Polyether F-38 (Poloxamer 108) is a nonionic surfactant, and its toxicological data indicate that the product has high safety. The acute oral toxicity (rat) LD₅₀ value is greater than 5 g/kg, belonging to the low toxicity level. In the skin irritation test (rabbit), no irritating reaction was observed, and the skin sensitization test result was also non-sensitizing. Only eye contact may cause mild reversible conjunctival redness and swelling, without permanent damage. Overall, under normal industrial use conditions, the health risk of polyether F-38 to humans is extremely low.
In terms of environmental safety, polyether F-38 also performs well. According to the OECD 301B standard test, its biodegradation rate exceeds 60%, making it easily biodegradable, and it can be rapidly decomposed by microorganisms in the natural environment without causing long-term accumulation. The ecotoxicity data for aquatic organisms (fish/water flea) show that LC₅₀/EC₅₀ are all greater than 100 mg/L, belonging to the low toxicity level, and it is not classified as a substance harmful to the aquatic environment. Therefore, under normal industrial discharge and disposal conditions, the ecological and environmental risk of polyether F-38 is low.
This product is non-flammable, non-explosive, chemically stable, and does not decompose to produce harmful substances under normal storage and operating conditions. Only during combustion may it produce carbon monoxide, carbon dioxide, and other irritating or toxic fumes, but this is not a risk under normal use scenarios.
| Test Item | Test Result | Conclusion |
|---|---|---|
| Acute Oral Toxicity (Rat) LD₅₀ | > 5 g/kg | Low Toxicity |
| Skin Irritation (Rabbit) | Non-irritating | Safe |
| Eye Irritation (Rabbit) | Mild Irritation (Reversible conjunctival redness and swelling) | Requires Protective Measures |
| Skin Sensitization | Non-sensitizing | Safe |
| Biodegradability (OECD 301B) | >60% | Readily Biodegradable |
| Acute Fish Toxicity LC₅₀ | >100 mg/L | Low Toxicity |
| Acute Daphnia Toxicity EC₅₀ | >100 mg/L | Low Toxicity |
| Environmental Hazard Classification | Not classified as a substance harmful to the aquatic environment | Environmentally Friendly |
| Flammability | Non-flammable, no auto-ignition temperature | Non-hazardous Material |
Given the low toxicity and environmental friendliness of polyether F-38, this product is particularly suitable for industries with high requirements for safety and environmental protection, such as textile auxiliaries, paper chemicals, and polyurethane foam products. In formulation design, its excellent chemical stability and low-foaming characteristics also help reduce the amount of additives and wastewater treatment burden in subsequent processes.