Question

How to use PEG-300? What is the recommended addition amount?

Answer
2026-06-06 官方文档 聚乙二醇PEG-300

PEG-300 is flexible in use, and the addition amount varies by industry and application scenario. The optimal ratio needs to be determined through experiments. Commonly used as a humectant, plasticizer, or solvent, the recommended addition amount ranges from 1% to 30%.

Detailed Explanation

Polyethylene Glycol PEG-300 (CAS No.: 25322-68-3), produced by Guoli Chemical, is a nonionic surfactant. It appears as a colorless to slightly yellow transparent viscous liquid and exhibits excellent emulsifying, wetting, dispersing, and solubilizing capabilities. It also has outstanding chemical stability and can withstand acid, alkali, and hard water environments. Its core value lies in its versatility—it can play key roles in multiple fields such as pharmaceuticals, daily chemicals, industry, and agriculture, allowing users to flexibly adjust the dosage according to formulation goals.

The recommended addition amount is not a fixed value; it should be optimized based on system characteristics, target effects, and cost control. Generally, lower addition amounts (e.g., spreading agents, lubricants) use 0.5%–3%, medium amounts (e.g., humectants, plasticizers) range from 2%–10%, and high amounts (e.g., ointment bases, suppository bases) can reach 15%–30%. Below are specific reference suggestions for various industries:

Application Recommendations

Application Field Usage Method Recommended Addition Amount (Mass Fraction)
Pharmaceutical Ointment Base Blend with other pharmaceutical excipients, heat in a water bath to 50–60°C, and stir until homogeneous 20%–30%
Injection Solvent Used as one component of a co-solvent system, requiring strict aseptic operation 10%–20% (depending on drug solubility)
Tablet Coating/Lubricant Prepare coating solution for direct spraying, or add directly to powder blend 0.5%–3%
Daily Chemical Humectant Add to the water phase, stir at room temperature until dissolved, then mix with other components 2%–8%
Skincare Product/Shampoo Can be added directly as a lubricant and humectant 1%–5%
Coating/Ink Plasticizer Add during grinding or paint mixing stage, mix thoroughly 3%–10%
Textile Antistatic/Lubricant Prepare treatment solution for soaking or spraying on fibers 0.5%–3% (working solution concentration)
Pesticide Emulsifier/Spreading Agent Dilute and mix with pesticide concentrate 0.1%–1% (field dilution ratio)
Rubber Mold Release Agent Apply or spray directly onto the mold surface 5%–15% (use after dilution)

(Note: The above addition amounts are industry general reference values; specific formulation dosages should be determined through preliminary experiments.)

Technical Parameters

Performance Parameter Guoli Chemical PEG-300 Specification
Ionic Type Nonionic
Active Content ≥99%
HLB Value Approximately 16.5
pH Value (1% Aqueous Solution) 4.5–7.5
Hydroxyl Value 356–394 (mg KOH/g)
Kinematic Viscosity 60–75 mm²/s
Moisture Content ≤1.0%
Solidification Point -15 to -8°C
Solubility Easily soluble in water, ethanol, acetone

Precautions

  • Dissolution Suggestions: This product is a viscous liquid at room temperature; it may become thicker at low temperatures in winter. It is recommended to warm it to 20–30°C before use. Add slowly while stirring until fully dispersed to avoid local high concentration.
  • Compatibility with Active Ingredients: PEG-300 may form complexes with hydroxyl-containing drugs (e.g., phenols, flavonoids), affecting efficacy. Compatibility studies should be conducted in pharmaceutical formulations.
  • Hygroscopicity Management: This product is hygroscopic (based on Guoli Chemical database). After opening, seal and store promptly. For solid formulations containing PEG-300, evaluate the impact of moisture absorption on stability.
  • Incompatibilities: Avoid contact with strong oxidizing agents. It may reduce the antimicrobial efficacy of phenol-based preservatives. Pay attention to stability when compounding with salicylic acid, tannic acid, etc.
  • Safe Handling: Although not hazardous (based on Guoli Chemical database), it is recommended to wear protective gloves and goggles during operation. Control operating temperature below 170°C.