Polyethylene glycol PEG-300 (CAS number: 25322-68-3) is a non-ionic surfactant, appearing as a colorless to slightly yellow transparent viscous liquid. It is widely used in pharmaceuticals, daily chemicals, industry, coatings, and agriculture. Although this product is not classified as hazardous according to GHS assessment, with an acute oral toxicity LD50 > 20 g/kg (practically non-toxic) and being non-irritating and non-sensitizing to the skin, standard operating procedures still need to be followed during actual use to ensure personnel safety and maintain product quality.
One of the most notable characteristics of this product is its strong hygroscopicity. It easily absorbs moisture from the air after opening. Therefore, during use, the time it is exposed to air should be minimized, and the container should be immediately resealed after removal to avoid product dilution or deterioration due to prolonged exposure to humid air. Additionally, the operating temperature should be controlled within a safe range, recommended to be below 170°C, away from its flash point (closed cup 195°C~234°C), to prevent the generation of irritating decomposition products at high temperatures.
Furthermore, although PEG-300 has excellent chemical stability and can withstand acidic, alkaline, and hard water environments, contact with strong oxidizing agents (such as peroxides, permanganates, concentrated nitric acid, etc.) must be strictly avoided, as it may cause hazardous reactions. When pumping or stirring in large quantities, anti-static grounding measures are recommended to eliminate potential risks.
| Protection Item | Specific Requirements |
|---|---|
| Eye Protection | Wear chemical safety goggles to prevent splashing into eyes (this product is slightly irritating to the eyes) |
| Hand Protection | Wear chemical-resistant gloves (e.g., nitrile rubber or neoprene material) |
| Body Protection | Wear appropriate protective clothing to avoid extensive skin contact |
| Ventilation Requirements | Maintain good ventilation at the workplace to avoid accumulation of vapors generated by heating |
| Operating Temperature | Recommended to be controlled below 170°C in a safe range, away from the flash point |
| Incompatible Materials | Strictly avoid contact with strong oxidizing agents (peroxides, permanganates, concentrated nitric acid, etc.) |
| Static Prevention | Anti-static grounding measures are recommended when pumping or stirring in large quantities |
| Personal Hygiene | Thoroughly wash hands and any skin areas that come into contact after operation; avoid eating, drinking, and smoking during operation |
| Storage Conditions | Specific Requirements |
|---|---|
| Storage Temperature | Recommended 5°C~40°C, in a cool, dry place, avoid freezing or prolonged high-temperature exposure |
| Container Material | Use original sealed containers or dedicated containers made of stainless steel or polyethylene (HDPE/LDPE) |
| Sealing Requirements | Keep containers sealed to prevent moisture absorption and contamination; reseal promptly after opening |
| Isolated Storage | Store separately from incompatible substances such as strong oxidizing agents, strong acids, and strong bases; keep away from open flames and heat sources |
| Stacking and Labeling | Ensure stable stacking with stack height in compliance with safety regulations; set clear chemical labels and safety warning signs in the storage area |
Skin Contact: Immediately remove contaminated clothing, flush with plenty of running water and soap for at least 15 minutes; seek medical attention if discomfort persists.
Eye Contact: Immediately lift eyelids and rinse thoroughly with plenty of running water or saline for at least 15 minutes; seek ophthalmological care if irritation persists.
Inhalation: Move to fresh air quickly, keep airways open; seek immediate medical attention if respiratory discomfort or persistent cough occurs.
Ingestion: Rinse mouth with water immediately, do not induce vomiting; if conscious, drink appropriate amount of water or milk to dilute, then seek medical help promptly.
Spill Treatment: For small spills, cover and absorb with inert absorbent materials (sand, vermiculite, etc.), then shovel into closed containers; for large spills, contain with dikes and transfer using explosion-proof pumps. Prevent spills from entering sewers, surface water, and soil.
Depending on the application field, special attention is needed during use: