Question 1

Is Tween T-80 harmful to humans? Does it have an impact on the environment?

Accepted Answer

Tween T-80 is classified as low toxicity and non-hazardous, posing no significant harm to human health or the environment. However, standard operating procedures should be followed to avoid direct contact, and untreated products must not be discharged directly into the environment. Detailed Explanation According to the GHS (Globally Harmonized System of Classification and Labeling of Chemicals), Tween T-80 is classified as a non-hazardous substance or mixture with no known significant hazards. Under normal use conditions, it poses no obvious danger to human health or the environment. As a classic non-ionic surctant, Tween T-80 is mild in nature and is widely used in fields with extremely high safety requirements, such as pharmaceutical injections, oral liquids, the food industry, and cosmetics. This widespread use itself fully demonstrates its good human safety profile. In terms of operational safety, although the product itself is of very low toxicity, it is still recommended to wear chemical protective gloves and goggles to avoid prolonged or repeated direct contact with eyes and skin. Use in a well-ventilated area, avoid prolonged inhalation of vapors or mists, and thoroughly wash hands and exposed skin after handling. In case of skin contact, rinse immediately with soap and plenty of water; if it gets into the eyes, rinse with running water for at least 15 minutes and seek medical attention promptly. Regarding the ecological environment, Tween T-80 exhibits low toxicity to aquatic organisms and has no significant ecotoxicity at recommended usage and normal discharge concentrations. Based on its raw material composition, the product is biodegradable and does not persist in the environment. Special attention should be paid to prevent large spills from forming a physical film on the water surce, which could hinder oxygen exchange and cause local hypoxia. Therefore, undiluted or untreated products must not be directly discharged into drainage systems, surce water, or groundwater. Technical Parameters ItemData GHS ClassificationNon-hazardous substance or mixture Human Health RiskNo known significant hazards, no obvious danger under normal use conditions Aquatic ToxicityLow toxicity, no significant ecotoxicity at recommended usage concentrations BiodegradabilityBiodegradable Recommended Storage Temperature10-30°C, avoid freezing and excessive heat Application Recommendations Due to its mild and low-toxicity characteristics, Tween T-80 is approved for use in several sensitive fields: In pharmaceutical preparations, it serves as an efficient solubilizer and emulsifier for injections and oral liquids, ensuring the bioavailability of active ingredients. In the food industry, it is used as an emulsifier and stabilizer for products such as ice cream, baking ts, and beverages. In cosmetics and personal care products, it is used in creams, lotions, and cleansing oils to provide a refreshing skin feel. Precautions It is recommended to wear chemical protective gloves and goggles during operation to avoid direct contact with eyes and skin. Use in a well-ventilated area to avoid prolonged inhalation of vapors or mists. Store in a cool, dry, and well-ventilated place, keep containers sealed, and away from strong oxidizers. Do not discharge untreated products directly into drainage systems or natural water bodies. In case of large spills, use inert absorbent materials (such as sand, vermiculite) to contain and collect, and dispose of according to local regulations. In case of fire, suitable extinguishing agents: water spray, alcohol-resistant foam, dry powder, carbon dioxide.

Question 2

What should I do if problems occur during the use of Tween 80? How to get technical support?

Accepted Answer

If you encounter problems during the use of Tween 80, it is recommended to first check common causes based on the phenomenon. If the problem cannot be resolved, contact Haian Guoli Chemical Co., Ltd. for professional technical support. Detailed Explanation Tween 80 is a classic nonionic surctant. Problems encountered during use are usually related to poor emulsification, incomplete dissolution, product delamination, or low-temperature effects. First, check whether the storage conditions meet the requirements (cool, dry, ventilated, 10-30°C). Because Tween 80 is hygroscopic, prolonged exposure to humid air may increase its moisture content and affect performance. Second, confirm the pH environment during use—this product will hydrolyze under strong acid or strong alkaline conditions, which may lead to performance degradation. If the problem is related to the formulation application, it is recommended to investigate from the following aspects: whether the HLB value of the system matches, whether the addition sequence is correct, whether there are incompatible additives (e.g., strong oxidizers), and whether the water temperature or stirring is sufficient. The HLB value of Tween 80 is 15, suitable for O/W emulsification systems. If the required HLB value of the oil phase deviates greatly, the emulsification effect will be significantly weakened. Its cloud point is approximately 93°C (1% aqueous solution). If the operating temperature approaches or exceeds the cloud point, the surce activity will drop sharply, leading to demulsification or turbidity. If the above self-check still does not resolve the issue, or if you encounter batch quality problems or technical difficulties, the most direct and effective approach is to contact the product supplier or manucturer. You can call Guoli Chemical's sales or technical support hotline and explain to the technician the specific application scenario, dosage ratio, process conditions, and abnormal phenomena observed. It is recommended to prepare the batch number, usage records, and environmental parameters in advance so that the technician can quickly locate the problem. Technical Parameters The following are key technical indicators closely related to troubleshooting. You can refer to them when communicating with the technician: Parameter ItemTypical ValueImpact on Usage AppearanceLight yellow to amber liquidSignificant darkening may indicate oxidation or decomposition HLB Value15Determines emulsification/solubilization suitability; deviation affects emulsion stability Cloud Point (1% aqueous solution)Approx. 93°COperating temperature approaching or exceeding this value leads to functional ilure pH of 1% Aqueous Solution5.0–7.0Deviation from normal range indicates possible product deterioration Moisture Content≤3.0%Increased moisture after moisture absorption reduces effective component ratio Chemical StabilityHydrolyzes under strong acid/alkaliExtreme pH environment damages product structure, loses emulsifying power Active Substance Content≥97%Directly affects effective dosage Application Recommendations Emulsification ilure or delamination: First, verify whether the required HLB value of the oil phase is close to 15. If not, adjust by combining with other emulsifiers. Confirm the addition sequence: first dissolve Tween 80 in the water phase, then slowly add the oil phase while stirring at high speed. Poor solubility or turbidity: Tween 80 is easily soluble in water but has high viscosity at low temperatures (about 600 mPa·s at 25°C). It is recommended to warm it up at 20-30°C before use and pre-dilute with warm water while stirring to avoid adding directly to cold water and causing air bubbles through vigorous stirring. Insufficient spreading ability in agricultural or coating applications: Check whether the water hardness is too high or pH is alkaline; add chelating agents or buffers if necessary. Tween 80 has relatively poor alkali resistance; strong alkaline environments will cause it to lose wetting and spreading ability. Batch variation in pharmaceutical/food applications: Such applications require strict checking of batch numbers and quality standards. If allergic reactions or abnormalities occur, stop using immediately and submit samples to the manucturer for re-testing. Injectable-grade for pharmaceutical use has extremely strict requirements; do not change suppliers arbitrarily without explicit permission from the manucturer. How to Get Technical Support According to the product database, there is currently no direct online contact information. It is recommended to obtain official technical support through the following channels: Contact the purchase channel: Ask the dealer or trader from whom you purchased Tween 80 to provide the manucturer's technical service hotline. Check the official website: Visit the official website of Haian Guoli Chemical Co., Ltd. and look for phone numbers and emails under "Contact Us" or "Technical Support". Send samples: Send the problematic batch sample along with a detailed description (usage process, additives, problem description, photos) to Guoli Chemical's technical department for analysis. Safety emergencies: In case of leakage, human exposure, or accidental ingestion, refer to the emergency measures in the product safety data sheet and seek immediate medical attention; also call the manucturer to report the incident.

Question 3

How to purchase Tween T-80? What is the minimum order quantity?

Accepted Answer

Purchase of Tween T-80 can be directly contacted with the sales team of Haian Guoli Chemical Co., Ltd. The minimum order quantity is subject to actual consultation confirmation. The conventional packaging specifications are 50kg and 200kg plastic drums. Detailed Description Tween T-80 (CAS No.: 9005-65-6) is a regular product of Guoli Chemical, with the chemical name polyoxyethylene (20) sorbitan monooleate, which belongs to nonionic surctants. This product is widely used in multiple industries such as pharmaceuticals, food, cosmetics, textiles, coatings, pesticides, etc. It is one of the company's standardized products with stable supply. According to the database information, the standard packaging specification of Tween T-80 is 50kg/200kg plastic drum. The product price is quoted in "yuan/ton", and the actual quotation needs to contact the sales team of Guoli Chemical for the latest price, because the chemical raw material market fluctuates, and the reference price in the database is time-sensitive. You can directly inquire about procurement matters through Guoli Chemical's official website, customer service phone, or corporate email. Regarding the Minimum Order Quantity (MOQ): There is currently no clear minimum order quantity parameter in the database. Usually, Guoli Chemical sets a minimum order quantity based on packaging specifications. It is recommended that you directly contact the sales department, explain your required usage and industry, and the sales team will provide you with targeted quotations, sample applications, and ordering solutions. Packaging Specifications Packaging TypeSpecificationRemarks Plastic drum50 kg/drumSuitable for small and medium users Plastic drum200 kg/drumSuitable for large-scale industrial users Application Suggestions Before placing an order, it is recommended that you confirm whether the product specifications meet your needs based on the application scenario: Pharmaceutical/Food grade requirements: Please clearly inform the sales team so that product batches meeting pharmacopoeia or food additive standards can be provided. Industrial grade requirements: Can be used in coatings, textiles, pesticide emulsification, daily chemical cleaning, etc. Standard industrial grade products can meet the needs. Sample testing: If using for the first time, you can apply for free samples from Guoli Chemical for compatibility tests, and confirm the effect before batch procurement. Precautions The product has slight hygroscopicity. After receipt, it should be sealed and stored immediately in a cool and dry place. The recommended storage temperature is 10-30°C. The product is non-hazardous. There are no special transportation restrictions, but exposure to direct sunlight and inverted leakage should be avoided. The price is affected by ctors such as raw material market conditions, order quantity, payment method, etc., and the final price is subject to the sales contract.

Question 4

Does Tween-80 meet environmental requirements? Can a test report be provided?

Accepted Answer

Tween-80 has good environmental performance, but the specific impact on the ecology needs to be evaluated based on the application scenario. Specific test reports need to be obtained from Guoli Chemical officially. Detailed Explanation According to China's GHS classification standards, Tween-80 (CAS: 9005-65-6) is classified as a non-hazardous substance or mixture, and under normal use conditions, it poses no significant harm to human health or the environment. This product is a classic non-ionic surctant, and its raw material composition determines that it has a certain degree of biodegradability. When used at recommended concentrations and discharged properly, it will not cause significant toxic effects on aquatic ecology. From an ecotoxicological perspective, Tween-80 has low toxicity to aquatic organisms, with no significant risk of ecological toxicity accumulation at recommended application concentrations. However, special attention should be paid to the ct that if a large spill occurs into water bodies, the product may form a physical oil film on the water surce, hindering oxygen exchange, thereby indirectly causing local hypoxia. Therefore, during use, environmental regulations must be strictly followed, and untreated materials must not be directly discharged into drainage systems or natural water bodies. Unlike some surctants containing phosphorus or heavy metals, Tween-80 does not involve components that pose persistent risks to the environment during production and use. It aligns with the current development trend of green chemistry and human/environment-friendly auxiliaries, and has been widely recognized and long-term applied in fields with strict environmental and safety requirements, such as pharmaceuticals, food, and cosmetics. Environmental Performance Overview Environmental IndicatorData/Description GHS Hazard ClassificationNon-hazardous substance or mixture Aquatic ToxicityLow toxicity (no significant ecological toxicity at normal use concentration) BiodegradabilityBiodegradable (based on raw material composition) Heavy Metal Content≤10 ppm Arsenic Content≤2 ppm Phosphorus Content (free phosphoric acid/combined phosphorus)None pH Value (1% or 5% aqueous solution)5.0–7.0 Risk of Large SpillsMay form a physical film on the water surce, affecting oxygen exchange Note: The above data is from Guoli Chemical product database. Regarding Test Reports Routine ctory inspections of this product cover core indicators such as appearance, active content (≥97%), acid value (≤2.0), saponification value (45–55), hydroxyl value (65–80), moisture (≤3.0%), pH value (5.0–7.0), heavy metal and arsenic content. Currently, the above parameters have been stated in our communication, but the database does not yet contain electronic versions of independent third-party environmental test reports (such as RoHS, REACH, biodegradability test reports, acute aquatic toxicity reports, etc.) that can be directly downloaded. If you need a formal stamped Certificate of Analysis (COA) or specific environmental compliance test reports, it is recommended to directly contact Guoli Chemical's sales or quality control department. They can provide corresponding batch test data and compliance documents based on your specific application (e.g., REACH compliance statement required for export to the EU, pharmaceutical excipients meeting pharmacopoeia standards, etc.). Precautions Do not directly discharge undiluted or untreated Tween-80 into environmental water bodies or soil. In case of a spill, immediately contain it with an inert absorbent material and dispose of waste according to local environmental regulations, avoiding entry into drainage systems. The product may hydrolyze under strong acid or strong alkali conditions, affecting its performance and degradation behavior; such extreme conditions should be avoided as much as possible.

Question 5

What are the advantages of Tween T-80 compared to other similar products?

Accepted Answer

According to the technical data from Guoli Chemical, the database does not currently include detailed comparison data with other similar Tween series products (such as Tween T-20, Tween T-60, etc.), so direct horizontal parameter comparison cannot be provided. However, based on the available product data for Tween T-80, its own technical characteristics and application advantages can be explained. --- ## Core Technical Advantages of Tween T-80 According to the technical data from Guoli Chemical, Tween T-80 (Polyoxyethylene (20) Sorbitan Monooleate), as a classic nonionic surctant, has advantages mainly reflected in the following aspects: ### 1. Excellent Hydrophilic-Lipophilic Balance Performance Tween T-80 has an HLB value of up to 15, making it a typical O/W emulsifier. It can significantly reduce the oil-water intercial tension, forming a stable, fine oil-in-water emulsion system. This characteristic gives it outstanding emulsifying and solubilizing capabilities in water-based formulations. ### 2. Efficient Solubilization and Emulsifying Capacity | Performance Indicator | Value | Technical Significance | |---------|------|---------| | HLB Value | 15 | Strong hydrophilicity, suitable for O/W emulsion systems | | Critical Micelle Concentration (CMC) | 1.3×10⁻⁵ mol/L | Extremely low CMC value indicates excellent solubilization effect at low concentrations | | Surce Tension (0.1% aqueous solution) | 42.5 mN/m | Effectively reduces surce tension, good wetting and spreading | | Monoester Content | ≥70% | High monoester content ensures stable emulsifying performance | | Diester Content | ≤10% | Low diester content ensures emulsion stability | ### 3. Broad Application Compatibility Tween T-80 is a **nonionic** surctant with stable chemical properties. It maintains excellent performance in acid, alkali, and hard water environments, and has good compatibility with ionic and nonionic additives. This characteristic allows it to be flexibly applied across different industries and systems. ### 4. High Purity and Low Safety Risk According to the technical data from Guoli Chemical, key quality indicators of the product are strictly controlled: | Quality Indicator | Guoli Chemical Standard | |---------|--------------| | Active Content | ≥97% | | Acid Value | ≤2.0 mgKOH/g | | Moisture | ≤3.0% | | Heavy Metals | ≤10 ppm | | Arsenic | ≤2 ppm | | Iodine Value | ≤2 g/100g | The product has high purity and low impurities (especially extremely low heavy metals and arsenic content), meeting strict requirements of high-end fields such as food grade and pharmaceutical grade. It is classified as a non-hazardous substance according to GHS classification, with a high safety ctor. ### 5. Cross-Industry Multi-Field Applicability With excellent emulsifying, solubilizing, dispersing, wetting, and other properties, Tween T-80 is widely used in pharmaceutical preparation solubilization, food emulsification stabilization, cosmetic emulsification and solubilization, textile antistatic softening, water-based coating pigment dispersion, pesticide emulsifiable concentrate emulsification, petroleum drilling fluids, and daily chemical cleaning agents. ### 6. Eco-Friendly Tween T-80 is biodegradable and has low toxicity to aquatic organisms, aligning with the trend of green chemistry applications. --- ## Application Suggestions - **General Emulsification/Solubilization Dosage**: Suggested dosage is 0.1% to 5% (based on total formulation weight). Specific ratios need to be adjusted according to the system. - **Combination Use**: Often used in combination with Span series to obtain emulsion systems with different HLB values to meet specific application needs. --- ## Reminder For detailed parameter comparison with other Tween series products from Guoli Chemical (such as Tween T-20, Tween T-60, Tween T-85, etc.), it is recommended to contact the sales or technical department of Guoli Chemical to obtain a complete product data manual for targeted solution evaluation.

Question 6

How to store Tween T-80? What is the shelf life?

Accepted Answer

Tween T-80 should be stored in a cool, dry, well-ventilated place in a tightly sealed container. The recommended temperature is 10-30°C. Under recommended storage conditions, the typical shelf life is 2 years. Detailed Explanation Tween T-80 (Polysorbate 80) is a classic non-ionic surctant with slight hygroscopicity. The core principles for its storage are moisture prevention, heat prevention, and contamination prevention. The product is chemically stable under normal conditions, but it may undergo hydrolysis when exposed to strong acids or strong alkalis, so it must be kept away from such incompatible substances. Following the safety guidelines from Guoli Chemical and strictly adhering to storage specifications ensures that the product's performance does not significantly degrade within its shelf life. Regarding the shelf life, the Guoli Chemical product database does not provide an exact shelf life value. Based on general industry standards and the chemical stability of Tween T-80, under unopened conditions and with proper storage as mentioned, the typical shelf life is 2 years from the date of manucture. It is recommended that users follow the specific expiration date indicated on the product outer packaging label, use the product as soon as possible after opening, and reseal the container tightly after each use. Storage Conditions and Technical Points Storage ItemSpecific Requirement Environmental RequirementsCool, dry, well-ventilated dedicated warehouse Temperature RangeRecommended 10-30°C; avoid freezing (low melting point, liquid form) and excessively high temperatures Container StatusMust remain tightly sealed; after opening and use, immediately reseal and keep labels clear Keep Away from Hazard SourcesKeep away from heat sources, sparks, open flames, strong oxidizers, strong acids, strong alkalis, and other incompatible substances Hygroscopicity ManagementThe product is hygroscopic; prevent moisture ingress into the container to avoid increased water content Emergency TemperatureFlash point >149°C, but still avoid extremely high temperatures to prevent decomposition Shelf Life and Quality Monitoring Recommendations Although the typical shelf life is 2 years, for products stored long-term or under harsh conditions, it is recommended to check key quality indicators before use. Focus on appearance (should be a pale yellow to amber liquid, no stratification or turbidity), pH value (1% aqueous solution should be within 5.0-7.0), acid value (should be ≤2.0 mgKOH/g), and moisture content (should be ≤3.0%). If these indicators deviate from the normal range, it may indicate that the product has undergone hydrolysis or moisture absorption deterioration and should not be used. In fields with strict microbiological requirements, such as pharmaceuticals and food, products stored for extended periods after opening should also be checked for microbial limits. It is recommended to re-test according to relevant pharmacopoeia or national standard methods before use to ensure safety. Precautions Strictly avoid mixing with water and impurities: Tools used for dispensing must be clean and dry to avoid introducing contaminants that could cause product deterioration. Packaging selection: The standard packaging provided by Guoli Chemical is 50kg/200kg plastic drums, suitable for routine storage. When repackaging, also choose containers with good sealing properties. Prevent physical water pollution: If a large spill occurs into water bodies, although the product itself has low ecotoxicity, the surce film it forms may impede oxygen exchange, causing localized hypoxia in the aquatic environment. Dispose of waste in accordance with local regulations.

Question 7

What safety precautions should be taken when using Tween T-80?

Accepted Answer

Tween T-80 is a non-hazardous substance, with no significant harm to humans and the environment under normal use conditions, but basic safety operating procedures should still be followed to ensure safe use. Detailed Description Tween T-80 (Polyoxyethylene (20) sorbitan monooleate) is a classic non-ionic surctant. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), this product is classified as a non-hazardous substance or mixture. It has mild properties and low toxicity to aquatic organisms, and is widely used in fields with high safety requirements such as pharmaceuticals, food, and cosmetics, fully demonstrating its good safety characteristics. Although Tween T-80 itself has relatively high safety, precautions should still be taken during industrial operations: it is recommended to wear chemical protective gloves and goggles during operation to avoid direct contact with eyes and skin; use in a well-ventilated area to avoid prolonged inhalation of vapors or mists; after operation, thoroughly wash hands and exposed skin areas. The workplace should follow good industrial hygiene practices, prohibit eating and smoking, keep work surces clean, and avoid the formation of dust-air mixtures. From an ecological perspective, this product has no significant ecotoxicity at recommended use and normal discharge concentrations and is biodegradable. However, it should be noted that large spills into water bodies can form a physical film on the surce, which may affect oxygen exchange and cause local hypoxia. Therefore, it is prohibited to discharge undiluted or untreated product directly into the environment or drainage system. Safety Operation and Storage Requirements ItemSpecific Requirements Personal ProtectionWear chemical protective gloves and goggles to avoid direct contact with eyes and skin Operating EnvironmentUse in a well-ventilated area, avoid prolonged inhalation of vapors or mists Post-operation HandlingThoroughly wash hands and exposed skin Storage TemperatureRecommended 10–30°C, avoid freezing and excessive heat Container RequirementsKeep completely sealed to prevent moisture absorption and contamination; reseal after opening Incompatible SubstancesHeat sources, sparks, open flames, and strong oxidizers Storage EnvironmentCool, dry, well-ventilated dedicated storage area Emergency Handling Guidelines Spill Emergency Procedures Wear appropriate personal protective equipment. Contain and absorb the spilled liquid with inert absorbent materials (such as sand, vermiculite, universal absorbent). Collect the contaminated material in a sealable waste container and dispose of according to local regulations. Prevent the spill from entering drainage systems, surce water, and groundwater. First Aid Measures Inhalation: Move the patient to fresh air and keep at rest. If breathing difficulties or persistent discomfort occur, seek medical attention immediately. Skin Contact: Immediately remove contaminated clothing and thoroughly wash skin with soap and plenty of water. If irritation or rash occurs, seek medical attention. Eye Contact: Rinse the conjunctival sac continuously with running water or saline solution for at least 15 minutes. If wearing contact lenses, remove them if easy to do so and continue rinsing. If irritation persists, seek medical attention immediately. Ingestion: Rinse mouth with water, do not induce vomiting. Seek medical attention immediately and show the product container or label. Never give anything by mouth to an unconscious person. Firefighting Measures Suitable extinguishing media: water spray, alcohol-resistant foam, dry powder, carbon dioxide. Wear self-contained breathing apparatus and full protective clothing when fighting fire. Fire may produce irritating or toxic gases such as carbon monoxide and carbon dioxide. Use water spray to cool unaffected containers. Precautions Although Tween T-80 is a non-hazardous substance, prolonged direct contact may still cause skin irritation. It is recommended to develop the habit of wearing protective equipment during operation. The product is prone to moisture absorption after opening; be sure to reseal promptly to maintain product performance stability. Large spills into water bodies may cause physical hazards (surce film effect); ensure spill prevention and control. Disposal must follow local regulations; do not dump indiscriminately.

Question 8

How to use Tween T-80? What is the recommended dosage?

Accepted Answer

Tween T-80 (Polyoxyethylene (20) Sorbitan Monooleate) is a classic O/W nonionic emulsifier with an HLB value as high as 15. Its usage and dosage vary significantly depending on the application field, typically involving direct addition to the oil or water phase with stirring to dissolve. Detailed Instructions Tween T-80 is a light yellow to amber viscous liquid at room temperature (viscosity about 600 mPa·s at 25°C). It is easily soluble in water, benzene, and organic solvents. When used, it can be directly added to the oil or water phase of the system to be emulsified and stirred to dissolve. Due to its hygroscopic nature, the product should be used promptly after opening and resealed for storage. For solubilization of poorly soluble substances, Tween T-80 is generally pre-mixed with the substance to be solubilized (such as fragrances, essential oils, t-soluble drugs, etc.) until uniform, then water is slowly added with continuous stirring to form a clear or translucent solubilized system. As a high HLB value (15) O/W emulsifier, Tween T-80 is often used in combination with low HLB emulsifiers (such as Span series) to achieve a wider emulsification range and a more stable emulsion system. Its cloud point is approximately 93°C (1% aqueous solution), providing good stability in high-temperature processes. The product is chemically mild and maintains good performance in acidic, alkaline, and hard water environments. However, it should be noted that hydrolysis may occur under strong acidic or alkaline conditions, so long-term use in such extreme environments is not recommended. Regarding dosage: Insufficient addition will not achieve the desired emulsification and solubilization effect, while excessive amounts may cause stickiness, increased foaming, or cost waste. It is recommended to determine the optimal dosage for a specific formula through small-scale trials. The Guoli Chemical database does not provide precise dosage data for each specific application area; the following recommended dosages are general reference ranges based on industry practical experience. Technical Parameters Parameter ItemValueData Source AppearanceLight yellow to amber liquidGuoli Chemical Database Ionic TypeNonionicGuoli Chemical Database HLB Value15Guoli Chemical Database Active Content≥97%Guoli Chemical Database pH Value (1% Aqueous Solution)5.0～7.0Guoli Chemical Database Density (25°C)1.06～1.10 g/cm³Guoli Chemical Database Viscosity (25°C)About 600 mPa·s (low shear)Guoli Chemical Database Kinematic Viscosity (40°C)About 425 mm²/sGuoli Chemical Database Cloud Point (1% Aqueous Solution)About 93°CGuoli Chemical Database Surce Tension (0.1% Aqueous Solution)42.5 mN/mGuoli Chemical Database Critical Micelle Concentration (CMC)1.3×10⁻⁵ mol/LGuoli Chemical Database Hydroxyl Value65～80 mgKOH/gGuoli Chemical Database Saponification Value45～55 mgKOH/gGuoli Chemical Database Acid Value≤2.0 mgKOH/gGuoli Chemical Database Moisture Content≤3.0%Guoli Chemical Database Flash Point>149°CGuoli Chemical Database SolubilityEasily soluble in water, benzene, and organic solventsGuoli Chemical Database Application Recommendations The following are recommended usage methods and dosage ranges for typical application fields (based on general industry experience; actual dosage should be verified through small-scale trials): Pharmaceutical Preparation Solubilization: Premix Tween T-80 with poorly soluble drugs, then slowly add water for injection or buffer solution with stirring to dissolve. Recommended dosage: Generally 5 to 20 times the drug amount, with a final concentration of 0.5% to 5% in the product. For injectable preparations, strictly follow pharmacopoeia standards and use injection-grade product. Food Emulsification and Stabilization: Directly add to the oil phase, heat to melt, then mix with the water phase and homogenize, or use in combination with other emulsifiers. Recommended dosage: 0.1%～0.5% for bakery products, 0.1%～0.3% for ice cream and dairy products, 0.05%～0.1% for beverages (based on total product weight). Cosmetic Creams/Lotions: Add to the oil phase as the primary emulsifier (can be combined with

Question 9

In which industries and processes is Tween T-80 mainly used?

Accepted Answer

Tween T-80 is widely used in eight major industries including pharmaceuticals, food, cosmetics, textiles, coatings, pesticides, petroleum, and daily chemicals, playing a core role as an efficient emulsifier, solubilizer, dispersant, and wetting agent. Detailed Description Tween T-80 (Polyoxyethylene (20) sorbitan monooleate) is a classic nonionic surctant with an HLB value of approximately 15.0. It is a hydrophilic emulsifier, particularly suitable for O/W (oil-in-water) emulsion systems. With excellent hydrophilic-lipophilic balance and broad-spectrum chemical compatibility, Tween T-80 maintains outstanding stability in acidic, alkaline, and hard water environments. It can be well compounded with both ionic and nonionic auxiliaries, making it one of the most widely used surctants across industries. In the pharmaceutical field, Tween T-80 is used as an efficient solubilizer for poorly soluble drugs and as an emulsifier for injections, oral solutions, and topical ointments, significantly improving the bioavailability and formulation stability of active pharmaceutical ingredients. In the food industry, it serves as an emulsifier and stabilizer for products such as ice cream, baking oils, and beverages, enhancing texture, consistency, and shelf life. In cosmetics and personal care, Tween T-80 performs emulsification and solubilization functions in creams, lotions, makeup removers, and perfumes, helping to uniformly disperse oily ingredients and fragrances while providing a refreshing skin feel. In industrial fields, Tween T-80 also excels: in textile processing, it acts as an antistatic agent and softener component to reduce static electricity accumulation in synthetic fibers; in water-based coatings and inks, it serves as a pigment dispersant and emulsion polymerization emulsifier; in pesticide formulations, it functions as an emulsifier for emulsifiable concentrates and a tank-mix spreader to enhance spreading and penetration; in petroleum drilling fluids, it acts as an emulsifier to ensure system stability under extreme conditions; in daily chemical cleaners, it is used to solubilize fragrances and oils, improving detergency and product transparency. Application Overview Industry Process/Use Functional Role Pharmaceutical Preparations Preparation of injections, oral solutions, topical ointments Solubilizer, O/W emulsifier, enhancing drug bioavailability Food Industry Production of ice cream, baking oils, beverages Emulsifier, stabilizer, dispersant Cosmetics & Personal Care Formulation of creams, lotions, makeup removers, perfumes Emulsifier, solubilizer, uniformly dispersing oily ingredients and fragrances Textiles & Fibers Spinning oils for synthetic fibers, finishing treatments Antistatic agent, softener component Coatings & Inks Production of water-based coatings and inks; emulsion polymerization Pigment wetting dispersant, emulsion polymerization emulsifier Agrochemicals Formulation of pesticide emulsifiable concentrates and water emulsions; tank-mix use Emulsifier, spreader, enhancing spreading and penetration Petroleum & Industrial Lubricants Preparation of drilling fluids, metalworking fluids Emulsifier, lubricant component, ensuring system stability Daily Chemical Cleaning Formulations for laundry detergents, kitchen cleaners, etc. Solubilizer, improving detergency and product transparency Application Recommendations As an O/W emulsifier, Tween T-80 is often compounded with Span series (e.g., Span S-80) to achieve better emulsification effects. In practical formulations, it is recommended to adjust the ratio with Span emulsifiers based on the HLB value requirement of the target system. For water-based coatings and inks, it is recommended to add it during the pigment grinding stage for optimal wetting and dispersion. In pesticide emulsifiable concentrate formulations, the recommended addition amount is 8%-15% of the active ingredient content (specific adjustment based on the characteristics of the active ingredient). For pharmaceutical and food grade applications, product specifications meeting relevant pharmacopoeia standards (e.g., ChP, USP, EP) should be selected. Precautions This product is not classified as hazardous, but it is still recommended to operate in a well-ventilated area and wear chemical protective gloves and safety goggles. Recommended storage temperature: 10-30&deg;C, avoid freezing and excessive heat; keep containers sealed and protected from moisture. Do not discharge undiluted or untreated product directly into water bodies. For pharmaceutical and food grade applications, ensure the product meets relevant regulatory and standard requirements. Incompatible with strong oxidizing agents; avoid mixed storage.

Question 10

What are the physicochemical and technical parameters of Tween T-80?

Accepted Answer

Tween T-80 is a pale yellow to amber viscous liquid nonionic surctant, with an HLB value as high as 15. It is easily soluble in water and organic solvents and has excellent comprehensive physicochemical properties. It is a classic O/W emulsifier and solubilizer. Detailed Description Tween T-80 (Polyoxyethylene (20) sorbitan monooleate, CAS 9005-65-6) is a classic nonionic surctant product produced by Guoli Chemical. Its molecular formula is C64H124O26, with a molecular weight of approximately 1310. It appears as a pale yellow to amber viscous liquid with a slight characteristic odor and hygroscopicity. The product has an HLB value as high as 15, making it a hydrophilic surctant especially suitable for preparing oil-in-water (O\/W) emulsion systems. It is widely used in pharmaceutical, food, cosmetic, and industrial fields. Under normal storage conditions, this product is chemically stable, but it may hydrolyze under strong acid or strong alkaline environments. Therefore, pH control in the formulation is important. Tween T-80 exhibits low foaming properties, relatively poor penetration, and average alkali resistance, but it has excellent emulsifying and solubilizing abilities. Its critical micelle concentration (CMC) is 1.3×10-5 mol\/L, indicating that it can form micelles and exert solubilizing effects at very low concentrations. In terms of product specifications, Guoli Chemical's Tween T-80 has an active content of ≥97%, moisture ≤3.0%, acid value ≤2.0 mgKOH\/g, heavy metals (as Pb) ≤10 ppm, and arsenic ≤2 ppm, meeting the stringent standards for pharmaceutical and food applications. The product is packaged in 50 kg or 200 kg plastic drums, with a recommended storage temperature of 10-30°C, and should be kept sealed and moisture-proof. Technical Parameters Parameter Name Technical Index Chemical Name Polyoxyethylene (20) sorbitan monooleate CAS No. 9005-65-6 Molecular Formula C64H124O26 Molecular Weight Approx. 1310 Ionic Type Nonionic Appearance (25°C) Pale yellow to amber viscous liquid HLB Value 15 Cloud Point (1% Aqueous Solution) Approx. 93°C Active Content ≥97% Moisture ≤3.0% pH (1% Aqueous Solution) 5.0-7.0 pH (5% Aqueous Solution) 5.0-7.0 Density (25°C) 1.06-1.10 g\/cm³ Refractive Index 1.472-1.476 Viscosity (25°C, Low Shear) Approx. 600 mPa·s Kinematic Viscosity (40°C) Approx. 425 mm²\/s Flash Point >149°C Acid Value ≤2.0 mgKOH\/g Saponification Value 45-55 mgKOH\/g Hydroxyl Value 65-80 mgKOH\/g Iodine Value ≤2 gI₂\/100g Surce Tension (0.1% Aqueous Solution) 42.5 mN\/m Critical Micelle Concentration (CMC) 1.3×10-5 mol\/L Monoester Content ≥70% Diester Content ≤10% Free Alcohol ≤2% Heavy Metals (as Pb) ≤10 ppm Arsenic (As) ≤2 ppm Solubility Easily soluble in water, benzene, and organic solvents Foam Performance Low foaming Chemical Stability Stable under normal conditions; hydrolyzes under strong acid and strong alkali Parameter Interpretation and Application Suggestions Emulsifying characteristics of HLB value 15: The high HLB value gives Tween T-80 strong hydrophilicity, making it an ideal O\/W emulsifier. In pharmaceutical emulsions, cosmetic creams, and food emulsions, the recommended dosage is 5%-20% of the oil phase weight. The preferred emulsification method is to compound it with low HLB value emulsifiers (such as Span series) to achieve more stable emulsification results. For example, compounding with Span 80 (HLB 4.3) in a certain proportion can precisely adjust the system HLB value to meet different oil phase requirements. High CMC and solubilizing ability: The CMC of 1.3×10-5 mol\/L indicates that micelles can be formed at very low concentrations, which is crucial for solubilizing poorly soluble drugs. In pharmaceutical injections, Tween T-80 is recognized as an efficient solubilizer, but the actual dosage must follow pharmacopoeia and relevant regulatory guidelines. Generally, the recommended concentration in injections should not exceed 1%-2%. Viscosity and operation guidelines: The product has a low-shear viscosity of about 600 mPa·s at 25°C, indicating a certain thickness. The viscosity increases further at low temperatures. It is recommended to allow the product to warm up to 20-30°C before operation to cilitate drum pouring and pumping. For pumping, gear pumps or diaphragm pumps suitable for medium viscosity liquids should be used. Precautions Acid and alkali limitations: Tween T-80 will hydrolyze under strong acid (pH11) environments. When designing formulations, the system pH should be controlled within the range of 5-8 to ensure product stability. Peroxidation risk: As a product containing unsaturated tty acid esters, prolonged exposure to air and light may lead to the formation of peroxides. Particularly for pharmaceutical-grade applications, attention should be paid to the peroxide value indicator. It is recommended to seal with an inert gas (such as nitrogen). Cloud point adaptation: The cloud point of a 1% aqueous solution is about 93°C. In pharmaceutical preparations requiring high-temperature sterilization (121°C), phase separation may occur. The tolerance should be evaluated during formulation.

Tween T-80 (Polysorbate 80)

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Property	Value
CAS No.	9005-65-6
Molecular Formula	C64H124O26
Appearance	Pale yellow to brownish-yellow oily viscous liquid
Ionic Type	Nonionic
Avg. Molecular Weight	~1310
Cloud Point	~93 (1%aq. soln.)
Active Content	≥97
pH Value(1%)	5.0-7.0
pH Value(5%)	5.0-7.0
Iodine Value	≤2
Solubility	Readily soluble in water, ethanol
Surface Tension	42.5 (0.1%aq. soln.)
CMC	1.3×10^-5 mol/L
Acid Value	≤2.0
Saponification Value	45~55
Hydroxyl Value	65~80
Moisture	≤3.0
Density	1.06~1.10
Kinematic Viscosity	~425 (40°C)
Refractive Index	1.472~1.476
Flash Point	>149
Hygroscopicity	Hygroscopic
Chemical Stability	Stable under normal conditions; hydrolyzes under strong acid/alkali
Penetration	Poor
Foam Property	Low foam
Alkali Resistance	Poor
Unsaturation	Low
Viscosity	~600 mPa·s (25°C)
Melting Point	Liquid
Monoester Content	≥70
Diester Content	≤10
Low Shear Viscosity	~600 mPa·s
Solid Content	≥97
Free Alcohol	≤2
Heavy Metal	≤10
Arsenic	≤2

Tween T-80 (Polysorbate 80)

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Packaging and Storage

Tween / Polysorbate Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

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