Question 1

Is Polyether L-44 harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Polyether L-44 is a low-toxicity, safe substance for the human body, with very low health risks under normal use; for the environment, direct discharge should be avoided, but it is not classified as a highly ecotoxic substance. Detailed Explanation Polyether L-44 (Poloxamer 124) is a non-ionic surctant widely used in pharmaceuticals, cosmetics, and industrial fields. Its toxicological data indicates high safety for the human body. According to the toxicological information from the Guoli Chemical Product Database, its acute oral toxicity (rat) LD₅₀ > 5,000 mg\/kg, which is classified as practically non-toxic; the primary skin irritation index is less than 0.5, indicating no skin irritation; the skin sensitization test result shows no sensitization; and the mutagenicity test result is also negative. In the GHS chemical classification system, this product is classified as a non-hazardous substance. Despite its overall good safety profile, attention should be paid to its potential impact on the eyes. Contact with the eyes may cause mild to moderate conjunctival redness and swelling, which is a reversible injury and does not cause permanent damage. During routine handling, it is recommended to wear basic protective equipment such as safety goggles and gloves to avoid prolonged or repeated contact. If accidentally splashed into the eyes, rinse immediately with plenty of water for at least 15 minutes and seek medical attention. In terms of the environment, as a block copolymer of ethylene oxide and propylene oxide, the molecular structure of Polyether L-44 gives it a certain persistence in the natural environment. The Guoli Chemical Database clearly states that waste disposal must comply with local environmental regulations; random discharge is prohibited. In case of large spills, diking should be constructed to prevent the product from entering sewers or natural water bodies. This product is not a volatile organic compound nor a hazardous chemical, and the environmental risks during handling and storage are controllable. Toxicological Parameters Toxicological IndicatorDataConclusion Acute oral toxicity (rat) LD₅₀> 5,000 mg\/kgPractically non-toxic Primary skin irritation indexNon-irritating Eye irritationMild to moderateReversible injury, may cause conjunctival redness and swelling Skin sensitizationNoneNon-sensitizing MutagenicityNoneNon-mutagenic GHS classification—Non-hazardous Heavy metal content≤10 mg\/kgComplies with conventional safety standards Arsenic content≤2 mg\/kgComplies with conventional safety standards Application Recommendations Based on the good biocompatibility and low toxicity of Polyether L-44, it has been widely used in personal care and cosmetic formulations as a mild emollient component to provide a smooth skin feel. When used in polyurethane industry, industrial cleaning, metalworking fluids, and pesticide formulations, it is recommended to follow standard industrial hygiene practices and use basic protective measures. Precautions During operation, it is recommended to wear chemical safety goggles and protective gloves to avoid splashing into eyes or prolonged skin contact. Use in a well-ventilated area to avoid inhalation of vapors or aerosols generated by heating. The product is not flammable, but thermal decomposition may produce irritating fumes; keep away from high heat sources. Do not discharge waste or spills directly into sewers or natural water bodies; they must be disposed of in compliance with local environmental regulations. In case of large spills, construct dikes, collect with inert absorbent material, transfer to sealed containers, and hand over to professional agencies for disposal. Storage temperature should not exceed 40°C; avoid repeated freeze-thaw cycles; keep containers tightly sealed to prevent moisture absorption and contamination.

Question 2

What should I do if problems occur during the use of Polyether L-44? How to obtain technical support?

Accepted Answer

If problems occur during the use of Polyether L-44, please first refer to the common phenomena for troubleshooting. If the issue cannot be resolved, you can directly contact the Guoli Chemical technical team for one-on-one professional support. Detailed Explanation Polyether L-44 (Poloxamer 124), as a mature nonionic surctant, performs stably and reliably in daily applications. However, improper operating conditions, formulation systems, or storage methods may still lead to abnormal foam, poor emulsification, or phase separation. When encountering problems, it is recommended to first review the operating procedures and perform preliminary diagnosis by referencing typical issues. In most cases, the problem can be quickly resolved by adjusting the dosage, changing the feeding sequence, or optimizing process parameters. If the problem persists after self-troubleshooting, Hai'an Guoli Chemical Co., Ltd. provides multi-level technical support channels: you can call the sales or technical hotline for real-time communication, or leave a message on the company's official website or send an email with the product batch number and a detailed problem description. Technical engineers will respond within working days. For complex formulations or special processes, Guoli Chemical can also provide sample testing and formulation optimization suggestions to assist customers in product selection and application debugging. Quick Troubleshooting Guide for Common Issues Problem Phenomenon Possible Cause Suggested Action Unsatisctory emulsification effect, lotion stratification Insufficient dosage; mismatch between oil phase type and HLB value; improper feeding sequence or homogenization process Appropriately increase the dosage of Polyether L-44 (suggest a gradient test in the range of 0.5%–5%); confirm the HLB value required by the oil phase and its compatibility with the product; optimize emulsification temperature and homogenization time Abnormal increase in foam System contains high-foaming components; low operating temperature; improper compatibility with other surctants Polyether L-44 itself is a low-foaming type; abnormal foam is mostly caused by blended components, so check the formulation one by one; appropriately increase the operating temperature to accelerate foam breaking Product appearance turbid or stratified Low storage temperature causing cloud point phenomenon; product moisture absorption or contamination; repeated freeze-thaw cycles Return the product to room temperature (20–30℃), stir evenly before use; check container sealing to avoid moisture ingress; strictly avoid repeated freeze-thaw cycles Uneven cell structure in polyurethane foam Inappropriate dosage; unbalanced ratio with other additives (catalyst, silicone oil); insufficient mixing Adjust the dosage of L-44 to optimize cell fineness; check overall formulation balance; strengthen mixing process control Poor wetting and spreading effect Contamination on substrate surce; low concentration; extreme pH affecting activity Clean the substrate surce; increase Polyether L-44 concentration for testing; this product has good stability in acid, alkali, and hard water systems. If encountering extreme pH (12), it is recommended to perform tolerance verification Technical Support Channels Phone Consultation: Call the Sales or Technical Department of Hai'an Guoli Chemical Co., Ltd. directly, providing the product batch number and details of the problem for immediate guidance. Email Support: Send a description of the problem, formulation overview, process conditions, and related photos to the company's official email. Technical engineers will reply within 1–2 working days. Website Message: Submit a request form through the technical support portal on Guoli Chemical's official website. Customer service staff will promptly connect you with the relevant technical person in charge. Sample Testing and Formulation Optimization: If needed, send the problematic sample to the Guoli Chemical Technology Center for professional analysis and testing, and assistance in optimizing the formulation. On-site Service: For key customers or complex projects, Guoli Chemical can arrange for technical engineers to visit and provide on-site debugging support. Preparations Before Contact To efficiently resolve the problem, it is recommended to prepare the following information before contacting technical support: Product name and batch number (located on the barrel label) Description of product appearance status (color, transparency, presence of sediment or stratification) Storage conditions (temperature, storage duration, whether container is sealed) Specific application field and process flow Other major components in the formulation and approximate ratios Time point of problem occurrence and detailed phenomena Precautions Polyether L-44 is not classified as a hazardous chemical, but it is still recommended to wear chemical safety goggles and protective gloves during use, and wash hands thoroughly after operation. If accidentally splashed into eyes, immediately rinse with plenty of water for at least 15 minutes and seek medical attention. The product storage temperature should not exceed 40°C. Avoid repeated freeze-thaw cycles. Check the container integrity and label clarity before use. For any formulation adjustment experiments, it is recommended to first perform small-scale tests to verify, and then proceed to scale-up production after confirmation.

Question 3

How to purchase Polyether L-44? What is the minimum order quantity?

Accepted Answer

Purchase Method and Minimum Order Quantity for Polyether L-44 How to Purchase Polyether L-44 (Poloxamer 124 / Pluronic L-44) is a core product of Haian Guoli Chemical Co., Ltd. and currently supports direct corporate procurement. Since chemical product prices fluctuate with raw material prices and market supply and demand, the latest quotation must be obtained by directly contacting the Guoli Chemical sales team. It is recommended that you complete the procurement process through the following methods: call the Guoli Chemical Sales Department or send an inquiry email, specifying the required product specifications, packaging requirements, and estimated purchase quantity. The sales team will provide you with a formal quotation, delivery cycle, and logistics plan. When making an inquiry, it is recommended to prepare the following information: product name (Polyether L-44), required quantity, target packaging specifications (e.g., 50kg drum, 200kg drum, or IBC tote), and application field, so that the sales team can accurately match the product and provide technical support. Minimum Order Quantity According to the Guoli Chemical product database, the standard packaging specifications for Polyether L-44 are: 50kg plastic drum, 200kg plastic drum, and IBC tote (approx. 1000kg). Generally, the minimum order quantity is the smallest packaging unit, i.e., at least 1 drum (50kg). However, the specific minimum order quantity needs to be confirmed with the sales team, as cooperation policies may vary by period and customer. For sample testing needs, you can separately request sample support from the sales team. Packaging Specifications Overview Packaging TypeSpecificationApplicable Scenario Plastic drum50kgSmall batch trial or small to medium production needs Plastic drum200kgRegular batch purchase, more cost-effective IBC toteApprox. 1000kgLarge-scale continuous production, reducing packaging and logistics costs Tips The above price information is for reference only; the actual transaction price is subject to the contract It is recommended to contact Guoli Chemical Sales Department directly for the latest quotation and inventory information If sample testing is needed, you can apply for samples from the sales team Bulk purchases usually enjoy tiered price discounts

Question 4

Does Polyether L-44 meet environmental protection requirements? Can a test report be provided?

Accepted Answer

Polyether L-44 meets general industrial chemical environmental requirements and is a GHS non-hazardous substance Detailed description From the safety data sheet of Polyether L-44, it can be seen that this product has a good foundation in terms of environmental compliance. According to the GHS classification standard, this product is not classified as a hazardous chemical and has low toxicity and biodegradability. Acute oral toxicity (rat) LD₅₀ > 5,000 mg/kg, which is practically non-toxic; Primary skin irritation index The product database explicitly requires that "waste disposal should comply with local environmental regulations, and arbitrary discharge is prohibited". This means that during use and disposal, enterprises need to operate according to specific regulations of local environmental authorities. Polyether surctants generally have good biodegradability, but specific degradation half-life and environmental te data need to be evaluated based on actual discharge conditions and local water quality standards. Technical parameters The heavy metal content control indicators for this product are: Heavy metals ≤ 10 mg/kg, Arsenic ≤ 2 mg/kg, which meet the limits for harmful elements in general industrial chemicals, providing product quality support for environmental compliance. Application suggestions For application scenarios requiring environmental compliance certification (such as export products, environmental certification applications, or customer audits), you can commission a third-party testing agency to conduct the following tests based on the requirements of the end market: Biodegradability test (e.g., OECD 301 series) Heavy metal and harmful element content analysis Volatile organic compound (VOC) content test Ecotoxicity assessment (fish, algae, daphnia toxicity tests) Notes Regarding the test report, the current product database of Guoli Chemical does not include specific test report documents for this product. If you need batch test reports or declarations of conformity, it is recommended that you directly contact the sales or technical department of Guoli Chemical. They will provide the corresponding batch's ctory test data or assist in arranging third-party testing based on your specific needs. Commonly available test indicators include: appearance, pH value (1% aqueous solution), cloud point, hydroxyl value, moisture, heavy metal content, and other routine items.

Question 5

What are the advantages of polyether L-44 compared to other similar products?

Accepted Answer

Polyether L-44, with its excellent HLB balance, low foam characteristics, and multifunctional compatibility in the same series of poloxamer products, forms a unique comprehensive performance advantage in emulsification, wetting, and dispersion. It is a cost-effective choice in the L series that balances hydrophilicity and ease of operation. Detailed Explanation In the poloxamer product sequence of Guoli Chemical, the molecular structure of polyether L-44 (Poloxamer 124) is characterized by its precise EO/PO block ratio — the ratio of ethylene oxide chain segments (a≈12) to propylene oxide chain segments (b≈20) gives it an ideal HLB value range of about 12-16. Compared with the less hydrophilic polyether L-42 (Poloxamer 122) and L-62 (Poloxamer 182) in the same L series, L-44 has superior emulsifying ability and can stabilize a wider variety of oil phase systems; Compared with the more hydrophilic L-64 (Poloxamer 184) and F series, L-44 retains moderate hydrophobicity, allowing it to play an irreplaceable regulatory role in the nucleation and cell refinement process of polyurethane foam systems. Another outstanding advantage of polyether L-44 is its excellent low-foaming property and rapid defoaming ability. This feature makes it significantly superior to the higher-foaming F series products (such as F-38, F-68) in industrial cleaning (especially high-pressure spray and circulating cleaning processes) and metalworking fluids. In polyurethane foam formulations that also require foam control, L-44 as a foam stabilizer can precisely regulate the cell structure without introducing excessive foam, which is particularly critical in the industrial production of semi-rigid and high-resilience foams. In addition, polyether L-44, with its excellent chemical stability and multifunctional compatibility, maintains stable performance in acidic, alkaline, and hard water environments, and can be well compounded with anionic, cationic, and other nonionic surctants. In terms of biosafety, its extremely low skin irritation (PII5,000 mg/kg) give it better compliance advantages than many traditional ionic surctants in fields with high requirements for human and environmental safety, such as personal care products and pesticide formulations. Technical Parameters Comparison Item Polyether L-44 (Poloxamer 124) L-42 (Poloxamer 122) L-62 (Poloxamer 182) L-64 (Poloxamer 184) F-68 (Poloxamer 188) Appearance Colorless to pale yellow transparent liquid Colorless to pale yellow liquid Colorless to light yellow transparent liquid Colorless to pale yellow transparent liquid White to slightly yellow waxy solid Hydrophilic-Lipophilic Balance (HLB) About 12-16 (Moderately hydrophilic) About 7-9 (Lipophilic) About 7 (Lipophilic) About 15 (Hydrophilic) About 29 (Strongly hydrophilic) Low Foam Characteristic Excellent (low foam volume, rapid defoaming) Excellent Excellent Moderate Higher foaming Emulsifying Ability Excellent (suitable for various oil phases) Moderate (suitable for light oils) Moderate Good Excellent (O/W type emulsification) Effectiveness in Polyurethane Foam Suitable for soft foam/hard foam/semi-rigid foam Mainly suitable for low-density foam Suitable for controlled formulations Suitable for hydrophilic foams Suitable for highly absorbent foams Chemical Stability (Acid/Base/Hard Water) Excellent Excellent Excellent Excellent Excellent Skin Irritation (PII) < 0.5 (Non-irritating) Not available Not available Not available Not available Acute Oral Toxicity LD₅₀ > 5,000 mg/kg (Practically non-toxic) Not available Not available Not available Not available Note: The HLB comparison of similar products is based on industry common estimates from structural characteristics. Specific parameters for other products are marked as "Not available" due to incomplete data in the database. Application Suggestions Scenarios for priority selection of polyether L-44: Polyurethane foam systems: In soft foam, hard foam, and semi-rigid foam formulations as a foam stabilizer, the EO/PO ratio of L-44 accurately balances nucleation rate and cell stability, improving cell uniformity better than purely hydrophilic or purely lipophilic similar products. Industrial cleaners: Suitable for high-pressure spray and circulating cleaning processes. The low-foaming characteristic ensures cleaning efficiency without the risk of foam overflow, making operation safer and more convenient compared to F series products. Pesticide emulsifiable concentrates and microemulsions: Excellent emulsifying stability, effectively enhancing the wetting and spreading performance of the liquid on plant surces, avoiding spray clogging issues that may occur when compounding with high-foaming surctants. Metalworking fluids: Integrates lubrication, wetting, and low foaming, reducing the amount of defoamer added to the formulation while providing good rust inhibition synergy. Cosmetic formulations: The mild and non-irritating nature makes it suitable for cial cleansing,

Question 6

How should Polyether L-44 be stored? What is the shelf life?

Accepted Answer

Polyether L-44 should be stored in a sealed container in a cool, dry, and well-ventilated environment. The recommended storage temperature is not exceeding 40°C, avoiding high temperatures, direct sunlight, and repeated freeze-thaw cycles. Under the recommended storage conditions, performance remains stable within the shelf life. Detailed Explanation Polyether L-44 (Poloxamer 124) is a nonionic polyether surctant with stable chemical properties. It is not classified as a hazardous chemical and is not easily combustible, making storage relatively convenient. However, as a surctant product, care should be taken to prevent moisture absorption and contamination to ensure performance consistency during use. The key points for storage are: keep the container tightly sealed, away from heat sources and open flames, and avoid coexistence with strong oxidizers, strong acids, or strong alkalis. Although the product itself has a low freezing point, repeated freeze-thaw cycles should be avoided to prevent potential effects on appearance and uniformity. Before use, check that the container is intact and the label is clear. Regarding the shelf life, the product database does not provide a specific duration (e.g., 1 year or 2 years), but it clearly states that performance remains stable within the shelf life under recommended storage conditions. Generally, industrial-grade polyether surctants, when sealed properly, typically have a shelf life of 1–2 years. For specific recommendations, refer to the product packaging label or contact Guoli Chemical's technical service team for confirmation. Storage Conditions Summary Storage ElementSpecific Requirement EnvironmentCool, dry, and well-ventilated warehouse TemperatureRecommended not exceeding 40°C, avoid repeated freeze-thaw cycles ContainerKeep tightly sealed to prevent moisture absorption and contamination ProhibitionsAway from heat sources, sparks, open flames; avoid coexistence with strong oxidizers, strong acids, and strong alkalis LightAvoid direct sunlight Before UseCheck container integrity and label clarity Application Recommendations Polyether L-44 is widely used in polyurethane foam, industrial cleaning, metalworking fluids, pesticide formulations, and personal care products. Storage conditions directly affect its core properties such as emulsification, wetting, dispersion, and low foaming. Especially when used in polyurethane foaming formulations, improper storage leading to moisture absorption or contamination may cause uneven foam structure or collapse. It is recommended to use the product promptly after opening. Precautions After opening, seal promptly to avoid prolonged exposure to air and moisture absorption. Although the product is not flammable, thermal decomposition may produce irritating fumes, so keep away from high-temperature sources. When disposing of waste, comply with local environmental regulations and do not discharge arbitrarily. For long-term bulk storage, periodically inspect product appearance and performance indicators.

Question 7

What safety precautions should be taken when using Polyether L-44?

Accepted Answer

Polyether L-44 is a safe surctant with actual non-toxic grade and no sensitization, but basic chemical operation specifications still need to be followed, with a focus on preventing eye contact and adhering to proper storage and emergency response measures. Safe Operation Precautions Polyether L-44 (Poloxamer 124) is not classified as a hazardous chemical, with an acute oral toxicity (rat) LD₅₀ > 5,000 mg/kg, making it an actually non-toxic substance, GHS classified as non-hazardous. Nevertheless, it is recommended to wear chemical safety goggles, appropriate protective gloves and clothing, and to use in a well-ventilated area, avoiding inhalation of aerosols or vapors generated by heating. Hands and exposed skin should be thoroughly washed after handling, and eating, drinking, and smoking are prohibited in the workplace. The primary skin irritation index of the product is less than 0.5, indicating no irritation; skin sensitization and mutagenicity are both negative. However, it may cause mild to moderate eye irritation, leading to conjunctival redness and swelling. Although this is reversible damage, special care must be taken to avoid direct eye contact. Storage Conditions Polyether L-44 should be stored in a cool, dry, and well-ventilated warehouse, keeping the container tightly sealed to prevent moisture absorption and contamination. The recommended storage temperature should not exceed 40°C, and repeated freeze-thaw cycles should be avoided. The product is not flammable, but it should be kept away from heat sources, sparks, and open flames, and should not be stored with strong oxidizers, strong acids, or strong bases. Check the container integrity and label clarity before use. Emergency Response Guide Contact TypeEmergency Response Measures Skin ContactImmediately flush with plenty of water and soap for at least 15 minutes; remove contaminated clothing and wash it before reuse; if skin irritation or discomfort occurs, seek medical advice. Eye ContactImmediately flush with plenty of water or normal saline for at least 15 minutes, occasionally lifting the upper and lower eyelids; if wearing contact lenses, remove them if safe to do so and continue flushing; seek medical attention immediately, and present the product safety data sheet. InhalationMove the affected person to fresh air and maintain an open airway; if breathing difficulty occurs, administer oxygen and seek medical attention immediately. IngestionRinse mouth with water, do not induce vomiting (unless instructed by medical personnel); immediately drink 1–2 glasses of water to dilute; never give anything by mouth to an unconscious person; seek medical attention immediately. Spill HandlingSmall spills: cover with inert absorbent material (e.g., sand, vermiculite) and collect in a sealed container, dispose of according to local regulations. Large spills: contain with dikes to prevent entry into sewers or waterways, transfer with pumps or specialized tools to spare containers. Be aware of slip hazards when cleaning the floor. Safety Recommendations in Applications In applications such as polyurethane foam, industrial cleaning, metalworking fluids, pesticide formulations, and personal care products, the low-foaming property and chemical stability of Polyether L-44 allow safe use under high-pressure spraying and high-temperature conditions. However, it is still recommended to ensure adequate ventilation during formulation and production to avoid prolonged repeated exposure. Thermal decomposition of the product may generate irritating fumes, so exhaust ventilation should be ensured during baking or high-temperature processes. Disposal should comply with local environmental regulations; do not discharge into sewers or waterways. Although the product is non-hazardous, waste should be managed according to general industrial chemical waste management requirements. Key Points to Note Eye protection is the top priority—mild to moderate eye irritation; if splashed, rinse immediately and seek medical attention. Storage temperature should not exceed 40°C; avoid repeated freeze-thaw cycles to prevent stability issues. Do not store with strong oxidizers, strong acids, or strong bases. The product is not flammable, but thermal decomposition may produce irritating fumes. In emergency situations, do not induce vomiting; never give liquids to an unconscious person.

Question 8

How to use Polyether L-44? What is the recommended dosage?

Accepted Answer

Polyether L-44 is a water-soluble nonionic surctant that can be used by directly dissolving in water or organic solvents; the database does not list a unified recommended dosage. The specific amount should be determined through experiments based on the application field and formulation. Industry practice typically ranges from 0.1% to 5% of the total system weight. Method of Use Polyether L-44 (Poloxamer 124) appears as a colorless to light yellow transparent liquid and is easy to operate. According to the Guoli Chemical database, this product is soluble in water, ethanol, ether, and other common solvents, and can be directly added to the formulation system under stirring. The specific operation method depends on the application scenario: in polyurethane foam, it is usually used as a foam stabilizer and mixed with polyol, water, catalyst, and other components before foaming; in industrial cleaning and metalworking fluids, it is directly added to the aqueous phase system for dissolution, and if necessary, slight heating can be applied to accelerate dispersion; in agrochemical formulations, it is often premixed with oil-phase raw materials before emulsification; in personal care products, it is generally added in the later stage of the formulation and stirred evenly. This product is resistant to acid, alkali, and hard water, has good chemical stability, and can be well compounded with anionic, cationic, and other nonionic surctants, broadening its applicability in different complex systems. Key Usage Parameters ParameterValueSignificance Ionic TypeNonionicCompatible with various surctants HLB Value16Strong hydrophilicity, suitable for O/W emulsion systems Cloud Point (1% aqueous solution)Approximately 70°CAffects the upper limit of application in high-temperature systems Surce Tension (1%, 25°C)Approximately 38 mN/mReflects wetting and spreading ability Critical Micelle ConcentrationApproximately 0.004% (w/v)Very low CMC, effective even in small amounts Foam CharacteristicsLow foaming, rapid defoamingSuitable for high-pressure spraying and circulating stirring processes pH of 1% Aqueous Solution5.0–7.0Neutral range, minimal impact on formulation pH Density (25°C)1.05–1.06 g/cm³Reference for metering Viscosity (25°C)Approximately 260 mm²/sReference for pumping and batching Application Suggestions and Industry Reference Dosages Note: The Guoli Chemical product database does not provide specific dosage values for Polyether L-44 in various application fields. The following dosage ranges are empirical values commonly used in the industry; the actual dosage should be determined through formulation experiments and performance evaluation: Application FieldFunctionRecommended Reference Dosage (as percentage of total formulation weight) Polyurethane Foam (Flexible and Rigid)Foam stabilizer, emulsifier, nucleating agent0.5%–2% Polyurethane Coatings/Adhesives/ElastomersLeveling agent, wetting agent0.2%–1% Industrial CleanersLow-foaming surctant, detergency and emulsification1%–5% Metalworking FluidsLubrication, wetting, cleaning1%–3% Pesticide Formulations (Emulsifiable Concentrates, Microemulsions)Emulsifier, spreader2%–5% (by weight of oil phase) Personal Care Products (Cosmetics)Mild emollient, skin feel modifier0.1%–1% Precautions It is recommended to conduct small-scale experiments before use to determine the optimal dosage and process conditions, avoiding insufficient dosage leading to poor results or excessive dosage causing foam issues and increased costs. This product has an HLB value of 16, indicating strong hydrophilicity; in oil-based systems, it should be used in combination with low HLB emulsifiers to achieve the best emulsification effect. It is recommended to wear protective goggles and gloves during operation to avoid prolonged direct contact with eyes; if eye contact occurs, rinse immediately with clean water and seek medical attention. Storage temperature should not exceed 40°C, avoid repeated freeze-thaw cycles, and keep the container tightly sealed to prevent moisture absorption. This product is a non-hazardous chemical, but thermal decomposition may produce irritating fumes; keep away from high-temperature heat sources.

Question 9

In which industries and processes is Polyether L-44 mainly used?

Accepted Answer

Polyether L-44 (Poloxamer 124) is widely used in five major fields: polyurethane industry, industrial cleaning, metalworking fluids, pesticide formulations, and personal care products. It is a multifunctional nonionic surctant. Detailed Description Polyether L-44 is a nonionic surctant composed of ethylene oxide (EO) and propylene oxide (PO) block copolymers. With its excellent emulsifying, wetting, dispersing properties and low foaming characteristics, it is widely used in multiple industries. Its chemical stability is outstanding, capable of withstanding acids, bases, and hard water environments, and it can be well compounded with anionic, cationic, and other nonionic surctants, greatly expanding its application range. In the polyurethane field, Polyether L-44 plays a core auxiliary role; in industrial cleaning and metalworking, it solves foam problems in many processes with its low foaming properties; while in pesticides and daily chemicals, it offers advantages in emulsification enhancement and mild skin affinity, respectively. The following details its specific uses and process value by industry. Main Application Industries and Processes Application Industry Specific Process/Use Function Description Polyurethane Industry Flexible foam, rigid foam, semi-rigid foam formulations As an efficient foam stabilizer, it provides emulsification, nucleation, and cell refining functions, ensuring uniform and stable foam and improving cell structure uniformity. Polyurethane coatings, adhesives, and elastomers Acts as a leveling agent and wetting agent, reducing system surce tension, improving substrate wetting, reducing surce defects such as shrinkage holes and orange peel, and enhancing coating or bonding interce quality. Industrial Cleaning High-pressure spray cleaning, circulating cleaning processes Used as a low-foaming surctant, it effectively controls foam generation even under high shear conditions such as high-pressure spraying and stirring, while providing good emulsifying and cleaning ability. Metalworking Fluids Cutting fluids, grinding fluids, rust preventive fluids Provides lubrication, wetting, and cleaning effects, helping to extend tool life and improve workpiece surce quality, with synergistic anti-rust effects. Pesticide Formulations Emulsifiable concentrates (EC), microemulsions (ME), oil-in-water emulsions (EW) As a pesticide emulsifier, it enhances the wetting and spreading ability of the spray solution, improves the emulsification stability and dilution dispersibility of the formulation, thereby increasing the utilization efficiency of the active ingredient. Personal Care Products Creams, lotions, cial cleansers As a mild emollient component, it provides a smooth skin feel; low skin irritation, non-sensitizing, good biocompatibility, suitable for various cosmetic formulations. Application Recommendations In formulation design, it is recommended to adjust the dosage of Polyether L-44 according to different application scenarios: Polyurethane Foam: Typically 0.5%–2.0% of the total polyether polyol weight, with specific dosage optimized based on foam density and cell size requirements. Industrial Cleaners: Recommended dosage 1%–10%, can be compounded with other surctants to enhance overall cleaning performance. Metalworking Fluids: Suggested addition 0.5%–5%, better effect when used in synergy with rust inhibitors and extreme pressure additives. Pesticide Formulations: Depending on the specific formulation type, the total amount of emulsifier is generally 5%–15%, and L-44 can be used alone or compounded with nonionic/anionic emulsifiers. Cosmetics: Recommended dosage 0.5%–5%, can be used as an auxiliary emulsifier and emollient in emulsion systems. The above dosages are empirical reference ranges; actual formulations should determine the optimal addition through experimentation. (Data source: Guoli Chemical product database and industry application experience) Precautions Although this product is not classified as a hazardous chemical, it is recommended to wear chemical safety goggles and protective gloves during operation to avoid prolonged direct contact with eyes. Storage temperature should not exceed 40℃, avoid repeated freezing and thawing, keep the container sealed to prevent moisture absorption and contamination. Avoid coexistence with strong oxidizers, strong acids, and strong bases. This product is a low-foaming surctant; it should not be used as the main surctant in applications requiring high foam (e.g., some shampoo and body wash products). Applications in pesticides and cosmetics must comply with relevant industry regulations to ensure formulation compliance.

Question 10

What are the physical and technical parameters of Polyether L-44?

Accepted Answer

Polyether L-44 (Poloxamer 124) is a nonionic surctant with excellent emulsifying and wetting properties, with an HLB value of up to 16 and a cloud point of approximately 70°C. Comprehensive physical and chemical parameters are as follows. Detailed Description Polyether L-44 (Poloxamer 124 / Poloxamer 124) is a high-performance nonionic polyoxyethylene-polyoxypropylene block copolymer produced by Guoli Chemical. Its molecular structure is HO(C₂H₄O)ₐ(C₃H₆O)b(C₂H₄O)ₐH, where a≈12, b≈20, with a molecular weight of approximately 2200. The product appears as a colorless to slightly yellow transparent liquid, with CAS number 9003-11-6. This product has a high HLB value (16), strong hydrophilicity, and is soluble in various solvents such as water, ethanol, and ether. The cloud point in a 1% aqueous solution is approximately 70°C, indicating good solubility and surce activity within room temperature to moderate temperature ranges. Its critical micelle concentration (CMC) is approximately 0.004% (w/v), meaning it can effectively reduce the surce tension of the system at extremely low concentrations. The surce tension of a 1% aqueous solution at 25°C is approximately 38 mN/m. Polyether L-44 has good chemical stability and is resistant to acids, alkalis, and hard water environments. It has low foaming characteristics and excellent wetting and penetrating capabilities. Its density is 1.05~1.06 g/cm³ (25°C), kinematic viscosity is approximately 260 mm²/s (25°C), refractive index is 1.453~1.457 (25°C), flash point (closed cup) is >200°C, and pour point is . All indicators comply with Guoli Chemical's enterprise standards, with an active ingredient content of ≥99%. Technical Parameters Parameter Item Specification Value Product Name / Alias Polyether L-44 / Poloxamer 124 / Pluronic L-44 CAS Number 9003-11-6 Ionic Type Nonionic Appearance Colorless to slightly yellow transparent liquid Molecular Formula HO(C₂H₄O)ₐ(C₃H₆O)b(C₂H₄O)ₐH (a≈12, b≈20) Molecular Weight Approx. 2200 Active Content ≥99% HLB Value 16 Cloud Point (1% Aqueous Solution) Approx. 70°C Density (25°C) 1.05~1.06 g/cm³ Kinematic Viscosity (25°C) Approx. 260 mm²/s Refractive Index (25°C) 1.453~1.457 pH Value (1% Aqueous Solution) 5.0~7.0 Surce Tension (1% Aqueous Solution, 25°C) Approx. 38 mN/m Critical Micelle Concentration (CMC) Approx. 0.004% (w/v) Hydroxyl Value 45~55 mg KOH/g Acid Value ≤0.5 mg KOH/g Saponification Value ≤1 Iodine Value ≤1 Water Content ≤0.5% Flash Point (Closed Cup) >200°C Pour Point Solubility Soluble in water, ethanol, ether, etc. Foaming Characteristics Low foaming Heavy Metal Content ≤10 ppm Arsenic Content ≤2 ppm Chemical Stability Stable, incompatible with strong oxidizing agents <h3

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Property	Value
CAS No.	9003-11-6
Molecular Formula	HO(C2H4O)a(C3H6O)b(C2H4O)aH, wherea≈12, b≈20
Appearance	Colorless to pale yellow transparent liquid
Ionic Type	Nonionic
Avg. Molecular Weight	Approx. 2200
Cloud Point	~70 (1%aq. soln.)
Active Content	≥99
pH Value(1%)	5.0-7.0
pH Value(5%)	5.0-7.0
Iodine Value	≤1
Solubility	Soluble in water, ethanol, ethyl ether etc.
Surface Tension	~38 (1%aq. soln., 25°C)
CMC	~0.004 (%, w/v)
Acid Value	≤0.5
Saponification Value	≤1
Hydroxyl Value	45-55 (mg KOH/g)
Moisture	≤0.5
Density	1.05-1.06 (25°C)
Kinematic Viscosity	~260 (25°C, mm²/s)
Refractive Index	1.453-1.457 (25°C)
Flash Point	>200 (closed cup, °C)
Hygroscopicity	Slightly hygroscopic
Chemical Stability	Stable; incompatible with strong oxidizers
Amine Value	≤1
Tertiary Amine Content	≤1
Penetration	Good
Foam Property	Low foam
Alkali Resistance	Good
Unsaturation	Extremely low, Iodine Value ≤1
Viscosity	~270 mPa·s
Melting Point	< -20°C (pour point)
Low Shear Viscosity	~270 (mPa·s)
Solid Content	≥99
Free Alcohol	≤1
Heavy Metal	≤10
Arsenic	≤2

Polyether L-44

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