The usage method of Polyether F-68 varies significantly depending on the application field. In biotechnology/cell culture, there is a clear typical dosage (0.5～3 g/L), while in pharmaceutical, cosmetic, and industrial applications, optimization based on the specific formulation is required. The database currently does not have a uniform fixed dosage.
Detailed Description
Polyether F-68 (Poloxamer 188) is a white to slightly yellow waxy solid with a melting point of 52~57°C. It is readily soluble in water and has an HLB value of 29, classifying it as a highly hydrophilic nonionic surfactant. In practice, it usually needs to be pre-dissolved in the aqueous phase. Since the product is a solid and has some hygroscopicity, it is recommended to operate in a well-ventilated area. Weigh out the required amount and slowly add it to warm water (approximately 40~50°C) under continuous stirring until completely dissolved, preparing it as a stock solution of the desired concentration or directly adding it to the formulation system.
This product features low foaming properties, good acid and alkali resistance, and stability in hard water, allowing it to maintain stable interfacial activity even in high-shear processes such as stirring and homogenization. The critical micelle concentration (CMC) in aqueous solution is approximately 0.5 g/L (25°C), meaning it can exert its surface-active effect at very low concentrations. In applications requiring high emulsification efficiency, the use concentration usually needs to be far above the CMC value.
The usage methods and dosages vary greatly across different application scenarios. In cell culture, a clear concentration range for use as a shear protectant has been established. In pharmaceutical preparations (such as intravenous emulsions and oral liquids) and personal care formulations, the dosage strictly depends on the drug properties, formulation type, oil-to-water ratio, and target product performance, requiring determination through experimental optimization.
Technical Parameters
| Parameter Item | Value | Remarks |
|---|
| HLB Value | 29 | Highly Hydrophilic |
| Cloud Point | >100°C | 1% Aqueous Solution |
| Critical Micelle Concentration (CMC) | Approx. 0.5 g/L | 25°C |
| Surface Tension | Approx. 43 mN/m | 0.1% Aqueous Solution, 25°C |
| Melting Point | 52~57°C | — |
| Active Content | ≥99.0% | — |
| pH Value (1% Aqueous Solution) | 5.0~8.0 | — |
| Hydroxyl Value | 9~12 mg KOH/g | — |
| Foaming Property | Low Foaming | — |
| Solubility | Readily Soluble in Water | — |
| Appearance | White to Slightly Yellow Waxy Solid | — |
Application Recommendations
1. Biotechnology and Cell Culture (With Clear Recommended Dosage)
- Typical Use Concentration: 0.5～3 g/L (Data source: Guoli Chemical Product Database)
- Usage Method: Add the polyether F-68 powder directly to the culture medium, stir to dissolve, and then filter sterilize through a 0.22 μm filter membrane. Alternatively, prepare a high-concentration sterile stock solution and add it to the medium as needed.
- Mechanism of Action: Functions as a shear protectant, protecting sensitive cells from fluid mechanical damage during stirring and aeration, thereby improving cell viability and yield.
2. Pharmaceutical Industry
- Used as an emulsifier in intravenous emulsions, a solubilizer and stabilizer in oral liquid preparations, and a hydrophilic base in suppositories.
- The database currently does not have a uniform fixed dosage. The specific amount needs to be determined through formulation screening and process optimization based on the properties of the active pharmaceutical ingredient, the formulation type, and the target release characteristics.
- Generally, it must comply with the quality standards for Poloxamer 188 in the Chinese Pharmacopoeia and be used under GMP conditions.
3. Personal Care and Cosmetics
- Used as a mild nonionic emulsifier, dispersant, and foam stabilizer in formulations such as creams, lotions, shampoos, and body washes.
- The database currently does not have a uniform fixed dosage. It is recommended to start testing at 0.5%~5% (based on the total weight of the formulation) and adjust according to the requirements of the emulsification system, the type and content of oils and fats, and the desired product texture.
- Due to its low foaming property, it is particularly suitable for formulating low-foaming or easy-to-rinse facial cleansing products.
4. Industrial Auxiliaries
- Applied in formulations such as high-performance lubricants, low-foaming defoamers, mold release agents, and dispersants for coatings and inks.
- The database currently does not have a uniform fixed dosage. It needs to be determined through experimental optimization based on specific process requirements and the formulation system.
Precautions
- Personal Protection: It is recommended to wear a dust mask, chemical safety goggles, and protective gloves (such as nitrile rubber gloves) during handling to avoid dust inhalation and skin/eye contact. According to GHS classification, this product is classified as Skin Irritation Category 2, Serious Eye Damage/Eye Irritation Category 2A, and Respiratory Irritation Category 3, with the signal word "Warning".
- Dissolution Operation: It is recommended to use warm water (40~50°C) with continuous stirring during dissolution. Avoid prolonged heating at high temperatures. The prepared aqueous solution should be used as soon as possible or appropriate preservative measures should be taken.
- Storage Conditions: Keep the container tightly closed and store in a cool (recommended temperature below 25°C), dry, and well-ventilated area. The product is hygroscopic; avoid prolonged exposure to humid environments to prevent caking.
- Pharmaceutical Grade Application: When used for injectable routes, products meeting pharmaceutical grade standards must be used. Sterile processing is required before injection, and strict adherence to relevant Good Manufacturing Practices for pharmaceuticals is necessary.
