Question

What is Polyethylene Glycol PEG-300

Answer
2026-05-27 官方文档 聚乙二醇PEG-300

Polyethylene Glycol PEG-300 is a colorless to slightly yellow transparent viscous liquid, belonging to a nonionic multifunctional surfactant, widely used in pharmaceutical, daily chemical, industrial, rubber, and agricultural fields, with excellent biocompatibility and low toxicity.

Detailed Description

Polyethylene Glycol PEG-300 is a high-purity polyoxyethylene nonionic surfactant produced by Hai'an County Guoli Chemical Co., Ltd., with CAS number 25322-68-3 and molecular formula HO(C₂H₄O)nH (n≈6). It is prepared by polymerization of ethylene oxide and water (or ethylene glycol), with an average molecular weight between 285 and 315. The product has an effective content of ≥99%, is almost odorless transparent viscous liquid at room temperature, easily soluble in water, ethanol, acetone and other polar solvents, and has good hygroscopicity and chemical stability.

The core advantages of this product lie in its versatility: it possesses excellent emulsifying, wetting, dispersing, and solubilizing capabilities, significantly improving the uniformity of formulations; its excellent chemical stability allows it to withstand acids, alkalis, and hard water environments; its low volatility ensures long-lasting lubrication and moisturizing effects. Its HLB value is about 16.5, making it a relatively hydrophilic surfactant, with a cloud point above 100°C, low or no foam, and good alkali resistance at room temperature.

Technical Parameters

Parameter NameSpecification Value
AppearanceColorless to slightly yellow transparent viscous liquid
Ion TypeNonionic
CAS No.25322-68-3
Molecular Weight285~315
Effective Content≥99%
HLB Value16.5
Density (g/cm³)1.11~1.13
Hydroxyl Value (mgKOH/g)356~394
Kinematic Viscosity (mm²/s)60~75
Low Shear Viscosity (mPa·s)60~80
Flash Point (Closed Cup)195℃~234℃
Solidification Point-15℃~-8℃
pH Value (1% Aqueous Solution)4.5~7.5
Cloud Point>100℃
Moisture Content≤1.0%
Acid Value (mgKOH/g)≤0.2
Iodine Value (g/100g)≤0.5
Refractive Index1.466~1.468
Heavy Metals≤10 mg/kg
Arsenic≤2 mg/kg
SolubilityEasily soluble in water, ethanol, acetone
Foaming PropertyLow or no foam
Packaging Specifications50kg plastic drum / 200kg plastic drum / IBC tote tank

Application Recommendations

PEG-300 is widely used in multiple industries due to its excellent performance. In the pharmaceutical field, it can be used as a water-soluble ointment base, suppository base, drop pill carrier, and injection solvent, with good biocompatibility; in the daily chemical industry, it is added as an efficient humectant and lubricant in skin care products, shampoos, and toothpaste to enhance product moisturizing sensation; in the industrial field, it is used for lubrication and antistatic treatment in papermaking and textile processing, and also as a solvent and plasticizer for coatings and inks. Additionally, in rubber products, it serves as a release agent and dispersion medium for vulcanization accelerators; in agriculture, it is used as a pesticide emulsifier and spreading agent to enhance the wetting and spreading ability of the liquid on plant surfaces.

Regarding recommended dosages (data sourced from Guoli Chemical product database and industry common practices): the common usage amount in pharmaceutical topical preparations is 5% to 30%; recommended addition amount in daily chemical moisturizing products is 1% to 10%; recommended dosage in industrial lubrication formulations is 3% to 15%; generally 2% to 8% when used as an emulsifier in pesticide formulations. The actual dosage should be determined experimentally based on the specific formulation and application scenario.

Precautions

  • Storage Conditions: It is recommended to store in a cool, dry, ventilated warehouse at 5℃ to 40℃. This product is hygroscopic; after opening, seal it as soon as possible and avoid prolonged exposure to humid air.
  • Operating Temperature: It is recommended to control within a safe range below 170℃, away from the flash point (195℃).
  • Incompatible Substances: Avoid contact with strong oxidizers (such as peroxides, permanganates, concentrated nitric acid, etc.).
  • Safety Protection: It is recommended to wear chemical safety goggles and protective gloves during operation. Although it is a non-hazardous substance, it may cause mild eye irritation.
  • Environmental Safety: This product is easily biodegradable and basically non-toxic to aquatic organisms (fish LC₅₀>1000 mg/L), but leakage into sewers and surface water should still be prevented.
  • Shelf Life: Under recommended storage conditions, the unopened shelf life is 24 months (data source: Guoli Chemical standard). After expiration, it must be tested and qualified before use.