Question 1

Is polyether L-64, Pluronic L64 harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Polyether L-64 is a low-toxicity, low-irritation chemical with minimal harm to humans, but it may cause mild skin and eye irritation; it has potential impact on aquatic environments, with low biodegradation rate, and direct discharge should be avoided. Detailed Explanation Effects on Human Health According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) assessment, polyether L-64 (Poloxamer 184) is generally classified as a low-toxicity substance with good toxicological safety, and is therefore widely used in cosmetics, personal care products, and pharmaceutical excipients that require high safety standards. However, this does not mean it is completely harmless—its hazard classification is: Skin corrosion/irritation Category 2 (H316: Causes mild skin irritation) and Serious eye damage/eye irritation Category 2 (H320: Causes eye irritation), with the signal word "Warning". In practice, short-term skin contact may cause minor discomfort, and eye splashes may produce irritation. Therefore, it is recommended to wear nitrile rubber gloves and chemical safety goggles during operation, and to thoroughly wash the skin after work. If accidentally splashed into the eyes, rinse immediately with plenty of water for several minutes; remove contact lenses if present and continue rinsing. If irritation persists, seek medical attention. Overall, under normal use conditions and with reasonable protection, the risk to human health from this product is controllable. Environmental Impact Polyether L-64 has a low inherent biodegradation rate in the natural environment, meaning that once in water or soil, it is difficult for microorganisms to rapidly decompose, potentially leading to long-term persistence in aquatic environments. Therefore, untreated waste liquids containing this product should be avoided from direct discharge into rivers, lakes, groundwater, or soil to prevent cumulative environmental pollution. Currently, this product is classified as "not classified" in other physical, health, and environmental hazard categories; it is not an acute aquatic toxic substance and is not subject to hazardous chemical controls such as ozone depletion or persistent organic pollutants. Safe Handling and Protective Recommendations Protective ItemRecommended Measures Respiratory ProtectionEnsure ventilation in the operating area; avoid inhaling vapors or aerosols Skin ProtectionWear protective gloves (nitrile rubber gloves recommended); thoroughly wash after work Eye ProtectionWear chemical safety goggles to prevent splashes into the eyes Work HabitsNo eating, drinking, or smoking in the workplace; wash contaminated clothing before reuse Storage RequirementsStore tightly closed in a cool, dry, well-ventilated area, away from strong oxidizing agents, strong acids, and strong bases Emergency Response Eye Contact: Immediately rinse cautiously with plenty of water or saline for at least 15 minutes. If wearing contact lenses and easy to remove, continue rinsing after removal. If irritation persists, seek medical attention (follow P305+P351+P338 and P337+P313). Skin Contact: Remove contaminated clothing and wash the affected area thoroughly with soap and water. If skin irritation occurs, seek medical advice/attention (follow P332+P313). Spill Handling: Contain and collect spilled liquid with inert absorbent materials (e.g., sand, diatomaceous earth), place in a closed container for disposal according to regulations; avoid flushing into drains or waterways. Summary Polyether L-64 is a low-hazard substance to humans, with the main risks being mild skin and eye irritation, which can be effectively avoided through basic protection; the primary environmental concern is its low biodegradability, so waste liquid discharge should be strictly controlled during use and disposal to avoid long-term burden on aquatic ecosystems. Under conditions of compliant use and proper disposal, this product is a relatively safe industrial and cosmetic raw material.

Question 2

What should I do if problems occur during the use of polyether L-64 (Pluronic L64)? How to obtain technical support?

Accepted Answer

If problems occur during the use of polyether L-64, professional solutions can be obtained through multiple channels. It is recommended to first check the formulation and process, and then contact the Guoli Chemical technical team for targeted support. Common usage problems and troubleshooting directions Typical problems that may be encountered during the use of polyether L-64 (Poloxamer 184) include: poor emulsion stability, suboptimal defoaming effect, abnormal compatibility with other components in the system, and product turbidity or stratification. When encountering problems, it is recommended to first self-check from the following dimensions: 1. Addition sequence and process conditions — Polyether L-64 is recommended to be added during the cooling or dilution stage of the formulation, and moderate stirring is sufficient for uniform dispersion. If added too early under high temperature or high shear conditions, it may lead to partial deactivation or uneven dispersion. Please check whether the process temperature is within a reasonable range and whether the stirring intensity matches. 2. Dosage ratio — The specific addition amount should be determined through experiments based on the formulation system and expected functions. Insufficient dosage may lead to inadequate emulsification, dispersion, or defoaming effects; excessive dosage may cause foam re-increase or abnormal system viscosity. It is recommended to conduct gradient dosage tests during the laboratory small-scale trial stage to determine the optimal addition range. 3. Compatibility and system pH — Polyether L-64 maintains good stability against acids, alkalis, and high-hardness water, and has excellent compatibility with anionic, cationic, and other nonionic surctants. However, if there are extreme pH conditions or high-concentration electrolytes in the system, its impact on functionality still needs to be verified. If turbidity or precipitation occurs, adjust the system pH to a neutral to slightly weak range and then observe. 4. Storage conditions — The product has certain hygroscopicity. If not sealed properly or exposed to extreme temperature and humidity conditions for a long time, it may absorb moisture, deteriorate, or degrade in performance. Please check whether the product appearance is normal (should be a colorless to pale yellow transparent liquid). If abnormal, contact the supplier. How to obtain technical support from Guoli Chemical Hai'an County Guoli Chemical Co., Ltd. provides professional technical service support for all products. You can obtain help through the following methods: Phone consultation — Call Guoli Chemical's official technical service hotline to communicate directly with engineers, describing your specific problem (including product batch number, application system, process conditions, and abnormal phenomena). Email/Online message — Submit a technical consultation ticket via the company's official website or official email, attaching basic formulation information (which can be desensitized) and a description of the problem. The technical team will reply as soon as possible during working days. Sample re-inspection and analysis — If product quality abnormality is suspected, under the guidance of technical personnel, send the retained sample or the problematic batch sample to Guoli Chemical's quality inspection center for physical and chemical index re-inspection and performance evaluation. On-site technical service — For major application problems or formulation optimization needs, you can arrange an appointment for technical engineers to provide on-site support to help troubleshoot process issues and optimize application solutions. Customized application development — If standard products cannot fully meet the needs of a specific system, Guoli Chemical can provide formulation optimization suggestions or product customization solutions. Please prepare the following information before contacting To speed up problem diagnosis, it is recommended to prepare the following information before contacting technical support: Product name and batch number (located on the packaging drum label) Specific application field and process conditions (temperature, pH, addition sequence, shear conditions, etc.) Detailed description of the problem phenomenon (time of occurrence, abnormal performance, difference compared to normal batches) Chemical types and approximate ratios of other main components in the formulation Product storage time and storage environment conditions Precautions Before the cause of the problem is identified, it is recommended to suspend large-scale use of this batch of products, and retain the problematic samples and original packaging for inspection. Always wear protective gloves and goggles during operation, and maintain good ventilation. In case of skin or eye contact, follow the emergency treatment measures in the Product Safety Data Sheet (SDS) and seek medical attention promptly if necessary.

Question 3

How to purchase Polyether L-64, Pluronic L64? What is the minimum order quantity?

Accepted Answer

You can directly purchase Polyether L-64 through the sales channels of Haian Guoli Chemical Co., Ltd. The minimum order quantity is usually based on the smallest packaging unit. Please confirm the specific policy with the sales team. Detailed Description Haian Guoli Chemical Co., Ltd. is the manucturer and supplier of Polyether L-64 (Pluronic L64 / Poloxamer 184). To purchase this product, we recommend contacting the sales team of Guoli Chemical for an official quotation, inventory status, and delivery lead time. As chemical raw material market prices are affected by fluctuations in raw material costs, the unit price is subject to the latest quotation from the sales team. This product is available in three standard packaging specifications: 50kg plastic drum, 200kg plastic drum, and IBC tote. You can choose flexibly based on your actual usage and storage conditions. The product has certain hygroscopicity, and the packaging adopts sealed moisture-proof design to ensure stable quality during transportation and storage. Technical Parameters ParameterValue CAS No.9003-11-6 Appearance (Room Temperature)Colorless to light yellow clear liquid Ionic TypeNonionic Active Content≥99% HLB Value15 Cloud Point (10% Aqueous Solution)61℃ Hydroxyl Value28~36 mgKOH/g pH Value (1% Aqueous Solution)5.5-7.5 Kinematic Viscosity (25℃)Approx. 850 mm²/s Density (25℃)Approx. 1.06 g/cm³ Flash Point (Closed Cup)>230℃ Packaging Specifications50kg plastic drum / 200kg plastic drum / IBC tote Application Suggestions Polyether L-64 is a versatile nonionic high-molecular-weight surctant. With its low-foaming wetting and efficient emulsifying & dispersing properties, it is widely used in industrial cleaners, metalworking fluids, water-based coatings and inks, textile auxiliaries, emulsion polymerization, and cosmetic and pharmaceutical formulations. During formulation development, it is recommended to add it during the cooling or dilution stage and stir moderately for uniform dispersion. The specific addition amount should be determined through sample tests based on your formulation system and desired functionality. Precautions According to GHS classification, this product is classified as a mild skin/eye irritant (H316/H320). Wear protective gloves and goggles during handling and wash skin thoroughly after use. The product is hygroscopic. After opening, seal tightly and store in a cool, dry, and well-ventilated area, away from heat sources and strong oxidizing agents. For minimum order quantity and sample requests, it is recommended to contact the sales department of Guoli Chemical directly by phone or email for the most accurate business policy response.

Question 4

Does Polyether L-64 (Pluronic L64) comply with environmental requirements? Can a test report be provided?

Accepted Answer

Polyether L-64 (Pluronic L64) is not classified as an environmental hazard under the current GHS classification system, but its inherent biodegradation rate is low, so attention must be paid to wastewater discharge control. Detailed Explanation According to the GHS hazard classification data of Polyether L-64 in the Guoli Chemical product database, this product is clearly marked as 'Not Classified' in the 'Other physical, health and environmental hazard categories', which means that based on the available evaluation data, Polyether L-64 is not classified into environmental hazard categories such as acute aquatic toxicity, chronic aquatic toxicity, persistent organic pollutants, etc. The heavy metal content of the product is controlled at ≤10 mg/kg and arsenic content at ≤2 mg/kg, meeting the safety requirements for general industrial chemicals. At the same time, the product safety technical data clearly states: 'This product has a low inherent biodegradation rate in the natural environment and should be avoided from direct discharge into water bodies.' This indicates that although Polyether L-64 is not a high environmental hazard substance, it is difficult to degrade quickly under natural conditions. If large quantities are discharged into water or soil, it may cause accumulation effects over a certain period. Therefore, during use, wastewater treatment measures should be implemented to avoid direct discharge into environmental water bodies. Overall, under normal industrial application conditions (closed systems, reasonable dosage, compliant discharge), Polyether L-64 is a product with controllable environmental safety. Chinese regulations such as the 'Integrated Wastewater Discharge Standard' have clear limits on the discharge of surctant substances. It is recommended that enterprises pretreat wastewater containing Polyether L-64 according to local environmental protection department requirements to ensure compliant discharge. Technical Parameters (Environmental Related Indicators) Indicator Item Parameter Value Data Source Environmental Hazard Category (GHS) Not Classified Guoli Chemical Safety Technical Data Sheet Biodegradability Low inherent biodegradation rate Guoli Chemical Product Specification Heavy Metals (as Pb) ≤10 mg/kg Guoli Chemical Product Database Arsenic (As) ≤2 mg/kg Guoli Chemical Product Database GHS Signal Word Warning Guoli Chemical Safety Technical Data Sheet Skin/Eye Irritation Mild irritation (Category 2) Guoli Chemical Safety Technical Data Sheet Application Recommendations When using Polyether L-64 in circulating systems such as industrial cleaning, metalworking fluids, and water-based coatings, waste liquid should be incorporated into the enterprise's wastewater treatment system for centralized treatment before discharge. In open application scenarios such as textiles and agrochemicals, the dilution and assimilation capacity of local soil and water bodies should be evaluated to avoid high-concentration centralized discharge. Applications in cosmetics and pharmaceuticals are not subject to this restriction because the product itself is used in very small amounts and can be effectively degraded in human metabolism or wastewater treatment systems. Regarding the Test Report In the Guoli Chemical product database, there is no electronic archive available for direct viewing of a specific environmental compliance test report for Polyether L-64 (such as biodegradation rate test report, REACH compliance statement, RoHS test report, etc.). It is recommended that you: Contact the sales or quality management department of Guoli Chemical to confirm whether they can provide the latest SDS (Safety Data Sheet), COA (Certificate of Analysis), and third-party environmental test reports. If the product is used for export or in areas governed by EU REACH regulations, US TSCA, etc., simultaneously inquire whether there is a REACH registration certificate or SVHC (Substances of Very High Concern) test results. If there are specific customer or industry audit requirements (such as OEKO-TEX textile ecological certification, cosmetic ingredient compliance statement, etc.), request the manucturer to issue a targeted technical declaration letter or commission a third party for special testing.

Question 5

What are the advantages of Polyether L-64, Pluronic L64 compared to similar products?

Accepted Answer

The core advantage of Polyether L-64 lies in its combination of "excellent low foaming and rapid defoaming ability", "high efficient emulsification and dispersion", and "excellent physiological safety". It is a multifunctional nonionic surctant that simultaneously solves foam issues and enhances formulation stability. Detailed Description The most distinctive feature of Polyether L-64 (Poloxamer 184) compared to conventional nonionic surctants is its unique integrated foam control and wetting performance. It is a block copolymer of propylene oxide (PO) and ethylene oxide (EO). Its special molecular structure provides excellent substrate wetting and penetration while producing very low foam in the working solution, with extremely rapid defoaming. This allows it to significantly reduce or even eliminate the need for additional defoamers in highly foam-sensitive applications such as high-pressure spray cleaning and metalworking fluid circulation systems, thereby reducing formulation costs and avoiding coating defects (such as craters) caused by defoamers. Secondly, Polyether L-64 has a very high functional integration. A single product can simultaneously play multiple roles as a defoamer, wetting agent, emulsifier, and dispersant. In industrial cleaning, it effectively degreases and cleans without foam overflowing from the tank; in water-based coatings and inks, it promotes pigment dispersion, prevents flocculation, adjusts dynamic surce tension to improve leveling, and eliminates microfoam. Compared to single-function surctants, L-64 simplifies formulation design and, due to its broad compatibility with anionic, cationic, and other nonionic surctants, shows excellent formulation compatibility. Additionally, Polyether L-64 has excellent mildness and safety. Compared to some APG (alkyl polyglycosides) or traditional tty alcohol polyether surctants, as a high-molecular-weight polymer, it is more difficult to penetrate the skin's stratum corneum, resulting in very low irritation. This makes it suitable not only for harsh industrial environments but also safe for use in cosmetics, personal care products, and even pharmaceutical excipients as a mild cleanser, solubilizer, or micellar carrier, achieving full coverage from heavy industry to daily medical fields. Technical Parameters The following key indicators explain its low foam and high stability at a data level (tested at 25°C): Key Performance IndicatorTypical ValuePerformance Interpretation and Advantages HLB Value15Strong hydrophilicity, can be used as an efficient oil-in-water (O/W) emulsifier and solubilizer Cloud Point (10% Aqueous Solution)61°CSurce activity drops sharply near the cloud point; this characteristic helps control foam and achieve controlled demulsification Foam CharacteristicsLow foaming, easy defoamingExtremely low dynamic foam, no need for additional silicone or polyether defoamers, avoiding the risk of craters Surce Tension (0.1%)Approx. 32 mN/mExcellent ability to reduce surce tension, ensuring rapid wetting and penetration of low-energy surces and fiber brics Critical Micelle Concentration (CMC)Approx. 0.064%Low CMC value means micelles form at very low concentrations, enabling solubilization and detergency Kinematic Viscosity (25°C)Approx. 850 mm²/sLiquid at room temperature with moderate viscosity, easy to pump and pour during production, easy to handle Pour PointApprox. -20°CExcellent low-temperature fluidity, easy to use in cold regions or winter, resistant to solidification and pipeline blockage pH Value (1% Aqueous Solution)5.5 - 7.5Nearly neutral pH, very friendly to metal substrates, sensitive skin, and weakly acidic formulation systems Data source: Measured indicators from Guoli Chemical product database Application Recommendations Based on its multiple advantages, Polyether L-64 is particularly suitable for the following demanding fields: High-Pressure and Circulating Cleaning: In spray cleaning and CIP (Clean-in-Place) systems, use its strong wetting power and low-foam characteristics to improve cleaning efficiency and prevent foam overflow. Waterborne Coatings and Inks: As a pigment dispersion promoter during the grinding stage or as a low-foam wetting and leveling agent during paint mixing, helping eliminate microfoam pinholes and improve film gloss. High-End Cosmetics: As a foam regulator or mild solubilizer for main surctants in "tear-free" or low-irritation products such as amino acid cial cleansers and micellar waters. Textile Pretreatment: As a low-foaming penetrant in desizing and scouring processes, achieving rapid wetting while preventing foam from blocking the liquid circulation. Precautions Polyether L-64 exhibits reverse gelation characteristics, meaning it forms a gel in high-concentration aqueous solutions as temperature increases. Therefore, it is recommended to add it during the cold feeding stage or when the material is cooling down, and it can be efficiently and uniformly dispersed with moderate stirring. If directly preparing high-concentration stock solutions, control the water temperature below its gelation point to maintain fluidity. Wear conventional protective gloves during operation.

Question 6

How should Polyether L-64, Pluronic L64 be stored? What is the shelf life?

Accepted Answer

Polyether L-64 should be stored sealed in a cool, dry, and well-ventilated environment. Under normal temperature and sealed conditions, the shelf life is stable (for specific years, please refer to the product's COA). Detailed Explanation Polyether L-64 (Pluronic L64 / Poloxamer 184) is a non-ionic high-molecular surctant with certain hygroscopicity. Therefore, moisture-proof sealing is the core point of its storage management. The product should be packaged in clean, dry plastic drums or composite intermediate bulk containers (IBC totes). After opening and use, the container must be immediately re-sealed tightly to prevent moisture from entering and causing product deterioration. The storage environment should be away from heat sources, sparks, open flames, and direct sunlight. It is recommended to maintain storage temperature within the room temperature range (usually 5°C~35°C), avoiding extreme low or high temperatures. Extreme low temperatures may cause increased viscosity or even solidification, while extreme high temperatures may accelerate oxidation or color changes. At the same time, it should be stored separately from incompatible substances such as strong oxidizers, strong acids, and strong bases to prevent cross-contamination. Regarding shelf life, according to product data from Guoli Chemical, this product has a stable shelf life under normal temperature and sealed conditions. Generally, for unopened Polyether L-64 stored under recommended conditions, the shelf life can reach 24 months from the date of production (specifically subject to the product's COA or outer packaging label). It is recommended to follow the first-in-first-out principle and regularly inspect the appearance of inventory products. Storage Condition Key Points Storage ElementSpecific Requirements TemperatureMaintain room temperature range (recommended 5°C~35°C), avoid extreme temperatures HumidityKeep dry; product has certain hygroscopicity, strictly prevent moisture SealingContainer must be kept airtight; reseal immediately after opening LightAvoid direct sunlight Heat SourcesKeep away from heat sources, sparks, and open flames VentilationWarehouse must be well-ventilated Isolation RequirementsStore separately from incompatible substances such as strong oxidizers, strong acids, and strong bases Packaging ContainerClean, dry plastic drums or composite intermediate bulk containers (IBC totes) Application Suggestions It is recommended to establish an inventory management system and follow the "First In, First Out" (FIFO) principle. Before each use, quickly visually inspect the appearance of the product. Under normal conditions, it should be a colorless to light yellow transparent liquid. If any abnormalities such as turbidity, stratification, or significant color deepening occur, stop use and perform quality verification. Use clean and dry tools when taking materials to avoid introducing impurities or moisture into the container. Precautions Remove contaminated clothing and wash it before reuse. Equip the storage area with spill emergency response cilities (such as absorbent materials) to deal with accidental spills. The product has a low inherent biodegradation rate in the natural environment; avoid direct discharge into water bodies. It is recommended to wear basic protective gloves and goggles during operation to avoid eye splashes and prolonged skin contact.

Question 7

What safety precautions should be taken when using Polyether L-64, Pluronic L64?

Accepted Answer

Polyether L-64 is a low-toxicity, low-irritation non-hazardous chemical, but basic safety specifications should still be followed during operation, especially regarding eye and skin protection to avoid direct contact. Detailed Explanation Polyether L-64 (Poloxamer 184) is evaluated as a non-hazardous substance according to the current hazardous chemical classification standards, with overall good safety. However, according to GHS classification, this product has mild irritancy to skin and eyes, classified as Skin corrosion\/irritation Category 2 (H316: Causes mild skin irritation) and Serious eye damage\/eye irritation Category 2 (H320: Causes eye irritation). Therefore, safety protection cannot be completely ignored during operation. This product has a signal word "Warning" with no special pictogram. Its toxicological safety is relatively mild and is widely accepted in the fields of cosmetics, personal care products, and pharmaceutical excipients. However, this only applies to the use of the final formulation within compliant dosages. For pure or high-concentration operations, appropriate protective measures must still be taken. Specific Safety Operation Requirements Personal Protective Equipment Wear chemical safety goggles during operation to prevent product splashing into eyes Wear appropriate protective gloves (recommended nitrile rubber gloves) to avoid prolonged skin contact If necessary, wear protective clothing to avoid contamination of daily clothes Operating Environment and Behavioral Specifications Ensure the operating area is well-ventilated to avoid inhaling generated vapors or aerosols No eating, drinking, or smoking in the workplace After finishing work, before eating, drinking, or leaving the work area, thoroughly wash hands and any potentially contaminated body parts (according to P264 precautionary statement) Avoid generating and inhaling dust, vapors, or aerosols Remove contaminated clothing and wash it before reuse Emergency Response Measures Eye contact: Immediately rinse eyelids carefully with plenty of water or saline for at least several minutes. If wearing contact lenses and can be easily removed, remove them and continue rinsing. If eye irritation persists, seek medical attention (according to P305+P351+P338 and P337+P313). Skin contact: If skin irritation occurs, immediately remove contaminated clothing and thoroughly wash the affected area with soap and water. If irritation persists, seek medical attention (according to P332+P313). Inhalation: Move the person to fresh air and maintain comfortable breathing. If symptoms of discomfort occur, seek medical help. Ingestion: Rinse mouth immediately, do not induce vomiting, and seek medical attention as soon as possible. Storage Precautions Store in a cool, dry, well-ventilated warehouse Keep the container tightly sealed to avoid moisture absorption and contamination; reseal after opening Keep away from heat sources, sparks, open flames, and direct sunlight Store separately from incompatible substances such as strong oxidizers, strong acids, and strong bases Recommended storage temperature is maintained at room temperature range to avoid extreme low or high temperatures that may alter product properties Environmental Precautions Polyether L-64 has a low inherent biodegradation rate in the natural environment. Avoid direct discharge into water bodies. Waste disposal should follow local environmental regulations and must not be dumped arbitrarily. Usage Recommendations In formulation development, it is recommended to add Polyether L-64 during the cooling or dilution stage and stir moderately for uniform dispersion. The specific addition amount should be determined through experiments based on the formulation system and desired function. This product is not sensitive to hard water ions, remains active over a wide pH range, and has good compatibility with anionic, cationic, and other nonionic surctants. Summary of Precautions Polyether L-64 has high safety, but do not take pure product operations lightly Core protective points are goggles + protective gloves + good ventilation Eye splashing is the biggest risk point; ensure immediate and thorough flushing The product is hygroscopic; keep the container sealed during storage Low biodegradability; do not discharge directly into the environment

Question 8

How to use Polyether L-64 (Pluronic L64)? What is the recommended dosage?

Accepted Answer

Polyether L-64 (Poloxamer 184) is flexible and easy to use. It is recommended to add it during the cooling or dilution stage of the formulation; moderate stirring ensures uniform dispersion. There is no fixed dosage; it must be determined through experiments based on the specific formulation system and desired function. In industrial applications, the common reference range is 0.1% to 5%. Detailed Description Polyether L-64 (Pluronic L64, CAS No.: 9003-11-6) is a nonionic polymer surctant. At room temperature, it appears as a colorless to light yellow transparent liquid with an HLB value of approximately 15. It is readily soluble in water, ethanol, and other solvents. Its unique polyoxyethylene-polyoxypropylene block copolymer structure imparts excellent low-foaming, wetting, emulsifying, and dispersing properties. It has good compatibility with anionic, cationic, and other nonionic surctants and remains stable in acidic, alkaline, and hard water conditions. Regarding usage, Guoli Chemical recommends adding Polyether L-64 when the formulation system cools to room temperature or during the dilution stage. Uniform dispersion can be achieved with moderate stirring, requiring no special high-speed shear equipment. Since it is insensitive to hard water ions, it maintains activity over a wide pH range, making it suitable for various process systems. For emulsion polymerization, it is typically added together with the aqueous phase during the pre-emulsification stage. For coatings or inks, it is recommended to add it in the later stages of paint mixing to avoid introducing excessive air. Technical Parameters ParameterIndicator (Source: Guoli Chemical Product Database) AppearanceColorless to light yellow transparent liquid Ionic TypeNonionic HLB Value15 Cloud Point (10% Aqueous Solution)61°C Active Content≥99% pH Value (1%/5% Aqueous Solution)5.5–7.5 Critical Micelle Concentration (25°C)Approximately 0.064% Surce Tension (0.1% Aqueous Solution, 25°C)Approximately 32 mN/m Viscosity (25°C)Approximately 850 mm²/s (kinematic viscosity); approximately 900 mPa·s (low shear viscosity) DensityApproximately 1.06 Pour PointApproximately -20°C Flash Point (Closed Cup)>230°C Hydroxyl Value28–36 Foam CharacteristicsLow foaming SolubilityReadily soluble in water, ethanol, ether, and other organic solvents Heavy Metals≤10 mg/kg Arsenic≤2 mg/kg Application Recommendations The specific dosage of Polyether L-64 varies depending on the application field and functional requirements. The Guoli Chemical database notes that "the specific dosage must be determined through experiments based on the formulation system and desired function". Below are common reference dosage ranges for various application areas (based on total formulation weight): Application AreaFunctional RoleReference Dosage (Requires Experimental Validation) Industrial CleanersLow-foaming wetting agent, degreasing aid0.5%–3% Metalworking FluidsEmulsifying dispersant, lubricant additive1%–5% Water-based Coatings/InksWetting dispersant, defoaming aid0.1%–1% (for pigment dispersion, 2%–10% based on pigment weight) Textile AuxiliariesLow-foaming penetrant, leveling agent0.5–3 g/L (working solution) Emulsion PolymerizationNonionic emulsifier and stabilizer1%–3% (based on monomer weight) Defoamer FormulationsDefoaming component or carrier5%–30% (in defoamer formulations) Cosmetics/Personal Care ProductsMild surctant, solubilizer0.5%–5% Pharmaceutical ExcipientsSolubilizer, micellar carrierMust comply with pharmacopoeia and formulation process requirements; determined based on R&D data Precautions Safety Protection: This product is classified as GHS Category 2 and may cause mild skin irritation (H316) and eye irritation (H320). It is recommended to wear nitrile rubber gloves and chemical safety goggles during handling, and wash skin thoroughly after operation. If it gets into eyes, rinse immediately with plenty of water for several minutes, remove contact lenses if present, and continue rinsing. If irritation persists, seek medical attention promptly. Storage Requirements: The product is hygroscopic and must be stored sealed in a cool, dry, well-ventilated warehouse away from heat sources and direct sunlight. Re-seal the container immediately after opening. The shelf life is stable under normal sealed conditions at room temperature, but extreme temperature environments should be avoided. Process Compatibility: Store separately from incompatible substances such as strong oxidizers, strong acids, and strong bases. If used in combination with other defoamers in low-foaming systems, compatibility testing is recommended first. Environmental Note: This product has a low inherent biodegradation rate in the natural environment. Avoid direct discharge into water bodies, and dispose of waste liquid in accordance with local environmental regulations. Addition Method: The product has relatively high viscosity (approximately 850 mm²/s at 25°C). Decreased fluidity at low winter temperatures is normal. It can be used after warming to room temperature or preheated in a warm water bath (not exceeding 40°C) without affecting product performance. Packaging Specifications: Guoli Chemical offers packaging in 50 kg plastic drums, 200 kg plastic drums, and IBC totes, which can be selected as needed.

Question 9

What are the main industries and processes where Polyether L-64 (Pluronic L64) is primarily used?

Accepted Answer

Polyether L-64 (Poloxamer 184) is a multifunctional nonionic polymer surctant widely used in more than ten industries and process fields, including industrial cleaning, metalworking, water-based coatings and inks, textile auxiliaries, emulsion polymerization, cosmetics and personal care products, pharmaceutical excipients, and defoamers. Detailed Description Polyether L-64 is produced by block copolymerization of propylene oxide and ethylene oxide. At room temperature, it appears as a colorless to light yellow transparent liquid. Its unique molecular structure provides an excellent balance between intercial activity, emulsifying, and dispersing capabilities, while also offering superior low-foaming properties and broad chemical compatibility, remaining stable against acids, alkalis, and hard water. These characteristics make it a versatile functional additive across industries and multiple process scenarios. In industrial applications, the most prominent value of Polyether L-64 lies in its integrated foam control and wetting ability—it not only provides efficient substrate wetting and spreading but also maintains the working fluid foam at an extremely low level and rapidly eliminates foam. Therefore, it is particularly suitable for foam-sensitive systems such as high-pressure spray cleaning, CIP inline cleaning, and circulating metalworking fluids. In the personal care and pharmaceutical fields, its mild physiological properties and good toxicological safety make it a reliable emulsifying and solubilizing agent in cial cleansers, topical preparations, and oral liquids. According to the Guoli Chemical Product Database, the applications of Polyether L-64 cover the entire industrial chain from heavy industry (metalworking fluids, industrial cleaning) to fine chemicals (coatings, inks, emulsion polymerization) and consumer end products (cosmetics, pharmaceutical excipients), making it a truly versatile platform-type surctant. Application Industries and Processes at a Glance Industry/Field Specific Process Functional Role Industrial Cleaning High-pressure spray cleaning, metal parts degreasing, CIP inline cleaning system, ultrasonic cleaning Low-foaming wetting agent, emulsifier, detergency and degreasing component Metalworking Fluids Cutting, grinding, forming Emulsifier, dispersant, lubricant additive, low-foaming wetting component Water-based Coatings Pigment dispersion, coating application, colorant preparation Pigment wetting and dispersing agent, dynamic surce tension regulator, defoaming additive Inks Water-based inks, flexographic printing, gravure printing Wetting and leveling agent, pigment dispersing aid, low-foaming regulator Textile Auxiliaries Pretreatment scouring, dyeing leveling, finishing Low-foaming wetting penetrant, leveling agent, anti-redeposition agent Emulsion Polymerization Synthesis of polyacrylates, polyvinyl acetate, etc. Nonionic emulsifier, latex stabilizer, particle size control additive Defoamers Fermentation, food processing, industrial cleaning defoaming systems Defoamer component, carrier, synergist Cosmetics & Personal Care cial cleansers, shampoos, body washes, makeup removers Mild low-foaming surctant, foam regulator, active ingredient solubilizing carrier Pharmaceutical Preparations Oral liquids, topical preparations Solubilizer, emulsifier, micellar carrier Agrochemical Formulations Pesticide emulsifiable concentrates, soluble concentrates Low-foaming wetting spreading agent, emulsifier Application Recommendations Polyether L-64 is recommended to be added during the cooling or dilution stage of formulation development; moderate stirring ensures uniform dispersion. The specific dosage should be determined through experiments based on the formulation system and desired function. The product is insensitive to hard water ions, remains active over a wide pH range, and exhibits excellent compatibility with anionic, cationic, and other nonionic surctants, allowing flexible compounding. In defoaming and foam control applications, Polyether L-64 can be used directly as a defoamer component or as a carrier and synergist in combination with other active defoaming agents. In coatings and inks, it effectively reduces foam defects during spraying, roller coating, and other application processes, improving the surce quality of the coating film. Precautions It is recommended to wear protective gloves and goggles during operation to avoid prolonged skin contact and eye splashes. Ensure good ventilation in the usage area. The product is somewhat hygroscopic; after opening, it should be sealed and stored in a cool, dry, and well-ventilated place. Avoid direct discharge into waterways; the product has a relatively low inherent biodegradation rate. Store separately from incompatible substances such as strong oxidizers, strong acids, and strong bases.

Question 10

What are the physicochemical and technical parameters of Polyether L-64 and Pluronic L64?

Accepted Answer

Polyether L-64 (Pluronic L64) is a nonionic polymer surctant, appearing as a colorless to pale yellow transparent liquid at room temperature, with an HLB value of about 15, a cloud point of 61°C, and unique low-foaming characteristics. Its physicochemical parameters are comprehensive and suitable for various industrial formulations. Detailed Description Polyether L-64 (CAS No.: 9003-11-6), chemical name: polyoxyethylene-polyoxypropylene block copolymer, also known as Poloxamer 184, molecular formula: HO(C₂H₄O)ₓ(C₃H₆O)y(C₂H₄O)ₓH, average molecular weight of about 2900. This product is formed by block copolymerization of propylene oxide (PO) and ethylene oxide (EO). Its unique ABA-type triblock structure imparts excellent intercial activity and broad compatibility, making it a representative model in the poloxamer series with a balanced hydrophilicity-lipophilicity. From a physical property perspective, Polyether L-64 is a liquid at room temperature, with a pour point of about -20°C, maintaining good fluidity in low-temperature environments. Its density is approximately 1.06 g/cm³, refractive index between 1.458 and 1.460 (25°C), dynamic viscosity (low shear) of about 900 mPa·s, and kinematic viscosity of about 850 mm²/s. The flash point is greater than 230°C (closed cup), indicating a high flash point substance with low fire risk under normal operating conditions. The product is somewhat hygroscopic and should be stored sealed in a cool, dry place. Technical Parameters Parameter Value Product Name Polyether L-64 / Pluronic L64 (Poloxamer 184) CAS No. 9003-11-6 Ionic Type Nonionic Appearance (Room Temperature) Colorless to pale yellow transparent liquid Molecular Formula HO(C₂H₄O)ₓ(C₃H₆O)y(C₂H₄O)ₓH Average Molecular Weight Approx. 2900 HLB Value 15 Cloud Point (10% Aqueous Solution) 61°C Active Content ≥ 99% pH Value (1% Aqueous Solution) 5.5 - 7.5 pH Value (5% Aqueous Solution) 5.5 - 7.5 Density Approx. 1.06 g/cm³ Kinematic Viscosity (25°C) Approx. 850 mm²/s Low Shear Viscosity (25°C) Approx. 900 mPa·s Refractive Index (25°C) 1.458 - 1.460 Flash Point (Closed Cup) > 230°C Pour Point Approx. -20°C Surce Tension (0.1% Aqueous Solution, 25°C) Approx. 32 mN/m Critical Micelle Concentration CMC (25°C) Approx. 0.064% Hydroxyl Value 28 - 36 mgKOH/g Acid Value ≤ 0.5 mgKOH/g Saponification Value ≤ 1 mgKOH/g Iodine Value ≤ 1 Moisture Content ≤ 0.5% Heavy Metal Content ≤ 10 mg/kg Arsenic Content ≤ 2 mg/kg Solubility Easily soluble in water, ethanol, ether, and other organic solvents Foaming Characteristics Low foaming Alkali Resistance Good Hygroscopicity Hygroscopic Chemical Stability Stable under general conditions; avoid strong oxidizers Note: The above data are from the Guoli Chemical product database. Parameters such as amine value, tertiary amine value, free phosphoric acid, monoester/diester content, unsaturation, and penetrating power are not applicable for this product (shown as "None" or "Not available"). Application Suggestions Polyether L-64 has an HLB value of 15 and a cloud point of 61°C, indicating strong hydrophilicity. It is suitable as an emulsifier for O/W emulsions and as a wetting and dispersing agent in aqueous systems. Its low-foaming property makes it outstanding in high-pressure spray cleaning, CIP online cleaning, and circulating systems. It is recommended to add it during the cooling or dilution stage of formulation development. Moderate stirring ensures uniform dispersion. The specific dosage should be determined through experiments based on the actual application. Typical dosage reference (adjust according to actual formulation): as a wetting and dispersing agent, 0.1%-1.0%; as an emulsifier, 1%-5%; as a defoaming aid, 0.05%-0.5%. Precautions The product is hygroscopic. After opening, seal it promptly to avoid prolonged exposure to humid air. GHS classification: Skin irritation Category 2 (H316) and Eye irritation Category 2 (H320). It is recommended to wear protective gloves and goggles during handling. In case of eye contact, immediately rinse with plenty of water for several minutes. Remove contact lenses if present and continue rinsing. If irritation persists, seek medical attention. Store in a cool, dry, well-ventilated place away from strong oxidizers, strong acids, and strong bases, and avoid direct sunlight. Biodegradation rate is low; avoid direct discharge into natural water bodies.

Polyether L-64 / Pluronic L64

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Application Guidelines

Packaging and Storage

Polyether/Poloxamer Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

Related Products

Property	Value
CAS No.	9003-11-6
Molecular Formula	HO(C2H4O)x(C3H6O)y(C2H4O)xH
Appearance	Colorless to pale yellow transparent liquid
Ionic Type	Nonionic
Avg. Molecular Weight	Approx. 2900
Cloud Point	61°C (10%aq. soln.)
Active Content	≥99%
pH Value(1%)	5.5-7.5 (1%aq. soln.)
pH Value(5%)	5.5-7.5 (5%aq. soln.)
Iodine Value	≤1
Solubility	Readily soluble in water, ethanol, ethyl ether and other organic solvents
Surface Tension	~32 mN/m (0.1%aq. soln., 25°C)
CMC	~0.064% (25℃)
Acid Value	≤0.5
Saponification Value	≤1
Hydroxyl Value	28~36
Moisture	≤0.5
Density	~1.06
Kinematic Viscosity	~850 mm²/s (25°C)
Refractive Index	1.458-1.460 (25°C)
Flash Point	>230°C (closed cup)
Hygroscopicity	Hygroscopic
Chemical Stability	Stable under general conditions; avoid strong oxidizers
Foam Property	Low foam
Alkali Resistance	Good
Melting Point	Liquid; pour point ~-20°C
Low Shear Viscosity	~900 mPa·s (25℃)
Solid Content	≥99%
Heavy Metal	≤10 mg/kg
Arsenic	≤2 mg/kg

Polyether L-64 / Pluronic L64

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Application Guidelines

Packaging and Storage

Polyether/Poloxamer Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

Related Products

Premium Polyether F-6

OPE-108 (OPEP-108)

OPE-105 (OPEP-105)

Polyether F-68

Polyether F-38