Question 1

Is polypropylene glycol PPG-400 harmful to the human body? Does it have any impact on the environment?

Accepted Answer

Polypropylene glycol PPG-400 is a low-toxicity substance with good safety for the human body (no skin irritation, no sensitization), and low toxicity to aquatic organisms in the environment, but its biodegradability is poor, so large-scale environmental release should be avoided. Detailed Explanation Polypropylene glycol PPG-400 has relatively high overall safety for the human body. According to acute toxicity data, the oral LD₅₀ in rats is > 2000 mg\/kg, classifying it as a low-toxicity substance. Skin irritation tests (New Zealand White rabbits) showed no irritation; eye contact may cause mild and transient irritation (Draize score ≤2 in rabbit eye test, recovery within 24 hours), but no lasting damage. The sensitization test (guinea pig closed patch test) result was negative, indicating no sensitization. Nevertheless, it is still recommended to wear protective gloves and goggles during handling to avoid unnecessary contact. In the pharmaceutical and personal care fields, PPG-400 has been widely used in suppository bases, ointment bases, cosmetic humectants, and other formulations, with safety meeting relevant application requirements. If accidentally ingested, do not induce vomiting; rinse the mouth with water and drink 1-2 glasses of water; seek medical attention if discomfort occurs. If splashed into the eyes, immediately rinse with plenty of water for at least 15 minutes. In terms of the environment, PPG-400 exhibits low toxicity to aquatic organisms—the L(E)C₅₀ values for fish, daphnia, and algae are all >100 mg\/L, causing no acute harm to aquatic ecosystems. However, it should be noted that this substance is not readily biodegradable (≤20% degradation over 28 days under OECD 301B standard), showing some persistence in the environment. Therefore, although low in toxicity, it must not be discharged into sewers, surce water, or groundwater; in case of leakage, contain with inert absorbent materials and dispose of as hazardous waste. Safety Data Summary Toxicity IndicatorTest ResultConclusion Acute oral toxicity (rat)LD₅₀ > 2000 mg\/kgLow toxicity Skin irritation (New Zealand White rabbit)No irritationSafe Eye irritation (rabbit eye test)Draize score ≤2, recovery within 24hMild transient irritation Skin sensitization (guinea pig)Negative (closed patch test)No sensitization Flash point (closed cup)Approx. 220–230°CNot easily ignitable Environmental IndicatorTest ResultConclusion Aquatic toxicity (fish\/daphnia\/algae)L(E)C₅₀ all >100 mg\/LLow toxicity to aquatic organisms Biodegradability (OECD 301B)Degradation rate ≤20% over 28 daysNot readily biodegradable Application Recommendations Given the low toxicity and excellent biocompatibility of PPG-400, it can be safely used in pharmaceuticals (suppository bases, ointment bases), cosmetics (humectants, lubricants), and personal care products. In industrial applications such as polyurethane synthesis and lubricant blending, although no special protective grade is required, it is still recommended to operate in a well-ventilated area and wear basic protective equipment. Precautions Wash hands thoroughly after handling; no eating or smoking in the work area. Store at 0–40°C in a cool, dry place, keeping containers tightly sealed to prevent moisture absorption. Do not discard waste casually or discharge it into the environment; hand over to qualified units for disposal in accordance with hazardous waste regulations. Although the flash point is high, keep away from heat sources, sparks, and open flames.

Question 2

What should I do if problems occur during the use of polypropylene glycol PPG-400? How to obtain technical support?

Accepted Answer

If problems occur during the use of polypropylene glycol PPG-400, first refer to the emergency measures in the product Safety Data Sheet (SDS) according to the type of problem, and you can also contact the technical team of Haian Guoli Chemical Co., Ltd. for professional support. Detailed explanation Polypropylene glycol PPG-400 is chemically stable under normal use conditions, but operational problems that may be encountered in actual operation mainly include: product moisture absorption leading to excessive water content, increased viscosity due to low temperature during storage or transportation, formula delamination or turbidity caused by poor compatibility with other raw materials, and occasional leakage or contact accidents. For different problems, first conduct self-inspection based on the product SDS and the data provided on this page. For example, if the viscosity is abnormal, check the storage temperature (recommended 0–40°C). If the product freezes, it should be naturally returned to room temperature and stirred evenly before use. If the problem is still not resolved after self-inspection, Guoli Chemical will provide customers with comprehensive after-sales technical support services. You can organize the batch number of the problematic product, a detailed description of the phenomenon (such as appearance changes, performance degradation, process abnormalities, etc.), and relevant operating condition records, and contact our technical engineers through official channels. We usually provide preliminary diagnosis and solution suggestions within 1-2 working days. Emergency treatment reference In case of emergency (leakage, contact, fire, etc.), please handle immediately according to the following points: SituationTreatment measures Skin contactImmediately rinse with plenty of water and soap. This product is non-irritating to the skin, but still needs to be thoroughly cleaned. Eye contactRinse continuously for at least 15 minutes, lifting eyelids. If irritation persists (may cause mild transient discomfort), seek medical attention promptly. Leakage treatmentAbsorb with inert materials such as sand, place in a closed container and dispose of as hazardous waste, prevent from entering sewers. FireUse water mist, foam, dry powder, or CO₂ to extinguish. Flash point is approximately 220–230°C. Combustion may produce CO and irritating smoke. How to obtain technical support Currently, there is no publicly available technical support hotline or online customer service link in Guoli Chemical's product database. It is recommended that you contact us through the following channels: Visit the official website of Haian Guoli Chemical Co., Ltd. (www.guolichem.com), submit a ticket on the "Contact Us" or "Technical Support" page, attaching the product name (polypropylene glycol PPG-400), CAS number (25322-69-4), and detailed description of the problem. Call the company's sales or after-sales department phone number (see the contact information published on the official website) to communicate directly with technical engineers. If you have the contact information of a business manager when purchasing, you can contact them directly, and they will transfer you to the appropriate technical support personnel. Preparing the following information can speed up processing: product batch number, purchase date, storage conditions, usage process parameters, photos or test data of abnormal phenomena. Precautions Operators should receive professional training and be miliar with all contents of this product's SDS before troubleshooting; do not blindly test. In case of personal injury or large-scale leakage, first take emergency treatment measures, then report the situation to technical personnel. Although this product has hygroscopicity, it can guarantee a shelf life of at least 12 months when stored in sealed original containers at 0–40°C. For products beyond the shelf life or opened and unused for a long time, it is recommended to sample and test before use.

Question 3

How to purchase polypropylene glycol PPG-400? What is the minimum order quantity?

Accepted Answer

Polypropylene glycol PPG-400 can be purchased directly through the official sales channels of Guoli Chemical, with a minimum order quantity typically of 50 kg (per drum). For specific pricing, please contact the sales team for the latest quotation. Detailed Description Polypropylene glycol PPG-400 (CAS No.: 25322-69-4) produced by Haian Guoli Chemical Co., Ltd. is a high-quality nonionic surctant. You can inquire about purchasing through the company's official website, telephone hotline, or authorized distributors. Due to ctors such as raw material price fluctuations, order quantity, and transportation costs in the chemical raw material market, the prices displayed on the product page are for reference only and cannot be considered as final transaction prices. We strongly recommend contacting Guoli Chemical's sales team directly to obtain the latest quotation and technical support tailored to your needs. Polypropylene glycol PPG-400 is available in various packaging specifications to meet the needs of different scale customers, including 50 kg plastic drums, 200 kg plastic drums, and IBC totes. For new customers or small batch trials, a minimum order of a single 50 kg drum is typically supported. If you have large-scale production needs, you can negotiate tote or full truckload procurement options to enjoy better bulk discounts. Please confirm the specific packaging form you require when placing an order so that we can arrange production and logistics for you. Before contacting the sales team, it is recommended that you prepare the following information for more efficient service: basic company information, estimated annual usage, target application areas (such as polyurethane synthesis, lubricants, cosmetics, etc.), and special requirements for technical parameters (such as hydroxyl value, viscosity, moisture content, etc.). Our technical engineers can also provide targeted application suggestions and sample testing support based on your specific formulation. Technical Parameters Parameter ItemGuoli Chemical Product SpecificationsRemarks AppearanceColorless to slightly yellow transparent viscous liquidVisual inspection CAS No.25322-69-4- Hydroxyl Value260~300 mg KOH/gKey indicator, affects reactivity Molecular Weight380~420- Active Content≥99%- Moisture≤0.1%- Acid Value≤0.1 mg KOH/g- pH Value (1% Aqueous Solution)6.0~8.0- Density (20°C)1.004~1.010 g/cm³- Kinematic Viscosity (40°C)Approx. 70 mm²/s- Flash Point (Closed Cup)≥200°C- HLB ValueApprox. 2.0Strong lipophilicity Application Recommendations Polypropylene glycol PPG-400 has a wide range of applications. After purchase, please refer to the following recommended dosages based on your specific field: Polyurethane Industry: As a soft segment component, it is recommended to add it proportionally to the polyol component based on the required flexibility and hardness. During formulation design, pay attention to its hydroxyl value (260~300) to accurately calculate the amount of isocyanate needed. Lubricants and Functional Fluids: As a base oil or co-solvent, the recommended addition amount is 10%~50%. Its excellent lubricity and thermal stability make it suitable for high-temperature environments, but attention should be paid to viscosity adjustment. Daily Chemicals and Cosmetics: As a moisturizer and lubricant, the recommended addition amount is 1%~5%. The product is non-irritating and non-sensitizing to the skin, and can be safely used in creams and cial cleansers. However, due to its low HLB value (approx. 2.0), it may need to be compounded with emulsifiers in water-containing formulations. Pharmaceutical Applications: As a suppository or ointment base, prescription screening is required based on specific formulation requirements. The product meets relevant safety requirements but still needs end-use validation. Important Notes Minimum Order Quantity: The standard minimum order is 50 kg/drum, and sample testing is supported (please consult sales for specific policies). IBC totes (approx. 1000 kg) are suitable for large-scale procurement with better cost efficiency. Packaging and Storage: After receiving the goods, store them in a cool, ventilated, and dry place. The recommended storage temperature is 0~40°C, and keep the container tightly sealed to prevent moisture absorption. Under original sealed conditions, the shelf life is no less than 12 months. Safe Handling: Although this product has low toxicity and is non-irritating, it is recommended to wear safety goggles and protective gloves during operation to avoid prolonged skin contact. In case of accidental eye contact, rinse immediately with plenty of water and seek medical attention. Obtaining a Quote: The prices marked on the page are for reference only. For the latest quotation and shipping costs, please be sure to confirm with Guoli Chemical's sales team.

Question 4

Does polypropylene glycol PPG-400 meet environmental protection requirements? Can a test report be provided?

Accepted Answer

Polypropylene glycol PPG-400 has the advantages of low toxicity and low toxicity to aquatic organisms in terms of environmental compliance, but its 28-day rapid biodegradation rate is low (≤20%), so it is not classified as a "readily biodegradable" substance, and large-scale discharge requires careful control. Detailed Description According to the product safety data from Guoli Chemical, the environmental characteristics of polypropylene glycol PPG-400 have two sides. On one hand, its acute toxicity is low, with an oral LD₅₀ in rats > 2000 mg/kg, making it a low-toxicity substance; its toxicity to aquatic organisms is also low—the L(E)C₅₀ values for fish, daphnia, and algae are all > 100 mg/L, indicating that under normal use and minor leakage conditions, it poses little immediate harm to aquatic ecosystems. The product also meets stringent safety requirements in personal care and pharmaceutical fields, with negative results in skin irritation and sensitization tests. On the other hand, according to OECD 301B test standards, the biodegradation rate of PPG-400 within 28 days is ≤20%, which does not qualify it as "readily biodegradable" or "rapidly biodegradable". This means that if large amounts enter environmental water bodies or soil, its natural degradation rate is slow, potentially causing long-term accumulation. Therefore, in enterprise wastewater discharge and waste disposal, it must be managed according to regulations, and it must not be directly discharged into sewers or surce waters. Key Points for Environmental Compliance Assessment ItemData/ConclusionReference Standard Acute Oral ToxicityLD₅₀ > 2000 mg/kg (Low toxicity)OECD 401/420 Skin IrritationNon-irritating (New Zealand White Rabbit test)OECD 404 Eye IrritationSlight, transient irritation (recovery within 24h, Draize score ≤2)OECD 405 SensitizationNon-sensitizing (Guinea pig Buehler test negative)OECD 406 Fish Acute ToxicityLC₅₀ > 100 mg/L (Low toxicity)OECD 203 Daphnia Acute ToxicityEC₅₀ > 100 mg/L (Low toxicity)OECD 202 Algal ToxicityEC₅₀ > 100 mg/L (Low toxicity)OECD 201 28-day Biodegradation Rate≤ 20% (Slow degradation)OECD 301B Flash Point (Closed Cup)Approx. 220–230°C— Application Recommendations Based on the above environmental characteristics, PPG-400 has good environmental safety in the following application scenarios: Personal Care and Pharmaceutical Fields: Sufficient safety data allow direct use as a humectant in cosmetics, suppository base, ointment base, etc., meeting relevant industry access requirements. Industrial Closed Systems: Such as polyurethane synthesis, synthetic lubricants, and other closed or semi-closed process steps, where environmental release risks are controllable. Cleaning and Auxiliary Industries: Must be used in conjunction with wastewater treatment cilities; direct discharge is prohibited. It is recommended that enterprises establish waste liquid recovery or treatment processes. Regarding Test Reports Guoli Chemical has a complete product quality testing system and safety management system. Under normal circumstances, the following testing and compliance documents can be provided: Safety Data Sheet (SDS): Covers physicochemical properties, toxicological, and ecotoxicological data Certificate of Analysis (COA): Technical parameter test data for each batch of product RoHS/REACH Compliance Declarations: Provided upon customer request To obtain specific formal test report documents, it is recommended to directly contact Guoli Chemical's sales or technical support department, specifying the required report type (e.g., SDS, COA, REACH compliance declaration, etc.). We will provide the corresponding formal documents based on your specific application and local regulatory requirements. Precautions It is strictly prohibited to directly discharge waste liquid or washing water containing PPG-400 into sewers, surce water, or groundwater. In case of leakage, use inert absorbent materials (sand, vermiculite, etc.) to contain and adsorb, and dispose of according to hazardous waste regulations. Product waste and contaminated packaging must be handed over to qualified hazardous waste disposal units and must not be mixed with household waste. Due to the slow biodegradation rate, large-scale usage scenarios are recommended to be equipped with pretreatment processes before biological wastewater treatment.

Question 5

What are the advantages of polypropylene glycol PPG-400 compared with other similar products?

Accepted Answer

According to the technical data of Guoli Chemical, the core advantages of polypropylene glycol PPG-400 compared with similar products are its outstanding chemical stability, safety and mildness, and compatibility with a variety of materials. It is a balanced industrial-grade nonionic surctant and synthesis intermediate. Compared with lower or higher molecular weight polypropylene glycols (such as PPG-200, PPG-600, PPG-1000, etc.), PPG-400 achieves an ideal balance in several key properties, making it extremely versatile. The following is a detailed analysis for you: ### 1. Balanced performance PPG-400 has a moderate molecular weight, which enables it to combine the high reactivity of low molecular weight products with the flexibility and lubricity of high molecular weight products. | Property | PPG-400 Performance | Advantages Compared with Similar Products | | :--- | :--- | :--- | | **Reactivity** | High primary hydroxyl content, moderate reactivity | Compared with PPG-200, it provides better flexibility as a polyurethane soft segment; compared with PPG-600/1000, it has higher reactivity and is easier to react uniformly during synthesis. | | **Lubrication and moisturizing** | Moderate viscosity index, stable viscosity-temperature characteristics | Lubrication and moisturizing properties are superior to low molecular weight PPG-200, while it is easier to operate and compound than high molecular weight PPG-600/1000, with a refreshing and non-sticky skin feel. | | **Compatibility** | Excellent compatibility with a variety of organic solvents, resins and polymers | Compared with high molecular weight products, it has better solubility in water and polar solvents, and is more efficient as a solubilizer and cosolvent. | ### 2. Excellent chemical stability and system adaptability The ether bond structure in the molecular chain of PPG-400 enables it to remain stable over a wide pH range. - **Hydrolysis resistance**: Not prone to hydrolysis and ilure, with better tolerance in acidic or alkaline systems than many ester surctants. - **Hard water resistance**: Maintains excellent surce activity in hard water, unaffected by calcium and magnesium ions, which is a significant advantage in industrial cleaning and textile auxiliaries. ### 3. Outstanding safety and mildness Based on product safety technical data, PPG-400 performs excellently in safety, which is a key advantage for its entry into high-end personal care and pharmaceutical fields. - **Low toxicity and low irritation**: Low acute oral toxicity (rat oral LD₅₀ > 2000 mg/kg), non-irritating to skin, only causes mild and transient eye irritation, non-sensitizing. - **Application expansion**: This high level of safety enables its use not only in industrial fields but also in meeting strict requirements for cosmetics and pharmaceutical excipients (such as suppository bases, ointment bases), an advantage not shared by many industrial surctants. ### Application suggestions Based on the above advantages, PPG-400 performs particularly well in the following applications: - **Polyurethane industry**: As a soft segment component, it provides ideal flexibility and hydrolysis resistance balance for adhesives, coatings, and elastomers. The recommended dosage should be calculated based on the specific formulation hydroxyl value and isocyanate index. - **Personal care products**: Used as a **moisturizer and lubricant** in creams and cial cleansers to improve skin feel, recommended addition amount is 1%-5%. - **Industrial auxiliaries**: As a core raw material for **defoamers and mold release agents**, leveraging its good spreadability and chemical stability. As an intermediate for synthetic ester lubricants, it provides excellent lubricity. ### Precautions - PPG-400 is hygroscopic; please seal the container immediately after use and store in a cool, dry place. - Despite its high safety, it is still recommended to wear protective gloves and goggles during industrial production operations to avoid unnecessary contact. If you have a specific application scenario, such as requiring a specific viscosity or hydroxyl value range, you can provide more detailed requirements, and I will conduct further analysis for you.

Question 6

How to store polypropylene glycol PPG-400? What is its shelf life?

Accepted Answer

Polypropylene glycol PPG-400 should be stored in a cool, dry, well-ventilated place at a recommended temperature of 0–40°C. Keep the container tightly sealed. Under original sealed conditions, the shelf life is no less than 12 months. Detailed Description Polypropylene glycol PPG-400 (CAS: 25322-69-4) is a viscous liquid with low hygroscopicity, but prolonged exposure to air may still cause moisture absorption, affecting product quality. Therefore, keeping the container tightly sealed is the primary storage principle. It is recommended to use corrosion-resistant, well-sealed containers such as stainless steel, polyethylene, or resin-lined iron drums. The storage environment should be away from fire sources and heat, and equipped with appropriate fire-fighting equipment. Although PPG-400 has a high flash point (closed cup approx. 220–230°C) and is not a flammable liquid, it may still form combustible vapors under high temperature or specific conditions. Therefore, a no-smoking and no-open-flame sign should be posted in the storage area. In addition, PPG-400 should be stored separately from incompatible substances such as strong oxidizing agents, strong acids, and strong bases to prevent hazardous reactions. The warehouse should be equipped with spill containment cilities to handle accidental leaks. Technical Parameters Storage ParameterSpecific Requirement Recommended Storage Temperature0–40°C Packaging Container MaterialStainless steel, polyethylene, resin-lined iron drum Shelf Life after OpeningNo less than 12 months (under original sealed condition) Flash Point (Closed Cup)Approx. 220–230°C Incompatible SubstancesStrong oxidizing agents, strong acids, strong bases Application Recommendations To maximize product shelf life, it is recommended to follow the "first in, first out" principle for inventory. After each use, immediately seal the container to minimize the time the product is exposed to air. If the product shows significant color deepening or transparency changes after long-term storage, it is recommended to perform a small sample test before putting it into use. Precautions Avoid freezing or excessively high temperatures that may cause packaging damage. Do not store the product outdoors or in direct sunlight. Eating, drinking, and smoking are strictly prohibited in the storage area. Operators should wear protective gloves and safety goggles. In case of spillage, contain and absorb with inert absorbent materials (sand, vermiculite, etc.), then place into a closed container and dispose of according to hazardous waste management regulations. It is strictly prohibited to discharge the product into sewers, surce water, or groundwater. PPG-400 is not readily biodegradable (OECD 301B 28-day degradation rate ≤ 20%), so large-scale environmental release should be avoided. For detailed safety information, please refer to the product's Safety Data Sheet (SDS).

Question 7

What safety precautions should be taken when using polypropylene glycol PPG-400?

Accepted Answer

Polypropylene glycol PPG-400 is a low-toxicity, low-irritation chemical, but standardized operation and personal protection are still required, with a focus on preventing high-temperature burns, eye contact, and environmental leakage. Detailed Explanation Polypropylene glycol PPG-400 (CAS: 25322-69-4) is generally safe—its acute oral toxicity is low (rat LD₅₀ > 2000 mg/kg), it is non-irritating to the skin (confirmed by New Zealand white rabbit tests), causes only mild and transient eye irritation (rabbit eye Draize score ≤2, recovery within 24 hours), and is non-sensitizing (negative in guinea pig closed patch test). However, this does not mean that safety standards can be ignored. In actual use, attention must be paid to the entire chain from operational protection and storage management to emergency response. The main risks during use are concentrated in two aspects: first, under high-temperature conditions (product flash point approximately 220–230°C), exposure to open flames or high heat may generate combustible vapors, especially in sealed reactors or high-temperature processing steps where temperature must be strictly controlled and sources of ignition kept away; second, although the product has low toxicity, large spills entering water bodies, due to its poor biodegradability (OECD 301B 28-day degradation ≤20%), may impose a continuous burden on aquatic ecosystems, so it must be prevented from entering sewers or surce waters. Additionally, PPG-400 is a viscous liquid. Care should be taken to prevent slipping and splashing during operation. After work, thoroughly wash hands to avoid transferring residues to food or eyes. If accidental eye contact occurs, flush immediately with plenty of water for at least 15 minutes, lifting the eyelids to ensure thorough rinsing. Those wearing contact lenses should remove them before rinsing. Personal Protection and Operating Procedures Personal Protective Equipment: Wear chemical safety goggles, protective gloves, and work clothes during operation to avoid contact with eyes, skin, and clothing. Ventilation Requirements: Use in well-ventilated areas. If vapors or aerosols are generated, employ local exhaust or general ventilation. Ignition Source Control: Keep away from heat sources, sparks, open flames, and hot surces. Do not smoke in the work area. Chemical Incompatibilities: Avoid contact with strong oxidizers to prevent hazardous reactions. Hygiene Management: Do not eat or drink in the work area. Wash hands thoroughly after operation. Storage Conditions Storage ElementSpecific Requirements Storage TemperatureRecommended 0–40°C, avoid freezing or excessive temperatures that may damage packaging Environmental RequirementsCool, dry, well-ventilated warehouse, away from fire and heat sources Container RequirementsKeep containers tightly closed. Use stainless steel, polyethylene, or resin-lined iron drums Isolation StorageStore separately from incompatible materials such as strong oxidizers, strong acids, and strong bases Fire EquipmentPost "No Smoking or Open Flames" signs in storage areas, and equip with appropriate fire-fighting apparatus Emergency Response Measures SituationHandling Method Skin ContactRemove contaminated clothing and immediately flush with plenty of water and soap; if irritation persists, consult a doctor Eye ContactImmediately flush with plenty of water for at least 15 minutes, lifting eyelids to ensure thorough rinsing; if irritation persists, seek medical attention promptly InhalationMove to fresh air and maintain an open airway; if discomfort persists, seek medical attention IngestionDo not induce vomiting, rinse mouth with water, immediately drink 1-2 glasses of water; if discomfort occurs, seek medical attention Small SpillsContain and absorb with inert absorbent materials such as sand or vermiculite, place in a sealed container for disposal as hazardous waste, then rinse the spill area with water Large SpillsDike to control spread, transfer to a spare container using explosion-proof pumps, prevent entry into sewers or water bodies FireUse water spray, foam, dry powder, carbon dioxide for extinguishing; firefighters must wear self-contained breathing apparatus and full protective clothing Key Fire Parameters ParameterData Flash Point (Closed Cup)Approximately 220–230°C Combustion ProductsMay produce carbon monoxide, carbon dioxide, and irritating fumes Suitable Extinguishing MediaWater spray, foam, dry powder, carbon dioxide Dust Explosion RiskNo combustible dust explosion risk (liquid form) Notes Operators should receive professional training and be miliar with the Safety Data Sheet (SDS) for this product before starting work. Waste product and contaminated packaging should be emptied of residues and disposed of by qualified units; do not discharge into the environment or mix with household waste, and comply with local and national environmental regulations. Although this product has low toxicity to aquatic organisms (L(E)C₅₀ for fish, daphnia, algae all >100 mg/L), due to its poor biodegradability, large-scale environmental release should still be avoided. The product shelf life is at least 12 months. Prolonged exposure to air and moisture should be avoided to prevent moisture absorption and deterioration.

Question 8

How to use polypropylene glycol PPG-400? What is the recommended addition amount?

Accepted Answer

The usage method of polypropylene glycol PPG-400 depends on the specific application field, and there is no unified standard for the addition amount, which must be determined through experiments based on formulation requirements and process conditions. Detailed Description Polypropylene glycol PPG-400 (CAS No.: 25322-69-4) is a nonionic surctant, appearing as a colorless to slightly yellow transparent viscous liquid, with a molecular weight of about 380~420, and a hydroxyl value of 260~300 mgKOH/g. Its molecular structure contains primary hydroxyl groups and ether bonds, giving it excellent solubility, reactivity, and surce activity. The usage method varies greatly depending on the application scenario: In the polyurethane industry, PPG-400 directly participates in the polymerization reaction as a soft segment polyol component, typically reacting with isocyanates (such as TDI, MDI) and other polyols, catalysts, blowing agents, etc., according to the formula ratio; In the personal care and pharmaceutical fields, it can be directly added to the water phase or oil phase and stirred to dissolve, used as a humectant, lubricant, or solubilizer; In lubricants and industrial fluids, it can be used alone or compounded with other base oils. Since PPG-400 is easily soluble in various solvents such as water, alcohols, esters, and ketones, solubility is usually not an issue in practical operations. It is recommended to slowly add it to the formulation system under stirring conditions to ensure uniform dispersion. If used for polyurethane synthesis, the moisture content must be strictly controlled (moisture of this product ≤0.1%) to avoid side reactions between water and isocyanates. The product has low foam characteristics, with a cloud point of about 50°C (1% aqueous solution), and the aqueous solution may become turbid when approaching or exceeding the cloud point temperature, so attention should be paid to the operating temperature conditions. Technical Parameters Parameter Item Indicator Value Description Appearance Colorless to slightly yellow transparent viscous liquid — Molecular Weight 380~420 — Hydroxyl Value 260~300 mgKOH/g High primary hydroxyl content, moderate reactivity pH Value (1% Aqueous Solution) 6.0~8.0 — Moisture ≤0.1% — Acid Value ≤0.1 mgKOH/g — Density (25°C) 1.004~1.010 g/cm³ — Kinematic Viscosity (40°C) About 70 mm²/s Stable viscosity-temperature characteristics Viscosity (25°C) 70~90 mPa·s — Flash Point (Closed Cup) ≥200°C (about 220~230°C) — Cloud Point (1% Aqueous Solution) About 50°C — HLB Value About 2.0 Low HLB value, suitable for W/O emulsification Surce Tension (1% Aqueous Solution) About 38 mN/m — Freezing Point ＜-30°C — Application Recommendations Special Note: The product database of Guoli Chemical does not provide specific recommended addition amounts for various application fields. The following are reference dosage ranges based on general industry experience. The actual addition amount must be determined through formulation experiments. Application Field Typical Usage Method Reference Addition Amount (Industry Common Value) Polyurethane Foam/Elastomer As a soft segment polyol component, mixed and reacted with other polyols, isocyanates, catalysts, etc. 10%~50% of total polyol Polyurethane Coatings/Adhesives As a polyol component involved in prepolymer or curing system 5%~30% of resin solid content Personal Care Products (Creams/Lotions) Directly added to water phase or oil phase, stirred until uniformly dissolved 1%~10% Pharmaceutical Ointments/Suppository Bases Melted and mixed with other base materials, then cooled and molded 5%~30% (depending on formulation) Synthetic Lubricant Base Oil Used alone or compounded with ester oils, PAO, etc. 10%~100% Metalworking Fluids Added as a lubricity additive or co-solvent in the formulation 5%~20% Defoamer Raw Material Compounded with hydrophobic silica, emulsifiers, etc. to prepare defoamers 20%~60% Mold Release Agent Component Compounded with other mold release ingredients, diluted and sprayed for use 5%~30% Industrial Cleaning/Textile Auxiliaries Used as a nonionic surctant intermediate or directly 1%~10% Usage Operation Recommendations Preheating: When the product viscosity increases at low temperatures in winter, it is recommended to preheat in a 20~40°C environment before use.

Question 9

What are the main industries and processes where polypropylene glycol PPG-400 is applied?

Accepted Answer

Polypropylene Glycol PPG-400 is widely used in six core areas: the polyurethane industry, synthetic lubricants, surctants, daily chemicals and pharmaceuticals, and industrial auxiliaries. It is a multifunctional nonionic surctant and synthetic intermediate. Detailed Description Polypropylene Glycol PPG-400 (CAS: 25322-69-4) is a nonionic high-molecular-weight polymer synthesized through catalytic polymerization of propylene oxide and propylene glycol. It has an average molecular weight of approximately 380–420 and appears as a colorless to slightly yellow transparent viscous liquid. Its molecular structure contains abundant ether bonds and terminal hydroxyl groups, with an HLB value of about 2.0. It exhibits excellent chemical stability and is resistant to hydrolysis or decomposition in acidic, alkaline, and hard water media. The core functional advantages of this product lie in four aspects: first, outstanding surce activity, effectively reducing intercial tension for emulsification, wetting, dispersion, and solubilization; second, excellent reactivity, with high primary hydroxyl content suitable as a quality raw material for synthesizing polyurethanes, ester derivatives, and other products; third, good lubrication and moisturizing capabilities, with stable viscosity-temperature characteristics providing sustained lubrication across a wide temperature range; fourth, significant safety and mildness, with low acute oral toxicity (rat LD₅₀ > 2000 mg/kg), non-irritating to skin, non-sensitizing, meeting strict safety requirements for personal care and pharmaceutical applications. Guoli Chemical uses clean and dry galvanized iron drums, plastic drums, or IBC totes for packaging, with specifications of 50 kg, 200 kg, and tote drums to meet the needs of customers of various scales. Under sealed original containers and recommended storage temperatures of 0–40°C, the shelf life is no less than 12 months. Industry Applications and Process Details 1. Polyurethane Industry In the PU industry, PPG-400 is a key soft segment component in flexible and rigid polyurethane foams, elastomers, coatings, and adhesives. Its core role is to regulate chain flexibility and hydrophilic-hydrophobic balance, imparting excellent flexibility, hydrolysis resistance, and low-temperature elasticity to final products. When reacting with isocyanates (e.g., MDI, TDI), the primary hydroxyl groups of PPG-400 effectively participate in chain extension and crosslinking reactions, making it an indispensable polyol raw material in high-end polyurethane product formulations. 2. Synthetic Lubricants and Functional Fluids PPG-400 can be directly used as a base oil or co-solvent component for synthetic high-temperature lubricants, hydraulic fluids, and compressor oils. Benefiting from its excellent viscosity-temperature characteristics (kinematic viscosity at 40°C of about 70 mm²/s) and high flash point (closed cup approximately 220–230°C), it maintains stable lubricating film strength under high-temperature conditions, while also offering good detergency and synergistic effects with antioxidants. It is widely used in metalworking fluids, industrial gear oils, and specialized hydraulic transmission systems. 3. Surctant and Emulsifier Preparation As an intermediate for nonionic surctants, PPG-400 is extensively used in industrial cleaning, textile auxiliaries, and pesticide emulsification. Its cloud point is approximately 50°C (1% aqueous solution), and it is readily soluble in water, alcohols, esters, and ketone solvents. It can be further processed via ethoxylation or converted into anionic derivatives such as phosphate esters and sultes to expand its dispersion and emulsification performance in different media. 4. Personal Care and Cosmetics In creams, lotions, cial cleansers, and color cosmetics formulations, PPG-400 acts as a humectant, lubricant, and emollient, significantly improving skin feel, reducing stickiness, and aiding in the uniform dispersion of active ingredients. Its low irritation and low sensitization characteristics make it suitable for baby care products and products for sensitive skin. 5. Pharmaceutical Applications With good biocompatibility and safety, PPG-400 is primarily used in the pharmaceutical field as a suppository base, ointment base, and drug solubilizer. It can serve as a consistency modifier to adjust the spreadability and extensibility of ointments while also acting as a plasticizer to enhance formulation stability. 6. Industrial Auxiliaries and Others Additionally, PPG-400 can be used as a core raw material for defoamers and mold release agents (especially in polyurethane molding processes), as a base component for heat transfer fluids, and as a nonionic lubricating component in synthetic fiber oils and textile spinning oils. Its low foaming properties and good chemical stability also make it perform excellently in demanding applications such as metal cutting fluids and quenchants. Technical Parameters Parameter Name Specification Description Appearance Colorless to slightly yellow transparent viscous liquid Visual inspection Molecular Weight 380~420 Average molecular weight Hydroxyl Value (mg KOH/g) 260~300 Reflects terminal hydroxyl content HLB Value Approx. 2.0 Hydrophilic-lipophilic balance Cloud Point (1% aqueous solution) Approx. 50°C Inversion temperature point Kinematic Viscosity (40°C) Approx. 70 mm²/s Characterizes fluidity Density (25°C) 1.004~1.010 g/cm³ — Refractive Index (25°C) 1.450~1.452 — pH Value (1% aqueous solution) 6.0~8.0 Near neutral Flash Point (Closed Cup) ≥200°C (approx. 220~230°C) High flash point, good safety Moisture Content ≤0.1% Low moisture Acid Value (mg KOH/g) ≤0.1 Low acidity Heavy Metals ≤10 mg/kg Meets safety requirements Arsenic ≤2 mg/kg Meets safety requirements Application Recommendations In Polyurethane Synthesis: It is recommended to combine PPG-400 with other high-molecular-weight polyether polyols based on the target product's soft-to-hard segment ratio to precisely control chain flexibility and glass transition temperature. Thorough dehydration is required before reaction to prevent moisture from consuming isocyanate. In Lubricant Formulations: The recommended dosage of PPG-400 varies depending on the final product type. As a base oil co-solvent, it typically accounts for 10% to 50% of the total formulation, balancing compatibility with mineral oil or synthetic esters. In metalworking fluids, it can be used in synergy with anti-wear agents and rust inhibitors. In Cosmetic Formulations: The recommended usage is 1% to 10%. It can be added to either the water phase or oil phase of the emulsion system, depending on the formulation type. Due to its low HLB value (approx. 2.0), it is more suitable as a co-emulsifier for W/O systems. In Pharmaceutical Applications: The dosage in suppository bases can reach 20% to 60%, requiring adjustment of the ratio with solid ts or PEG-based bases based on drug release characteristics. The common usage in ointment bases is 5% to

Question 10

What are the physicochemical technical parameters of Polypropylene glycol PPG-400?

Accepted Answer

Polypropylene glycol PPG-400 is a nonionic surctant with low HLB value (approximately 2.0), medium hydroxyl value (260~300 mgKOH/g), excellent chemical stability, and good compatibility with organic solvents. Its core physicochemical parameters have been verified through systematic testing by the Guoli Chemical Laboratory. Detailed Description Polypropylene glycol PPG-400 (CAS: 25322-69-4) appears as a colorless to slightly yellow transparent viscous liquid with the molecular formula HO(C3H6O)nH (n≈6.7) and a molecular weight range of 380~420. The product is synthesized by catalytic polymerization of propylene oxide and propylene glycol. Its molecular structure contains primary hydroxyl groups and ether bonds, endowing it with unique solubility and reactivity. This product is classified as a nonionic surctant with an HLB value of about 2.0, exhibiting low foaming characteristics in water and a cloud point of approximately 50°C (1% aqueous solution). In terms of physical properties, PPG-400 has a density of 1.004~1.010 g/cm³, refractive index of 1.450~1.452 (25°C), kinematic viscosity of approximately 70 mm²/s (40°C), and low shear viscosity of about 70 mPa·s. Its melting point is below -30°C, flash point ≥200°C, and it is chemically stable, resistant to acids, alkalis, and hard water media. The product is readily soluble in water, alcohols, esters, ketones, and other organic solvents, with low hygroscopicity and excellent compatibility with a variety of organic solvents, resins, and polymers. Regarding chemical indicators, the product has an active content ≥99%, moisture ≤0.1%, acid value ≤0.1 mgKOH/g, saponification value ≤0.5 mgKOH/g, iodine value ≤0.1 gI2/100g, amine value ≤0.1 mgKOH/g, unsaturation ≤0.1 mmol/g, free alcohol ≤0.1%, heavy metals ≤10 mg/kg, and arsenic ≤2 mg/kg. These parameters indicate high purity and low impurity content of PPG-400, making it suitable for applications with strict quality requirements such as polyurethane synthesis, pharmaceuticals, and personal care fields. Technical Parameters Parameter ItemSpecificationRemarks AppearanceColorless to slightly yellow transparent viscous liquidVisual inspection CAS Number25322-69-4— Molecular FormulaHO(C3H6O)nH, n≈6.7— Molecular Weight380~420— Ionic TypeNonionic— HLB ValueApproximately 2.0Low hydrophilic-lipophilic balance Active Content≥99%— Moisture≤0.1%— pH Value (1% Aqueous Solution)6.0~8.0— pH Value (5% Aqueous Solution)5.0~7.0— Density1.004~1.010 g/cm³25°C Refractive Index1.450~1.45225°C Kinematic ViscosityApproximately 70 mm²/s40°C Low Shear Viscosity70~90 mPa·s25°C Cloud PointApproximately 50°C1% Aqueous Solution Flash Point (Closed Cup)≥200°C— Melting Point— Surce TensionApproximately 38 mN/m1% Aqueous Solution Hydroxyl Value260~300 mgKOH/g— Acid Value≤0.1 mgKOH/g— Saponification Value≤0.5 mgKOH/g— Iodine Value≤0.1 gI2/100g— Amine Value≤0.1 mgKOH/g— Unsaturation≤0.1 mmol/g— Free Alcohol≤0.1%— Heavy Metals≤10 mg/kg— Arsenic≤2 mg/kg— SolubilityReadily soluble in water, alcohols, esters, ketones, and other solvents— Foam CharacteristicsLow foaming— Chemical StabilityStable (resistant to acids, alkalis, and hard water)— Packaging Specifications50kg plastic drum / 200kg plastic drum / IBC tote— Application Suggestions Based on the physicochemical properties of PPG-400, it is recommended for the following key applications: Polyurethane Industry: With a hydroxyl value of 260~300 mgKOH/g and moderate reactivity, it is an ideal raw material for flexible and rigid polyurethane foams, elastomers, coatings, and adhesives.

Polypropylene Glycol PPG-400

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Property	Value
CAS No.	25322-69-4
Molecular Formula	HO(C3H6O)nH, n≈6.7
Appearance	Colorless to slightly yellow transparent viscous liquid
Ionic Type	Nonionic
Avg. Molecular Weight	380~420
Cloud Point	~50°C (1%aq. soln.)
Active Content	≥99%
pH Value(1%)	6.0~8.0
pH Value(5%)	5.0~7.0
Iodine Value	≤0.1
Solubility	Readily soluble in water, alcohols, esters and ketones
Surface Tension	~38 mN/m (1%aq. soln.)
Acid Value	≤0.1
Saponification Value	≤0.5
Hydroxyl Value	260~300
Moisture	≤0.1
Density	1.004~1.010
Kinematic Viscosity	~70 mm²/s (40°C)
Refractive Index	1.450~1.452 (25°C)
Flash Point	≥200°C
Hygroscopicity	Hygroscopic
Chemical Stability	Stable
Amine Value	≤0.1
Foam Property	Low foam
Alkali Resistance	Stable
Unsaturation	≤0.1 mmol/g
Viscosity	70-90 mPa·s (25°C)
Melting Point	＜-30°C
Low Shear Viscosity	~70 mPa·s
Solid Content	≥99%
Free Alcohol	≤0.1%
Heavy Metal	≤10 mg/kg
Arsenic	≤2 mg/kg

Polypropylene Glycol PPG-400

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Application Guidelines

Packaging and Storage

PPG Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

Related Products

Polypropylene Glycol PPG-600

Polypropylene Glycol PPG-200