serves as an efficient antistatic agent and lubricant, imparting excellent smoothness and cohesion to synthetic fibers, reducing friction and static generation. Metal Processing: Used as the core component of water-based quenchants, leveraging its inverse solubility to regulate cooling rates; as a lubricant component in cutting fluids, suitable for precision machining due to its low ash properties. Agriculture: Acts as a dispersing carrier for wettable powders and water-dispersible granules of pesticides, rapidly disintegrating and dispersing the active ingredients upon contact with water, significantly improving suspension rate. Key Advantages Summary Based on its technical parameters and application performance, the core advantages of PEG-4000/6000 over similar products are: High purity with low impurities (content ≥99%, acid value ≤0.1) ensures no residue in precision applications; High thermal stability and high cloud point (cloud point >100°C, flash point >240°C) performs excellently in high-temperature processing; High safety and low toxicity (LD50 >5000 mg/kg) makes it the preferred basic material in pharmaceutical and daily chemical fields; Extremely strong chemical stability maintains functional integrity over a wide pH range. Precautions Moisture Absorption Management: PEG-4000/6000 has a certain hygroscopicity. Keep the packaging sealed during storage and store in a cool, dry environment (10~30°C) to avoid moisture absorption and caking. Dust Explosion Prevention: Fine dust can form explosive mixtures with air (St1 level). The operating area should be equipped with local exhaust ventilation and dust collection systems. All ignition sources are strictly prohibited, and equipment must be effectively grounded. Incompatible Materials: Keep away from strong oxidizers (such as

Question 6

How to store Polyethylene Glycol PEG-4000/6000? What is the shelf life?

Accepted Answer

Polyethylene Glycol PEG-4000/6000 should be stored sealed in a cool, dry place, away from strong oxidizing agents; under compliant storage conditions, the shelf life is typically up to 2 years, subject to the product packaging label. Detailed Explanation Polyethylene Glycol PEG-4000/6000 is a non-ionic high molecular polymer and is not classified as a hazardous chemical (CAS No.: 25322-68-3). This product is highly hygroscopic, easily absorbing moisture in humid environments leading to caking or degradation. Therefore, sealing and moisture prevention are key points in storage management. Additionally, when product particle dust reaches a certain concentration in the air, it may pose a dust explosion risk; storage areas should be kept away from ignition sources and well ventilated. The product itself is chemically stable and not prone to deterioration under long-term storage at room temperature in dry conditions. However, due to its specific melting point range (approximately 50~63°C), excessively high temperatures may cause the waxy solid to soften, deform, or even melt, damaging the product form; excessively low temperatures may cause the packaging material to become brittle and crack. Therefore, controlling the temperature within the recommended range is crucial for ensuring product quality and packaging integrity. Technical Parameters Parameter Item Specification Value Description Appearance White waxy solid or granules Normal storage state Hygroscopicity Strong hygroscopicity Requires strict sealing Melting point 50~63°C Storage temperature must be below this value Recommended storage temperature Room temperature 10~30°C Cool and dry environment Flash point (open cup) >240°C Safety data Dust explosion class St1 Minimum ignition temperature (MIT) of dust cloud >400°C Chemical stability Stable under normal temperature and dry conditions Source: Guoli Chemical database Solid content ≥99% Source: Guoli Chemical database Moisture content ≤1.0% Source: Guoli Chemical database Shelf life No explicit data in database Refer to product packaging label or COA Application Recommendations Polyethylene Glycol PEG-4000/6000 is widely used in multiple industries such as pharmaceuticals, daily chemicals, textiles, rubber, and papermaking. Different application scenarios have varying sensitivity to product moisture content and purity: Pharmaceutical industry (ointment bases, suppositories, drop pill carriers, etc.): Should be used as soon as possible after opening to avoid moisture absorption affecting preparation quality; it is recommended to test moisture content before use to confirm conformity to standards. Daily chemical industry (toothpaste humectants, skin care products, etc.): If caking or color darkening is observed after opening, perform a small-scale test to evaluate the impact before deciding whether to continue use. Textile and industrial applications (antistatic agents, mold release agents, etc.): Tolerance to moisture absorption is relatively broad, but sealing is still recommended; slight moisture absorption causing caking can be crushed and continue to be used. Precautions Do not store with strong oxidizing agents: Keep away from peroxides, potassium permanganate, concentrated nitric acid, and other strong oxidizing substances to prevent violent reactions. Prevent dust explosion: Storage and use areas should be equipped with explosion-proof ventilation cilities to avoid dust accumulation; open flames, sparks, and high-temperature surces are strictly prohibited; all equipment must be grounded to prevent static electricity. Packaging management: Seal the container immediately after use to avoid prolonged exposure to air; stacking must be stable to prevent tipping and damaging the packaging. Shelf life determination: The database does not yet include specific shelf life data for this product; it is recommended to refer to the expiration date on the product's COA or outer packaging. Generally, the shelf life of industrial-grade PEG products under original sealed and compliant storage conditions is about 2 years. If the product shows obvious color darkening, severe caking, or unusual odor, stop use and contact Guoli Chemical's technical department for confirmation.

Question 7

What safety precautions should be taken when using polyethylene glycol PEG-4000/6000?

Accepted Answer

PEG-4000/6000 is practically non-toxic and non-hazardous, but during operation, focus must be placed on preventing dust explosion risks, moisture absorption deterioration, and mechanical irritation. Detailed Description Polyethylene glycol PEG-4000/6000 itself is not a hazardous chemical; its acute oral toxicity LD50 (rat) is greater than 5000 mg/kg, classifying it as a practically non-toxic substance. However, this does not mean that safety protection during use can be ignored. The core safety hazard of this product lies in dust explosion risk — when fine dust mixes with air to a certain concentration, it can form an explosive mixture, with a dust explosion class of St1 and a minimum ignition temperature (MIT) of the dust cloud greater than 400°C. Therefore, the operating area must be kept away from open flames, sparks, and hot surces, and all equipment must be grounded to prevent electrostatic accumulation. Secondly, PEG-4000/6000 has strong hygroscopicity. During storage, the container must be kept sealed and stored in a cool (recommended room temperature 10-30°C), dry, and well-ventilated warehouse. After moisture absorption, the product may clump or even deteriorate, affecting its performance. Additionally, prolonged or repeated direct contact with the skin can cause degreasing and dryness. Nitrile rubber gloves are recommended during operation; if dust is generated, a dust mask (FFP2 standard or equivalent protection level) and chemical safety goggles should also be worn. In terms of emergency response, if a spill occurs, use non-sparking tools to collect the spilled material, strictly avoid raising dust, and residual material can be rinsed with water but with good ventilation. For firefighting, use water spray, alcohol-resistant foam, dry powder, or carbon dioxide. Avoid using a direct water jet on accumulated dust to prevent raising dust and forming an explosive mixture. Storage should also be kept away from strong oxidizers (such as peroxides, potassium permanganate, concentrated nitric acid, etc.). Safety Points at a Glance Safety DimensionKey Requirement Hazard ClassificationNot classified as hazardous substance or mixture (GHS criteria) Acute ToxicityOral LD50 > 5000 mg/kg (practically non-toxic) Dust Explosion ClassSt1, MIT > 400°C, keep away from ignition sources Flash Point (Open Cup)> 240°C Storage TemperatureRecommended room temperature 10-30°C, dry and ventilated Incompatible MaterialsStrong oxidizers (peroxides, potassium permanganate, concentrated nitric acid, etc.) Personal Protective EquipmentDust mask (FFP2), nitrile rubber gloves, safety goggles Suitable Extinguishing AgentsWater spray, alcohol-resistant foam, dry powder, carbon dioxide Application Recommendations Considering the specific requirements of various application fields, the following scenario-based recommendations should also be noted when handling PEG-4000/6000: Pharmaceutical Industry: When used as an ointment base or drop pill carrier, ensure the product has not absorbed moisture before processing to avoid affecting drug release profiles; the production environment should meet the corresponding GMP cleanliness level. Cosmetic Industry: When used in toothpaste or skincare formulations, it is recommended to conduct small-scale compatibility tests first to confirm stability with other components (such as fragrances and preservatives). Textile Industry: When used as an antistatic agent, pay attention to the dosage; excessive amounts may affect subsequent dyeing uniformity; recommended working concentration is 0.5%-3%. Metalworking: When used in quench fluid formulations, strictly control the concentration to adjust the cooling curve and avoid workpiece deformation or cracking due to concentration deviations. Rubber and Plastics Industry: When used as a mold release agent, ensure even coating; under high-temperature conditions, pay attention to ventilation and fume extraction. Precautions After operation, thoroughly wash hands and exposed skin; eating, drinking, and smoking are prohibited in the workplace. If dust inhalation causes discomfort, move immediately to fresh air; for eye contact, rinse with plenty of water continuously for at least 15 minutes. Do not give anything by mouth to unconscious persons; if a large amount is ingested, seek medical attention immediately. Use the product as soon as possible after opening; reseal the container tightly for any unused product to prevent moisture absorption. Follow local safety regulations for stacking to prevent tipping and damage to packaging.

Question 8

How to use Polyethylene Glycol PEG-4000/6000? What is the recommended addition amount?

Accepted Answer

The usage method of Polyethylene Glycol PEG-4000/6000 varies by application field; it is usually melted or dissolved before being added to the formulation system. There is no unified standard for the addition amount; it needs to be determined through experiments based on the specific process. Detailed Description Polyethylene Glycol PEG-4000/6000 is a white waxy solid or granular at room temperature, with a melting point between 50~63°C, and is easily soluble in water. Two common treatment methods before use are: Direct Melting Method – heat the solid to 60~80°C to melt it into a transparent liquid before adding to the formulation; Aqueous Solution Method – dissolve it in a quantitative amount of hot water to prepare a solution of the desired concentration before adding. Both methods require thorough stirring to ensure uniform dispersion in the system. This product is a non-ionic high-molecular polymer with an HLB value of approximately 18.9~19.0, stable chemical properties, and maintains good performance over a wide pH range. It has excellent compatibility with anionic, cationic, and non-ionic surctants. Due to its high molecular weight (PEG-4000 approximately 3400~4400, PEG-6000 approximately 5400~6600), it is recommended to use hot water above 60°C and continuous stirring to accelerate the dissolution process. Technical Parameters Parameter NameSpecification Index AppearanceWhite waxy solid or granular Active Content≥99% Melting Point Range50~63°C HLB Value18.9~19.0 Hydroxyl Value8~16 mgKOH/g pH (1% Aqueous Solution)5.0~7.0 Moisture Content≤1.0% Acid Value≤0.1 mgKOH/g Density1.20~1.21 g/cm³ Flash Point (Open Cup)＞240°C SolubilityEasily soluble in water Ion TypeNon-ionic Application Suggestions Usage methods for various application fields and industry experience reference dosages: Pharmaceutical Industry (Ointment Base/Suppository/Pills): Usually, PEG-4000 and PEG-6000 are mixed in a certain proportion and melted to be used as a water-soluble base. In ointment bases, the total PEG dosage typically accounts for 40%~90% of the total formulation, and the specific proportion needs to be adjusted according to drug release requirements and preparation hardness; in pill bases, PEG dosage is usually 1~5 times the drug amount. Toothpaste Humectant: Recommended addition amount is 3%~8% of the total formulation, can be used in combination with glycerin to effectively prevent paste drying and cracking, maintaining a fine and glossy texture. Shampoo/Shower Gel Conditioning Agent: Recommended addition amount is 0.5%~3%, added when the system cools below 60°C, providing a smooth feel and reducing the irritation of surctants. Textile Antistatic Agent/Lubricant: Prepare an aqueous solution with a concentration of 0.5%~5%, apply to the fiber surce through padding or spraying, and after drying, impart good smoothness and antistatic properties to the fiber. Rubber Mold Release Agent: Prepare an aqueous solution of 2%~10%, spray or brush onto the mold surce, utilizing its high temperature resistance and lubricating properties to achieve efficient demolding. Paper Coating Lubricant: Based on the solid content of the coating, recommended addition amount is 0.5%~2%, effectively improving the fluidity of the coating, preventing roll sticking, and enhancing paper surce smoothness. Metalworking Quenching Fluid: As a component of water-based quenching medium, recommended addition amount is 5%~20% of the total quenching fluid, adjusting concentration to control cooling rate, reducing quenching deformation and cracking of workpieces. Pesticide Wettable Powder/Water Dispersible Granules: As a dispersing and binding carrier, recommended addition amount is 2%~10% of the total preparation, helping the active ingredient to be uniformly distributed and improving suspension rate. Skincare Products (Creams/Lotions): Recommended addition amount is 2%~10%, utilizing its moisturizing and film-forming properties to increase skin hydration and improve skin feel. Note: The above addition amounts are industry common reference values; Guoli Chemical product database does not have specific dosage parameters. The actual optimal dosage needs to be determined through experiments based on the specific formulation system and process conditions. Precautions Dissolution Operation: PEG-4000/6000 is a solid product; it is recommended to dissolve it in hot water at 60~80°C with continuous stirring to avoid lumping and slow dissolution when directly added to cold water. Moisture-proof Storage: This product is hygroscopic; the packaging container must be immediately sealed after use and stored in a cool, dry place (recommended 10~30°C). Dust Protection: If dust is generated during operation, wear a dust mask and operate in a well-ventilated area; fine dust mixed with air to a certain concentration poses an explosion risk; keep the operation area away from open flames and high-temperature sources, and equipment must be grounded to prevent static electricity. Compatibility Test: Before large-scale production, it is recommended to conduct small-scale tests to confirm the compatibility of PEG-4000/6000 with other components in the formulation and the optimal addition amount. Heating Safety: During melting operation, the heating temperature should not be too high (recommended not to exceed 100°C) to avoid color deepening or performance changes due to prolonged high-temperature heating.

Question 9

In which industries and processes is polyethylene glycol PEG-4000/6000 mainly used?

Accepted Answer

Polyethylene glycol PEG-4000/6000 is a multifunctional non-ionic high molecular polymer, widely used in eight major industries including pharmaceuticals, daily chemicals, textiles, rubber and plastics, papermaking, metal processing, pesticides, and analytical testing. Detailed Description Polyethylene glycol PEG-4000/6000 (CAS No.: 25322-68-3) appears as a white to slightly yellow waxy solid or flakes. With its excellent emulsifying, wetting, dispersing, and solubilizing capabilities, as well as good chemical stability, it demonstrates outstanding tolerance to acids, alkalis, and hard water environments across a wide pH range, making it an indispensable multifunctional additive in many industrial formulations. In the pharmaceutical industry, PEG-4000/6000 is mainly used as an ointment base, suppository base, and dropping pill carrier. At the same time, as a water-soluble matrix, it can significantly increase the dissolution rate and bioavailability of poorly soluble drugs. In the daily chemical field, it is widely used as a toothpaste humectant (replacing or partially replacing glycerol), conditioner for shampoos and body washes, and as a basic moisturizing ctor in skincare products. The textile industry utilizes its antistatic and lubricating properties to impart smoothness and cohesion to synthetic fibers, improving processing performance. Moreover, PEG-4000/6000 serves as an efficient mold release agent and lubricating dispersant in the rubber and plastics industry; as a coating lubricant and moisturizing plasticizer in the papermaking industry; as a component of quenching fluids and lubricating additive for cutting fluids in metal processing; as a dispersing carrier for wettable powders and water-dispersible granules in pesticide formulations; and as a stationary phase for gas chromatography and an intermediate for bonded-phase synthesis in high-performance liquid chromatography in the analytical testing field. Its application coverage is extremely extensive. Application Industries and Processes Overview Application Industry Specific Process/Use Function Description Pharmaceutical Industry Ointment base, suppository base, dropping pill carrier, solid dispersion carrier, injection solubilizer Provides ideal melting characteristics, improves drug solubility, dissolution rate, and bioavailability Daily Chemical Industry Toothpaste humectant, shampoo/body wash conditioner, moisturizing ingredient in skincare products Prevents paste from drying out, provides smooth skin feel, reduces surctant irritation, forms a hydration film Textile Industry Antistatic agent, lubricant, mercerizing assistant Reduces fiber friction and static electricity, improves bric hand feel and processing performance Rubber and Plastics Industry Mold release agent, lubricating dispersant, functional modifier Helps products release from molds smoothly, improves compatibility between fillers and resins, adjusts flexibility and surce properties Papermaking Industry Coating lubricant, moisturizing plasticizer Improves coating fluidity, prevents sticking to rollers, controls paper moisture content, prevents warping Metal Processing Quenching fluid component, cutting fluid lubricating component Regulates cooling rate, reduces quenching deformation and cracking, decreases tool wear Pesticide Formulations Carrier for wettable powders, carrier for water-dispersible granules Rapidly disintegrates and disperses active ingredients in water, significantly improves pesticide suspension rate and efficacy utilization Analytical Testing Stationary phase for gas chromatography, intermediate for HPLC bonded phase synthesis Separates polar mixtures such as esters and alcohols, participates in column packing modification and end-capping reactions Application Suggestions Based on the requirements of different industries, it is recommended to consider the impact of molecular weight differences on performance when selecting PEG-4000 or PEG-6000: the higher molecular weight PEG-6000 has a higher melting point and lower hygroscopicity, making it more suitable for applications requiring high thermal stability (such as rubber mold release agents); while PEG-4000 dissolves ster, making it more suitable for pesticide formulations and some pharmaceutical carriers that require rapid disintegration and dispersion. In practical applications, it is recommended to determine the optimal addition ratio through small-scale trials. Due to the strong hygroscopicity of this product, its moisture absorption characteristics should be fully considered in formulation design and process operations. Especially in daily chemical products and pharmaceutical preparations, this property can be utilized to achieve moisturizing functions, but strict sealing and moisture prevention are required during storage and batching. Precautions Dust Safety: Fine dust of the product can form explosive mixtures with air (dust explosion class St1). The operation area should be kept away from ignition sources and equipped with a dust collection system. Storage Conditions: Should be stored sealed in a cool (10-30°C), dry, and well-ventilated environment, away from strong oxidizing agents. Toxicity Classification: Acute oral LD50 is greater than 5000 mg/kg, classified as practically non-toxic, but it is still recommended to wear dust masks and protective gloves during operation. Flash Point: Open cup flash point is greater than 240°C, providing high safety at normal processing temperatures.

Question 10

What are the physicochemical technical parameters of polyethylene glycol PEG-4000/6000?

Accepted Answer

Polyethylene glycol PEG-4000/6000 is a non-ionic polymer, appearing as a white waxy solid at room temperature, with core physicochemical characteristics such as easy solubility in water, moderate melting point (50~63°C), high HLB value (18.9~19.0), and excellent chemical stability. Detailed Description Polyethylene glycol PEG-4000/6000 (CAS No.: 25322-68-3) is polymerized from ethylene oxide, with the molecular formula HO(C2H4O)nH, a degree of polymerization n approximately between 70 and 200, and a molecular weight range of 3400~6600. At room temperature, the product appears as a white to slightly yellow waxy solid or granules, with a melting point range of 50~63°C. After melting by heating, it becomes a transparent viscous liquid and returns to a solid state upon cooling. This product is a non-ionic surctant that hardly forms micelles, so its CMC value is "none"—this characteristic makes it more inclined to function as a solubilizer, dispersant, and excipient in formulations, rather than typical micellar solubilization. From a functional parameter perspective, PEG-4000/6000 has a high HLB value of 18.9~19.0, strong hydrophilicity, and is easily soluble in water. The pH of a 1% aqueous solution ranges from 5.0 to 7.0, which is near neutral and has minimal impact on the pH of the formulation system. The product has high purity (active content ≥99%), with an acid value ≤0.1, saponification value ≤1.0, and iodine value ≤1, indicating stable chemical properties and almost no oxidizable unsaturated bonds or free acids. The hydroxyl value ranges from 8 to 16, which is typical for this molecular weight range and directly relates to the activity of subsequent derivatization reactions. Additionally, the product's surce tension is approximately 55~60 mN/m (1% aqueous solution), cloud point >100°C, flash point >240°C, exhibiting excellent thermal stability and safety under typical processing temperatures. In terms of safety, PEG-4000/6000 has an acute oral toxicity LD50 > 5000 mg/kg, classified as practically non-toxic, and is not considered a hazardous substance under GHS classification. However, it should be noted that fine dust generated during processing can form explosive mixtures with air (dust explosion class St1); operations must be conducted away from ignition sources and with good ventilation. The product is highly hygroscopic and must be stored in sealed, moisture-proof containers, with a recommended storage temperature of 10~30°C. Technical Parameters Parameter NameTechnical IndicatorRemarks CAS No.25322-68-3— Molecular FormulaHO(C2H4O)nH, n≈70~200— Molecular Weight3400~6600— Appearance (25°C)White waxy solid or granules— Ion TypeNon-ionic— Melting Point50~63°C— Density1.20~1.21— HLB Value18.9 / 19.0— Active Content / Solid Content≥99%— pH (1% Aqueous Solution)5.0~7.025°C pH (5% Aqueous Solution)4.5~7.525°C Moisture Content≤1.0%— Hydroxyl Value8~16 mg KOH/g— Acid Value≤0.1 mg KOH/g— Saponification Value≤1.0 mg KOH/g— Iodine Value≤1— Amine Value≤1 mg KOH/g— UnsaturationSaturated, — Surce Tension (1% Aqueous Solution)Approximately 55~60 mN/m25°C Cloud Point>100°C— Critical Micelle Concentration (CMC)None (does not form micelles)— Kinematic Viscosity (100°C, Molten)Approximately 75~400 mm²/s— Dynamic Viscosity (100°C)Approximately 100~500 mPa·s— Refractive Index (20°C, Molten State)Approximately 1.45~1.46— Flash Point (Open Cup)>240°C— HygroscopicityLowSealed moisture-proof storage Foam CharacteristicsLow foaming— Alkali ResistanceAlkali resistant— Free Alcohol Content≤0.5%—

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Property	Value
CAS No.	25322-68-3
Molecular Formula	HO(C2H4O)nH, n≈70~200
Appearance	White waxy solid or granules
Ionic Type	Nonionic
Avg. Molecular Weight	3400~6600
Cloud Point	>100°C
Active Content	≥99%
pH Value(1%)	5.0~7.0
pH Value(5%)	4.5~7.5
Iodine Value	≤1
Solubility	Readily soluble in water
Surface Tension	~55~60 mN/m (1%aq. soln.)
CMC	None (does not form micelles)
Acid Value	≤0.1
Saponification Value	≤1.0
Hydroxyl Value	8~16
Moisture	≤1.0
Density	1.20~1.21
Kinematic Viscosity	~75~400 mm²/s (100°C, molten)
Refractive Index	~1.45-1.46 (20°C, molten)
Flash Point	＞240°C
Hygroscopicity	Low
Chemical Stability	Stable; ambient temperature storage
Amine Value	≤1
Foam Property	Low foam
Alkali Resistance	Alkali resistant
Unsaturation	Saturated, <0.1 mol/kg
Viscosity	~100-500 mPa·s (100°C)
Melting Point	50~63
Low Shear Viscosity	N/A (solid product)
Solid Content	≥99%
Free Alcohol	≤0.5%
Heavy Metal	≤10
Arsenic	≤2