Polyether F-68 (Poloxamer 188) is generally recognized as a low-toxicity substance with good biocompatibility, which is why it is widely used in high-risk fields such as pharmaceutical injections, oral solutions, and cell culture. However, according to the GHS chemical classification system, this substance is still classified as a skin irritant (Category 2) and an eye irritant (Category 2A), with the signal word "Warning" and the pictogram GHS07 (Exclamation mark).
Specifically, direct contact may cause the following health issues: Skin contact (H315) may cause irritation reactions such as erythema, dryness, or cracking; Eye contact (H319) may cause severe eye irritation, resulting in pain, redness, and tearing; Inhalation of dust (H335) may cause respiratory tract irritation, leading to coughing or breathing discomfort. Therefore, nitrile rubber protective gloves, chemical safety goggles, and operation in a well-ventilated area are required. In case of accidental contact, immediately rinse with plenty of water, and seek medical attention if irritation persists.
Polyether F-68 is an environmentally friendly surfactant. The polyoxyethylene-polyoxypropylene block in its molecular structure can gradually degrade in the natural environment. It does not exhibit characteristics of persistent organic pollutants, and there is no evidence of significant bioaccumulation in living organisms. The product itself is not flammable and is not classified as a marine pollutant. It is not listed as a dangerous good under the United Nations classification for the transport of dangerous goods.
Nevertheless, it is not recommended to release it into the environment in large quantities or in an uncontrolled manner. In the event of a large spill, it should be contained by diking and collected using inert absorbent materials such as sand or vermiculite. It is strictly prohibited to discharge into drainage systems, surface water, or soil. Waste products and contaminated containers must be disposed of by incineration or neutralization through a licensed professional waste treatment facility, and must not be discarded arbitrarily or mixed with household waste.
| Item | Parameter |
|---|---|
| GHS Skin Corrosion/Irritation Classification | Category 2 |
| GHS Eye Damage/Irritation Classification | Category 2A |
| Specific Target Organ Toxicity (Single Exposure) | Category 3 (Respiratory Tract Irritation) |
| Hazard Statement Codes | H315 · H319 · H335 |
| Signal Word | Warning |
| Pictogram | GHS07 (Exclamation Mark) |
| Flammability | Non-flammable Solid |
| Transport Hazard Classification | Non-Dangerous Goods (Not Restricted) |
Pharmaceutical and Biotechnology Fields: In applications such as intravenous emulsions and cell culture media, Polyether F-68 has undergone extensive toxicological evaluation and is safe when used at specified dosages (e.g., 0.5~3 g/L in cell culture). It exhibits extremely low toxicity to humans and cells.
Personal Care Products and Cosmetics: When used as a mild nonionic emulsifier in finished products such as creams, lotions, and shampoos, it generally does not cause skin irritation at the product concentration. However, formulation engineers should still pay attention to skin compatibility testing of the final product.
Industrial Operating Environment: When handling solids, minimize mechanical agitation and dust generation. Operators must wear dust masks, protective gloves, and goggles. The work area should be equipped with eyewash stations and emergency showers.