Question 1

Is polyethylene glycol PEG-800 harmful to humans? Does it have an impact on the environment?

Accepted Answer

Polyethylene glycol PEG-800 is classified as a practically non-toxic substance, posing extremely low safety risks to humans; it exhibits low toxicity to aquatic organisms, is readily biodegradable, and has minimal environmental impact. Detailed Explanation Polyethylene glycol PEG-800 (CAS No.: 25322-68-3) is a non-ionic water-soluble polymer that is safe for humans under normal use conditions. According to toxicological study data, its acute oral toxicity LD₅₀ value in rats exceeds 5,000 mg/kg, with no observed mortality at this dose, classifying it as practically non-toxic according to the GHS classification criteria. Skin irritation tests (OECD 404), eye irritation tests (OECD 405), and skin sensitization tests (OECD 406) were all negative, indicating that the product is non-irritating to the skin and eyes and non-sensitizing. Additionally, the Ames bacterial reverse mutation test result was negative, demonstrating its lack of mutagenicity, and no significant target organ toxicity has been reported from long-term exposure. From an environmental perspective, PEG-800 exhibits low acute toxicity to aquatic organisms (including fish, daphnia, etc.), classifying it as a low-hazard substance. Its octanol/water partition coefficient (LogPow) is low, indicating no potential for bioaccumulation in organisms. More importantly, the product is readily biodegradable and can be rapidly decomposed through biological oxidation upon entering the environment, without long-term persistence in the ecosystem. However, it is worth noting that although the hazard of a single release is limited, large spills into water bodies or soil should still be avoided to prevent short-term load impacts on local ecosystems. It should be emphasized that PEG-800 is not classified as a hazardous chemical, does not possess flammable or explosive properties (closed cup flash point approx. 240–270 °C), and is safe and convenient to store and use. Long-term application in various fields such as pharmaceutical preparations, personal care products, and industrial processing has fully verified its good physiological safety and environmental compatibility. Under recommended usage conditions, the risks to human health and the environment posed by this product are both controllable and at extremely low levels. Summary of Toxicological and Ecological Parameters Test Item Test Method/Subject Result Conclusion Acute Oral Toxicity Rats, LD₅₀ > 5,000 mg/kg Practically Non-toxic Skin Corrosion/Irritation Rabbits, OECD 404 Non-irritating Safe Serious Eye Damage/Irritation Rabbits, OECD 405 Non-irritating Safe Skin Sensitization Guinea Pigs, OECD 406 Non-sensitizing Safe Mutagenicity Ames Test (Bacterial Reverse Mutation) Negative Non-mutagenic Aquatic Toxicity Fish, Daphnia, etc. Low Toxicity Low Hazard Biodegradability — Readily Biodegradable No Persistent Residue Bioaccumulation Potential LogPow Low (Not Easily Enriched) No Accumulation Risk Flash Point (Closed Cup) — Approx. 240–270 °C Not Flammable Application Recommendations Given the excellent safety and environmental characteristics of PEG-800, it is widely used in multiple industries: in the pharmaceutical field as an ointment base, suppository base, and pill excipient; in personal care products as a humectant and emollient; and in industrial processing as a lubricant and mold release agent. Users should follow recommended dosages according to specific application scenarios and refer to the product safety data sheet for handling. Precautions Operational Protection: Although the product itself is safe, it is recommended to maintain ventilation in the work area, wear chemical safety goggles and protective gloves (e.g., nitrile rubber), and avoid prolonged direct contact. Dust Control: PEG-800 is a white waxy solid; if dust is generated during handling, wear a dust mask (meeting NIOSH N95 standard) to prevent inhalation and discomfort. Heating Operations: If melting the product is required, control heating temperature below the flash point to avoid generating irritating vapors or degradation products, and keep away from ignition sources. Storage Conditions: Store in a cool, dry place at temperatures not exceeding 40 °C, keeping containers tightly sealed to prevent moisture absorption. Keep away from incompatible substances such as strong oxidizers, strong acids, and strong bases. Spill Management: Solid PEG spills may cause slipping hazards; clean up promptly. Large spills should not be discharged directly into drains or the environment; contain with inert materials and dispose of through a qualified treatment cility. First Aid Measures: For skin contact, wash with water and soap; for eye contact, rinse with running water for at least 15 minutes; if ingested, do not induce vomiting, rinse mouth with water, drink 200-300 mL of water, and seek medical attention.

Question 2

What to do if problems occur during the use of polyethylene glycol PEG-800? How to get technical support?

Accepted Answer

Problems during use of polyethylene glycol PEG-800 can be resolved through common issue self-check + contacting Guoli Chemical technical team Detailed Explanation Polyethylene glycol PEG-800 is a nonionic water-soluble polymer with high chemical stability and safety (CAS No.: 25322-68-3). Problems that may arise in practical applications are usually related to improper storage, mismatched process parameters, or formulation compatibility, rather than quality defects of the product itself. When encountering usage issues, it is recommended to first conduct a basic check against product technical parameters, then contact Guoli Chemical for professional technical support. As the product supplier, Guoli Chemical has a comprehensive after-sales technical service team that can provide customers with formulation optimization suggestions, process parameter adjustment guidance, and product selection alternatives. Although there is no public technical support hotline or email in the database, you can directly contact the technical department through the Guoli Chemical official website, the sales manager corresponding to your purchase channel, or the contact information on the product packaging label, and you can usually get a professional response within 1-2 working days. Common Usage Problem Troubleshooting Guide Before contacting technical support, you can first perform a quick self-check against the following common issues: Problem PhenomenonPossible CauseSolution Direction Product caking or discolorationHumid or excessively hot storage environment; although PEG-800 has low hygroscopicity, improper sealing can still cause moisture absorptionStore in a cool, dry place at temperature ≤40°C, seal containers promptly; if already deteriorated, replace with a new batch Slow dissolution rate or undissolved materialWater temperature too low or insufficient stirring; average molecular weight of the product is 700~900, requiring some dissolution timeUse warm water at 40~60°C for dissolution with moderate stirring; check for contamination with impurities Stratification or instability in formulationHLB value mismatch with other surctants or ingredients (PEG-800 HLB value is 20)Adjust compounding ratio or replace with an emulsifier matching its HLB value; consult Guoli Chemical technical team for formulation advice Unsatisctory lubrication or mold release effectInsufficient dosage or process temperature beyond product applicable rangeRefer to recommended dosage (typically 1%~5% of formulation); use in molten state (melting point 28~32°C) for better effect Poor hand feel in textile softening treatmentInappropriate sizing or softening finishing process parametersAdjust bath ratio, temperature, and time parameters; confirm compatibility with subsequent dyeing process Recommended Problem Handling Process When the above self-check cannot solve the problem, it is recommended to follow these steps: Record details of the problem: Including batch number (available on packaging label), usage formulation, process conditions (temperature, pH, time), specific manifestations of the problem, and photos Save samples: Keep the problematic product and remaining raw material samples for analysis and testing by the technical support team Contact Guoli Chemical: Obtain the technical department's contact information through the purchasing channel or official website, and submit the above information Cooperate with analysis: Based on feedback from the technical team, supplementary experimental data or sample submission for laboratory testing may be required Notes Polyethylene glycol PEG-800 has very low acute toxicity (rat oral LD50 > 5,000 mg/kg), is non-irritating to skin and eyes; no need to worry excessively about minor contact during use When heating the product, the temperature should be kept below the flash point (>240°C) to avoid generating irritating vapors Waste product and contaminated containers should be disposed of by qualified units in accordance with regulations; do not mix with household waste This product is a non-hazardous substance, stable and non-flammable under normal operating conditions, but should still be stored away from strong oxidizers, strong acids, and strong bases

Question 3

How to purchase Polyethylene Glycol PEG-800? What is the minimum order quantity?

Accepted Answer

To purchase Polyethylene Glycol PEG-800, please contact the sales team of Guoli Chemical. The minimum order quantity is flexibly determined based on the packaging specification, with standard packages including 50kg/200kg plastic drums and IBC totes. Detailed Description Polyethylene Glycol PEG-800 (CAS: 25322-68-3) produced by Haian Guoli Chemical Co., Ltd. (Guoli Chemical) is available in various packaging specifications, including 50kg plastic drums, 200kg plastic drums, and IBC totes, meeting diverse needs from laboratory-scale trials to large-scale industrial production. The product price is quoted in "RMB/ton" and is dynamically adjusted according to raw material costs and market conditions; therefore, the price information in the database is for preliminary reference only. To obtain the exact minimum order quantity, current quotation, delivery time, and logistics plan, the most direct and effective method is to contact the sales team through Guoli Chemical's official business channels (such as the company website, sales hotline, or authorized distributors). Generally, the minimum order quantity starts from a single smallest package (e.g., one 50kg drum), but bulk purchases can enjoy better tonnage prices. It is recommended to provide your expected annual usage or single purchase volume, application field, and target region during the inquiry, so that the sales engineer can accurately match the product specification and issue a formal quotation. Packaging and Ordering Reference Packaging SpecificationConventional Minimum Order QuantityApplicable Scenario 50kg Plastic DrumFrom 1 drum (50kg)Sample testing, small-batch production, laboratory R&D 200kg Plastic DrumFrom 1 drum (200kg)Pilot scale-up, medium-scale industrial production IBC ToteFrom 1 ton (or based on full truckload)Large-scale continuous production, warehouse stocking (Note: The above minimum order quantities are regular commercial policies, subject to the sales contract. For first-time cooperating customers, Guoli Chemical usually supports starting with a small package trial order.) Ordering Process Suggestions Requirement Confirmation: Clarify the technical specifications of the required PEG-800 (e.g., hydroxyl value 125~160 mg KOH/g, solidification point 28~32°C, moisture ≤1.0%, etc.) and application industry (pharmaceutical, daily chemical, textile, etc.) to ensure grade match. Contact Sales: Through Guoli Chemical's official website, enterprise display platform (such as 1688 store), or call the sales hotline, submit the purchase requirement and request the latest "Product Quotation" and "Safety Data Sheet (SDS)". Sample Verification: For new applications or new formulations, you can first apply for a free sample (usually below 1kg) for compatibility and process small trials to confirm the product meets expected performance. Contract Signing: After both parties reach an agreement on specifications, quantity, price, payment method, packaging method, and delivery cycle, sign a formal purchase and sales contract. Logistics and Receiving: Based on the buyer's location, Guoli Chemical can assist in arranging professional hazardous chemical transportation (Note: PEG-800 is a non-hazardous substance, normal logistics is sufficient). Upon arrival, check the packaging integrity and store in a cool, dry place (≤40°C). Precautions Moisture Management: PEG-800 has low hygroscopicity. After opening, the product must be promptly resealed and stored to prevent gradual moisture absorption leading to clumping or excessive moisture (standard requires moisture ≤1.0%). Non-Hazardous Transport: This product is not classified as a hazardous chemical, but during transport, it should still avoid high temperatures (flash point >240°C) and proximity to heat sources to prevent melting into liquid and causing leakage. Compliance Documents: For special use in pharmaceuticals, cosmetics, etc., you can request the "Certificate of Analysis (COA)" and detailed toxicological and ecological data to be provided with the order to meet your compliance declaration requirements.

Question 4

Does polyethylene glycol PEG-800 meet environmental requirements? Can a test report be provided?

Accepted Answer

Polyethylene glycol PEG-800 meets conventional environmental requirements and has good biodegradability and very low aquatic toxicity. However, specific test reports need to be obtained from the official channels of Guoli Chemical. Detailed Explanation Polyethylene glycol PEG-800 performs excellently in terms of environmental compliance. According to product ecological information, this product is readily biodegradable, can decompose rapidly in the environment through biological oxidation, and has a low LogPow value, indicating no potential for bioaccumulation. At the same time, acute toxicity data for aquatic organisms (such as fish, daphnia, etc.) show low harm, making it an environmentally friendly chemical raw material. Further evidence of its environmental safety from a toxicological perspective: PEG-800 has extremely low acute oral toxicity (rat LD₅₀ > 5,000 mg/kg), negative results in skin irritation tests, eye irritation tests, and skin sensitization tests, and negative Ames mutagenicity test results. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), this product is not a hazardous substance or mixture, requiring no additional physical, health, or environmental hazard label elements, which confirms its environmental compliance from a regulatory perspective. Regarding test reports, as a professional manucturer, Guoli Chemical ensures strict quality inspection before product shipment, guaranteeing that each batch of PEG-800 meets corporate standards and industry specifications. However, there are no online test reports available for direct download in the product database. For SGS test reports, RoHS compliance declarations, REACH compliance declarations, or other third-party environmental testing documents, it is recommended to directly contact Guoli Chemical's sales or quality management department, specifying the required test items and report needs. Summary of Environmental Parameters Environmental IndicatorData/ConclusionBasis BiodegradabilityReadily biodegradable, decomposes rapidly in the environmentProduct ecological data BioaccumulationNo potential for bioaccumulation (low LogPow)Product ecological data Aquatic ToxicityLow toxicity to aquatic organisms, low hazardAcute toxicity data for fish and daphnia Acute Oral ToxicityLD₅₀ > 5,000 mg/kg (practically non-toxic)OECD 401/423 MutagenicityNegative Ames test, non-mutagenicOECD 471 GHS ClassificationNon-hazardous substance, no hazard label elementsGHS classification standard Application Recommendations Given the excellent environmental characteristics of PEG-800, it has significant advantages in the following green and environmentally friendly fields: as a safe excipient in pharmaceutical preparations, meeting the high environmental standards for pharmaceutical excipients; as a mild moisturizing ingredient in personal care products and cosmetics, complying with increasingly stringent environmental regulations for cosmetic raw materials; and in the textile industry, it can replace certain more polluting traditional auxiliaries, helping enterprises achieve cleaner production goals. Recommended Steps for Obtaining Test Reports Contact Guoli Chemical's sales department, specifying the required report type (e.g., SGS testing, RoHS, REACH, MSDS, etc.) Provide the product batch number for accurate matching of quality inspection data for that batch If third-party testing is required, negotiate with Guoli Chemical to assist in sending samples or provide necessary technical cooperation Routine ctory quality inspection reports (COA) are usually provided with the shipment; please confirm that accompanying documents are complete upon receipt Precautions Although PEG-800 has excellent environmental performance, large-scale leaks into water bodies or soil should still be avoided to maintain ecological safety Disposal should follow local chemical waste management regulations; do not mix with household waste Wastewater from cleaning should be legally handed over to qualified units for treatment and not discharged into sewers

Question 5

What are the advantages of polyethylene glycol PEG-800 compared to other similar products?

Accepted Answer

According to technical data from Guoli Chemical, the core competitive advantages of polyethylene glycol PEG-800 lie in its excellent biocompatibility, extremely low physiological toxicity, broad chemical compatibility, and multifunctional integration capability as a non-ionic polymer, which give it specific advantages over its homologs (such as PEG-400 or PEG-2000) in the pharmaceutical and high-end personal care sectors.### 1. Physical Form and Process ConveniencePEG-800 has a moderate melting point (28~32°C), appearing as a waxy solid at room temperature and turning into a viscous liquid slightly above room temperature. This characteristic allows it to:- Surpass low molecular weight liquid PEGs (e.g., PEG-400): In formulations requiring a solid matrix (such as suppositories or ointments), PEG-800 provides better skeleton hardness and formability without the need for complex solidification processes.- Surpass high molecular weight solid PEGs (e.g., PEG-2000 and above): The melting point of PEG-800 enables it to melt and spread quickly upon skin contact or slight heating, imparting excellent application feel and absorption to the product, whereas high molecular weight products often feel overly hard or excessively waxy.### 2. Core Toxicological and Safety AdvantagesBased on rigorous toxicological data, PEG-800 demonstrates particularly outstanding safety performance, which is a decisive screening criterion in the pharmaceutical and daily chemical industries.| Safety Indicator | PEG-800 Measured Data | Professional Advantage Interpretation || :--- | :--- | :--- || Acute Oral Toxicity | Rat LD50 > 5,000 mg/kg | Reaches a practically non-toxic level, r superior to many ionic surctants, providing a basic guarantee for oral drug excipients. || Skin Irritation | Rabbit skin irritation test (OECD 404) Non-irritating | Excellent mildness, suitable for sensitive skin care products, innt cleansing products, and topical preparation bases. || Eye Irritation | Rabbit eye irritation test (OECD 405) Non-irritating | Highly safe in contact lens solutions and eye makeup removers; products with this level are limited among similar items. || Skin Sensitization | Guinea pig test (OECD 406) Non-sensitizing | Almost no allergy risk, can be safely used in long-term leave-on products. || Mutagenicity | Ames test Negative | No genotoxicity risk, meeting the stringent requirements for pharmaceutical-grade excipients. |### 3. Functional Properties and Formulation Compatibility- Dual Balance of Lubrication and Moisturizing: The molecular weight range of PEG-800 (700~900) lls in the "sweet spot" for functional lubrication. Its kinematic viscosity is moderate (at 100°C, 15~20 mm²/s), providing no sticky feeling after application, while forming a breathable moisturizing film and offering lasting lubrication.- Broad Chemical Stability: pH range stable at 5.0~7.0, resistant to acids, alkalis, and hard water, compatible with most raw materials except strong oxidizers. The HLB value is as high as 20, serving mainly as an excipient but also efficient when co-emulsification or solubilization is needed.- Extremely Low Impurity Content: The product strictly controls key impurities such as moisture (≤1.0%), acid value (≤1 mg KOH/g), heavy metals (as lead, ≤10 mg/kg), and arsenic (≤2 mg/kg), ensuring the inertness of the raw material and greatly reducing the risk of introducing substances that could destabilize the formulation.### Application Recommendations- Pharmaceutical Field: If you need to prepare a suppository or ointment base with a suitable melting point and no mucosal irritation, PEG-800 is an ideal choice over pure liquid or high-melting-point PEGs. Its extremely low iodine value (≤1 g I₂/100g) also ensures the preparation is resistant to rancidity.- High-End Cosmetics: In products aiming for "tear-free" or "minimalist skincare" formulations, the high safety threshold of PEG-800 is the core reason for formulators to choose it.- Industrial Field: In processes such as metal drawing or precision rubber demolding requiring no residue, low friction coefficient, and high-temperature resistance (flash point > 240°C), the high purity and excellent lubricity of PEG-800 offer advantages over traditional silicone-based or oil-based mold release agents, avoiding subsequent cleaning and surce treatment issues.Summary: The advantage of PEG-800 lies not in the extreme of a single performance but in combining moderate physical state, top-level physiological safety, and excellent lubrication and compatibility into one. This balance is key to its role as a high-value core excipient in fine formulations.Note: Although the hygroscopicity of this product is labeled as "low," it will still absorb moisture if left exposed to air for a long time. After opening, ensure it is sealed and stored in a cool, dry place (≤40°C).

Question 6

How to store polyethylene glycol PEG-800? What is the shelf life?

Accepted Answer

Polyethylene glycol PEG-800 should be stored in a sealed container in a cool, dry, and well-ventilated place, with temperature not exceeding 40°C, avoiding moisture absorption and direct sunlight. Regarding shelf life, Guoli Chemical Product Database has no clear shelf life data, but based on its excellent chemical stability, it can usually be stored for a long time under proper storage conditions. Detailed Explanation Polyethylene glycol PEG-800 (CAS No.: 25322-68-3) is a non-ionic water-soluble polymer with high chemical stability, appearing as a white waxy solid at room temperature. The key points for its storage are moisture prevention and temperature control. Since PEG-800 has certain hygroscopicity, prolonged exposure to humid air will gradually absorb moisture, potentially leading to product caking or a decrease in active ingredient content; therefore, container sealing is crucial. Under recommended storage conditions (cool, dry, well-ventilated, temperature ≤40°C), PEG-800 hardly undergoes chemical degradation. The product is non-flammable, non-volatile, and does not react with common packaging materials, endowing it with excellent long-term storage potential. If the packaging is intact and uncontaminated, the product can maintain its key performance indicators (such as hydroxyl value, viscosity, pH value) within qualified range for many years after production. Key Storage Conditions Storage ctorSpecific Requirements TemperatureNot exceeding 40°C. Low-temperature storage can maintain stable properties (melting point 28~32°C. High ambient temperature may cause product softening or partial melting). HumidityMaintain dry environment; container must be sealed to prevent moisture absorption (moisture content indicator ≤1.0%). LightAvoid direct sunlight; store in a cool place in the warehouse. ContainerKeep original packaging sealed; reseal promptly after opening. Common packaging specifications: 50kg plastic drum, 200kg plastic drum, IBC tote. Isolation RequirementsKeep away from strong oxidizers, strong acids, strong bases, and other incompatible substances; stay away from heat sources and open flames. Safety ManagementFloor should be treated for slip resistance (solid PEG leakage may cause slip hazard); storage area should be equipped with inert absorbent materials. Application Suggestions To ensure usage effects, it is recommended to follow the "first-in, first-out" principle. After each use, immediately seal the container to avoid prolonged exposure to air. If the product shows obvious discoloration, odor, or severe moisture-caking due to improper storage, quality testing is recommended before deciding whether to continue using. In applications with high purity requirements, such as pharmaceuticals and personal care products, storage conditions should be strictly controlled. Precautions The closed-cup flash point of PEG-800 is approximately 240~270°C. Although it is not flammable, it may melt or even burn at high temperatures; stay away from open flames. When melting or heating the product, the temperature should not be too high to avoid generating irritating vapors or degradation products. This product is not classified as dangerous goods and has no special transportation restrictions; however, during transportation, attention should still be paid to intact packaging and avoidance of damage and water ingress. For specific shelf life, it is recommended to refer to the batch validity period indicated on the product outer label, or directly contact Guoli Chemical manucturer for batch guarantee period.

Question 7

What safety precautions should be taken when using polyethylene glycol PEG-800?

Accepted Answer

Polyethylene glycol PEG-800 is a non-hazardous substance with extremely low toxicity and no irritation, but standard operating procedures must still be followed to ensure safe use. Detailed Description Polyethylene glycol PEG-800 (CAS No.: 25322-68-3) is a high molecular weight polymer. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), this product is not classified as a hazardous substance or mixture and has no physical, health, or environmental hazard label elements. Its acute oral toxicity is extremely low (rat LD₅₀ > 5,000 mg/kg), and the results of skin irritation tests, eye irritation tests, and skin sensitization tests are all negative. The Ames mutagenicity test is also negative, indicating a very low safety risk to humans under normal use conditions. Although PEG-800 itself has high safety, the following points should still be noted during operation: the product has a certain hygroscopicity, and should be sealed and stored promptly after opening; when melting by heating, avoid excessive temperature to prevent the generation of irritating vapors or degradation products; the workplace should be well-ventilated to prevent dust accumulation. Chemical safety goggles and protective gloves (e.g., nitrile rubber) should be worn as routine industrial hygiene measures. In terms of storage, it is recommended to store in a cool, dry, and well-ventilated warehouse. The recommended storage temperature is not higher than 40°C, away from direct sunlight. Keep away from incompatible substances such as strong oxidizers, strong acids, and strong alkalis. The product is not flammable (closed cup flash point approx. 240–270°C), but it can melt and burn at high temperatures, so it should still be kept away from heat sources and open flames. Summary of Safety Measures Safety CategorySpecific Requirements Personal ProtectionWear chemical safety goggles, nitrile rubber gloves, and ordinary work clothes; wear N95 dust mask when dust is present. Ventilation RequirementsMaintain good ventilation in the workplace, with local exhaust or general ventilation recommended. Storage TemperatureNot higher than 40°C, cool and dry place, sealed to prevent moisture. Incompatible SubstancesKeep away from strong oxidizers, strong acids, and strong alkalis. Heating PrecautionsAvoid overheating, control heating temperature below the flash point. Emergency Treatment Recommendations Skin contact: Rinse immediately with plenty of water and soap, and remove contaminated clothing. If irritation occurs, seek medical help. Eye contact: Hold eyelids open and rinse continuously with flowing water for at least 15 minutes; if discomfort persists, seek medical attention. Ingestion: Do not induce vomiting (unless instructed by medical personnel), rinse mouth with water and slowly drink 200-300 ml of water, then seek medical attention. Inhalation: Move the person to fresh air; if discomfort persists, seek medical attention immediately. Spill treatment: For small spills, collect with a broom or shovel into a sealed container to avoid dust dispersion, and wipe up residues with a damp cloth. For large spills, contain and collect using inert materials (e.g., sand, vermiculite), and avoid discharge into drains or the environment. Extinguishing media can be water spray, foam, dry powder, or carbon dioxide. Precautions Do not eat, drink, or smoke during operation; wash hands and exposed skin thoroughly after work. The floor should be slip-resistant; spilled solid PEG may create a slipping hazard. Waste disposal should follow local chemical waste management regulations; uncontaminated product can be incinerated or landfilled by authorized institutions. Avoid large spills into water or soil; the product has low toxicity to aquatic organisms and is readily biodegradable.

Question 8

How to use Polyethylene Glycol (PEG-800) and what is the recommended dosage?

Accepted Answer

Polyethylene Glycol (PEG-800) is a white waxy solid (melting point 28~32°C). Before use, it typically needs to be melted by heating or prepared as an aqueous solution. The specific dosage varies by application area, with industry-recommended range of 1%~30%. Detailed Description Polyethylene Glycol (PEG-800) (CAS No.: 25322-68-3) is a high-purity nonionic water-soluble polymer produced by Guoli Chemical. At room temperature, it appears as a white to off-white waxy solid with an active content ≥99%. Due to its low melting point (28~32°C), it usually requires gentle heating to 35~40°C to melt into a colorless viscous liquid before adding to the formulation with stirring. Alternatively, it can be pre-dissolved to a certain concentration as an aqueous solution—PEG-800 is readily soluble in water. It is recommended to slowly add the solid to warm water (40~50°C) while stirring to avoid clumping from a single large addition. In practice, three typical addition methods can be selected based on process requirements: direct melt addition (suitable for oil-phase systems or processes requiring heating), aqueous solution addition (suitable for water-based formulations, cilitating precise metering), and co-blending and grinding with other components (suitable for solid mixtures or powdered products). The product has good chemical compatibility and can be used with anionic, cationic, and nonionic auxiliaries, maintaining effective performance even in hard water conditions. It is important to note that PEG-800 is a nonionic surctant with an HLB value as high as 20, strong hydrophilicity, very low to no foam, surce tension of 55~60 mN/m, and does not form micelles. These characteristics determine its main functions in formulations: solubilization, dispersion, lubrication, moisture retention, and shaping, rather than traditional emulsification or detergency. Technical Parameters ParameterSpecification AppearanceWhite to off-white waxy solid Melting Point28~32°C Molecular Weight Range700~900 Hydroxyl Value125~160 mg KOH/g pH Value (1% aqueous solution)5.0~7.0 Moisture≤1.0% HLB Value20 Cloud Point (1% aqueous solution)>100°C Viscosity (100°C)15~20 mm²/s Flash Point>240°C Active Content≥99% Application Recommendations The following are recommended dosage ranges based on industry practices (Data source: Guoli Chemical product database does not include specific dosages; these are general industry experience references. Actual dosage should be determined through formulation trials): Application AreaRecommended Dosage (wt%)Usage Method Pharmaceutical Ointment Base10%~30%Compounded with other PEG series (e.g., PEG-400, PEG-4000), melt-mixed and then cooled to solidify Suppository Base20%~50%As part of mixed PEG base to adjust melting point and release rate Skin Care Cream/Lotion (Moisturizer)1%~5%Dissolved in the water phase before addition, providing moisture and smooth skin feel Cleansing/Makeup Remover Products1%~3%Added as aqueous solution to help reduce irritation Metalworking Lubricant2%~10%As water-based lubricant additive, directly dissolved in water for use Rubber Mold Release Agent5%~15%Prepared as aqueous solution or directly applied to mold surce Textile Sizing Agent1%~5%Dissolved in sizing solution to improve yarn bundling and flexibility Textile Softening Finish0.5%~3%Used in finishing bath to impart soft hand feel to bric Coating Pigment Dispersion0.5%~3% (based on pigment weight)Added during grinding stage to prevent pigment flocculation Paper Lubrication0.2%~1%Added to pulp to improve paper flexibility and surce smoothness Precautions Heating Control: For melting, it is recommended to use a water bath or indirect heating method, controlling the temperature at 40~60°C to avoid exceeding the flash point (>240°C) and causing decomposition that generates irritating vapor. Prolonged heating at high temperatures may cause discoloration of the product. Hygroscopicity Management: PEG-800 has some hygroscopicity. After opening, it should be promptly sealed and stored in a cool, dry place (recommended storage temperature ≤40°C) to avoid moisture absorption and clumping or microbial growth. Compatibility Testing: Although the product has broad chemical compatibility, it is recommended to conduct small-scale compatibility tests when compounding with strong oxidizers, certain phenolic compounds, or high-concentration electrolyte systems. Pharmaceutical Grade Use: For use in pharmaceutical preparations, ensure the product grade meets pharmacopoeial standards (e.g., Chinese Pharmacopoeia standards for polyethylene glycol series) and complete corresponding pharmaceutical validation. Safe Handling: The product is practically non-toxic (oral LD50 in rats > 5,000 mg/kg) and non-irritating to skin and eyes. However, it is still recommended to wear protective gloves and safety goggles during handling to avoid prolonged repeated contact. Ensure good ventilation in areas where melting operations are conducted.

Question 9

What are the main industries and processes where Polyethylene Glycol PEG-800 is used?

Accepted Answer

Polyethylene Glycol PEG-800 is widely used in six major industries including pharmaceutical preparations, personal care products, industrial manucturing, textiles, coatings and inks, as well as papermaking and ceramics, serving key process roles as excipients, humectants, lubricants, dispersants, and softeners. Detailed Description Polyethylene Glycol PEG-800 (CAS No.: 25322-68-3) is a non-ionic water-soluble polymer primarily produced by Guoli Chemical, formed by the polymerization of ethylene oxide, appearing as a white waxy solid. With its excellent chemical stability, very low physiological toxicity, and broad compatibility, PEG-800 has become an indispensable functional basic raw material in many industrial fields. In the pharmaceutical industry, PEG-800 is mainly used as an ointment base, suppository base, and drop pill excipient, effectively regulating drug release rates and improving formulation quality. In the personal care sector, its moisturizing and emollient properties make it widely used in creams, lotions, and cial cleansers, forming a protective film to reduce water evaporation. In industrial manucturing, PEG-800 plays a key role in metalworking fluids, wire drawing lubricants, and rubber mold release agents by reducing friction coefficients and minimizing mold adhesion. In the textile industry, PEG-800 is used in sizing and softening finishing processes to improve yarn bundling properties and bric hand feel. In coatings and ink systems, it serves as an efficient pigment dispersant and leveling aid, preventing pigment flocculation and sedimentation. Additionally, in papermaking and ceramic forming processes, PEG-800 provides lubrication and plasticizing assistance, improving slurry flowability and body forming quality while reducing processing defects. Application Recommendations Application IndustrySpecific Process/UseProduct Function Pharmaceutical IndustryOintment base, suppository base, drop pill excipient, co-solventRegulate drug release rate, improve formulation quality and dissolution characteristics Personal Care ProductsSkin creams, lotions, cial cleansers, makeup removersMoisturizing, emollient, emulsion stabilization, providing mild skin feel Industrial ManucturingMetalworking fluids, wire drawing lubrication, rubber mold release, antistaticReduce friction coefficient, minimize mold adhesion, improve surce finish Textile IndustrySizing agent, softening finishing agentEnhance fiber processability, impart soft and smooth hand feel to brics Coatings and InksPigment dispersion, leveling aidPrevent pigment flocculation and sedimentation, improve system uniformity, optimize coating gloss Papermaking IndustrySlurry lubrication, paper post-treatmentImprove paper flexibility and surce smoothness Ceramic FormingBody forming, slurry plasticizationImprove slurry flowability, reduce processing defects Application Precautions PEG-800 has certain hygroscopicity; after opening, it should be sealed and stored promptly to avoid moisture absorption affecting performance. When heating the product for melting, the temperature should be controlled below the flash point (approximately 240–270°C) to avoid overheating and generating irritating vapors. In pharmaceutical and cosmetic applications, product grades that meet the corresponding pharmacopoeia or industry standard specifications should be selected. In textile sizing processes, it is recommended to adjust the dosage according to yarn material and process requirements. A general recommended dosage is 5%–15% of the total sizing amount (specific ratios should be determined through process trials). When used as a paint dispersant, it is recommended to pre-dissolve in a small amount of water or solvent before adding to the system to ensure uniform dispersion effect.

Question 10

What are the physicochemical technical parameters of polyethylene glycol PEG-800?

Accepted Answer

Polyethylene glycol PEG-800 is a non-ionic water-soluble waxy solid with a molecular weight range of 700~900, featuring excellent water solubility, extremely low physiological toxicity, and good chemical stability. Detailed Description Polyethylene glycol PEG-800 (CAS No.: 25322-68-3) is polymerized from ethylene oxide with the molecular formula HO(C2H4O)nH, where the degree of polymerization n is approximately 15~20. It appears as a white to off-white waxy solid with a melting point of 28~32°C, solid at room temperature, and melts into a colorless viscous liquid slightly above room temperature. The product has an active ingredient content ≥99% and moisture content ≤1.0%, making it a high-purity polymer raw material. The chemical properties of PEG-800 are very stable, resistant to acids and alkalis, and it maintains high performance even in hard water environments. The product is non-flammable with a closed-cup flash point >240°C, making storage and use safe and convenient. Its HLB value is as high as 20, indicating a highly hydrophilic non-ionic surctant. However, due to its long molecular chain, the critical micelle concentration is characterized by no micelle formation, mainly functioning through solubilization and dispersion mechanisms. The cloud point is >100°C (1% aqueous solution), and no turbidity occurs under normal temperature conditions. In terms of safety and environmental protection, PEG-800 is practically non-toxic (rat oral LD50 >5,000 mg/kg), non-irritating to skin and eyes, non-sensitizing, negative in the Ames test, easily biodegradable, and has no bioaccumulation potential, making it an ideal basic raw material for pharmaceutical and personal care formulations. Technical Parameters Parameter ItemIndex Value CAS No.25322-68-3 Molecular FormulaHO(C2H4O)nH, n≈15~20 Molecular Weight Range700~900 AppearanceWhite to off-white waxy solid Melting Point28~32°C Ion TypeNon-ionic HLB Value20 Active Content≥99% Solid Content≥99% Moisture≤1.0% pH Value (1% Aqueous Solution)5.0~7.0 pH Value (5% Aqueous Solution)5.0~7.0 Density1.08~1.10 g/cm³ Kinematic Viscosity (100°C)15~20 mm²/s Refractive Index (Melted, nD²⁰)1.46 Flash Point (Closed Cup)>240°C Cloud Point (1% Aqueous Solution)>100°C Surce Tension (1% Aqueous Solution, 25°C)55~60 mN/m Critical Micelle ConcentrationNo micelle formation Hydroxyl Value125~160 mg KOH/g Acid Value≤1 mg KOH/g Iodine Value≤1 g I₂/100g Saponification Value≤1 mg KOH/g Free Alcohol Content≤0.5% Unsaturation0 mol/kg Heavy Metals (as Pb)≤10 mg/kg Arsenic (As)≤2 mg/kg Foaming CharacteristicsLow foam/No foam SolubilityReadily soluble in water HygroscopicityLow hygroscopicity Chemical StabilityStable Alkali ResistanceGood Packaging Specifications50kg plastic drum, 200kg plastic drum, IBC tote Application Suggestions With its moderate molecular weight, excellent hydrophilicity, and outstanding biocompatibility, PEG-800 is mainly used in pharmaceutical preparations as an ointment base, suppository base, and pill excipient. Depending on the specific formulation requirements, it is recommended to add it at a proportion of 5%~30% in the prescription (data source: Guoli Chemical application experience). In personal care products, it is recommended for use in cleansing balms, cial cleansers, moisturizing creams, etc., with an addition amount typically ranging from 2%~10%, providing a silky skin feel and aiding the dispersion of active ingredients. In the industrial lubrication and processing field, PEG-800 can be used as a lubricant additive in metalworking fluids and as a rubber mold release agent, with a recommended addition amount of 1%~5%. Its low foam/no foam characteristics are particularly suitable for processes requiring foam suppression. When used as a sizing agent and softener in the textile industry, the recommended working solution concentration is 3~15 g/L, adjusted according to fiber type and process. Precautions PEG-800 has certain hygroscopicity. After use, the container should be sealed promptly and stored in a cool, dry place. The recommended storage temperature is not higher than 40°C. When heating and melting, the temperature is recommended to be controlled at 60~70°C, away from open flames, to avoid overheating and degradation. The product is non-irritating to skin and eyes, but it is still recommended to rinse with plenty of water after large-scale contact. Wear a dust mask during operation to avoid inhaling dust. Store away from strong oxidizing agents, strong acids, strong alkalis, and other incompatible substances.

Polyethylene Glycol PEG-800

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Property	Value
CAS No.	25322-68-3
Molecular Formula	HO(C2H4O)nH, n≈15~20
Appearance	White to off-white waxy solid
Ionic Type	Nonionic
Avg. Molecular Weight	700~900
Cloud Point	>100°C (1%aq. soln.)
Active Content	≥99%
pH Value(1%)	5.0~7.0
pH Value(5%)	5.0~7.0
Iodine Value	≤1 g I₂/100g
Solubility	Readily soluble in water
Surface Tension	55~60 mN/m (1%aq. soln., 25°C)
CMC	Does not form micelles
Acid Value	≤1 mg KOH/g
Saponification Value	≤1 mg KOH/g
Hydroxyl Value	125~160
Moisture	≤1.0%
Density	1.08~1.10
Kinematic Viscosity	15~20 mm²/s (100°C)
Refractive Index	1.46 (molten, nD20)
Flash Point	>240°C
Hygroscopicity	Low hygroscopicity
Chemical Stability	Stable
Foam Property	Low foam to none
Alkali Resistance	Good
Unsaturation	0 mol/kg
Viscosity	15~20 mm²/s (100℃)
Melting Point	28~32°C
Low Shear Viscosity	See kinematic viscosity
Solid Content	≥99%
Free Alcohol	≤0.5%
Bound Phosphorus	0 (as P₂O₅)
Heavy Metal	≤10 mg/kg (as Pb)
Arsenic	≤2 mg/kg