Question

Is polypropylene glycol PPG-600 harmful to the human body? Does it have an impact on the environment?

Answer
2026-06-06 官方文档 聚丙二醇PPG-600

Polypropylene glycol PPG-600 is a low-toxicity substance and has no significant harm to human health under normal use conditions; it has low aquatic toxicity and is not easily bioaccumulated in the environment, but direct discharge into water bodies should be avoided.

Detailed Description

Impact on Human Health

According to the safety data from the Guoli Chemical Product Database, polypropylene glycol PPG-600 is not classified as a dangerous substance under GHS classification. Its acute oral toxicity LD₅₀ is greater than 2,000 mg\/kg (rat), indicating low toxicity. In terms of skin irritation, this product is non-irritating, but prolonged or repeated contact may cause skin defatting; it is recommended to wear nitrile or neoprene gloves during operation. Eye contact may cause mild discomfort, such as redness and tearing, and it is advised to wear chemical safety goggles. Under normal use conditions, it has no significant harm to human health, but inhalation of oil mist or vapor should be avoided, and hands should be thoroughly washed after operation.

Impact on the Environment

Polypropylene glycol PPG-600 has low aquatic toxicity and is not easily bioaccumulated, making it an environmentally friendly chemical. However, large amounts of untreated product directly discharged into water bodies may still adversely affect aquatic ecosystems. According to the product safety instructions, effective measures should be taken during use to prevent leaks from entering sewers, surface water, or groundwater. Waste disposal should comply with local regulations, and it is recommended to incinerate or recycle at qualified waste treatment facilities; direct discharge into water bodies or soil is strictly prohibited.

Technical Parameters

Safety-Related Technical Indicators (Data Source: Guoli Chemical Database)

Parameter ItemValue\/Description
GHS ClassificationNot classified as a dangerous substance
Acute Toxicity (Oral, Rat)LD₅₀ > 2,000 mg\/kg (low toxicity)
Skin IrritationNon-irritating
Eye IrritationMay cause mild discomfort
Flash Point (Closed Cup)> 200 ℃ (not flammable at normal operating temperatures)
Aquatic ToxicityLow aquatic toxicity
BioaccumulationNot easily bioaccumulated
Transport ClassificationNot classified as dangerous goods
Heavy Metal Content≤10 mg\/kg
Arsenic Content≤2 mg\/kg

Application Recommendations

Given the low toxicity and good biocompatibility of polypropylene glycol PPG-600, it is widely used in fields that involve direct or indirect contact with the human body, such as cosmetics and pharmaceuticals:

  • Cosmetics Field: Can be used as a solvent, humectant, and skin feel modifier, with mild skin-friendly properties
  • Pharmaceutical Field: Can be used as a water-soluble base material for ointments and suppositories, with good drug release performance
  • Industrial Field: Used as a raw material for polyurethane synthesis, defoamer, base oil for lubricants, metalworking fluids, etc., safe and controllable under normal industrial operating conditions

Precautions

  • Maintain good ventilation during operation; processes involving heating or generating aerosols should be equipped with local exhaust ventilation
  • Store in a cool, dry, well-ventilated place, recommended temperature 5°C to 40°C, away from strong oxidizers and strong acids
  • In case of large spills, contain with inert absorbent material to prevent entry into water bodies; combustion may produce toxic fumes such as carbon monoxide; firefighters should wear self-contained positive-pressure breathing apparatus
  • Waste disposal must comply with local regulations; incineration or recycling recommended; direct discharge into the environment is prohibited
  • The above data is based on the Guoli Chemical Product Database and the product safety data sheet; please refer to the complete MSDS for specific use