G-25 Glycereth-25 is a nonionic surfactant produced by the polymerization of natural glycerin with ethylene oxide. From a human health perspective, this product exhibits excellent safety performance: the acute oral toxicity LD50 in rats is greater than 5000 mg/kg, classifying it as practically non-toxic; under standard experimental conditions, it is non-irritating to the skin (rabbit primary irritation index is 0), and eye irritation is only mild and reversible within 48 hours; the skin sensitization test (guinea pig maximization test) is negative, and the Ames bacterial reverse mutation test is also negative, indicating no genotoxicity. According to the GHS hazard classification criteria, this product does not belong to any physical, health, or environmental hazard category, making it a mild and safe chemical.
From an environmental impact perspective, this product also performs well. As determined by the OECD 301F standard method, its 28-day biodegradation rate exceeds 60%, classifying it as readily biodegradable, and it is not expected to persist in the environment. Additionally, this product does not have bioaccumulation potential and has no known specific ecotoxicological effects, meeting the requirements of modern green chemistry. Under normal use and compliant discharge conditions, it will not cause persistent impacts on water, soil, or atmospheric environments.
| Assessment Item | Data/Conclusion | Test Method/Standard |
|---|---|---|
| Acute Oral Toxicity (Rat) | LD50 > 5000 mg/kg (practically non-toxic level) | Standard toxicology test |
| Acute Dermal Toxicity (Rat) | LD50 > 2000 mg/kg | Standard toxicology test |
| Skin Irritation (Rabbit) | Non-irritating (primary irritation index 0) | Standard skin irritation test |
| Eye Irritation (Rabbit) | Mildly irritating (reversible within 48 hours) | Standard eye irritation test |
| Skin Sensitization (Guinea Pig) | Negative (no sensitization) | Guinea pig maximization test |
| Genotoxicity (Ames Test) | Negative (no genotoxicity) | Bacterial reverse mutation test |
| Biodegradability | 28-day degradation rate > 60% (readily biodegradable) | OECD 301F |
| Bioaccumulation Potential | No bioaccumulation potential | — |
| GHS Hazard Classification | Not classified as any physical, health, or environmental hazard | GHS classification criteria |
Based on its excellent toxicological and environmental safety, G-25 Glycereth-25 is particularly suitable for use in personal care products and cosmetics (such as makeup removers, skin care serums, facial cleansers, shampoos, and body washes), meeting the development needs of mild formulations. It is also widely used in textile industry for spinning oils and finishing softeners, as well as in metalworking fluids and industrial cleaning agents. In addition, its good environmental degradation characteristics make it suitable for pesticide formulations and emulsion polymerization fields with strict environmental requirements.