Isomeric alcohol polyether E-1303 has an acute toxicity level classified as low toxicity (oral LD50 in rats > 2000 mg/kg). Under normal industrial use conditions, it does not cause acute poisoning. However, it is classified by GHS as Skin Irritation Category 2 (H315) and Serious Eye Damage/Eye Irritation Category 2A (H319). Direct contact may cause mild skin irritation and moderate eye irritation, so gloves and protective goggles should be worn during operation. Skin sensitization tests show that the product is non-sensitizing and does not cause allergic reactions.
In terms of the environment, isomeric alcohol polyether E-1303 has low acute toxicity to aquatic organisms—fish LC50, algae EC50, and daphnia EC50 are all > 100 mg/L, indicating it is not highly toxic to aquatic life. More importantly, according to OECD 301 test methods, the product is readily biodegradable (BOD/COD ≥ 60% or DOC removal ≥ 70%), meaning it can be effectively decomposed by microorganisms in the natural environment without causing long-term ecological accumulation. Nevertheless, it is strictly prohibited to directly discharge wastewater containing this product into sewers, surface water, or soil. The final disposal of waste should follow local environmental regulations, and incineration is recommended.
| Test Item | Test Object/Method | Result |
|---|---|---|
| Acute oral toxicity (LD50) | Rat | > 2000 mg/kg (low toxicity) |
| Skin irritation | Rabbit | Mild irritation |
| Eye irritation | Rabbit | Moderate irritation |
| Skin sensitization | Guinea pig | Non-sensitizing |
| Fish acute toxicity (LC50) | — | > 100 mg/L (low toxicity) |
| Algae toxicity (EC50) | — | > 100 mg/L (low toxicity) |
| Daphnia toxicity (EC50) | — | > 100 mg/L (low toxicity) |
| Biodegradability | OECD 301 | Readily biodegradable (≥ 60% BOD/COD or ≥ 70% DOC removal) |
In industrial and household cleaning, textile printing and dyeing, leather processing, pesticide formulations, emulsion polymerization, and other applications, the use concentration of isomeric alcohol polyether E-1303 is typically far below toxicologically relevant levels, and under normal conditions, it has minimal impact on human health. However, when preparing high-concentration stock solutions or performing dispensing operations, protective measures should still be taken. The excellent chemical stability of the product ensures that it does not readily decompose to produce harmful byproducts during storage and transportation, further reducing safety risks.