Polyether L-63 (a poloxamer non-ionic surfactant) is classified as a non-hazardous substance or mixture under the GHS classification system, with no hazard categories, no pictograms, and no signal words. Its acute oral toxicity LD50 (rat) is greater than 5000 mg/kg, belonging to the practically non-toxic level; it is not irritating to skin; it has low toxicity to aquatic organisms and is readily biodegradable. These characteristics make it relatively safe under normal use conditions, but this does not mean that safe handling practices can be completely ignored.
In practical handling, the main potential risk is eye contact. According to OECD 405 test results, Polyether L-63 may cause mild temporary eye irritation. Therefore, eye protection is the top priority in personal protective equipment — chemical safety goggles or face shields must be worn during handling. Although it is not irritating to the skin, it is still recommended to wear chemical protective gloves (such as nitrile or neoprene gloves) and appropriate protective work clothing during prolonged or repeated contact, and to thoroughly wash hands immediately after handling.
Polyether L-63 has a closed-cup flash point greater than 200°C, making it a non-flammable liquid with low fire and explosion risk. However, thermal decomposition at high temperatures may produce harmful gases, so it should still be stored away from heat sources and open flames. In the event of a fire, use dry powder, carbon dioxide, alcohol-resistant foam, or water mist for extinguishing; do not use direct water jets. During spill handling, prevent the product from entering drains, waterways, or soil; collect it with inert absorbent materials (such as sand, vermiculite) and place it in a sealed chemical waste container for proper disposal.
| Protection Category | Specific Requirements |
|---|---|
| Hand Protection | Wear chemical protective gloves (nitrile or neoprene), replace regularly |
| Eye/Face Protection | Wear chemical safety goggles or face shields (most critical protection item) |
| Body Protection | Wear appropriate protective work clothing to avoid prolonged repeated skin contact |
| Respiratory Protection | No special protection required under normal ventilation conditions; wear an organic vapor respirator in poorly ventilated areas |
| Operating Environment | Operate in well-ventilated areas with local exhaust ventilation |
| Prohibited Actions | No eating, drinking, or smoking during handling |
| Emergency Situation | Response Measures |
|---|---|
| Skin Contact | Immediately remove contaminated clothing, rinse thoroughly with plenty of water and soap; if irritation persists, seek medical advice |
| Eye Contact | Immediately rinse carefully with plenty of water for several minutes; if wearing contact lenses and easy to remove, remove them during rinsing and continue rinsing thoroughly; if irritation persists, seek medical attention |
| Inhalation | Move the person to fresh air; if feeling unwell, seek medical attention immediately |
| Ingestion | Rinse mouth, do NOT induce vomiting; immediately call a poison control center or doctor |
| Spill Handling | Evacuate non-essential personnel; wear protective equipment; collect with inert absorbent materials (sand, vermiculite); prevent entry into drains and waterways; dispose of waste according to regulations |
Polyether L-63 should be stored in a cool, dry, well-ventilated dedicated warehouse or area, with a recommended storage temperature of 5–40°C, avoiding freezing or prolonged exposure to high temperatures. Containers must be kept tightly closed, preferably made of carbon steel, stainless steel, or specific plastics. After opening, containers should be properly resealed to prevent moisture absorption or contamination. Do not mix-store with food, feed, or pharmaceuticals; keep away from incompatible substances such as strong oxidizing agents and strong acids. Use within the specified shelf life under recommended storage conditions; it is advisable to test before use after prolonged storage.