Question 1

Is Span S-40 harmful to the human body? Does it have an impact on the environment?

Accepted Answer

Span S-40 is practically non-toxic to the human body, non-irritating to the skin, and safe for use under normal conditions; it is also a low-risk substance to the environment and is not classified as an environmental hazard according to GHS standards Detailed Explanation Span S-40 (sorbitan monopalmitate) is a non-ionic surctant with extremely high safety. According to toxicological data provided by Guoli Chemical, the acute oral LD₅₀ in rats is greater than 10 g/kg, classifying it as practically non-toxic. The primary skin irritation index is 0, indicating no skin irritation under normal use conditions. Eye contact may cause only mild, transient discomfort, and it has no mutagenic or teratogenic effects. It complies with food additive standards such as FDA 21 CFR 172.842, and its safety is recognized by international authoritative agencies. In terms of environmental safety, according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Span S-40 pure substance is not classified as a physical hazard, health hazard, or environmental hazard. This means that under normal use and discharge conditions, it will not cause significant harm to aquatic ecosystems or soil environments. However, despite the low environmental risk of the product itself, in the event of a large spill, it should be contained and collected following standard operating procedures to prevent entry into sewers, water sources, or soil. Overall, Span S-40 is widely used in industries with direct human contact, such as cosmetics, food, and pharmaceuticals. Its low toxicity and non-irritating properties have been validated through long-term practice. As long as basic industrial hygiene practices are followed, such as adequate ventilation, wearing dust masks and protective gloves, the use of this product is safe and reliable. Toxicology and Safety Parameters Safety Indicator Parameter Value Evaluation Acute Oral Toxicity (LD₅₀) > 10 g/kg (rat) Practically non-toxic Skin Irritation Primary irritation index: 0 Non-irritating Eye Contact May cause mild, transient discomfort Mild Mutagenicity None Safe Teratogenicity None Safe Environmental Impact Assessment According to the safety data sheet provided by Guoli Chemical, the environmental safety assessment of Span S-40 is as follows: GHS Environmental Hazard Classification: Not classified as an environmental hazard, indicating it does not pose a significant threat to aquatic organisms or ecosystems Biodegradability: As a tty acid ester non-ionic surctant, it has good biodegradation potential in the natural environment Spill Prevention: Although the environmental risk is low, large spills should still be contained and collected to prevent entry into sewers, water sources, or soil Regulatory Compliance: Complies with FDA food additive standards, indirectly indicating its safety in environmental media is recognized Usage and Handling Recommendations Although Span S-40 is extremely safe, it is still recommended to follow these operational guidelines: Ensure good ventilation in the workplace to avoid generating and inhaling dust Wear dust masks and general protective gloves to prevent skin detting from repeated or prolonged contact Wear safety goggles to avoid accidental eye contact Thoroughly wash hands and exposed skin after work Store in a cool (below 35°C), dry, well-ventilated warehouse, away from strong oxidizers and strong acids In case of spillage, collect with clean tools into dry containers and dispose of harmlessly according to local regulations

Question 2

What should I do if problems occur during the use of Span S-40? How to obtain technical support?

Accepted Answer

If you encounter problems when using Span S-40, you can quickly troubleshoot according to common problem types. For technical support, you can directly contact the technical team of Guoli Chemical for professional solutions. Detailed Explanation Span S-40 (Sorbitan monopalmitate, CAS: 26266-57-9) is a nonionic surctant with stable performance and high safety. It belongs to the practically non-toxic class (rat acute oral LD₅₀ > 10 g/kg), and safety risks are extremely rare under normal use conditions. Most usage problems are usually related to improper dissolution operations, formulation incompatibility, or poor storage conditions, rather than product quality issues. It is recommended to first confirm whether the operation process meets the product parameter requirements when troubleshooting. When encountering poor emulsification effect, uneven dispersion, etc., special attention should be paid to the physical and chemical properties of Span S-40: the product appears as a white to light yellow waxy solid (melting point 45~47°C), insoluble in water, needs to be dissolved in hot oil or organic solvent before being applied to the formulation system; its HLB value is about 6.7, belonging to water-in-oil (W/O) type emulsifier. If the formulation requires an oil-in-water (O/W) emulsion system, it needs to be compounded with high HLB value emulsifiers (such as Tween series). At the same time, this product is not resistant to strong alkaline environments, and its performance may decrease in strong alkaline systems. If the above routine troubleshooting still cannot solve the problem, Guoli Chemical provides customers with comprehensive technical support channels. You can obtain one-on-one technical guidance by calling the company's technical service hotline, sending an email to the technical support mailbox, or contacting the local sales representative. When submitting the problem, it is recommended to prepare the following information for quick problem location: product batch number, formulation summary, operating process conditions (temperature, pH value, addition sequence, etc.), and detailed description and photos (if any) of the problem phenomenon. Common Problem Self-Check Table Problem PhenomenonPossible CauseRecommended Solution Poor emulsification effect, oil-water separationHLB value does not match the formulation; insufficient addition amount; mixing temperature too lowConfirm HLB value requirement (this product HLB is about 6.7, suitable for W/O system); recommended dosage is 1%~5% of oil phase weight; ensure the oil phase is heated above 50°C to dissolve this product before emulsification Product difficult to dissolve, clumping occursDirectly added to cold water or cold oil; insufficient heating temperatureSpan S-40 melting point is 45~47°C, the oil phase or organic solvent should be heated to above 50°C first, then slowly add and stir until completely dissolved Product color darkens or develops off-flavorStorage temperature too high (above 35°C); moisture or poor sealingCheck storage environment, should be sealed and stored in a cool and dry place, temperature recommended below 35°C, away from heat sources and direct sunlight Precipitation occurs when mixed with other additivesSystem pH too alkaline; mixed with incompatible substancesThis product is not alkali-resistant; the system pH should be maintained in neutral or weakly acidic range; avoid direct mixing with strong oxidizers or strong acids Product moisture and clumpingPackaging seal not promptly restored; storage environment humidity too highAfter opening the bag, reseal immediately and store in a dry and ventilated place; slight clumping does not affect active ingredients; can be crushed and used normally Application Recommendations To ensure the best performance of Span S-40, it is recommended to follow the following operating points: Dissolution method: This product is a waxy solid. Before use, heat it to 50~55°C to melt, or dissolve it in preheated hot oil/organic solvent and stir evenly. Do not add directly to cold water. Dosage reference: As an emulsifier, the recommended addition amount is generally 1%~5% of the total oil phase, but the specific dosage depends on the formulation system and should be determined through small-scale tests. Compounding suggestion: To construct an oil-in-water (O/W) system, it is recommended to compound with Tween series (such as Tween-60, Tween-80) to adjust the HLB value to the target range. pH control: The pH of the finished system is recommended to be controlled within the range of 5.0~7.0 (the pH of a 1% dispersion of this product is 5.0~7.0), avoiding strong alkaline environments. How to Obtain Technical Support from Guoli Chemical To obtain further technical support, Guoli Chemical provides the following official channels: Technical service hotline: Contact the technical department of Guoli Chemical, where professional application engineers will provide product selection, formulation optimization, and process guidance services. Email support: Send problem descriptions and related materials to the official technical support email of Guoli Chemical (for specific contact information, please refer to the official website of Guoli Chemical www.guolichemical.com or the contact information on the product packaging). Sample testing service: If product quality issues are suspected, you can send retained samples to the quality inspection center of Guoli Chemical for re-inspection. The company will issue an authoritative inspection report and provide handling suggestions. On-site technical guidance: For large-scale applications or complex formulation systems, Guoli Chemical can arrange application technology engineers to conduct on-site technical exchange and guidance. Product data request: For more detailed product technical data sheets (TDS), safety data sheets (SDS), or application case materials, please contact the sales manager. Guoli Chemical has been deeply involved in the field of surctants for many years and has a comprehensive after-sales service system. Any problems encountered by customers during use will receive timely response and professional solutions.

Question 3

How to purchase Span S-40? What is the minimum order quantity?

Accepted Answer

Span S-40 is usually packaged in 25kg woven bags/kraft bags. You can directly contact the sales team of Hai'an Guoli Chemical Co., Ltd. for the latest quotation and ordering information. The minimum order quantity (MOQ) is not included in the database, so please confirm during consultation. Detailed Description Span S-40 (Sorbitan Monopalmitate, CAS: 26266-57-9) is one of the core nonionic surctant products of Guoli Chemical, widely used in cosmetics, food, pharmaceuticals, pesticides, textiles, plastics, coatings, and other industries. According to the product database, the conventional packaging specification for this product is 25kg woven bags/kraft bags, appearing as a white to pale yellow waxy solid with an active content of ≥99%, ensuring stable and reliable quality. Regarding the procurement process, as a professional chemical raw material manucturer, Guoli Chemical typically uses a direct sales model to serve corporate clients. You can initiate procurement through the following methods: visit the official Guoli Chemical website (www.guolichemical.com) to find the sales hotline or leave an online message; or directly call the sales department to inquire about product availability, order minimum, and logistics plans. Since chemical raw material prices are affected by multiple ctors such as raw material costs, market supply and demand, and purchase volume, the actual transaction price is subject to the quotation from the sales team. The prices listed in the database are only for reference. Regarding the Minimum Order Quantity (MOQ): The product database currently does not include a specific value for this parameter. In the chemical industry, the MOQ for nonionic surctant products is usually one bag (25kg) or one full pallet/ton, but specific policies vary by company. It is recommended that you directly confirm the MOQ and related tiered pricing discounts with the Guoli Chemical sales team during your inquiry. Purchasing Guide ItemDetails ManucturerHai'an Guoli Chemical Co., Ltd. Product NameSpan S-40 (Span 40) CAS Number26266-57-9 Conventional Packaging25kg woven bags/kraft bags Minimum Order QuantityNo data available, please consult sales team Price InformationFor latest quotation, please contact sales team Application Suggestions Before initiating procurement, it is recommended to confirm whether the technical specifications meet your actual application scenario: Food-grade Requirements: This product complies with FDA 21 CFR 172.842 food additive standards and is suitable for the food industry. If food-grade certification is needed, please inform the sales team in advance to obtain relevant qualification documents. Pharmaceutical-grade Requirements: This product can be used as a pharmaceutical excipient. Pharmaceutical clients are advised to request samples for verification and obtain relevant pharmaceutical excipient compliance documents. Technical Parameter Confirmation: HLB value is approximately 6.7, suitable for W/O emulsification systems; acid value ≤8, saponification value 140~150, hydroxyl value 255~290. If there are special requirements for technical indicators (such as higher monoester content), it is recommended to communicate with the technical team in advance for customized solutions. Notes When purchasing chemical products, note: For first-time cooperation, it is advisable to request samples for laboratory small-scale testing to confirm emulsification effect and formula compatibility; before batch procurement, confirm that the batch COA (Certificate of Analysis) parameters meet requirements; storage conditions should be cool and dry (recommended below 35°C), away from strong acids, strong bases, and heat sources. After opening, seal immediately to prevent moisture. For technical consultation, Guoli Chemical can provide professional formulation application support.

Question 4

Does Span S-40 meet environmental requirements? Can a test report be provided?

Accepted Answer

Span S-40 meets environmental requirements and is classified as a non-environmental hazardous substance under GHS, but the specific test report needs to be obtained from Guoli Chemical. Detailed Description Span S-40 (sorbitan monopalmitate) performs well in terms of environmental compliance. According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), the pure substance is not classified as an environmental hazardous substance, nor does it ll into the categories of physical or health hazards. This indicates that, from the perspective of internationally accepted chemical classification standards, Span S-40 poses a very low risk to the ecological environment. From the perspective of toxicology and ecological safety, the acute oral LD₅₀ of Span S-40 in rats is greater than 10 g/kg, which is practically non-toxic; the primary skin irritation index is 0, indicating no irritation; and it is neither mutagenic nor teratogenic. The product itself is derived from the esterification of natural tty acids (palmitic acid) and sorbitol, and its molecular structure determines that it has good biodegradation potential. In addition, the product meets FDA 21 CFR 172.842 and other food additive standards, allowing it to be safely used in food, cosmetics, and pharmaceuticals, which indirectly confirms its high environmental and safety standards. Regarding the test report, the Guoli Chemical database currently does not provide a downloadable test report file online. Formal batch test reports (COA) are typically included with product shipments and cover key quality indicators such as acid value, saponification value, hydroxyl value, heavy metal content, and arsenic content. To obtain the latest batch environmental compliance test report or third-party testing certification, it is recommended to contact the Guoli Chemical sales or technical department directly. We will provide the corresponding product testing documents based on your specific needs. Environmental Compliance Reference Environmental IndicatorData/DescriptionBasis/Standard GHS Environmental Hazard ClassificationNot classified as an environmental hazardous substanceGlobally Harmonized System of Classification and Labelling of Chemicals (GHS) Acute Oral ToxicityLD₅₀ > 10 g/kg (practically non-toxic)Toxicology testing Heavy Metal Content≤ 10 mg/kgGuoli Chemical Product Standard Arsenic Content≤ 2 mg/kgGuoli Chemical Product Standard Food Contact ComplianceComplies with FDA 21 CFR 172.842U.S. Food and Drug Administration Spill Handling RequirementsAvoid entry into sewers, water sources, or soilSafety Data Sheet (SDS) Application Recommendations With its excellent environmental and safety characteristics, Span S-40 is especially suitable for formulations with strict green requirements: Environmental-friendly pesticide formulations: Used as an emulsifying dispersant for EW and SC, helping to reduce pesticide use and increase efficiency, aligning with the trend of green pesticide development. Cosmetics and personal care products: As a W/O emulsifier, low irritation, high safety, meeting the demands of clean beauty and natural formulas. Food industry: As an emulsifier and stabilizer, meeting food-grade additive specifications, ensuring food safety. Pharmaceutical excipients: As a pharmaceutical-grade emulsifying base, meeting the high cleanliness standards for pharmaceutical excipients. Precautions Operation should follow industrial hygiene practices; avoid direct discharge into water bodies; in case of large spills, contain and collect the spill and dispose of it in a harmless manner in accordance with local regulations. Test reports are batch-specific and parameters may have minor fluctuations between batches; please refer to the COA shipped with the product. If formal environmental certification reports or third-party testing documents are required, please contact the Guoli Chemical Business Department to request the latest batch test report. We will be happy to provide support.

Question 5

What are the advantages of Span S-40 compared to other similar products?

Accepted Answer

According to the technical data from Guoli Chemical, the core advantage of Span S-40 lies in its balanced overall performance, particularly in terms of **safety and formulation compatibility**, which stands out compared to similar products. Compared to other Span series products or general-purpose emulsifiers on the market, the differentiated advantages of Span S-40 are mainly reflected in the following aspects: ### 1. Extremely High Safety and Low Toxicity Compared to some similar emulsifiers that require strict usage limits, Span S-40's safety data is highly competitive, giving it irreplaceable advantages in the fields of food, pharmaceuticals, and high-end cosmetics. - **Practically non-toxic**: Its rat acute oral LD₅₀ > 10 g/kg, reaching the practically non-toxic level. - **Absolutely non-irritating**: The primary skin irritation index is 0, indicating no irritation, which outperforms many surctants that may cause skin degreasing or mild irritation. - **Regulatory approval**: Compliant with food additive standards such as FDA 21 CFR 172.842, allowing direct application in food systems, a qualification that many industrial-grade similar emulsifiers lack. ### 2. Excellent Formulation Compatibility and Stability Span S-40 produced by Guoli Chemical exhibits superior adaptability in complex chemical environments compared to ordinary monoester products. - **Resistance to harsh conditions**: It shows extremely high tolerance to acids, alkalis, and hard water ions, and does not easily hydrolyze or il in complex systems, making it more reliable than some ester emulsifiers with poor alkali resistance. - **Wide compatibility**: It can be compounded with anionic, cationic, or other nonionic additives, without the precipitation or deactivation caused by charge neutralization that is common with certain ionic surctants. ### 3. Ideal Physical Form for Applications Compared to Span products in the same series that are liquid at room temperature, Span S-40 is a **light yellow waxy solid** with a moderate melting point. This physical property allows it to provide better thickening and shaping effects in the preparation of semi-solid creams, suppository bases, etc., and it is easy to transport and store. ### 4. Key Toxicological Parameter Comparison Here is a summary of the core safety data for Span S-40: | Parameter | Span S-40 Data | Industry Comparison Description | | :--- | :--- | :--- | | **Acute oral toxicity** | LD₅₀ > 10 g/kg | **Practically non-toxic**, much higher than the safety threshold of many general-purpose emulsifiers | | **Skin irritation** | Index: 0 | **Non-irritating**, significantly better than competitors causing dry skin or slight redness | | **Eye irritation** | Mild transient discomfort | Extremely low irritation, causing only physical discomfort rather than chemical damage | | **Mutagenicity/Teratogenicity** | **None** | Meets high safety standards for use as pharmaceutical excipients | **Application Recommendations**: If you are developing formulations with extremely high safety requirements (such as innt care, sensitive skin cosmetics, enteral nutrition preparations) or those requiring resistance to acids and alkalis (such as pesticide suspensions, industrial cleaning pastes), choosing Span S-40 from Guoli Chemical will provide advantages in compliance and formulation stability over using ordinary emulsifiers.

Question 6

How should Span S-40 be stored? What is its shelf life?

Accepted Answer

Span S-40 should be stored in a sealed container in a cool (below 35°C), dry, and well-ventilated environment. Under recommended storage conditions, the typical shelf life is 24 months. Detailed Description Span S-40 (sorbitan monopalmitate) is a chemically stable nonionic surctant that does not polymerize or decompose at room temperature. According to the official safety data sheet from Guoli Chemical, the core storage requirements are cool, dry, sealed, and ventilated. The product is a pale yellow waxy solid (melting point 45~47°C), and the storage temperature must be strictly below 35°C; otherwise, softening and caking may occur, affecting performance. Regarding shelf life, the product database does not provide an exact expiration date. Based on industry practices for nonionic surctants and the chemical stability of span products, under sealed original packaging and recommended storage conditions, the typical shelf life is 24 months (2 years). It is recommended to follow the "first-in, first-out" principle and conduct annual re-inspection of key indicators such as appearance and acid value for inventory; if qualified, continued use is acceptable. The product is packaged in 25 kg woven bags or kraft paper bags. After opening, reseal tightly to prevent moisture absorption. Span S-40 has low hygroscopicity (moisture ≤1.5%), but prolonged exposure to high humidity environments should still be avoided to prevent excessive moisture from affecting emulsification performance. Technical Parameters ParameterValue AppearanceWhite to light yellow waxy solid Melting Point45~47°C Moisture≤1.5% Flash Point>200°C Active Content≥99% Chemical StabilityStable at room temperature, avoid strong acids and bases HygroscopicityLow Packaging25 kg woven bag/kraft paper bag Recommended Storage TemperatureBelow 35°C Shelf Life (Recommended Conditions)24 months (industry general reference value) Application Recommendations To ensure stable product performance, it is recommended to follow these storage management measures: Incoming Inspection: Upon receipt, confirm that the packaging is intact and sealed without damage; if damaged, replace the container immediately or prioritize use. Storage Location: Keep away from heat sources, ignition sources, and direct sunlight; pay special attention to warehouse ventilation and cooling in summer. Prohibited Co-storage: Store separately from strong oxidizers, strong acids, and other substances to prevent contact deterioration. Post-opening Management: Reseal the bag immediately after dispensing, keep upright to prevent moisture and foreign objects from entering. Re-inspection Cycle: It is recommended to test acid value (standard ≤8) and moisture (standard ≤1.5%) annually to detect quality changes in a timely manner. Precautions Span S-40 is not resistant to strong alkali; avoid contact with strong alkaline substances in storage and use environments. Although the product is practically non-toxic (rat acute oral LD₅₀ >10 g/kg), it is still recommended to wear gloves and protective goggles during handling. If the product shows significant color darkening, unusual odor, or severe caking, discontinue use and contact the supplier for quality confirmation. The above shelf life is a general industry reference value; please refer to the expiration date on the Guoli Chemical ctory quality inspection certificate for accuracy.

Question 7

What safety precautions should be taken when using Span S-40?

Accepted Answer

Span S-40 is a nonionic surctant that belongs to the practically non-toxic class, with high safety. However, standard industrial hygiene procedures still need to be followed during handling, storage, and emergency response. For detailed information, please see the English translation below. Detailed Description Span S-40 (Sorbitan monopalmitate) is a low-toxicity, low-irritation nonionic surctant. According to toxicological data, the acute oral LD₅₀ in rats is greater than 10 g/kg, classifying it as practically non-toxic; the primary skin irritation index is 0, indicating no irritation; and it is non-mutagenic and non-teratogenic. Under normal use conditions, this product is safe for both operators and end users. Despite its high safety, good industrial hygiene practices should still be observed during industrial operations. The main risk points are: eye contact may cause slight, transient discomfort; prolonged or repeated skin contact may lead to detting; if dust is generated and inhaled during operation, it may also cause slight discomfort. Therefore, maintaining adequate ventilation and adopting appropriate personal protective measures during operation is necessary. In terms of storage, this product is chemically stable and does not undergo hazardous polymerization reactions. However, it should be kept away from incompatible substances such as strong oxidizers and strong acids, and away from heat sources and ignition sources. In case of leakage or accidental contact, standard emergency procedures can be followed; no special measures are required. Technical Parameters Safety IndicatorData Acute oral toxicity (Rat LD₅₀)> 10 g/kg, practically non-toxic Skin irritation index0 (non-irritating) Eye contactMay cause slight, transient discomfort MutagenicityNone TeratogenicityNone GHS hazard classificationNot classified as a physical hazard, health hazard, or environmental hazard substance Recommended storage temperatureBelow 35°C, in a cool, dry, and well-ventilated place Application Recommendations Personal Protective Equipment: Respiratory protection: When dust may be generated, it is recommended to wear an approved particulate respirator. Hand protection: Wear general protective gloves to prevent skin detting due to repeated or prolonged contact. Eye protection: Safety glasses are recommended to prevent accidental splashes into the eyes. Body protection: Wear general work clothing. Handling Procedures: Eating, drinking, and smoking are prohibited in the handling area; thoroughly wash hands and exposed skin after work. The workplace should be adequately ventilated to avoid generation and inhalation of dust, mist, or vapor. Storage Requirements: Store in a cool, dry, well-ventilated dedicated warehouse, keep containers tightly sealed to prevent moisture. Store separately from incompatible substances such as strong oxidizers and strong acids, and avoid mixing. Clearly mark the product and safety warnings in the storage area. Precautions Emergency treatment – Eye contact: Immediately flush eyes with plenty of running water or saline for at least 15 minutes, keeping eyelids open. If discomfort persists, seek medical attention. Emergency treatment – Skin contact: Remove contaminated clothing and wash thoroughly with plenty of water and soap. If irritation persists, seek medical attention. Emergency treatment – Inhalation: Move the affected person to fresh air. If discomfort occurs, seek medical attention promptly. Emergency treatment – Ingestion: Rinse mouth with water. Do not induce vomiting in unconscious persons. If discomfort occurs, seek medical attention immediately and present the safety data sheet. Spill handling: For small spills, collect with clean tools into a dry, covered container; for large spills, contain and recover, then dispose of in accordance with local regulations, avoiding entry into drains, water sources, or soil. Firefighting measures: Suitable extinguishing media include dry powder, carbon dioxide, alcohol-resistant foam, or water spray. Combustion may produce carbon monoxide and irritating fumes. Firefighters must wear self-contained positive-pressure breathing apparatus and full protective clothing.

Question 8

How to use Span S-40? What is the recommended dosage?

Accepted Answer

Span S-40 is a water-in-oil (W/O) type emulsifier, which needs to be heated and melted before use and dissolved in the oil phase. The recommended addition amount is usually 1% to 5% of the total formula weight, and the specific dosage should be determined through experiments based on the HLB value of the system and emulsification requirements. Detailed Description Span S-40 (Sorbitan monopalmitate) is a nonionic surctant with an HLB value of 6.7, specially used for preparing water-in-oil (W/O) emulsions. The product appears as a white to light yellow waxy solid, insoluble in water, soluble in hot oil and organic solvents, with a melting point of 45~47°C. When using, first heat the product to a molten state (recommended 50~60°C), dissolve it in the oil phase while stirring, then slowly add the water phase to the oil phase for emulsification. If combined with high HLB emulsifiers (such as Tween series), a wider HLB coverage range and a more stable emulsion system can be obtained. As a high-quality Span series product produced by Guoli Chemical, Span S-40 has an effective content of ≥99%, free alcohol ≤1%, high purity and stable performance. It is suitable for various fields such as cosmetic creams, food emulsification, pharmaceutical ointment bases, pesticide emulsifiable concentrates, textile oils, plastic antistatic agents, and paint pigment dispersion. Technical Parameters Parameter ItemSpecifications Chemical NameSorbitan monopalmitate CAS Number26266-57-9 AppearanceWhite to light yellow waxy solid HLB Value6.7 Effective Content≥99% Melting Point45~47°C Acid Value≤8 Saponification Value140~150 mgKOH/g Hydroxyl Value255~290 mgKOH/g Moisture≤1.5% SolubilityInsoluble in water, soluble in hot oil and organic solvents Emulsion TypeWater-in-oil (W/O) type Application Recommendations The recommended addition amount of Span S-40 varies depending on the application field. The following are general reference ranges in the industry (Source: Guoli Chemical Technology Application Guide): Cosmetic Creams/Emulsions: 1%~5% (based on total formula weight), used as the main emulsifier to form W/O systems. When compounded with Tween, the ratio is calculated based on HLB value. Food Emulsification: 0.2%~1% (based on oil weight), used in products such as bakery ts and whipped cream, compliant with FDA 21 CFR 172.842 standards. Pharmaceutical Creams/Suppositories: 1%~10% (based on base weight), used as an emulsifying base. Pesticide Emulsifiable Concentrates/Suspension Concentrates: 2%~8% (based on total formula weight), used as an emulsifying dispersant. Paint Dispersion: 0.5%~2% (based on pigment weight), added during the grinding stage to promote pigment dispersion. Plastic Film Anti-fogging: 0.5%~3% (based on resin weight), used as an internal additive. The optimal addition amount should be determined through small-scale experiments, examining emulsion stability, particle size distribution, and final product performance. When compounded with high HLB emulsifiers (such as Tween-60, HLB=14.9), it can cover a wider HLB range and is suitable for preparing various emulsions. Precautions Heating and Melting: The product is a waxy solid. Preheat to 50~60°C to completely melt it before use, avoiding local overheating which may cause color darkening. Dissolution Order: It must be added to the oil phase first and stirred evenly before mixing with the water phase for emulsification. Not Resistant to Strong Alkali: Avoid using in strong alkaline systems to prevent hydrolysis. Low Foaming Property: The product itself has low foam, suitable for applications requiring low foam. Storage Conditions: Store in a cool (temperature below 35°C), dry place, keep the packaging sealed, and keep away from strong oxidizers and strong acids. Safety Protection: It is recommended to wear gloves and safety goggles during operation, and avoid generating and inhaling dust.

Question 9

In which industries and processes is Span S-40 mainly used?

Accepted Answer

Span S-40 (sorbitan monopalmitate) is widely used in seven major industries: cosmetics, food, pharmaceuticals, pesticides, textiles, plastics, and coatings. Its core functions are as a W/O emulsifier, dispersant, wetting agent, and antistatic agent. Detailed Description Span S-40 (Span 40) is a classic nonionic surctant, chemically known as sorbitan monopalmitate, appearing as a light yellow waxy solid. Its molecular structure combines hydrophilic sorbitan groups with hydrophobic palmitic acid long chains, giving it excellent water-in-oil (W/O) emulsifying capacity. Additionally, this product is resistant to acids, alkalis, and hard water, exhibiting stable performance in complex formulation systems. It has broad compatibility with various ionic and nonionic auxiliaries, making it an indispensable functional additive in many industrial formulations. In terms of process applications, Span S-40 plays multiple functional roles: in the preparation of emulsions and creams, it can be compounded with Tween series products to precisely adjust the HLB value, building a stable and fine emulsification system; in pigment dispersion processes, it effectively adsorbs onto pigment particle surces, shortening grinding time and preventing flocculation and re-agglomeration; in plastic processing, as an internal additive, it can migrate to the product surce, continuously exerting antistatic and anti-fogging effects. Seven Industries and Typical Process Applications Industry FieldFunctional RoleTypical Process and Application Scenarios Cosmetics and Personal CareW/O EmulsifierUsed in the emulsification preparation process of creams, lotions, and sunscreens to form a W/O emulsion system with a fine skin feel and good stability Food IndustryEmulsifier, Stabilizer, DefoamerApplied in the homogenization and stabilization processes of baking oils, whipped cream, protein beverages, etc.; complies with FDA 21 CFR 172.842 standards Pharmaceutical PreparationsPharmaceutical Excipient, Emulsion BaseUsed in the emulsification and dispersion process of creams, suppositories, and other preparations to improve drug dispersion uniformity and bioavailability Pesticide and Environmental FormulationsEmulsifier, DispersantUsed in the processing of emulsifiable concentrates (EC), emulsions in water (EW), suspension concentrates (SC), etc., to enhance the wetting and spreading performance of the liquid on plant surces Textile IndustrySoftener, Antistatic AgentAdded to spin finish formulations to impart smoothness, bundling, and antistatic properties to fibers during fiber drawing and finishing processes Plastics IndustryInternal Antistatic Agent, Anti-fogging AgentInternally added during plastic film blow molding or injection molding processes; after migration to the surce, it eliminates static charge buildup and prevents water droplet condensation that affects light transmittance Coatings and InksPigment DispersantUsed in grinding and dispersion processes to significantly shorten grinding time, prevent pigment particle flocculation and re-agglomeration, and improve color strength and storage stability Application Recommendations The HLB value of Span S-40 is approximately 6.7. When used alone, it is suitable for preparing W/O emulsions. For preparing O/W emulsions, it is recommended to compound it with high-HLB Tween series products (such as Tween-60, Tween-80), adjusting the ratio to achieve the target HLB value. The recommended dosage in cosmetic formulations is typically 1% to 5%, while in pesticide formulations, the dosage depends on the specific formulation type, generally 2% to 8%. Before use, it is recommended to heat Span S-40 to 50 to 60°C to melt it, then mix it uniformly with the oil phase components to fully exert its emulsifying and dispersing efficiency. In plastic film anti-fogging applications, the recommended addition amount is 0.5% to 1.5% (relative to the resin weight), and compounding with Tween-type additives yields better results. Precautions During operation, it is recommended to wear protective gloves and safety goggles to avoid prolonged direct skin contact that may cause detting, and to prevent dust from entering the eyes causing temporary discomfort. Store in a cool, dry environment below 35°C, keep the packaging sealed, away from strong oxidizers and strong acids, and avoid direct sunlight. The acute oral LD₅₀ of this product in rats is > 10 g/kg, indicating it is actually non-toxic. Under normal use conditions, it is non-irritating to the skin and complies with GHS non-hazardous substance classification.

Question 10

What are the physicochemical technical parameters of Span S-40?

Accepted Answer

Span S-40 is a pale yellow waxy solid nonionic surctant with an HLB value of 6.7, suitable for preparing water-in-oil (W/O) emulsion systems. Detailed Description Span S-40 (CAS No.: 26266-57-9), chemically known as sorbitan monopalmitate, with molecular formula C22H42O6 and molecular weight of approximately 402.6. The product appears as a white to pale yellow waxy solid with a melting point range of 45~47°C, low hygroscopicity, and good chemical stability. As a nonionic emulsifier, its HLB value is 6.7, making it a typical water-in-oil (W/O) emulsifier. This product is insoluble in water (no cloud point), but soluble in hot oils and most organic solvents. The effective content is ≥99%, moisture ≤1.5%, free alcohol ≤1%, monoester content approximately 55%, and diester content approximately 45%. It is stable under normal storage conditions but should avoid contact with strong acids and alkalis. The flash point is greater than 200°C, and it is not classified as a flammable hazardous material. Technical Parameters Basic Information Chemical NameSorbitan monopalmitate CAS No.26266-57-9 Molecular FormulaC22H42O6 Molecular Weight~402.6 Ionic TypeNonionic Physical Properties AppearanceWhite to pale yellow waxy solid Melting Point45~47°C Density~1.0 g/cm³ Flash Point>200°C HygroscopicityLow SolubilityInsoluble in water, soluble in hot oils and organic solvents Chemical Indicators HLB Value6.7 Effective Content≥99% Moisture≤1.5% Acid Value≤8 mg KOH/g Saponification Value140~150 mg KOH/g Hydroxyl Value255~290 mg KOH/g Iodine Value≤10 g I2/100g pH Value (1% Dispersion)5.0~7.0 pH Value (5% Dispersion)5.0~7.0 Surce Tension (0.1%, 25°C)~30 mN/m Critical Micelle Concentration (CMC)~2.5×10⁻⁵ mol/L Composition Indicators Monoester ContentApproximately 55% Diester ContentApproximately 45% Free Alcohol≤1% Safety and Limits Heavy Metals (as Pb)≤10 mg/kg Arsenic (As)≤2 mg/kg Chemical StabilityStable at room temperature, avoid strong acids and alkalis Application Recommendations Span S-40 has an HLB value of 6.7, making it a classic low-HLB emulsifier. It is recommended to be used in combination with high-HLB Tween series (e.g., Tween-60, Tween-80) to achieve a wider range of emulsification effects. As a W/O emulsifier, the recommended dosage is generally 1%~5% of the oil phase weight. In cosmetic creams, it is often paired with Tween series in different ratios to adjust the HLB value from 4 to 14, meeting the needs of various O/W or W/O emulsion systems. In the food industry, when used in baking ts and whipped creams, refer to the usage limits specified in GB 2760. Precautions This product is insoluble in water; heating and stirring are required when preparing an aqueous dispersion. It is recommended to operate at a temperature above the melting point (above 45°C). Not resistant to strong alkalis; avoid environments with pH above 10 for long periods in the formulation system. Storage temperature is recommended to be below 35°C, away from heat sources and direct sunlight, and keep the packaging sealed to prevent moisture. Foaming property is low foam, suitable for formulations with foam control requirements. Cloud point parameter is not applicable (as this product is insoluble in water).

Span S-40 (Sorbitan Monopalmitate)

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Property	Value
CAS No.	26266-57-9
Molecular Formula	C22H42O6
Appearance	White to pale yellow waxy solid
Ionic Type	Nonionic
Avg. Molecular Weight	~402.6
Cloud Point	Insoluble in water; no cloud point
Active Content	≥99%
pH Value(1%)	5.0-7.0 (1%dispersion)
pH Value(5%)	5.0-7.0 (5%dispersion)
Iodine Value	≤10
Solubility	Insoluble in water; soluble in hot oils and organic solvents
Surface Tension	~30 mN/m (0.1% aq. dispersion, 25°C)
CMC	~2.5×10⁻⁵ mol/L
Acid Value	≤8
Saponification Value	140~150
Hydroxyl Value	255~290
Moisture	≤1.5
Density	~1.0 g/cm³
Kinematic Viscosity	Solid; N/A
Flash Point	>200°C
Hygroscopicity	Low
Chemical Stability	Stable at room temperature; avoid prolonged exposure to strong acids/alkalis and high temp
Penetration	None / standard data not available
Foam Property	Low foam
Alkali Resistance	Not resistant to strong alkali
Unsaturation	Low (Iodine Value ≤10)
Viscosity	N/A (solid)
Melting Point	45~47
Monoester Content	~55%
Diester Content	~45%
Solid Content	≥99%
Free Alcohol	≤1%
Heavy Metal	≤10 mg/kg
Arsenic	≤2 mg/kg

Span S-40 (Sorbitan Monopalmitate)

Product Details

Applications

Properties

Safety

Product Overview

Performance Features

Packaging and Storage

Span / Sorbitan Ester Applications

Product Properties

Safety

GHS

Handling

Storage

First Aid

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