Polyether F-68 (CAS No.: 9003-11-6) belongs to the polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO) ABA-type triblock copolymer with a molecular weight range of 7680~9510. The hydrophilic polyoxyethylene segment in its molecular structure accounts for about 80%, giving the product extremely high water solubility and an HLB value of 29, making it an ideal emulsifier for O\/W emulsions. It appears as a white to slightly yellowish waxy solid with a melting point of 52~57°C, stable at room temperature, and exhibits good tolerance to acidic and alkaline environments as well as metal ions in hard water.
In terms of surface activity, the critical micelle concentration (CMC) of Polyether F-68 is approximately 0.5 g\/L (25°C), and the surface tension of a 0.1% aqueous solution is about 43 mN\/m, demonstrating mild yet effective interfacial activity. The product also features low-foaming properties and excellent dispersion and wetting abilities. The pH value of a 1% aqueous solution is between 5.0 and 8.0, and the cloud point exceeds 100°C, indicating stable performance over a wide temperature range.
Safety is a distinctive feature of Polyether F-68 compared to common industrial surfactants. As a pharmaceutical excipient grade product, its active content is ≥99.0%, heavy metal content ≤10 mg\/kg (as Pb), and arsenic content ≤2 mg\/kg, meeting stringent pharmaceutical industry standards. The product is classified as a non-restricted dangerous good under the UN Recommendations on the Transport of Dangerous Goods, but according to GHS classification, it is categorized as Skin Irritant Category 2, Eye Irritant Category 2A, and Respiratory Irritant Category 3 (signal word: Warning). Appropriate personal protective equipment is recommended during handling.
| Parameter | Value | Parameter | Value |
|---|---|---|---|
| Ionic Type | Nonionic | Appearance | White to slightly yellowish waxy solid |
| CAS No. | 9003-11-6 | Molecular Weight | 7680~9510 |
| HLB Value | 29 | Cloud Point (1% aqueous solution) | >100°C |
| Melting Point | 52~57°C | Active Content | ≥99.0% |
| pH (1% aqueous solution) | 5.0~8.0 | pH (5% aqueous solution) | 5.0~7.5 |
| Surface Tension (0.1%, 25°C) | ~43 mN\/m | CMC (25°C) | ~0.5 g\/L |
| Hydroxyl Value | 9~12 mg KOH\/g | Acid Value | ≤0.5 mg KOH\/g |
| Moisture | ≤0.5% | Density | 1.00~1.10 g\/cm³ |
| Iodine Value | ≤1 g I₂\/100g | Heavy Metals (as Pb) | ≤10 mg\/kg |
| Arsenic Content | ≤2 mg\/kg | Flash Point | >260°C |
| Foaming Characteristics | Low Foaming | Alkali Resistance | Good |
| Hygroscopicity | Hygroscopic | Solubility | Easily soluble in water |
Data source: Guoli Chemical Product Database. Physicochemical indices are typical values. Please refer to the Certificate of Analysis (COA) for specific batch data.
Pharmaceutical Field (Core Application): As a highly effective emulsifier for intravenous fat emulsions, solubilizer and stabilizer for oral solutions and eye drops, it can significantly enhance the bioavailability of poorly soluble drugs. It can also be used as a hydrophilic base for suppositories. Applications in this field require the use of pharmaceutical excipient grade products that comply with relevant pharmacopoeia standards.
Biotechnology and Cell Culture: Added to culture media as a shear protectant, it effectively protects suspension-cultured cells from fluid mechanical damage caused by stirring and aeration by reducing gas-liquid interfacial tension. Typical usage concentration is 0.5~3 g\/L.
Personal Care and Cosmetics: Used as a mild nonionic emulsifier and dispersant in formulations such as creams, lotions, shampoos, and body washes, helping to improve spreadability and skin feel.
Industrial Auxiliaries: Used as a high-performance lubricant, low-foaming defoamer, mold release agent, and dispersant in coatings and inks.