Polyether F-68 (Poloxamer 188) is a white to slightly yellow waxy solid (melting point 52~57°C), readily soluble in water, with an HLB value as high as 29, making it a hydrophilic nonionic surfactant. Before use, it is typically heated to a molten state or directly dissolved in warm water (40~60°C) with stirring until completely dissolved, then added to the formulation system according to process requirements. The product has an effective content ≥99.0%, a pH of 5.0~8.0 for a 1% aqueous solution, a critical micelle concentration of approximately 0.5 g/L (25°C), low foaming, and resistance to acids, alkalis, and hard water.
According to the National Chemical Product Database and industry application standards, the usage methods vary significantly across different fields. The specific operational points are described below by application scenario.
Used as an emulsifier and solubilizer in intravenous injection emulsions, oral solutions, eye drops, and other preparations. Typically, Polyether F-68 is dissolved in water for injection (can be gently heated to 50~60°C to accelerate dissolution), sterile filtered through a 0.22 μm microporous membrane, and then added to the aqueous phase before emulsification. When used as a hydrophilic base for suppositories, it can be co-melted with the drug and poured into molds for solidification.
Used as a shear protectant added to culture media, typical usage concentration is 0.5~3 g/L (data source: National Chemical Product Database). Procedure: Weigh the required amount of Polyether F-68, dissolve it in a small amount of culture medium or PBS buffer, autoclave at 121°C for 15 minutes or sterile filter through a 0.22 μm filter, and then aseptically add it to the culture medium and mix thoroughly.
Used as a mild nonionic emulsifier, dispersant, and foam stabilizer in creams, lotions, shampoos, body washes, and other formulations. Typically added when the aqueous phase is heated to 55~60°C, stirred until completely dissolved, and then mixed with the oil phase for emulsification. Recommended dosage: 0.5% to 5% of the total formulation (refer to industry general range; specific adjustment depends on the formulation system).
Used as lubricants, defoamers, mold release agents, dispersants in coatings and inks. Can be added directly or pre-dissolved in water before addition to the system. Dosage depends on specific process requirements; there is no unified standard concentration for industrial applications.
| Parameter | Value | Parameter | Value |
|---|---|---|---|
| Appearance | White to slightly yellow waxy solid | HLB Value | 29 |
| Melting Point | 52~57°C | Active Content | ≥99.0% |
| pH of 1% Aqueous Solution | 5.0~8.0 | Cloud Point (1% Aqueous Solution) | >100°C |
| Critical Micelle Concentration | Approx. 0.5 g/L (25°C) | Surface Tension (0.1%) | Approx. 43 mN/m (25°C) |
| Molecular Weight | 7680~9510 | Moisture Content | ≤0.5% |
| Hydroxyl Value | 9~12 mg KOH/g | Flash Point | >260°C |