Question

What is Polyethylene Glycol PEG-4000/6000?

Answer
2026-05-17 官方文档 聚乙二醇PEG-4000/6000

Polyethylene Glycol PEG-4000/6000 is a non-ionic high molecular polymer, appearing as a white waxy solid or granules, with CAS number 25322-68-3. Due to its excellent water solubility, lubricity, and chemical stability, it is widely used in multiple industrial fields such as pharmaceuticals, daily chemicals, textiles, rubber and plastics, papermaking, and metal processing.

Detailed Description

Polyethylene Glycol PEG-4000/6000 (aliases: Macrogol 4000/6000, Polyethylene Glycol 4000/6000, Carbowax 4000/6000) is a linear high molecular compound polymerized from ethylene oxide, with the molecular formula HO(C2H4O)nH, where n≈70~200, and a molecular weight range of approximately 3400~6600. This product is a non-ionic surfactant, appearing as a white waxy solid or flakes at room temperature, with a melting point of 50~63°C, easily soluble in water, HLB value as high as 18.9~19.0, cloud point greater than 100°C, exhibiting strong hydrophilicity.

The core advantage of this product lies in its excellent compatibility and chemical stability. It remains stable over a wide pH range, exhibiting outstanding tolerance to acid, alkali, and hard water environments, while possessing excellent emulsifying, wetting, dispersing, and solubilizing capabilities. In terms of safety, this product is not classified as a dangerous substance or mixture; the acute oral toxicity LD50 (rat) is greater than 5000 mg/kg, which is practically non-toxic, and the flash point (open cup) is greater than 240°C. However, it should be noted that its fine dust can form explosive mixtures with air, so operations should be carried out away from ignition sources and with good ventilation.

Polyethylene Glycol PEG-4000/6000 produced by Guoli Chemical has an active content ≥99%, moisture ≤1.0%, acid value ≤0.1, saponification value ≤1.0, hydroxyl value between 8~16, iodine value ≤1, heavy metal content ≤10 ppm, arsenic ≤2 ppm, with stable and reliable quality. The product is packaged in 200 kg iron drums or 50 kg plastic drums. Storage should be sealed and moisture-proof, placed in a cool (10-30°C), dry, and well-ventilated environment.

Technical Parameters

Parameter NameTechnical Indicator
CAS number25322-68-3
Molecular formulaHO(C2H4O)nH, n≈70~200
Molecular weight3400~6600
AppearanceWhite waxy solid or granules
Ion typeNon-ionic
Active content≥99%
HLB value18.9 / 19.0
Melting point50~63°C
Density1.20~1.21
Cloud point>100°C
pH value (1% aqueous solution)5.0~7.0
Hydroxyl value8~16
Acid value≤0.1
Saponification value≤1.0
Iodine value≤1
Moisture≤1.0%
Flash point (open cup)>240°C
SolubilityEasily soluble in water
Heavy metals≤10 ppm
Arsenic≤2 ppm
Surface tension (1% aqueous solution)Approx. 55~60 mN/m
Packaging specification200 kg iron drum / 50 kg plastic drum

Application Suggestions

Pharmaceutical Industry: Used as an ointment base, suppository base, and drop pill carrier. Utilizing its suitable melting point (50~63°C) and good water solubility, it allows uniform drug dispersion and optimized release characteristics. It also serves as a solid dispersion carrier for poorly soluble drugs, significantly improving bioavailability.

Daily Chemical Industry: Used as a toothpaste humectant to replace or partially substitute glycerin, preventing paste from drying out; as a conditioner in shampoos and body washes to provide a smooth feel and reduce irritation from surfactants; also used as a moisturizing and nourishing ingredient in creams and lotions.

Textile Industry: Used as an antistatic agent and lubricant for synthetic fibers, effectively reducing fiber friction and static electricity, improving textile processing performance; as a penetrating and lubricating medium in cotton yarn mercerizing, ensuring uniform treatment.

Other Fields: In the rubber industry as an efficient mold release agent; in papermaking as a coating lubricant; in metal processing as a component of quenching fluid and cutting fluid lubricant; in pesticide formulations as a dispersion carrier to improve suspension rate and efficacy utilization.

Precautions

  • Dust Protection: Fine dust can form explosive mixtures with air (dust explosion class St1). The operation area must be kept away from open flames and well-ventilated. It is recommended to wear dust masks and local exhaust ventilation.
  • Moisture-proof Storage: This product is highly hygroscopic. The packaging container must be kept sealed and stored in a cool, dry place (recommended 10-30°C), away from strong oxidizing agents.
  • Personal Protection: Wear chemical-resistant gloves (e.g., nitrile rubber) and chemical safety goggles during operation. Thoroughly wash hands and exposed skin after handling.
  • Emergency Treatment: In case of eye contact, immediately rinse with plenty of water for at least 15 minutes. For spills, collect using non-sparking tools to avoid dust generation.