Polypropylene glycol PPG-400 (CAS: 25322-69-4) is generally safe—its acute oral toxicity is low (rat LD₅₀ > 2000 mg/kg), it is non-irritating to the skin (confirmed by New Zealand white rabbit tests), causes only mild and transient eye irritation (rabbit eye Draize score ≤2, recovery within 24 hours), and is non-sensitizing (negative in guinea pig closed patch test). However, this does not mean that safety standards can be ignored. In actual use, attention must be paid to the entire chain from operational protection and storage management to emergency response.
The main risks during use are concentrated in two aspects: first, under high-temperature conditions (product flash point approximately 220–230°C), exposure to open flames or high heat may generate combustible vapors, especially in sealed reactors or high-temperature processing steps where temperature must be strictly controlled and sources of ignition kept away; second, although the product has low toxicity, large spills entering water bodies, due to its poor biodegradability (OECD 301B 28-day degradation ≤20%), may impose a continuous burden on aquatic ecosystems, so it must be prevented from entering sewers or surface waters.
Additionally, PPG-400 is a viscous liquid. Care should be taken to prevent slipping and splashing during operation. After work, thoroughly wash hands to avoid transferring residues to food or eyes. If accidental eye contact occurs, flush immediately with plenty of water for at least 15 minutes, lifting the eyelids to ensure thorough rinsing. Those wearing contact lenses should remove them before rinsing.
| Storage Element | Specific Requirements |
|---|---|
| Storage Temperature | Recommended 0–40°C, avoid freezing or excessive temperatures that may damage packaging |
| Environmental Requirements | Cool, dry, well-ventilated warehouse, away from fire and heat sources |
| Container Requirements | Keep containers tightly closed. Use stainless steel, polyethylene, or resin-lined iron drums |
| Isolation Storage | Store separately from incompatible materials such as strong oxidizers, strong acids, and strong bases |
| Fire Equipment | Post "No Smoking or Open Flames" signs in storage areas, and equip with appropriate fire-fighting apparatus |
| Situation | Handling Method |
|---|---|
| Skin Contact | Remove contaminated clothing and immediately flush with plenty of water and soap; if irritation persists, consult a doctor |
| Eye Contact | Immediately flush with plenty of water for at least 15 minutes, lifting eyelids to ensure thorough rinsing; if irritation persists, seek medical attention promptly |
| Inhalation | Move to fresh air and maintain an open airway; if discomfort persists, seek medical attention |
| Ingestion | Do not induce vomiting, rinse mouth with water, immediately drink 1-2 glasses of water; if discomfort occurs, seek medical attention |
| Small Spills | Contain and absorb with inert absorbent materials such as sand or vermiculite, place in a sealed container for disposal as hazardous waste, then rinse the spill area with water |
| Large Spills | Dike to control spread, transfer to a spare container using explosion-proof pumps, prevent entry into sewers or water bodies |
| Fire | Use water spray, foam, dry powder, carbon dioxide for extinguishing; firefighters must wear self-contained breathing apparatus and full protective clothing |
| Parameter | Data |
|---|---|
| Flash Point (Closed Cup) | Approximately 220–230°C |
| Combustion Products | May produce carbon monoxide, carbon dioxide, and irritating fumes |
| Suitable Extinguishing Media | Water spray, foam, dry powder, carbon dioxide |
| Dust Explosion Risk | No combustible dust explosion risk (liquid form) |