The core component of Polyether F-68 is a block copolymer formed by the polymerization of ethylene oxide (EO) and propylene oxide (PO), with a structure of polyoxyethylene (PEO)-polyoxypropylene (PPO)-polyoxyethylene (PEO) triblock. Its molecular structure consists of hydrophilic polyoxyethylene segments at both ends and a hydrophobic polyoxypropylene segment in the middle, belonging to nonionic polymeric surfactants.
In international pharmacopoeias and industry standards, this component is uniformly named Poloxamer 188, with trade names including Pluronic F-68, Lutrol F68, Kolliphor P 188, etc., all referring to the same substance.
| Parameter | Value |
|---|---|
| CAS No. | 9003-11-6 |
| Molecular Formula | HO(C₂H₄O)x(C₃H₆O)y(C₂H₄O)xH |
| Average Molecular Weight | 7680 ~ 9510 |
| Active Content | ≥99.0% |
| HLB Value | 29 |
| Melting Point | 52~57℃ |
| Cloud Point (1% aqueous solution) | >100℃ |
| Appearance | White to slightly yellow waxy solid |
In Poloxamer 188, the polyoxyethylene (PEO) segment accounts for about 80% of the total molecular mass, endowing the product with excellent water solubility and hydrophilicity; the polyoxypropylene (PPO) segment accounts for about 20%, providing hydrophobic anchoring points, thus giving it surface activity and emulsifying ability. This specific block ratio and molecular weight distribution are key features distinguishing it from other poloxamer products (such as F-68, F-127, etc.).