PEG400DL (Polyethylene Glycol (400) Dilaurate) is a non-ionic surfactant with excellent safety performance. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), this product is classified as a non-hazardous substance, and no statutory hazard pictograms, signal words, or hazard statements are required. Under normal industrial and personal care product use conditions, the product does not pose a significant risk to human health.
In terms of toxicology, PEG400DL has extremely low acute oral toxicity, with a rat LD50 greater than 5,000 mg\/kg, which is considered practically non-toxic. Skin irritation tests (4-hour occlusive patch test in rabbits) show no irritation; the eye shows only mild irritation, and the effect is reversible, recovering within 72 hours. Regarding mutagenicity, the Ames test result is negative, indicating that this product does not pose a genotoxic risk.
In terms of environmental safety, PEG400DL exhibits low toxicity to aquatic organisms, with LC50\/EC50 values for fish and daphnia greater than 100 mg\/L. More importantly, this product is readily biodegradable. According to the OECD 301F standard test, the 28-day degradation rate exceeds 60%, indicating that it will not persist in the environment and meets the environmentally friendly requirements of modern chemicals.
| Safety Indicator | Test Data | Conclusion |
|---|---|---|
| Acute Oral Toxicity (Rat LD50) | > 5,000 mg\/kg | Practically Non-toxic |
| Skin Irritation (Rabbit) | No irritation (4-hour occlusive patch test) | Safe for Skin |
| Eye Irritation (Rabbit) | Mild irritation, reversible recovery within 72 hours | Avoid direct contact with eyes |
| Mutagenicity (Ames Test) | Negative | No Genotoxicity |
| Aquatic Toxicity (Fish\/Daphnia) | LC50\/EC50 > 100 mg\/L | Low Toxicity to Aquatic Organisms |
| Biodegradability (OECD 301F) | 28-day degradation rate > 60% | Readily Biodegradable |
| Flash Point (Closed Cup Method) | > 250 °C | Low Fire Risk |
| GHS Hazard Classification | Non-hazardous Substance | No Hazard Labeling Required |
PEG400DL is widely used in cosmetics and personal care products (creams, lotions, shampoos, body washes), industrial cleaners, metalworking fluids, textile auxiliaries, pesticide formulations, and coatings and inks. In these applications, the product is used as an emulsifier, solubilizer, and dispersant, and is safe for both humans and the environment at conventional dosage levels.