Polyethylene glycol PEG-2000 (CAS No.: 25322-68-3) is not classified as a hazardous chemical according to the EU CLP Regulation (EC) No 1272/2008 and the Chinese national standard GB 30000 series, and has no hazard or precautionary statements. Its acute toxicity is extremely low, with an oral LD₅₀ in rats > 2000 mg/kg (actual values are typically >5000 mg/kg). It has been confirmed by OECD standard test methods to have no skin irritation, no eye irritation, and no skin sensitization. At room temperature, its vapor pressure is extremely low, making inhalation exposure risks negligible under normal operating conditions.
In daily operations, personnel should wear appropriate work clothing to avoid direct skin contact. In areas where dust is generated, it is recommended to wear a dust mask. The work area should be well-ventilated. After work and before breaks, wash hands and exposed skin thoroughly with water and soap. Eating, drinking, and smoking are prohibited during work.
| Safety Parameter | Value/Description |
|---|---|
| Melting Point | Approx. 50–55°C |
| Flash Point (Closed Cup) | >220°C (Non-flammable solid or liquid) |
| Explosive Properties | None |
| Oxidizing Properties | None |
| Acute Toxicity (Rat Oral LD₅₀) | >2000 mg/kg (typically >5000 mg/kg) |
| Skin Irritation (OECD 404) | Non-irritating |
| Eye Irritation (OECD 405) | Non-irritating |
| Skin Sensitization (OECD 406) | Non-sensitizing |
| Recommended Operating Temperature | Room temperature to 70°C |
| Recommended Storage Temperature | 5–30°C |
The operating temperature should be controlled between room temperature and 70°C to avoid localized overheating that may cause thermal decomposition. Since PEG-2000 is a white waxy solid at room temperature, if melting is required, special care should be taken to prevent burns from high temperatures when handling the molten product. It is essential to wear insulated gloves and protective equipment. The product is thermally reversible; it becomes a transparent viscous liquid when melted and returns to a solid state upon cooling, facilitating processing operations.
When used in applications such as textiles, papermaking, and metalworking fluids, it is recommended to operate in a well-ventilated environment. When used as a pharmaceutical excipient, compliance with Good Manufacturing Practice (GMP) requirements is necessary. In cosmetic formulations, ensure the product meets relevant hygiene standards.
This product is not classified as dangerous goods under the UN Model Regulations for the Transport of Dangerous Goods (ADR/RID, IMDG, IATA). During transportation, prevent packaging damage, moisture, and exposure to direct sunlight. Waste and used containers should be disposed of in accordance with national and local environmental regulations, such as incineration or landfill, and avoid direct discharge into water bodies or the environment.