Question 1

Is polyethylene glycol PEG-300 harmful to humans? Does it affect the environment?

Accepted Answer

Polyethylene glycol PEG-300 is an actually non-toxic substance, essentially harmless to the human body, environmentally friendly, easily biodegradable, and has no bioaccumulation potential. Impact on human health Polyethylene glycol PEG-300 has been assessed by international toxicology as an actually non-toxic substance. Verified by extensive animal experiments: the acute oral LD50 in rats is greater than 20 g/kg, and the dermal LD50 in rabbits is also greater than 20 g/kg, classifying it as non-toxic. It is non-irritating to the skin, non-sensitizing, and multiple in vivo and in vitro genotoxicity tests have yielded negative results, with no carcinogenicity or reproductive/developmental toxicity. It may only cause mild, transient irritation to the eyes, and the risk of inhalation is negligible under normal operating conditions. In daily use or industrial operations, as long as basic safety practices are followed (such as wearing protective gloves and goggles, and avoiding prolonged direct contact), PEG-300 poses almost no threat to human health. Even in case of accidental skin contact, rinse with water and soap; if accidentally ingested, the substance has very low toxicity, but it is still recommended to rinse the mouth and seek medical observation. Impact on the environment PEG-300 also exhibits low-risk characteristics for the ecological environment. Aquatic toxicity data show: fish 96-hour LC50 > 1000 mg/L, daphnia 48-hour EC50 > 500 mg/L, algae 72-hour EC50 > 100 mg/L, all lling into the category of practically non-toxic or low toxicity to aquatic organisms. More importantly, this substance meets OECD criteria for ready biodegradability and is classified as easily biodegradable, meaning it will not persist in the natural environment. PEG-300 has an extremely low octanol/water partition coefficient, does not have bioaccumulation or biomagnification potential, and will not accumulate in organisms through the food chain. At typical industrial discharge concentrations, it will not inhibit the microbial activity of wastewater treatment systems. Overall, PEG-300 is an environmentally friendly chemical raw material. Summary of toxicological and ecotoxicological parameters Assessment itemTest resultConclusion Acute oral toxicity (rat)LD50 > 20 g/kgActually non-toxic Acute dermal toxicity (rabbit)LD50 > 20 g/kgVery low dermal toxicity Skin irritationNon-irritatingSafe Eye irritationMild, transient irritationMild irritant Skin sensitizationNon-sensitizingSafe GenotoxicityNegative in multiple testsNo genotoxicity CarcinogenicityNot classified as carcinogenic by IARC, etc.Non-carcinogenic Reproductive toxicityNo adverse effects in animal studiesNo reproductive/developmental toxicity Fish acute toxicity (96h LC50)> 1000 mg/LPractically non-toxic to fish Daphnia acute toxicity (48h EC50)> 500 mg/LLow toxicity Algal growth inhibition (72h EC50)> 100 mg/LLow toxicity to algae BiodegradabilityMeets OECD criteria for ready biodegradabilityEasily biodegradable Bioaccumulation potentialVery low log KowNo bioaccumulation Application recommendations Based on the above toxicological and ecotoxicological data, PEG-300 can be safely used in the following fields: Pharmaceutical field: As an ointment base, suppository base, drop pill carrier, and injection solvent, with good biocompatibility. Daily chemical field: Widely used in skin care products, shampoos, toothpaste, and other personal care products as a moisturizer and lubricant, with safe use. Industrial and agricultural fields: When used as a lubricant, antistatic agent, pesticide emulsifier, etc., it poses low risk to operators and the environment. Precautions Although PEG-300 has very low toxicity, it is still recommended to wear basic protective equipment (protective gloves, safety goggles) during operation to avoid prolonged or repeated skin contact. This substance is hygroscopic; after opening, it should be stored in a sealed container, with a recommended storage temperature of 5°C to 40°C. Avoid contact with strong oxidizing agents (such as peroxides, permanganates, concentrated nitric acid, etc.), as thermal decomposition may produce trace amounts of irritating gases. Waste disposal should comply with local regulations; do not discharge directly into surce water or soil. It is recommended to treat through compliant wastewater treatment systems or incineration. Although it has good biodegradability, in case of large spills, dikes should be constructed for containment to prevent concentrated discharge from causing short-term load on local water bodies.

Question 2

What to do if problems occur during the use of polyethylene glycol PEG-300? How to obtain technical support?

Accepted Answer

If problems occur during the use of polyethylene glycol PEG-300, first refer to the safety instructions for emergency treatment based on the type of problem, then obtain professional technical support through official channels of Guoli Chemical. Common usage problems and troubleshooting directions Problems that may occur during the use of polyethylene glycol PEG-300 usually involve the following situations: 1. Abnormal product state: For example, product color deepens, becomes turbid, or separates, usually related to improper storage conditions. PEG-300 is hygroscopic. If the container is not tightly sealed or exposed to humid air for a long time, it may cause product moisture absorption and deterioration. It is recommended to check whether the storage temperature is within 5°C to 40°C and whether the container uses original sealed containers or dedicated containers made of stainless steel, HDPE/LDPE. 2. Poor application effect: For example, the effect in emulsification, solubilization, or moisturizing does not meet expectations, which may involve formulation compatibility issues. It is necessary to check whether there is an adverse reaction with strong oxidants (such as peroxides, permanganates, concentrated nitric acid, etc.), or whether the pH value of other components in the formulation exceeds the tolerance range of PEG-300 (this product is resistant to acid, alkali, and hard water, but compatibility still needs to be verified under extreme conditions). The operating temperature should also be controlled within a safe range below 170°C, avoiding the flash point (195°C ~ 234°C). 3. Safety and health issues: In case of skin contact, eye contact, inhalation, or ingestion, please refer to the first aid measures in the product safety instructions for immediate treatment and seek medical attention promptly based on the severity of symptoms. Emergency treatment quick reference Contact typeEmergency treatment measures Skin contactRemove contaminated clothing, rinse with plenty of running water and soap for at least 15 minutes. Seek medical attention if irritation occurs. Eye contactImmediately open eyelids and rinse thoroughly with plenty of running water or saline for at least 15 minutes. Seek ophthalmological medical attention if discomfort persists. InhalationMove to fresh air, keep respiratory tract unobstructed, rest quietly. Seek medical attention if respiratory discomfort or persistent coughing occurs. IngestionRinse mouth with water, do not induce vomiting. If conscious, drink an appropriate amount of water or milk to dilute. Seek immediate medical attention and show product label. SpillageFor small spills, cover and absorb with inert absorbent materials (yellow sand, vermiculite, etc.) then seal for disposal. For large spills, construct dikes and transfer for recovery using explosion-proof pumps. How to obtain technical support from Guoli Chemical Haian Guoli Chemical Co., Ltd. provides professional technical support services to all customers. You can get help through the following methods: Official technical service hotline: Call Guoli Chemical's technical department directly, state the product batch number, application scenario, and specific problems encountered. Technical personnel will provide targeted solutions. Online consultation on the official website: Visit Guoli Chemical's official website, submit questions through online customer service or technical support form, attaching product batch number and relevant photos/videos to help quickly diagnose. Contact regional sales manager: Contact the regional sales representative serving you. They can coordinate the technical team for on-site inspection or remote guidance. Sample re-inspection service: If product batch quality issues are suspected, apply to return retained samples or products in use to the company for physicochemical index re-inspection (including appearance, hydroxyl value, pH value, moisture content, and other key parameters). Formulation optimization support: If the problem involves formulation compatibility in specific application scenarios, Guoli Chemical's technical team can provide customized formulation optimization suggestions based on your application field (pharmaceutical, daily chemical, industrial, coating, pesticide, rubber, etc.). Prepare the following information before contacting technical support Complete product name and product batch number (located on the packaging label) Purchase date and supplier information Specific application field and usage process conditions (temperature, dosage, compatible components, etc.) Detailed description of the problem occurrence (time, phenomenon, any abnormal operations, etc.) If possible, retain problem samples for testing and analysis Precautions Although this product is non-hazardous and practically non-toxic (LD50 > 20 g/kg), it is recommended to suspend use of the problematic batch until the cause is identified. All abnormalities during use should be recorded and archived for traceability and technical analysis. Do not arbitrarily mix problematic products with incompatible substances (strong oxidants, strong acids, strong bases). Disposal of waste must comply with local hazardous waste management regulations and must not be directly discharged into sewers or water bodies. If personal injury or major spillage occurs, in addition to contacting Guoli Chemical, report to local relevant departments as required by regulations.

Question 3

How to purchase polyethylene glycol PEG-300? What is the minimum order quantity?

Accepted Answer

For the specific price of polyethylene glycol PEG-300, please contact the sales team of Guoli Chemical for the latest quotation. There is no public minimum order quantity information in the database. It is recommended to consult directly for confirmation. Detailed Description Polyethylene glycol PEG-300 (CAS No.: 25322-68-3) is one of the core products of Hai'an County Guoli Chemical Co., Ltd., belonging to non-ionic surctants. To purchase this product, you need to go through the official sales channel. You can directly contact the sales team of Guoli Chemical to obtain the latest quotation and ordering process. According to the database information, the pricing unit of PEG-300 is yuan/ton, and the price will fluctuate with market conditions. The unit price in the current data is for reference only. The actual transaction price shall be subject to the formal quotation provided by the sales team. Product Packaging Specifications Guoli Chemical provides the following standard packaging options for polyethylene glycol PEG-300. You can choose the appropriate specification according to your needs: 50kg Plastic Drum 200kg Plastic Drum IBC Ton Barrel Purchasing Suggestions It is recommended to clarify the following information before purchasing so that the sales team can provide you with more accurate service: Estimated Quantity: Annual usage or single purchase quantity, so that the sales team can provide tiered pricing and supply guarantee solutions. Application Field: Such as pharmaceuticals, daily chemicals, industry, pesticides, etc. Different uses may have special requirements for product indicators. Whether Samples Are Needed: For the first cooperation, small samples can usually be requested for testing and verification. Delivery Address: Used to calculate logistics costs and transportation plans. Contact Suggestions You can directly contact through the sales hotline or corporate email published on the official website of Hai'an County Guoli Chemical Co., Ltd. Tell the salesperson that you need to purchase polyethylene glycol PEG-300 (Product No. 113) and inform them of your preferred packaging specification, and you will receive a detailed quotation and minimum order quantity explanation.

Question 4

Does polyethylene glycol PEG-300 meet environmental requirements? Can a test report be provided?

Accepted Answer

Polyethylene glycol PEG-300 has good environmental characteristics. It is an environmentally friendly chemical raw material that is easily biodegradable and has low ecotoxicity, meeting the OECD criteria for ready biodegradability. Detailed Description The polyethylene glycol PEG-300 (CAS No.: 25322-68-3) produced by Haian Guoli Chemical Co., Ltd. exhibits excellent environmental compliance. According to the product's ecotoxicological data, this product meets internationally recognized standards in key environmental indicators such as aquatic toxicity, biodegradability, and bioaccumulation, making it an environmentally friendly chemical product. In terms of biodegradability, PEG-300 meets the OECD (Organisation for Economic Co-operation and Development) criteria for ready biodegradability and is classified as an easily biodegradable substance. This means that in the natural environment, it can be rapidly decomposed by microorganisms and will not persist in soil or water bodies. Additionally, its octanol/water partition coefficient (log Kow) is very low, indicating no bioaccumulation or biomagnification effect, so it will not accumulate in organisms through the food chain, making it safe and reliable for the ecosystem. Regarding aquatic ecotoxicity, PEG-300 exhibits low toxicity or is essentially non-toxic to fish (LC50 > 1000 mg/L, 96 hours), daphnia (EC50 > 500 mg/L, 48 hours), and algae (EC50 > 100 mg/L, 72 hours). At typical industrial discharge concentrations, it does not inhibit biological wastewater treatment systems and does not deplete dissolved oxygen in water bodies. Technical Parameters Environmental IndicatorDataEvaluation Fish Acute Toxicity (LC50, 96h)> 1000 mg/LEssentially non-toxic to fish Daphnia Acute Toxicity (EC50, 48h)> 500 mg/LLow toxicity to aquatic invertebrates Algal Growth Inhibition (EC50, 72h)> 100 mg/LLow toxicity to algae BiodegradabilityMeets OECD ready biodegradability criteriaEasily biodegradable Bioaccumulation (log Kow)Very lowNo bioaccumulation Environmental PersistenceNon-persistent organic substanceDoes not persist in the environment Impact on Sewage SystemNo inhibition (at typical concentrations)Compatible with sewage systems Application Recommendations Given the excellent environmental characteristics of PEG-300, this product is particularly suitable for industries with strict environmental requirements: in the pharmaceutical industry, when used as a solvent for injections or as an ointment base, its low toxicity and easy degradability ensure drug safety; in the daily chemical industry, as a humectant and lubricant, it complies with increasingly stringent environmental regulations for personal care products; in the pesticide field, as an emulsifier and spreading agent, it will not cause persistent pollution to rmland soil and water bodies. Regarding Test Reports Regarding specific environmental test reports (e.g., biodegradability test reports, ecotoxicity test reports, RoHS/REACH compliance statements, etc.), the current product database does not include relevant test report files. It is recommended that you contact the business department or technical support team of Haian Guoli Chemical Co., Ltd. directly. They can provide batch-specific quality inspection reports (COA), MSDS safety data sheets, and third-party environmental test reports according to your specific needs. Commonly available report types include: product quality inspection certificates, SGS test reports, REACH compliance statements, RoHS test reports, etc. If you need assistance in contacting them, please also let us know your specific application and region so that we can provide more precise service.

Question 5

What are the advantages of polyethylene glycol PEG-300 compared to other similar products?

Accepted Answer

Polyethylene glycol PEG-300 has outstanding comprehensive advantages among similar products due to its superior safety performance, wide application adaptability, and excellent physicochemical stability. Detailed Explanation Compared to other molecular weights of polyethylene glycol (such as PEG-200, PEG-400, PEG-600, etc.) and traditional organic solvents or surctants, the polyethylene glycol PEG-300 produced by Guoli Chemical achieves a more delicate balance between safety and functionality. Its core advantage is first reflected in an extremely high safety margin: the acute oral toxicity LD50 > 20 g/kg, which is practically non-toxic, and it is non-irritating to the skin, non-sensitizing, and non-genotoxic. This means it can be safely used in fields with extremely strict requirements for purity and biocompatibility, such as pharmaceutical injections, topical ointments, and high-end personal care products, which many industrial-grade solvents or ionic surctants cannot match. In terms of application breadth, PEG-300 demonstrates multifunctionality as "one agent, multiple uses." It is an efficient emulsifier, solubilizer, and dispersant, and due to its moderate molecular weight (285~315), it combines low volatility with good fluidity, allowing it to be used alone as a plasticizer, humectant, and lubricant. Compared to lower molecular weight PEG (higher volatility, insufficient moisture retention) or higher molecular weight PEG (excessive viscosity, inconvenient operation), PEG-300 is a transparent viscous liquid at room temperature (with a freezing point as low as -15~-8°C), ensuring long-term formulation stability while cilitating pumping and metering. This greatly simplifies the process in coatings, inks, textiles, and pesticide formulation processing. Furthermore, the environmental friendliness of PEG-300 constitutes a key competitive advantage. Its characteristics of easy biodegradability and no bioaccumulation align with the global trend toward green chemical products. Additionally, its non-ionic nature allows it to maintain stable chemical performance over a wide pH range and in hard water conditions, with excellent compatibility with most components in formulations except acids, bases, and oxidizing agents. This significantly reduces the risk of formulation ilure due to incompatibility, ensuring the quality and batch consistency of downstream products from the raw material side. Technical Parameters Parameter CategoryItemGuoli Chemical PEG-300 Typical ValueAdvantage Explanation Basic Physical PropertiesAppearanceColorless to slightly yellow transparent liquidHigh purity, meeting pharmaceutical-grade sensory requirements Average Molecular Weight285 ~ 315Balances fluidity and low volatility Viscosity (40°C)60 ~ 75 mm²/sModerate, easy for transport and processing Freezing Point-15 ~ -8°CBetter low-temperature fluidity than PEG-400, etc. Functional IndicatorsHLB ValueApprox. 16.5Strong hydrophilicity, excellent O/W emulsification and solubilization Hydroxyl Value (mgKOH/g)356 ~ 394High reactivity, easy for derivatization modification Cloud Point (1% Aqueous Solution)> 100°CGood high-temperature stability, no precipitation Safety and Environmental ProtectionAcute Oral LD50> 20 g/kg (Practically Non-toxic)Pharmaceutical-grade safety level Flash Point (Closed Cup)> 200°CNon-flammable, safe for storage and transport BiodegradabilityReadily BiodegradableMeets OECD standards, low environmental burden Heavy Metals/Arsenic≤ 10 mg/kg / ≤ 2 mg/kgLow impurities, meeting strict regulations Application Recommendations First Choice for Pharmaceuticals: With its practically non-toxic grade and excellent biocompatibility, PEG-300 is an ideal choice for ointment bases, suppository carriers, pill matrices, and injection solvents. Its non-irritating and non-sensitizing properties to the skin make it especially suitable for pediatric and sensitive skin formulations. High-End Daily Chemical Moisturizing: In serums, creams, and toothpaste, the recommended addition amount is 2%~10% of the total formulation. Utilizing its dual function of moisture absorption and lubrication, it effectively improves the product's smooth application and post-application moisturizing feeling, with good low-temperature formulation stability. Green Industrial Alternatives: In coatings and inks, it serves as an environmentally friendly plasticizer and solvent, replacing traditional phthalates. The recommended dosage is 5%~15% of the resin solid content, significantly reducing VOC emissions while improving coating film flexibility. In pesticide formulations, it acts as an emulsifying spreading agent, enhancing the wetting and spreading of the spray liquid on hydrophobic leaf surces, thereby improving efficacy utilization. Rubber Processing Additive: As an internal mold release agent and dispersion medium for vulcanization accelerators, it is recommended to add 0.5%~2% during the mixing stage. Its moderate viscosity helps achieve uniform dispersion in the rubber matrix and is not easily volatilized, ensuring process stability during continuous production. Precautions Moisture-proof Sealing: This product is hygroscopic. After opening, reseal it as soon as possible to avoid prolonged exposure to moist air, which may reduce the effective component. Temperature Control: The operating temperature should be controlled below 170°C, away from the flash point; storage temperature should be maintained between 5°C and 40°C, avoiding freezing or prolonged high-temperature exposure to sunlight. Incompatible Substance Management: Avoid contact or mixing with strong oxidizing agents (such as peroxides, permanganates, concentrated nitric acid) to prevent violent reactions. Static Grounding: Although non-flammable, appropriate static grounding measures are still recommended during large-scale pumping or stirring to eliminate potential risks.

Question 6

How to store polyethylene glycol PEG-300? What is the shelf life?

Accepted Answer

PEG-300 should be stored in a cool, dry, well-ventilated warehouse, with a recommended temperature of 5°C to 40°C, keeping the container sealed and moisture-proof; under compliant storage conditions, the shelf life is typically 2 years (subject to the product's COA). Detailed Explanation Polyethylene glycol PEG-300 is a chemically stable non-ionic polymer, but its molecular structure contains numerous ether bonds and terminal hydroxyl groups, giving it strong hygroscopicity. Therefore, the key points for storage are moisture prevention, sealing, avoiding high temperatures, and keeping away from incompatible substances. This product is not classified as hazardous, has no risk of flammability or explosion, and storage management is relatively simple, but basic chemical storage regulations must still be followed. Regarding shelf life, PEG-300 has long-term chemical stability under ideal storage conditions. Industry practice indicates that unopened PEG-300 under compliant storage conditions typically has a shelf life of 2 years (from the production date). The specific shelf life should be based on the product's certificate of analysis (COA) and packaging label. After opening, it is recommended to use it as soon as possible and reseal immediately after each use to minimize the impact of moisture absorption on product quality. Storage Condition Details Storage ElementSpecific Requirements Storage EnvironmentCool, dry, well-ventilated warehouse; recommended temperature 5°C to 40°C; avoid freezing or prolonged high-temperature exposure Container MaterialOriginal sealed container, or dedicated containers made of stainless steel or polyethylene (HDPE/LDPE) Sealing RequirementKeep container sealed; reseal promptly after opening to prevent moisture absorption and contamination Away from Ignition SourcesAlthough this product is not flammable (flash point 195°C~234°C), it should still be kept away from open flames and heat sources Isolate StorageStore separately from strong oxidizing agents (e.g., peroxides, permanganates, concentrated nitric acid), strong acids, and strong bases Stacking and LabelingStable stacking, stack height compliant with safety regulations; storage area should have clear chemical labels and safety warning signs Operating TemperatureOperating temperature should be away from flash point; recommended to control below 170°C in a safe range Shelf Life and Quality Maintenance Recommendations Specific shelf life parameters for PEG-300 are not currently included in the database. Based on common industry practices and the chemical characteristics of polyethylene glycol products, the following recommendations are provided: Unopened Product: Under the storage conditions described above, the shelf life is typically 2 years from the production date. It is recommended to manage inventory using the "first-in, first-out" principle. Opened Product: Due to increased moisture absorption risk after opening, it is recommended to use within 6 to 12 months. After each use, ensure the container is sealed and check the opening for any crystallization or contamination. Quality Anomaly Detection: If the product shows significant color darkening, turbidity, off-odor, stratification, or significant viscosity changes, discontinue use and perform quality retesting. Precautions PEG-300 is hygroscopic; prolonged exposure to humid air will cause moisture absorption and dilution, affecting subsequent formulation accuracy. At low temperatures in winter, the product's viscosity increases or may even solidify; this is a normal physical phenomenon. Before use, slowly warm it to 20°C~40°C and stir evenly. Do not use direct open flame heating. In case of leakage, small amounts can be covered and absorbed with inert adsorbent materials (e.g., sand, vermiculite) then sealed for disposal; large leaks should be contained with dikes to prevent entry into sewers and water bodies. For the shelf life, storage conditions, and retest intervals of specific batches, refer to the certificate of analysis (COA) issued by the manucturer (Guoli Chemical).

Question 7

What safety precautions should be taken when using Polyethylene Glycol PEG-300?

Accepted Answer

Polyethylene Glycol PEG-300 belongs to the practically non-toxic and non-hazardous category. Under normal use conditions, it has no significant harm to human health and the environment. However, standard chemical handling procedures should still be followed, with emphasis on moisture-proof sealing, avoiding high temperatures, preventing contact with strong oxidizers, and taking basic personal protective measures. Detailed Description Polyethylene Glycol PEG-300 (CAS No.: 25322-68-3) has been evaluated according to the GHS (Globally Harmonized System of Classification and Labelling of Chemicals) and is classified as a non-hazardous substance. Its acute oral toxicity LD50 > 20 g/kg (rat) and acute dermal toxicity LD50 > 20 g/kg (rabbit) are both considered practically non-toxic. It is non-irritating to the skin, non-sensitizing, and non-genotoxic, with a high safety margin. However, this does not mean that operating procedures can be completely ignored; reasonable protective measures ensure occupational health and safety during long-term use. Three key aspects to focus on during handling: First, PEG-300 is hygroscopic, so the container should be sealed promptly after opening to avoid prolonged exposure to humid air, which could degrade product performance. Second, although it has a relatively high flash point (closed cup 195°C to 234°C) and is not classified as a flammable liquid, the operating temperature should be kept well below the flash point, ideally below 170°C for safety. Above this temperature, it may decompose and produce irritating fumes (carbon monoxide, carbon dioxide, and trace aldehydes). Third, contact with strong oxidizers such as peroxides, permanganates, and concentrated nitric acid must be avoided to prevent hazardous reactions. For personal protection, it is recommended to wear chemical safety goggles and protective gloves, as well as appropriate protective clothing, to avoid direct skin and eye contact. The work area should be well-ventilated. After handling, thoroughly wash hands. Work clothes should be washed regularly and not taken out of the workplace. Eating, drinking, and smoking are prohibited during operations. In case of skin contact, immediately flush with plenty of running water and soap for at least 15 minutes. In case of eye contact, hold eyelids open and rinse thoroughly with plenty of water or saline for at least 15 minutes. Seek medical attention if irritation persists. Technical Parameters Safety ParameterValue/Rating Hazard ClassificationNon-hazardous Acute Oral Toxicity (Rat LD50)> 20 g/kg (practically non-toxic) Acute Dermal Toxicity (Rabbit LD50)> 20 g/kg (very low dermal toxicity) Skin IrritationNon-irritating Eye IrritationMild irritant Skin SensitizationNon-sensitizing GenotoxicityNegative (multiple tests) CarcinogenicityNot classified as carcinogenic by IARC or other agencies Flash Point (Closed Cup)195°C ~ 234°C Autoignition TemperatureApprox. 310°C ~ 350°C ExplosivenessNot explosive Oxidizing PropertiesNot oxidizing BiodegradabilityReadily biodegradable (meets OECD criteria) Acute Fish Toxicity (LC50, 96h)> 1000 mg/L (practically non-toxic to fish) Application Recommendations Safety management priorities vary depending on the application scenario: Pharmaceutical field (ointment base, suppository base, pill carrier, injection solvent, etc.): Pharmaceutical-grade PEG-300 must be used, with strict control of microbial limits and impurity content. Operations should be conducted in a GMP clean environment to ensure compliance with pharmaceutical excipient standards. Cosmetics and personal care (skin care products, shampoos, toothpaste, etc.): Use cosmetic-grade raw materials, follow good manucturing practices, ensure the final concentration in the formulation meets cosmetic safety standards, and maintain batch traceability records. Industrial field (paper, textile, coatings, inks, rubber): Focus on operating temperature control and ventilation. When heating processes are involved, local exhaust ventilation should be provided to prevent vapor accumulation. In rubber mold release applications, be aware of decomposition risks at high temperatures. Agrochemical field (emulsifiers, spreaders): Operators need enhanced protection to prevent contact risks from the combined pesticide formulation (containing active ingredients). Do not lower protective standards solely based on the safety profile of PEG-300 alone. Additional Notes Storage conditions: Recommended storage temperature: 5°C to 40°C. Store in a cool, dry, well-ventilated warehouse. Use containers made of stainless steel or polyethylene (HDPE/LDPE) and keep them tightly sealed to prevent moisture. Store separately from strong oxidizers, strong acids, and strong bases. Spill handling: Small spills: cover with inert absorbent material (sand, vermiculite, etc.), absorb, and collect in a sealed container. Large spills: build dikes, transfer and recover using explosion-proof pumps. Prevent spill from entering sewers and surce waters. Dispose of all waste in compliance with local regulations. Firefighting measures: Although not classified as flammable, it may produce irritating fumes at high temperatures. Extinguishing media: water fog, alcohol-resistant foam, dry powder, or carbon dioxide. Do not use direct water streams on spilled material. Firefighters must wear self-contained positive-pressure breathing apparatus. First aid highlights: If ingested, rinse mouth immediately, do not induce vomiting. Drink适量的 water or milk to dilute, and seek medical attention promptly. There is no specific antidote; treatment is symptomatic and supportive. Static electricity prevention: During large-scale pumping or stirring operations, appropriate grounding measures should be taken to eliminate potential static risks.

Question 8

How to use PEG-300? What is the recommended addition amount?

Accepted Answer

PEG-300 is flexible in use, and the addition amount varies by industry and application scenario. The optimal ratio needs to be determined through experiments. Commonly used as a humectant, plasticizer, or solvent, the recommended addition amount ranges from 1% to 30%. Detailed Explanation Polyethylene Glycol PEG-300 (CAS No.: 25322-68-3), produced by Guoli Chemical, is a nonionic surctant. It appears as a colorless to slightly yellow transparent viscous liquid and exhibits excellent emulsifying, wetting, dispersing, and solubilizing capabilities. It also has outstanding chemical stability and can withstand acid, alkali, and hard water environments. Its core value lies in its versatility—it can play key roles in multiple fields such as pharmaceuticals, daily chemicals, industry, and agriculture, allowing users to flexibly adjust the dosage according to formulation goals. The recommended addition amount is not a fixed value; it should be optimized based on system characteristics, target effects, and cost control. Generally, lower addition amounts (e.g., spreading agents, lubricants) use 0.5%–3%, medium amounts (e.g., humectants, plasticizers) range from 2%–10%, and high amounts (e.g., ointment bases, suppository bases) can reach 15%–30%. Below are specific reference suggestions for various industries: Application Recommendations Application Field Usage Method Recommended Addition Amount (Mass Fraction) Pharmaceutical Ointment Base Blend with other pharmaceutical excipients, heat in a water bath to 50–60°C, and stir until homogeneous 20%–30% Injection Solvent Used as one component of a co-solvent system, requiring strict aseptic operation 10%–20% (depending on drug solubility) Tablet Coating/Lubricant Prepare coating solution for direct spraying, or add directly to powder blend 0.5%–3% Daily Chemical Humectant Add to the water phase, stir at room temperature until dissolved, then mix with other components 2%–8% Skincare Product/Shampoo Can be added directly as a lubricant and humectant 1%–5% Coating/Ink Plasticizer Add during grinding or paint mixing stage, mix thoroughly 3%–10% Textile Antistatic/Lubricant Prepare treatment solution for soaking or spraying on fibers 0.5%–3% (working solution concentration) Pesticide Emulsifier/Spreading Agent Dilute and mix with pesticide concentrate 0.1%–1% (field dilution ratio) Rubber Mold Release Agent Apply or spray directly onto the mold surce 5%–15% (use after dilution) (Note: The above addition amounts are industry general reference values; specific formulation dosages should be determined through preliminary experiments.) Technical Parameters Performance Parameter Guoli Chemical PEG-300 Specification Ionic Type Nonionic Active Content ≥99% HLB Value Approximately 16.5 pH Value (1% Aqueous Solution) 4.5–7.5 Hydroxyl Value 356–394 (mg KOH/g) Kinematic Viscosity 60–75 mm²/s Moisture Content ≤1.0% Solidification Point -15 to -8°C Solubility Easily soluble in water, ethanol, acetone Precautions Dissolution Suggestions: This product is a viscous liquid at room temperature; it may become thicker at low temperatures in winter. It is recommended to warm it to 20–30°C before use. Add slowly while stirring until fully dispersed to avoid local high concentration. Compatibility with Active Ingredients: PEG-300 may form complexes with hydroxyl-containing drugs (e.g., phenols, flavonoids), affecting efficacy. Compatibility studies should be conducted in pharmaceutical formulations. Hygroscopicity Management: This product is hygroscopic (based on Guoli Chemical database). After opening, seal and store promptly. For solid formulations containing PEG-300, evaluate the impact of moisture absorption on stability. Incompatibilities: Avoid contact with strong oxidizing agents. It may reduce the antimicrobial efficacy of phenol-based preservatives. Pay attention to stability when compounding with salicylic acid, tannic acid, etc. Safe Handling: Although not hazardous (based on Guoli Chemical database), it is recommended to wear protective gloves and goggles during operation. Control operating temperature below 170°C.

Question 9

In which industries and processes is polyethylene glycol PEG-300 mainly used?

Accepted Answer

Polyethylene glycol PEG-300 is widely used in five core fields: pharmaceuticals, daily chemicals, industrial manucturing, rubber processing, and agriculture. It is a multifunctional nonionic solvent, humectant, and processing aid. Detailed Description Polyethylene glycol PEG-300 (CAS No.: 25322-68-3) is a nonionic surctant produced by Guoli Chemical, appearing as a colorless to slightly yellow transparent viscous liquid. With its excellent emulsifying, wetting, dispersing, and solubilizing capabilities, as well as outstanding chemical stability (resistant to acids, bases, and hard water conditions), this product has become a key functional additive in multi-industry process steps. In the pharmaceutical industry, PEG-300 is widely used as a water-soluble ointment base, suppository base, pill carrier, and injection solvent due to its good biocompatibility and low toxicity. It is also used in tablet coating and lubrication. In the daily chemical industry, as an efficient humectant, lubricant, and surctant intermediate, it is extensively added to personal care products such as skin care products, shampoos, and toothpaste, significantly enhancing the moisturizing feel and user experience. In the industrial sector, PEG-300 has diverse applications: it provides lubrication and antistatic treatment in papermaking and textile processing; it is used as a solvent and plasticizer in coatings and inks to improve leveling and stability; in rubber products, it acts as an effective component of mold release agents and a dispersing medium for vulcanization accelerators; in agriculture, it is used as a pesticide emulsifier and spreader to enhance the wetting and spreading ability of the spray liquid on plant surces, thereby improving pesticide application efficacy. Technical Parameters Parameter ItemParameter Value Ion TypeNonionic AppearanceColorless to slightly yellow transparent viscous liquid CAS No.25322-68-3 Flash Point (Closed Cup)195℃～234℃ Autoignition TemperatureApproximately 310℃～350℃ Hazard ClassificationNon-hazardous Skin IrritationNon-irritating BiodegradabilityReadily biodegradable (meets OECD standards) Application Recommendations Pharmaceutical Processes: When used as an injection solvent or ointment base, it is recommended to be used in a clean environment and ensure sealed storage to prevent moisture absorption. For tablet coating, its plasticizing properties can be utilized to adjust the flexibility of the coating material. Daily Chemical Formulations: It is recommended to add it to creams, lotions, shampoos, and other formulations as a moisturizing and lubricating component. The reference dosage should be adjusted according to the formulation system, generally suggested in the range of 1% to 10%. Its nonionic nature provides good compatibility with anionic, cationic, and amphoteric surctants. Industrial Lubrication and Plasticization: In textile processing, it can be used for antistatic treatment of yarns or fibers. In coating and ink systems, it is recommended to be added during the paint mixing stage to improve application performance due to its low volatility and good solubility. Rubber Processing: As a component of mold release agents or a dispersing medium for vulcanization accelerators, it can improve dispersion uniformity and reduce surce defects of products. Pesticide Formulations: Used as an emulsifier and spreader, it effectively reduces the surce tension of the spray liquid, enhances the spreading and adhesion ability on leaves, and improves the utilization rate of pesticide efficacy. Precautions Hygroscopicity: PEG-300 is hygroscopic. After opening, reseal it as soon as possible to avoid prolonged exposure to humid air, which may affect product quality. Operating Temperature: It is recommended to control the operating temperature below 170℃, staying away from the flash point (195℃). Ensure good ventilation when heating. Incompatible Materials: Avoid contact with strong oxidizing agents (such as peroxides, permanganates, concentrated nitric acid, etc.) to prevent hazardous reactions. Storage Conditions: Recommended storage temperature is 5℃ to 40℃. Use stainless steel or polyethylene (HDPE/LDPE) containers sealed and stored away from open flames and heat sources. Safety Protection: Although this product is non-irritating to the skin and not classified as hazardous, it is still recommended to wear protective gloves and chemical safety goggles during operation, and thoroughly wash hands after use.

Question 10

What are the physical and chemical technical parameters of polyethylene glycol PEG-300?

Accepted Answer

The physical and chemical technical parameters of polyethylene glycol PEG-300 are comprehensive, covering basic physical properties, chemical indicators, and safety parameters, making it a high-quality non-ionic surctant commonly used in multiple industries. Detailed Description Polyethylene glycol PEG-300 (CAS No.: 25322-68-3) is a non-ionic surctant produced by Guoli Chemical, with the molecular formula HO(C2H4O)nH, where the average degree of polymerization n≈6, and the molecular weight distribution ranges from 285 to 315. The product appears as a colorless to slightly yellow transparent viscous liquid, almost odorless, with excellent chemical stability and low volatility, remaining stable in acidic, alkaline, and hard water environments. The product has an HLB value of approximately 16.5, indicating strong hydrophilicity, and a cloud point >100°C, demonstrating good high-temperature stability. The freezing point is -15 to -8°C, the flash point is >200°C, and under normal storage and handling conditions, there is no risk of flammability or explosion, classifying it as a non-hazardous material. The product is hygroscopic, so it should be sealed tightly after opening. PEG-300 is readily soluble in water, ethanol, and acetone, with good dissolution compatibility. Its surce tension is approximately 44.5 mN/m, and its foam performance is low-foaming or non-foaming, making it suitable for applications requiring low foaming characteristics. The core functions of the product include excellent emulsifying, wetting, dispersing, and solubilizing capabilities, which can be widely applied in fields such as pharmaceuticals, daily chemicals, industry, coatings, and pesticides. Technical Parameters Parameter CategoryParameter NameValue/Description Basic Physical PropertiesAppearanceColorless to slightly yellow transparent viscous liquid Ionic TypeNon-ionic Molecular Weight285~315 Density (20°C)1.11~1.13 g/cm³ Active Content≥99% Thermodynamic ParametersFreezing Point-15~-8°C Flash Point (Closed Cup)195°C~234°C (>200°C) Autoignition TemperatureApproximately 310°C~350°C Cloud Point>100°C Recommended Operating TemperatureBelow 170°C Chemical IndicatorsHydroxyl Value356~394 mgKOH/g Acid Value≤0.2 mgKOH/g Saponification Value≤1.0 mgKOH/g Iodine Value≤0.5 gI₂/100g Amine Value≤0.1 mgKOH/g Unsaturation≤0.1 mmol/g pH ValuepH of 1% Aqueous Solution4.5~7.5 pH of 5% Aqueous Solution4.5~7.5 Water Content≤1.0% Viscosity ParametersKinematic Viscosity (40°C)60~75 mm²/s Low Shear Viscosity60~80 mPa·s Refractive Index1.466~1.468 Surce PropertiesHLB Value16.5 Surce TensionApproximately 44.5 mN/m Purity IndicatorsFree Alcohol≤0.2% Heavy Metals (as Pb)≤10 mg/kg Arsenic (As)≤2 mg/kg SafetyExplosivityNon-explosive Oxidizing PropertiesNon-oxidizing Application Recommendations Thanks to its excellent solubility and safety, PEG-300 can be used in the pharmaceutical field as an ointment base, suppository base, pill carrier, and injection solvent, with good biocompatibility. In the daily chemical industry, it is widely added to skincare products, shampoos, and toothpaste as a humectant and lubricant. In industry, it can be used for lubrication and antistatic treatment in papermaking and textiles, as well as a solvent and plasticizer in coatings and inks. In the agricultural field, it serves as a pesticide emulsifier and spreader, significantly enhancing the wetting and spreading ability of the pesticide solution on plant surces. Precautions Moisture Absorption and Moisture Proofing: This product is hygroscopic. After opening, reseal it as soon as possible. The recommended storage environment temperature is 5°C~40°C, in a cool, dry, and well-ventilated area. Incompatible Materials: Avoid contact with strong oxidizers (such as peroxides, permanganates, concentrated nitric acid). Operational Protection: It is recommended to wear chemical safety goggles and protective gloves during operation, and ensure good ventilation in the workplace. Packaging Specifications: Guoli Chemical provides 50kg plastic drums, 200kg plastic drums, and IBC bulk container packaging.

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Property	Value
CAS No.	25322-68-3
Molecular Formula	HO(C2H4O)nH, n≈6 (avg.)
Appearance	Colorless to slightly yellow transparent liquid
Ionic Type	Nonionic
Avg. Molecular Weight	285 - 315
Cloud Point	>100°C
Active Content	≥99%
pH Value(1%)	4.5~7.5
pH Value(5%)	4.5~7.5
Iodine Value	≤0.5
Solubility	Readily soluble in water, ethanol and acetone
Surface Tension	~44.5 mN/m
Acid Value	≤0.2
Saponification Value	≤1.0
Hydroxyl Value	356 - 394
Moisture	≤1.0
Density	1.11~1.13
Kinematic Viscosity	60~75 mm²/s
Refractive Index	1.466~1.468
Flash Point	>200°C
Hygroscopicity	Hygroscopic
Chemical Stability	Stable at room temperature; avoid contact with strong oxidizers
Amine Value	≤0.1
Foam Property	Low foam to none
Alkali Resistance	Alkali resistant at ambient temperature
Unsaturation	≤0.1
Viscosity	60~80
Melting Point	-15~-8°C (freezing point)
Low Shear Viscosity	60~80 mPa·s
Solid Content	≥99%
Free Alcohol	≤0.2%
Heavy Metal	≤10 mg/kg
Arsenic	≤2 mg/kg