Polyethylene glycol PEG-400 (CAS No.: 25322-68-3) is a nonionic surfactant. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), this product is not classified as a hazardous chemical, with no hazard pictogram, no signal word, and no hazard statement. It is chemically stable at room temperature, with a closed cup flash point of approximately 238°C, is not flammable or explosive, and causes no severe irritation to skin or eyes. The water hazard class (WGK) is 1 (slightly hazardous to water).
Despite high safety, attention should be paid in actual use: PEG-400 is hygroscopic; prolonged exposure to air can absorb moisture, leading to quality degradation, so it should be sealed promptly after opening. At the same time, avoid contact with incompatible substances such as strong oxidizers and strong acids to prevent dangerous reactions. Maintain good ventilation during operation and avoid inhaling vapors or mists.
In different application scenarios (pharmaceutical preparations, daily chemical care, textile processing, metalworking fluids, etc.), PEG-400 can be stably compounded with anionic, cationic, and nonionic systems due to its excellent compatibility and chemical stability. However, it is still recommended to conduct small-scale tests to verify compatibility during formula development to ensure final product stability.
| Category | Precautions |
|---|---|
| Personal Protection | It is recommended to wear chemical safety goggles and nitrile rubber or chloroprene rubber gloves; thoroughly wash hands after operation |
| Ventilation Conditions | Maintain good ventilation and avoid inhaling vapors or mists |
| No Eating or Drinking | Eating, drinking, and smoking are prohibited in the workplace |
| Storage Temperature | It is recommended to control between 5°C and 30°C |
| Container Sealing | Keep the container sealed and avoid prolonged exposure to air to prevent moisture absorption |
| Keep Away from Fire Sources | Although the high flash point makes it non-flammable, it should still be kept away from heat sources, sparks, and open flames |
| Separate Storage | Store separately from incompatible substances such as strong oxidizers and strong acids |
| Environmental Protection | Strictly prevent the product from entering sewers or water bodies to avoid harm to the water environment |
| Emergency Situation | Treatment Method |
|---|---|
| Inhalation | Move the patient to fresh air and keep breathing unobstructed; if symptoms persist, seek medical attention immediately |
| Skin Contact | Immediately remove contaminated clothing and thoroughly flush the contact area with plenty of water and soap |
| Eye Contact | Lift the eyelids and rinse continuously with flowing water or saline for at least 15 minutes, and seek medical examination as soon as possible |
| Ingestion | Do not induce vomiting, rinse the mouth thoroughly with water, and seek medical attention immediately |
| Minor Spill | Cover with inert absorbent material (such as sand) and collect into a container |
| Major Spill | Build a dike or dig a pit for containment, transfer to a dedicated sealed container, and dispose according to local regulations |
When using PEG-400 in different industries, pay attention to the following points: